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| 1 | 一种由全球水循环产生的可能重要的CO_2汇显示文摘关于全球CO2汇的位置、大小、变化和机制目前仍不确定,还存有争议.在理论计算和野外观测数据证明的基础上发现,可能存在一种由全球水循环产生的重要的CO2汇(以溶解无机碳-DIC的形式).这个汇达到0.8013PgC/a(约占人类活动排放CO2总量的10.1%,或占所谓的遗漏CO2汇的28.6%),它是由水对CO2的溶解吸收形成的,并随着碳酸盐的溶解及水生植物光合作用对CO2的消耗的增加而显著增加.这部分汇中有0.5188PgC/a通过海上降水(0.2748PgC/a)和陆地河流(0.244PgC/a)进入海洋,有0.158PgC/a再次释放进入大气,还有0.1245PgC/a储存在陆地水生生态系统中.因此,净沉降是0.6433PgC/a.随着全球变暖引起的全球水循环的加强、CO2和大气圈中碳酸盐粉尘的增加,还有造林地区的增多(会引起土壤CO2的增加进而导致水中DIC浓度的增大),这部分汇也可能增加. | 刘再华 Wolfgang Dreybrodt 王海静 | 2007 | 科学通报2007，52，20： | 79 |
| 2 | Clinical characteristics and outcome of a cohort of 101 patients with hepatocellular carcinoma显示文摘AIM To conduct a cohort study of 101 patients with hepatocellular carcinoma (HCC) presenting to a tertiary care medical referral center in Germany between 1997 and 1999.METHODS AND RESULTS Data were retrospectively analyzed by chart review. In 95cases (72 males and 23 females) sufficient data were available for analysis. Twenty-five (29%)of 8.5 patients were HBsAg or anti-HBc positive,21/85 (25%) were anti-HCV positive, and 6/85(7%) were positive for both HBV and HCV-markers. Age was significantly lower in HBV-positive patients than in the other two groups.Thirty-one (34%) of 90 patients had histories of alcohol abuse, In 79/ 94 (84%) patients,cirrhosis was diagnosed. Of these cirrhotic patients, 29/79 (37%) belonged to Child-Pugh's group (CHILD) A, 32/79 (40%) to CHILD B, and 18/79 (23%) to CHILD C. AFP was elevated in 61/91 (67%) patients. A single tumor nodule was found in 38/94 (40%), more than one nodule in 31/94 (34%), and 25/94 (26%) had a diffusely infiltrating tumor, i.e. the tumor margins could not be seen on imaging procedures. Portal vein thrombosis was present in 19/ 94 (20%).Imaging data consistent with lymph node metastases were found in 10/92 (11%), while distant metastases were found in 8/93 (9%).According to Okuda 28/94 (30%) were grouped to stage Ⅰ, 53/94 (56%) were grouped to stage Ⅱ, and 13/94 (14%) were grouped to stage Ⅲ.Survival data were available for 83 patients. The Kaplan-Meier estimate for median survival was 8.4 months. Factors influencing survival were the Okuda score, the presence of portal vein thrombosis, and the presence of ascites. The presence of non-complicated liver cirrhosis by itself, distant metastases, or infection with hepatitis viruses did not influence survival. AFP positivity by itself did not influence survival,though patients with an AFP value greater than 100μg/L did experience shortened survival.Treatment besides tamoxifen or supportive care was associated with prolonged survival. The influence of therapy on survival was most pronounced in Okuda stage Ⅱ patients. There was longer survival in those Okuda stage Ⅱpatients who were treated with percutaneous ethanol injection.CONCLUSION Even in a Iow incidence area such as Germany, the majority of HCC is caused by viral hepatitis and therefore potentially preventable. Reflecting the high proportion of advanced stage tumors in our patients, the median survival was poor. Patients who received active therapy had a longer survival. | Christian Rabe Tillmann Pilz Christoph Klostermann Marc Berna Hans H.Schild Tilman Sauerbruch Wolfgang H.Caselmann | 2001 | World Journal of Gastroenterology2001，7，2： | 60 |
