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| 1 | Utility of arthroscopic guided synovial biopsy in understanding synovial tissue pathology in health and disease states显示文摘The synovium is the soft tissue lining diarthrodial joints, tendon sheaths and bursae and is composed of intimal and subintimal layers. The intimal layer is composed of type A cells(macrophages) and type B cells(fibroblasts); in health, the subintima has few inflammatory cells. The synovium performs several homeostatic functions and is the primary target in several inflammatory arthritides. Inflammatory states are characterised by thickening of the synovial lining, macrophage recruitment and fibroblast proliferation, and an influx of inflammatory cells including lymphocytes, monocytes and plasma cells. Of the various methods employed to perform synovial biopsies arthroscopic techniques are considered the 'gold standard', and have an established safety record. Synovial biopsy has been of critical importance in understanding disease pathogenesis and has provided insight into mechanisms of action of targeted therapies by way of direct evidence about eventsin the synovial tissue in various arthritides. It has been very useful as a research tool for proof of concept studies to assess efficacy and mechanisms of new therapies, provide tissue for in vitro studies, proteomics and microarrays and allow evaluation for biomarkers that may help predict response to therapy and identify new targets for drug development. It also has diagnostic value in the evaluation of neoplastic or granulomatous disease or infection when synovial fluid analysis is noncontributory. | Mihir D Wechalekar Malcolm D Smith | 2014 | World Journal of Orthopedics2014，5，5： | 4 |
| 2 | Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial显示文摘 | John Burn Anne-Marie Gerdes Finlay Macrae Jukka-Pekka Mecklin Gabriela Moeslein Sylviane Olschwang Diane Eccles D Gareth Evans Eamonn R Maher Lucio Bertario Marie-Luise Bisgaard Malcolm G Dunlop Judy WC Ho Shirley V Hodgson Annika Lindblom Jan Lubinski Pa | 2011 | The Lancet2011，，9809： | 3 |
| 3 | Bevacizumab plus oxaliplatin-based chemotherapy as adjuvant treatment for colon cancer (AVANT): a phase 3 randomised controlled trial显示文摘 | Aimery de Gramont Eric Van Cutsem Hans-Joachim Schmoll Josep Tabernero Stephen Clarke Malcolm J Moore David Cunningham Thomas H Cartwright J Randolph Hecht Fernando Rivera Seock-Ah Im Gy?rgy Bodoky Ramon Salazar Frédérique Maindrault-Goebel Einat Shacham- | 2012 | Lancet Oncology2012，，12： | 3 |
| 4 | 多重结局的多元Meta分析和多重治疗的网状Meta分析:原理、概念及实例显示文摘英国国家健康与临床优选研究所(NICE)等组织需要对现有研究获得的证据进行整合来指导决策,需要确定关于多重疗效及安全性结局的最佳治疗。但是,相关的研究不一定对所有关注的治疗或结局都进行了直接比较,多元Meta分析及网状Meta分析为如何确定最佳治疗这一问题提供了思路,该方法不仅考虑了直接证据,还利用了关联或间接的证据。本文中,研究者描述了这些方法学的重要概念及假设,并阐述关联及间接证据如何产生,同时通过图表说明这些证据在涉及多重结局和多重治疗的真实临床案例中如何使用。 | Richard D Riley Dan Jackson Georgia Salanti Danielle L Burke Malcolm Price Jamie Kirkham Ian R White 孙至佳(译) 张岩(译) 刘雪晴(译) 杨智荣(校) 孙凤(校) | 2018 | 英国医学杂志中文版2018，21，12： | 2 |
| 5 | A multicenter, double-blind, one-year study comparing safety and efficacy of atorvastatin versus simvastatin in patients witb hypercholesterolemia显示文摘 | Anthony Dart George Jerums Geoffrey Nicholson Michael d’Emden Ian Hamilton-Craig George Tallis James Best Malcolm West David Sullivan Peter Braes Donald Black | 1997 | The American Journal of Cardiology1997，，： | 2 |
| 6 | Effects of peroxynitrite-induced protein modifications on tyrosine phosphorylation and degradation 显示文摘 | Gow A J Duran D Malcolm S Ischiropoulos H | 1996 | Febs Lett1996，385，12： | 1 |
| 7 | Does anovulation exist in eumenorrheic women显示文摘 | MALCOLM C E CUMMING D C | 2003 | Obstet Gynecol2003，102，： | 1 |
| 8 | A comparison of the fine root component of a pure and mixed Coniferous stand显示文摘 | Mckay H M Malcolm D C | 1988 | CanadianJournal of Forestry Research1988，18，： | 1 |
| 9 | Spectroscopy and Dynamics of Ntromethane (CH3NO2) and Is Anionic States显示文摘 | ISOBEL C W MALCOLM A D FLUENDY | 2001 | Int J Mass Spcctrom2001，205，： | 1 |
| 10 | Size-fractionated nitrogen uptake and carbon fixation during a developing coccolithophore bloom in the North Sea during June 1999显示文摘 | Malcolm E Woodward S Robinson C Cummings D G Tarran G A Joint Ⅰ | 2002 | Deep-Sea Research Ⅱ2002，49，15： | 1 |
| 11 | Outcomes of the Arterial Switch Operation for Transposition of the Great Arteries: 25 Years of Experience显示文摘 | Tyson A. Fricke Yves d’Udekem Malcolm Richardson Clarke Thuys Mithilesh Dronavalli James M. Ramsay Gavin Wheaton Leeanne E. Grigg Christian P. Brizard Igor E. Konstantinov | 2012 | The Annals of Thoracic Surgery2012，，1： | 1 |
| 12 | Electron spin resonance detection of spin - trapped radicals formed during the glow- discharge electrolysis of aqueous solutions 显示文摘 | ANTHONY T DAVID L G MALCOLM D I | 1980 | J C S Faraday I1980，76，： | 1 |
| 13 | The evolution of the brow lift in aesthetic plastic显示文摘 | Paul Malcolm D MD Irvine | 2001 | Plast Reconstr Surg2001，108，5： | 1 |
| 14 | Multi element soil analysis: an assessment of its potential as an aid to archaeological in?terpretion显示文摘 | WILSON C A DAVIDSON D A MALCOLM S C | 2008 | Journal of Archaeological Science2008，35，： | 1 |
| 15 | Chlorination of humicmaterials: byproduct formation and chemical interpretations 显示文摘 | Reckhow D A Singer P C Malcolm R L | 1990 | Environmental Science and Technology1990，24，： | 1 |
| 16 | Diagnosis of patent ductus arteriosus in pretenn infants 显示文摘 | EVANS N MALCOLM G OSBORN D A | 2004 | Neoreviews2004，5，2： | 1 |
| 17 | Three-dimensional structure of the 'long' neurotoxin from cobra venom 显示文摘 | Malcolm D Wolfram S Alfred M | 1980 | Biochemistry1980，77，5： | 1 |
| 18 | Model predictive con- touting control for biaxial systems 显示文摘 | Lam D Manzie C Malcolm G | 2013 | IEEE Transac-tions on Control Systems Technology2013，21，2： | 1 |
| 19 | A survey of attitude representations显示文摘 | Shuster Malcolm D | 1993 | The Journal of the Astronautical Sciences1993，41，4： | 1 |
| 20 | Deterministic three-axis attitude deter-mination 显示文摘 | Malcolm D Shuster | 2004 | The Journal of the Astronautical Science2004，52，3： | 1 |
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