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| 1 | Intraductal ultrasound substantiates diagnostics of bile duct strictures of uncertain etiology显示文摘AIM:To report the largest patient cohort study investigating the diagnostic yield of intraductal ultrasound (IDUS) in indeterminate strictures of the common bile duct.METHODS:A patient cohort with bile duct strictures of unknown etiology was examined by IDUS.Sensitivity,specificity and accuracy rates of IDUS were calculated relating to the definite diagnoses proved by histopathology or long-term follow-up in those patients who did not undergo surgery.Analysis of the endosonographic report allowed drawing conclusions with respect to the T and N staging in 147 patients.IDUS staging was compared to the postoperative histopathological staging data allowing calculation of sensitivity,specificity and accuracy rates for T and N stages.The endoscopic retrograde cholangio-pancreatography and IDUS procedures were performed under fluoroscopic guidance using a side-viewing duodenoscope (Olympus TJF 160,Olympus,Ltd.,Tokyo,Japan).All procedures were performed under conscious sedation (propofol combined with pethidine) according to the German guidelines.For IDUS,a 6 F or 8 F ultrasound miniprobe was employed with a radial scanner of 15-20 MHz at the tip of the probe (Aloka Co.,Tokyo,Japan).RESULTS:A total of 397 patients (210 males,187 females,mean age 61.43 ± 13 years) with indeterminate bile duct strictures were included.Two hundred and sixty-four patients were referred to the department of surgery for operative exploration,thus surgical histopathological correlation was available for those patients.Out of 264 patients,174 had malignant disease proven by surgery,in 90 patients benign disease was found.In these patients decision for surgical exploration was made due to suspicion for malignant disease in multimodal diagnostics (computed tomography scan,endoscopic ultrasound or magnetic resonance imaging).Twenty benign bile duct strictures were misclassified by IDUS as malignant while 14 patients with malignant strictures were initially misdiagnosed by IDUS as benign resulting in sensitivity,specificity and accuracy ratesof 93.2%,89.5% and 91.4%,respectively.In the subgroup analysis of malignancy prediction,IDUS showed best performance in cholangiocellular carcinoma as underlying disease (sensitivity rate,97.6%) followed by pancreatic carcinoma (93.8%),gallbladder cancer (88.9%) and ampullary cancer (80.8%).A total of 133 patients were not surgically explored.32 patients had palliative therapy due to extended tumor disease in IDUS and other imaging modalities.Ninety-five patients had benign diagnosis by IDUS,forceps biopsy and radiographic imaging and were followed by a surveillance protocol with a follow-up of at least 12 mo;the mean follow-up was 39.7 mo.Tumor localization within the common bile duct did not have a significant influence on prediction of malignancy by IDUS.The accuracy rate for discriminating early T stage tumors (T1) was 84% while for T2 and T3 malignancies the accuracy rates were 73% and 71%,respectively.Relating to N0 and N1 staging,IDUS procedure achieved accuracy rates of 69% for N0 and N1,respectively.Limitations:Pretest likelihood of 52% may not rule out bias and overinterpretation due to the clinical scenario or other prior performed imaging tests.CONCLUSION:IDUS shows good results for accurate diagnostics of bile duct strictures of uncertain etiology thus allowing for adequate further clinical management. | Tobias Meister Hauke S Heinzow Carina Woestmeyer Philipp Lenz Josef Menzel Torsten Kucharzik Wolfram Domschke Dirk Domagk | 2013 | World Journal of Gastroenterology2013，19，6： | 19 |