| 3 | Anaerobic microbiologically influenced corrosion mechanisms interpreted using bioenergetics and bioelectrochemistry: A review显示文摘Microbiologically influenced corrosion(MIC) is a major cause of corrosion damages, facility failures, and financial losses, making MIC an important research topic. Due to complex microbiological activities and a lack of deep understanding of the interactions between biofilms and metal surfaces, MIC occurrences and mechanisms are difficult to predict and interpret. Many theories and mechanisms have been proposed to explain MIC. In this review, the mechanisms of MIC are discussed using bioenergetics, microbial respiration types, and biofilm extracellular electron transfer(EET). Two main MIC types, namely EET-MIC and metabolite MIC(M-MIC), are discussed. This brief review provides a state of the art insight into MIC mechanisms and it helps the diagnosis and prediction of occurrences of MIC under anaerobic conditions in the oil and gas industry. | Yingchao Li Dake Xu Changfeng Chen Xiaogang Li Ru Jia Dawei Zhang Wolfgang Sand Fuhui Wang Tingyue Cu | 2018 | Journal of Materials Science & Technology2018，34，10： | 43 |
| 4 | Assessment of metastatic liver disease in patients with primary extrahepatic tumors by contrast-enhanced sonography versus CT and MRI显示文摘瞄准:与已知的额外的肝的原发性瘤对包括 CT, MRI 和临床 / 组织学的数据的联合标准答案在病人在肝转移的察觉用 SonoVue 评估提高对比的 ultrasonography (CEUS ) 。方法:它是一国际多集中学习,并且有 12 个中心和 125 个病人(64 男性, 61 女性,变老 59+/-11 年) 包含,与 102 个病人一起每协议。原发性瘤是在 35% 表面的颜色,在 27% 的胸,在 17% 胰腺并且其它在 21% 。用 SonoVue 的 CEUS 用西门子 Elegra, Philips HDI 5000 和 Acuson 红杉与一种 low-mechanical-index 技术和对比特定的软件被采用;为至少五分钟的连续扫描。结果:有 SonoVue 的 CEUS 显著地增加了检测的焦点的肝损害对 unenhanced sonography 的数字。在 31.4% 病人,更多的损害在对比改进以后被发现。检测的损害的全部的数字与 CEUS (55 ) 是可比较的,三倍阶段的螺线 CT (61 ) 和有一个肝特定的对比代理人(53 ) 的 MRI。变形疾病的察觉的精确性(即至少一变形损害) 比为 unenhanced sonography (81.4%) 为 CEUS (91.2%) 是显著地更高的并且类似于三倍阶段的螺线 CT (89.2%) 的。在其 CEUS 检查否定的 53 个病人,后续考试 3-6 瞬间以后在 50 个病人(94.4%) 证实了变形损害的缺席。结论:CEUS 被证明在在有已知的额外的肝的原发性瘤的病人的肝转移的察觉可靠并且怀疑肝损害。 | Christoph F Dietrich Wolfgang Kratzer Deike Strobel Etienne Danse Robert Fessl Alfred Bunk Udo Vossas Karlheinz Hauenstein Wilhelm Koch Wolfgang Blank Matthijs Oudkerk Dietbert Hahn Christian Greis | 2006 | World Journal of Gastroenterology2006，12，11： | 39 |
| 5 | 不同沉积环境及成熟度干酪根的碳氢同位素地球化学特征显示文摘干酪根的碳同位素组成与源岩类型有无相关性存在不同认识,此次研究表明,在陆相沉积条件下,腐泥型干酪根相对富集轻碳同位素^(12)C(δ^(13)C一般小于-28‰),腐殖型干酪根相对富集重碳同位素^(13)C(δ^(13)C一般大于-26‰)。热模拟实验表明,热演化过程对干酪根碳同位素不产生明显影响,但其H/C原子比随热演化程度增高而减小。已有资料对干酪根氢同位素研究较少,本文研究表明,干酪根的氢同位素组成主要与沉积介质的盐度有关。笔作者将干酪根氢同位素组成δD=-130‰作为源岩沉积介质为淡水和咸水一半咸水的界限,前者小于-130‰,后者大小-130‰。 | 王万春 徐永昌 Manfred Schidlowski Eckhard Faber Wolfgang Stahl | 1997 | 沉积学报1997，15，A12： | 37 |
| 6 | 陆地水-碳酸盐-CO_2-水生光合生物相互作用产生碳汇的重要性(英文)显示文摘全球变化科学最重要的问题之一是如何平衡大气CO2收支.至今仍存在每年10亿吨级的陆地碳汇不知去向,即所谓的'遗失碳汇'问题.这些不明碳汇的位置、量级、变化和形成机制目前仍不确定,并存在巨大争议.尽管全球变化和岩石化学风化的正相关关系已体现在大气CO2的地球化学模型中,但这一反馈被认为只在地质长时间尺度起作用,因此,针对人类活动对碳收支影响的讨论时常不考虑风化碳汇的贡献.本文基于岩石风化研究的最新进展,并综合水生生态系统碳泵效应研究的成果,发现陆地水-碳酸盐-CO2-水生光合生物相互作用产生的碳汇不仅很重要(每年近5亿吨碳),而且在气候变暖和土地利用变化的影响下呈现显著的增加趋势,因此,必须包括在现今全球碳收支的评价中. | 刘再华 Wolfgang Dreybrodt | 2015 | Science Bulletin2015，60，2： | 38 |
