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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | EQ-5D and SF-36 quali- ty of life measures in systemic lupus erythematosus: Comparisons with rheumatoid arthritis, noninflammato- ry rheumatic disorders, and fibromyalgia显示文摘 | Wolfe F Michaud K Li T et aI | 2010 | J Rheuma- tol2010，37，2： | 1 |
| 3 | The pathology of tobacco black shank 显示文摘 | WOLF F T | 1933 | Phytopatho1933，23，： | 1 |
| 4 | Using sampling theory to build a more universal forest vegetation database显示文摘 | Martin F C Baggett T Wolfe T and Mita R | 2000 | Computers and Electronics in Agriculture2000，，3： | 1 |
| 5 | Impedance sensor technology for cell-based assays in the framework of a high-content screening system显示文摘 | Schwarzenberger T Wolf P Brischwein M Kleinhans R Demmel F Lechner A | 2011 | Physiol Meas2011，32，7： | 1 |
| 6 | Kinetics, FTIR, and controlled atmosphere EXAFS study of the effect of chlorine on ptsupported catalysts during oxidation reactions显示文摘 | GRACIA F J MILLER J T KROPF A J WOLF E E | 2002 | J Catal2002，209，2： | 1 |
| 7 | Th~ Pathology of tobacco black shank显示文摘 | WOLF F T | 1933 | PhytoPathology1933，，23： | 1 |
| 8 | Comparison and evaluation of methods for liver segmentation from CT datasets显示文摘 | Heimann T van Ginneken B Styner MA Arzhaeva Y Aurich V Bauer C Beck A Becket C Beichel R Bekes G Bello F Binnig G Bischof H Bornik A Cashman PM Chi Y Cordova A Dawant BM Fidrich M Furst JD Furukawa D Grenacher L Hornegger J Kainmuller D Kitney RI Kobatake H Lamecker H Lange T Lee J Lennon B Li R Li S Meinzer HP Nemeth G Raicu DS Rau AM van Rikxoort EM Rousson M Rusko L Saddi KA Schmidt G Seghers D Shimizu A Slagmolen P Sorantin E Soza G Susomboon R Waite JM Wimmer A Wolf I | 2009 | IEEE Transactions on Medical Imaging2009，28，8： | 1 |
| 9 | Hepatitis B virus surface antigen levels: a guide to sustained response to peginterferon alfa-2a in HBeAg-negative chronic hepatitis B 显示文摘 | Brunetto MR Moriconi F Bonino F Lau GK Farci 19 Yurdaydin C Piratvisuth T Luo K Wang Y Hadziyannis S Wolf E McCloud P Batrla R Marcellin P | 2009 | Hepatology2009，49，4： | 1 |
| 10 | A composite disease activity scale for clinical practice, observational studies, and clinical trials: the patient activity scale ( PAS/PAS - Ⅱ) 显示文摘 | Wolfe F Michaud K Pincus T | 2005 | J Rheamatol2005，32，： | 1 |
| 11 | Mortality risk by hemodialyzer reuse practice and dialyzer membrane characteristics:results from the USRDS Dialysis Morbidity and Mortality Study显示文摘 | Port F K Wolfe R A Hulbert-Shearon T E | 2001 | Am J Kidney Dis2001，37，2： | 1 |
| 12 | Development and validation of the health assessment questionnaire Ⅱ: a revised version of the health assessment questionnaire显示文摘 | Wolfe F Miehaud K Pineus T | 2004 | Arthritis Rheum2004，50，： | 1 |
| 13 | Toward a multidimensional Health Assessment Questionnaire (MDHAQ): assessment of advanced activities of daily living and psychological status in the patient- friendly health assessment questionnaire format 显示文摘 | Pincus T Swearingen C Wolfe F | 1999 | Arthritis Rheum1999，42，： | 1 |
| 14 | Rheumatoid arthritis 显示文摘 | Scott D L Wolfe F Huizinga T W | 2010 | Lancet2010，376，9746： | 1 |
| 15 | Premature mortality in patients with rheumatoictar thritis: evolvingconeepts显示文摘 | Pincus T Sokka T Wolfe F | 2001 | Arthritis Rheum2001，44，： | 1 |
| 16 | Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements显示文摘 | Schoffer A A Aravind L Madden T L Shavirin S Spouge J L Wolf Y I Koonin E V Altschul S F | 2001 | Nucleic Acids Res2001，29，： | 1 |
| 17 | Rheumatoid ar- thritis 显示文摘 | SCOOT D L WOLFE F HUIZINGA T W | 2010 | Lancet2010，376，9746： | 1 |
| 18 | Exploratory metallur-gical evaluation of worn rails from a 90 mm electromagneticrailgun显示文摘 | Wolfe T Spiegelberg W f Evangelisti M | 1995 | IEEE Trans Magn1995，31，1： | 1 |
| 19 | Synthesis and anticonvulsant activity of some new 2-substituted 3-ary-4(3H) quinazolinone显示文摘 | WOLF J F RATHMAN T L SLEEVI M C | 1990 | J Med Chem1990，33，： | 1 |
| 20 | A bacterium that can grow by using arsenic instead of phosphorus 显示文摘 | Wolfe S F Blum J S Kulp T R | 2011 | Science2011，332，： | 1 |
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