| 2 | Clinical outcome and predictors of survival after TIPS insertion in patients with liver cirrhosis显示文摘AIM:To determine the clinical outcome and predictors of survival after transjugular intrahepatic portosystemic stent shunt (TIPS) implantation in cirrhotic patients. METHODS:Eighty-one patients with liver cirrhosis and consequential portal hypertension had TIPS implantation (bare metal) for either refractory ascites (RA) (n= 27) or variceal bleeding (VB) (n = 54). Endpoints for the study were:technical success, stent occlusion and stent stenosis, rebleeding, RA and mortality. Clinical records of patients were collected and analysed. Baseline characteristics [e.g., age, sex, CHILD score and the model for end-stage liver disease score (MELD score), underlying disease] were retrieved. The Kaplan-Meier method was employed to calculate survival from the time of TIPS implantation and comparisons were made by log rank test. A multivariate analysis of factors influencing survival was carried out using the Cox proportional hazards regression model. Results were expressed as medians and ranges. Comparisons between groups were performed by using the Mann-Whitney Utest and the χ 2 test as appropriate. RESULTS:No difference could be seen in terms of age, sex, underlying disease or degree of portal pressure gradient (PPG) reduction between the ascites and the bleeding group. The PPG significantly decreased from 23.4 ± 5.3 mmHg (VB) vs 22.1 ± 5.5 mmHg (RA) before TIPS to 11.8 ± 4.0 vs 11.7 ± 4.2 after TIPS implantation (P = 0.001 within each group). There was a tendency towards more patients with stage CHILD A in the bleeding group compared to the ascites group (24 vs 6, P = 0.052). The median survival for the ascites group was 29 mo compared to > 60 mo for the bleeding group (P = 0.009). The number of radiological controls for stent patency was 6.3 for bleeders and 3.8 for ascites patients (P = 0.029). Kaplan-Meier calculation indicated that stent occlusion at first control (P = 0.027), ascites prior to TIPS implantation (P = 0.009), CHILD stage (P = 0.013), MELD score (P = 0.001) and those patients not having undergone liver transplantation (P = 0.024) were significant predictors of survival. In the Cox regression model, stent occlusion (P = 0.022), RA (P = 0.043), CHILD stage (P = 0.015) and MELD score (P = 0.004) turned out to be independent prognostic factors of survival. The anticoagulation management (P = 0.097), the porto-systemic pressure gradient (P= 0.460) and rebleeding episodes (P = 0.765) had no significant effect on the overall survival. CONCLUSION:RA, stent occlusion, initial CHILD stage and MELD score are independent predictors of survival in patients with TIPS, speaking for a close follow-up in these circumstances. | Hauke S Heinzow Philipp Lenz Michael Khler Frank Reinecke Hansjrg Ullerich Wolfram Domschke Dirk Domagk Tobias Meister | 2012 | World Journal of Gastroenterology2012，18，37： | 17 |
| 3 | BP神经网络在使用红外热像仪技术预测冬小麦产量中的应用(英文)显示文摘通过使用红外热像仪技术获得冬小麦冠层不同温度值,计算得到冬小麦主要需水阶段水分胁迫指标ICWSI(infrared crop water stress index)。并根据此数据,使用一次灌溉周期中3个时段不同的ICWSI的平均值作为输入因子,相应实测冬小麦产量作为输出因子,建立了BP神经网络模型对冬小麦的产量进行预测,本文采用三层BP神经网络,其拓扑结构为3-5-1,数据归一化处理后收敛性能增强。预测结果显示,平均相对误差最大只有3.42%;为了证实这一方法的优越性,同时建立了基于ICWSI和冬小麦产量关系的非线性函数的预测模型,预测结果与实际产量值进行比较,平均相对误差最大达到了18.87%。两种预测方法得到的不同预测结果表明,将红外热像仪技术与BP神经网络预测方法相结合,可以成功用来预测冬小麦产量,比使用非线性函数预测的效果更好,精度更高,可靠性更强,可以用于实际生产需要。 | 胡振方 张录达 王珏璇 Shamaila Z 曾爱君 宋坚利 刘亚佳 Wolfram S Joachim M 何雄奎 | 2013 | 光谱学与光谱分析2013，33，6： | 5 |
| 4 | Utilization of Thermal Infrared Image for Inversion of Winter Wheat Yield and Biomass显示文摘The present paper utilizes thermal infrared image for inversion of winter wheat yield and biomass with different technology of irrigation(drip irrigation,sprinkler irrigation,flood irrigation).It is the first time that thermal infrared image is used for predicting the winter wheat yield and biomass.The temperature of crop and background was measured by thermal infrared image.It is necessary to get the crop background separation index(CBSIL,CBSIH),which can be used for distinguishing the crop value from the image.CBSIL and CBSIH(the temperature when the leaves are wet adequately;the temperature when the stomata of leaf is closed completely) are the threshold values.The temperature of crop ranged from CBSIL to CBSIH.Then