| 7 | Regulation of Pain and Itch by TRP Channels显示文摘Nociception is an important physiological process that detects harmful signals and results in pain perception. In this review, we discuss important experimental evidence involving some TRP ion channels as molecular sensors of chemical, thermal, and mechanical noxious stimuli to evoke the pain and itch sensations.Among them are the TRPA1 channel, members of the vanilloid subfamily(TRPV1, TRPV3, and TRPV4), and finally members of the melastatin group(TRPM2, TRPM3,and TRPM8). Given that pain and itch are pro-survival,evolutionarily-honed protective mechanisms, care has to be exercised when developing inhibitory/modulatory compounds targeting specific pain/itch-TRPs so that physiological protective mechanisms are not disabled to a degree that stimulus-mediated injury can occur. Such events have impeded the development of safe and effective TRPV1-modulating compounds and have diverted substantial resources. A beneficial outcome can be readily accomplished via simple dosing strategies, and also by incorporating medicinal chemistry design features during compound design and synthesis. Beyond clinical use,where compounds that target more than one channel might have a place and possibly have advantageous features,highly specific and high-potency compounds will be helpful in mechanistic discovery at the structure-function level. | Carlene Moore Rupali Gupta Sven-Eric Jordt Yong Chen Wolfgang B.Liedtke | 2018 | Neuroscience Bulletin2018，34，1： | 39 |
| 8 | 积雪和有机质土对青藏高原冻土活动层的影响显示文摘随着全球气候变暖,青藏高原冻土活动层正在逐渐加深,为了理解积雪和表层有机质土壤对冻土活动层的影响机理,一维水热耦合模型CoupModel被用于模拟气象驱动下土壤冻融的动态过程.基于祁连山冰沟和青藏高原唐古拉站长期监测数据,CoupModel模型被成功的率定和验证.在冰沟站验证的模型被用于研究积雪对冻土活动层的影响,结果显示:目前较浅积雪情景(雪深<20cm)比完全忽略积雪的情景模拟的冬季土壤冻结深度深,说明青藏高原现状下较浅的积雪有利于冻土发育.原因是雪面较高的反照率造成地表吸收的太阳辐射减少,导致雪面温度较低,加之浅雪的阻热性能又较小,综合导致浅雪覆盖时表层土壤向大气释放的能量增加.但随着积雪深度逐渐增加,模拟的冬季土壤冻结深度反而越来越浅,说明较厚的积雪(>20cm的雪深)并不利于冻土的发育,主要是雪相对于空气低的热传导隔绝了表层土壤向大气的热损失.在唐古拉站验证的模型被用于研究有机质土对冻土活动层的影响,结果显示:随着有机质土壤深度增加,模拟的活动层夏季融化深度逐渐较小.有机质土壤较矿物质土壤低的热传导和高的热容性质减少了下伏土壤热状况对太阳辐射和气温波动的响应,说明有机质土有利于冻土的保护. | 张伟 周剑 王根绪 Wolfgang Kinzelbach 程国栋 叶柏生 何晓波 李弘毅 | 2013 | 冰川冻土2013，35，3： | 33 |
| 9 | Further Information of the Associated Li Deposits in the No.6 Coal Seam at Jungar Coalfield, Inner Mongolia, Northern China显示文摘Total 138 coal samples and 14 parting samples were taken from the No. 6 Seam of the Jungar Coalfield, Inner Mongolia. These samples were analysed by optical microscopy, sequential chemical extraction procedure (SCEP), inductively coupled plasma mass spectrometry (ICP-MS), X-ray powder diffraction (XRD), and scanning electron microscope in conjunction with an energy-dispersive X-ray spectrometer (SEM-EDX) analysis. The results indicate that the Li contents have reached the industrial grade of the coal associated Li deposit, and the total Li reserves have reached 2406600 tons, that is, 5157000 tons Li2O in the No. 6 seam in the Jungar Coalfield. The sequential chemical extraction procedure results suggest that the Li concentration is mainly related to inorganic matter. The minerals in the coals consist of kaolinite, boehmite, chlorite-group mineral, quartz, calcite, pyrite, siderite and amorphous clay material. Some Li could be absorbed by clay minerals in the Li-bearing coal seam. The chlorite phase?could be?most likely the host for a part of Li. The Yinshan Oldland should be the most possible source of Li of the coal. | SUN Yuzhuang ZHAO Cunliang LI Yanheng WANG Jinxi ZHANG Jianya JIN Zhe LIN Mingyue Wolfgang KALKREUTH | 2013 | Acta Geologica Sinica(English Edition)2013，87，4： | 33 |