the ICWSI was calculated based on relevant theoretical method.The value of stomata leaf has strong negative correlation with ICWSI proving the reliable value of ICWSI.In order to construct the high accuracy simulation model,the samples were divided into two parts.One was used for constructing the simulation model,the other for checking the accuracy of the model.Such result of the model was concluded as:(1) As for the simulation model of soil moisture,the correlation coefficient(R2) is larger than 0.887 6,the average of relative error(Er) ranges from 13.33% to 16.88%;(2) As for the simulation model of winter wheat yield,drip irrigation(0.887 6,16.89%,-0.12),sprinkler irrigation(0.970 0,14.85%,-0.12),flood irrigation(0.969 0,18.87%,0.18),with the values of R2,Er and CRM listed in the parentheses followed by the individual term.(3) As for winter wheat biomass,drip irrigation(0.980 0,13.70%,0.13),sprinkler irrigation(0.95,13.15%,-0.14),flood irrigation(0.970 0,14.48%,-0.13),and the values in the parentheses are demonstrated the same as above.Both the CRM and Er are shown to be very low values,which points to the accuracy and reliability of the model investigated.The accuracy of model is high and reliable.The results indicated that thermal infrared image can be used potentially for inversion of winter wheat yield and biomass. | DU Wen-yong ZHANG Lu-da HU Zhen-fang Shamaila Z ZENG Ai-jun SONG Jian-li LIU Ya-jia Wolfram S Joachim M HE Xiong-kui | 2011 | 光谱学与光谱分析2011，31，6： | 3 |
| 5 | Epigallocatechin gallate supplementation alleviates diabetes in rodents 显示文摘 | Wolfram S Wang Y Riegger C | 2006 | J Nutr2006，136，： | 1 |
| 6 | Continuum percolation of wireless ad hoc communication networks 显示文摘 | Ingmar G Wolfram K Rudolf S | 2003 | Statistical Mechanics and its Applications2003，325，34： | 1 |
| 7 | Three-dimensional structure of the 'long' neurotoxin from cobra venom 显示文摘 | Malcolm D Wolfram S Alfred M | 1980 | Biochemistry1980，77，5： | 1 |
| 8 | Molecular cloningand relationship to freezing tolerance of cold-acclimation-specific genes of Alfalfa显示文摘 | Mohapatra S S Wolfram L Poole R J | 1989 | Plant Physiol1989，89，： | 1 |
| 9 | TEAVIGOTM (Epigallocatechin gallate) supplementation prevents obesity in rodents by reducing adipose tissue mass 显示文摘 | Wolfram S Raederstorff D Wang Y | 2005 | Ann Nutr Metab2005，49，： | 1 |
| 10 | Epigallocat-echin gallate supplementation alleviates diabetes in rodents显示文摘 | Wolfram S Raederstorff D PrellerM | 2006 | J Nutr2006，136，10： | 1 |
| 11 | Statistical Mechanics of Cellular Automata 显示文摘 | Wolfram S | 1983 | Reviews of Modern Physics1983，55，3： | 1 |
| 12 | Cellular automata as models of complexity显示文摘 | Wolfram S | 1984 | Nature1984，311，5985： | 1 |
| 13 | Cellular Automata as models of complexity 显示文摘 | Wolfram S | 1984 | Nature1984，311，4： | 1 |
| 14 | Cellular Automata as Models of Complexity显示文摘 | Wolfram S | 1984 | Nature1984，311，10： | 1 |
| 15 | Diet supple- mentation with green tea extract epigallocatechin gallate prevents progression to glucose intolerance in db/db mice 显示文摘 | Ortsfiter H Grankvist N Wolfram S | 2012 | Nutr Metab (Lond)2012，9，： | 1 |
| 16 | Ischemic preconditioning protects the steatotic mouse liver against reperfusion injury:an ATP dependent mechanism显示文摘 | Nazia S Markus S Wolfram J | 2003 | J Hepatol2003，39，： | 1 |
| 17 | TEAVIGO (epigallocatechin gallate) supplementation prevents obesity in rodents by reducing adipose tissue mass显示文摘 | Wolfram S Raederstorff D Wang Y | 2005 | Ann Nutr Metab2005，49，1： | 1 |
| 18 | Epigallocatechin gallate supplementation alleviates diabetes in rodents 显示文摘 | Wolfram S Raederstorff D Preller M | 2006 | J Nutr2006，136，10： | 1 |
| 19 | Anti-obesity effects of green tea: From bedside to bench 显示文摘 | Wolfram S Wang Y Thielecke F | 2006 | Mol Nutr Food Res2006，50，2： | 1 |
| 20 | Anti-obesity effects of green tea: from bedside to bench 显示文摘 | Wolfram S Wang Y Thielecke F | 2006 | Mol Nutr Food Res2006，50，2： | 1 |
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