| 10 | Hepatic steatosis is associated with an increased risk of carotid atherosclerosis显示文摘AIM: Although an association between helatic steatosis and vascular risk factors has been described, direct relationships between fatty liver and atherosclerosis have not yet been investigated. The aim of the present study has been to investigate those relationships.METHODS: The Study of Health in Pomerania examined a random population sample aged between 20 and 79 years.A study population of 4 222 subjects without hepatitis B and C infections and without liver cirrhosis was available for the present analysis. Hepatic steatosis was defined sonographically and intima-media thickness (IMT) as well as plaque prevalence were estimated by carotid ultrasound.RESULTS: The prevalence rate of hepatic steatosis was 29.9%. Among subjects aged ≥45 years, an association between hepatic steatosis and IMT of the carotid arteries was found in bivariate analysis, but not after adjustment for atherosclerotic risk factors. Individuals with fatty liver had more often carotid plaques than persons without fatty liver (plaque prevalence rate 76.8% vs 66.6%; P<0.001).This association persisted after adjustment for confounding factors and was predominantly present in subjects with no to mild alcohol consumption.CONCLUSION: There is an independent association between hepatic steatosis and carotid atherosclerotic plaques. Metabolic changes due to nonalcoholic fatty liver disease may explain this relationship. | Henry V(o|¨)lzke Daniel M.Robinson Volker Kleine Roland Deutscher Wolfgang Hoffmann Jan Lüdemann Ulf Schminke Christof Kessler Ulrich John | 2005 | World Journal of Gastroenterology2005，11，12： | 29 |
| 11 | 结构有序、双重孔隙中孔炭材料的合成与表征(英文)显示文摘 采用纳米涂层技术,以介孔分子筛SBA 15为模板,在其纳米孔道内引入糠醇/草酸溶液,经原位聚合,炭化后制得炭/SBA 15复合物。采用化学法脱除模板后制得具有规则结构的中孔炭。高分辨TEM表征结果显示该中孔炭是由纳米炭管相互联接、堆积而成,且具有六方对称结构。氮吸附结果显示其比表面积高达2000m2/g,孔径呈双峰分布。孔径相对较大的孔隙来源于SBA 15孔道经纳米涂层后所保留的孔隙;孔径相对较小的孔隙来源于SiO2移除后遗留的纳米孔空间。该方法可应用于以其他多孔氧化硅为模板制备新型纳米复合物的研究过程。 | 陆安慧 Wolfgang Schmidt Ferdi Schütth | 2003 | 新型炭材料2003，18，3： | 28 |
| 12 | Cryoablation of malignant liver tumors: results of a single center study显示文摘BACKGROUND: Local ablative procedures such as cryo-surgery and thermo-ablation are increasingly employed as a supplement to liver resection for the therapy of primary and secondary liver tumors. It is still unclear if the survival time can be extended through local ablative procedures. This prospective study shows operative actions, complications and long-term follow-up of 19 patients undergoing cryotherapy. METHODS: Between 1997 and 1998, 19 patients underwent cryotherapy due to a non-resectable malignant liver tumor (17 patients with metastases of a colon carcinoma, 2 patients with a hepatocellular carcinoma). Twelve patients (63.2%) received cryotherapy only and seven patients (36.8%) received a combination of resection and cryotherapy. The median follow-up period was 23 months. RESULTS: In a total of 59 liver tumors (18 were resected and 41 received cryotherapy), 12 had cryotherapy only, and 7 had a combination of cryotherapy and resection. The 30-day lethality was 0%, and the rate of major complications was 21%. After one year, 27.3% of the patients were still recurrence- free. The recurrence rate for all tumors treated was 58.8%. The median survival time for all patients was 21 months. The one- and three-year survival rates were 62. 5% and 15.8%, respectively. CONCLUSIONS: The mortality for cryotherapy is low, but there is a high rate of complications and long-term tumor control is not sufficient. If local ablative procedures of hepatic lesions are to be performed, not laparotomy but percutaneous, percutaneous thermoablation should be discussed as an alternative therapeutic measure. | Wolfgang Jungraithmayr Dieter Burger Manfred Olschewski Stefan Eggstein | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，4： | 26 |
| 13 | 也谈h指数的机会和局限性显示文摘传统的文献计量学指标工具是建立在包括均值、相对频次和分位数等简单统计函数基础之上的。这些基于论文和引文的统计已被证明是测度科研活动和科研绩效的一种有效工具,尤其是那些标准化的指标在宏观和中观层面的比较中很有优势。但是,将其用在对科学家个人科研绩效的评估即微观层面的计估仍然存在很多问题。 | Wolfgang Gl nzel 刘俊婉 金碧辉 | 2006 | 科学观察2006，1，1： | 26 |
| 14 | 大别造山带北部卢镇关杂岩的U-Pb锆石年龄显示文摘对大别造山带北部卢镇关杂岩的2个花岗片麻岩和1个斜长角闪岩的U-Pb锆石同位素年龄测定,得到其分别为740Ma和725Ma左右的原岩年龄.此结果表明卢镇关杂岩主要由新元古代酸性和基性岩浆岩组成,指示大别造山带东段北部不存在代表华北陆块南缘古生代活动大陆边缘的岩石组合.据此年龄并结合地质和地球物理资料,将北淮阳带的中低变质岩分为以新元古代酸性和基性岩浆岩为主体的卢镇关杂岩,新元古代仙人冲组和祥云寨组及泥盆纪佛子岭群诸佛庵组和潘家岭组3部分,并推断南北陆块间的缝合线逆掩在北淮阳带之下. | 江来利 Wolfgang Siebel 陈福坤 刘贻灿 储东如 | 2005 | 中国科学(D辑)2005，35，5： | 23 |
| 15 | A possible important CO_2 sink by the global water cycle显示文摘The locations,magnitudes,variations and mechanisms responsible for the global CO2 sink are uncer-tain and under debate.Here,we show,based on theoretical calculations and evidences from field monitoring results,that there is a possible important CO2 sink(as DIC-dissolved inorganic carbon)by the global water cycle.The sink constitutes up to 0.8013 Pg C/a(or 10.1% of the total anthropogenic CO2 emission,or 28.6% of the missing CO2 sink),and is formed by the CO2 absorption of water and subsequent enhanced consumption by carbonate dissolution and aquatic plant photosynthesis.Of the sink,0.5188 Pg C/a goes to sea via precipitation over sea(0.2748 Pg C/a)and continental rivers(0.244 Pg C/a),0.158 Pg C/a is released to the atmosphere again,and 0.1245 Pg C/a is stored in the continental aquatic ecosystem.Therefore,the net sink could be 0.6433 Pg C/a.This sink may increase with the global-warming-intensified global water cycle,the increase in CO2 and carbonate dust in atmosphere,and reforestation/afforestation,the latter increasing soil CO2,and thus the concentration of the DIC in water. | LIU ZaiHua Wolfgang DREYBRODT WANG HaiJing | 2008 | Chinese Science Bulletin2008，53，3： | 22 |
| 16 | 埃森创伤问卷中文版的信度和效度研究显示文摘目的对埃森大学医院心身科编制的埃森创伤问卷(ETI)进行初步的修订和信度效度检验。方法收集1120名受试者,分为心理患者组、躯体患者组、地震受灾组以及健康对照组,分别使用ETI进行测试,分析ETI中文版的信度、结构效度及效标效度。结果ETI共23个项目的总体信度克隆巴赫系数为0.94,各维度的相关性系数为0.69~0.80,提示有较好的内部一致性。因子分析得到3个因子结构(包括闯入、回避、分离);效标关联效度理想。结论修订的ETI具有较高的信度和效度。 | 周娟 周肖榕 李航 董非 王琳丽 鄢利福 刘欢 江瑞芳 余萍 邬晓艳 陈静 刘莉 Sefik Tagay Wolfgang Senf 施琪嘉 | 2010 | 中华物理医学与康复杂志2010，32，2： | 22 |
| 17 | Diet therapy for inflammatory bowel diseases: The established and the new显示文摘Although patients with inflammatory bowel diseases(IBD) have a strong interest in dietary modifications as part of their therapeutic management, dietary advice plays only a minor part in published guidelines. The scientific literature shows that dietary factors might influence the risk of developing IBD, that dysbiosis induced by nutrition contributes to the pathogenesis of IBD, and that diet may serve as a symptomatic treatment for irritable bowel syndrome-like symptoms in IBD. The role of nutrition in IBD is underscored by the effect of various dietary therapies. In paediatric patients with Crohn's disease(CD) enteral nutrition(EN) reaches remission rates similar to steroids. In adult patients, however, EN is inferior to corticosteroids. EN is not effective in ulcerative colitis(UC). Total parenteral nutrition in IBD is not superior to steroids or EN. The use of specific probiotics in patients with IBD can be recommended only in special clinical situations. There is no evidence for efficacy of probiotics in CD. By contrast, studies in UC have shown a beneficial effect in selected patients. For patients with pouchitis, antibiotic treatment followed by probiotics, like VSL#3 or Lactobacillus GG, is effective. When probiotics are used, the risk of bacterial translocation and subsequent bacteremia has to be considered. More understanding of the normal intestinal microflora, and better characterization of probiotic strains at the phenotypic and genomic levels is needed as well as clarification of the mechanisms of action in different clinical settings. A FODMAP reduced diet may improve symptoms in IBD. | Franziska Durchschein Wolfgang Petritsch Heinz F Hammer | 2016 | World Journal of Gastroenterology2016，22，7： | 22 |
| 18 | Detection of disseminated pancreatic cells by amplification of cytokeratin-19 with quantitative RT-PCR in blood,bone marrow and peritoneal lavage of pancreatic carcinoma patients显示文摘AIM: To evaluate the diagnostic potential of cytokeratin-19 (CK-19) mRNA for the detection of disseminated tumor cells in blood, bone marrow and peritoneal lavage in patients with ductal adenocarcinoma of the pancreas. METHODS: Sixty-eight patients with pancreatic cancer (n = 37), chronic pancreatitis (n = 16), and non-pan- creatic benign surgical diseases (n = 15, control group) were included in the study. Venous blood was taken preoperatively, intraoperatively and at postoperative d 1 and 10. Preoperative bone marrow aspirates and peritoneal lavage taken before mobilization of the tumor were analyzed. All samples were evaluated for disseminated tumor cells by CK-19-specific nested-PCR and quantitative fluorogenic RT-PCR. RESULTS: CK-19 mRNA expression was increased in 24 (64%) blood samples and 11 (30%) of the peritoneal lavage samples in the patients with pancreatic cancer. In 15 (40%) of the patients with pancreatic cancer, disseminated tumor cells were detected in venous blood and bone marrow and/or peritoneal lavage. In the peritoneal lavage, the detection rates were correlated with the tumor size and the tumor differentiation. CK-19 levels were increased in pT3/T4 and moderately/poorly differentiated tumors (G2/G3). Pancreatic cancer patients with at least one CK-19 mRNA-positive sample showed a trend towards shorter survival. Pancreatic cancerpatients showed significantly increased detection rates of disseminated tumor cells in blood and peritoneal lavage compared to the controls and the patients with chronic pancreatitis. CONCLUSION: Disseminated tumor cells can be detected in patients with pancreatic ductal adenocar- cinoma by CK-19 fluorogenic RT-PCR. In peritoneal lavage, detection rate is correlated with tumor stage and differentiation. In the clinical use, CK-19 is suitable for the distinction between malignant and benign pancreatic disease in combination with other tumor-specific markers. | Katrin Hoffmann Christiane Kerner Wolfgang Wilfert Marc Mueller Joachim Thiery Johann Hauss Helmut Witzigmann | 2007 | World Journal of Gastroenterology2007，13，2： | 20 |
| 19 | In vitro activity of moxifloxacin and piperacillin/sulbactam against pathogens of acute cholangitis显示文摘AIM: To analyze the in vitro activity of moxifloxacin and piperacillin/sulbactam against pathogens isolated from patients with acute cholangitis. METHODS: In this prospective study a total of 65 patients with acute cholangitis due to biliary stone obstruction (n = 7), benign biliary stricture (n = 16), and malignant biliary stricture (n = 42) were investigated with regard to spectrum of bacterial infection and antibiotic resistance. Pathogens were isolated from bile cultures in all study patients. In 22 febrile patients, blood cultures were also obtained. In vitro activity of moxifloxacin and piperacillin/ sulbactam was determined by agar diffusion. RESULTS: Thirty-one out of 65 patients had positive bile and/or blood cultures. In 31 patients, 63 isolates with 17 different species were identified. The predominant strains were Enterococcus species (26/63), E.coli (13/63) and Klebsiella species (8/63). A comparable in vitro activity of moxifloxacin and piperacillin/sulbactam was observed for E.coli and Klebsiella species. In contrast, Enterococcus species had higher resistances towards moxifloxacin. Overall bacteria showed antibiotic resistances in vitro of 34.9% for piperacillin/sulbactam and 36.5% for moxifloxacin.CONCLUSION: Enterococcus species , E.coli and Klebsiella species were the most common bacteria isolated from bile and/or blood from patients with acute cholangitis. Overall, a mixed infection with several species was observed, and bacteria showed a comparable in vitro activity for piperacillin/sulbactam and moxifloxacin. | Andreas Weber Wolfgang Huber Klaus Kamereck Philipp Winkle Petra Voland Hans Weidenbach Roland M Schmid Christian Prinz | 2008 | World Journal of Gastroenterology2008，14，20： | 18 |
| 20 | 流动CO_2-H_2O系统中方解石溶解动力学机制——扩散边界层效应和CO_2转换控制显示文摘利用旋转盘实验装置和高分子生物催化剂技术,笔者研究了流动CO_2-H_2O系统中方解石溶解动力学及其控制机制。实验发现,方解石的溶解既受到固-液界面间扩散边界层(DBL)的控制,还受到扩散边界层内CO_2慢速转换反应(CO_2+H_2OH^+HCO_3^-)的控制。然而,高CO_2分压(P_(CO_2)>0.01 atm)时,溶解主要为CO_2慢速转换控制,而低CO_2分压(P_(CO)_2<0.01atm)时,溶解主要为扩散边界层控制。对于这些发现,利用DBL理论模型进行了成功的解释。 | 刘再华 Wolfgang Dreybrodt | 1998 | 地质学报1998，72，4： | 18 |
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