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| 1 | DNA-binding studies of valrubicin as a chemotherapy drug using spectroscopy and electrochemical techniques显示文摘In this study, the molecular interactions between valrubicin, an anticancer drug, and fish sperm DNA have been studied in phosphate buffer solution(pH 7.4) using UV–Vis spectrophotometry and cyclic voltammetry techniques. Valrubicin intercalated into double stranded DNA under a weak displacement reaction with methylene blue(MB) molecule in a competitive reaction. The binding constant(kb) of valrubicin-DNA was determined as 1.75×10~3L/mol by spectrophotometric titration. The value of non-electrostatic binding constant(k_t^0) was almost constant at different ionic strengths while the ratio of k_t^0/k_b increased from 4.51% to 23.77%.These results indicate that valrubicin binds to ds-DNA via electrostatic and intercalation modes.Thermodynamic parameters including ΔH^0, ΔS^0and ΔG^0for valrubicin-DNA interaction were determined as-25.21×10~3k J/mol, 1.55×10~2k J/mol K and-22.03 k J/mol, respectively. Cyclic voltammetry study shows a pair of redox peaks for valrubicin at 0.45 V and 0.36 V(vs. Ag/Ag Cl). The peak currents decreased and peak positions shifted to positive direction in the presence of DNA, showing intercalation mechanism due to the variation in formal potential. | Reza Hajian Parvin Hossaini Zahra Mehrayin Pei Meng Woi Nafiseh Shams | 2017 | Journal of Pharmaceutical Analysis2017，7，3： | 2 |
| 2 | Contrasting elastic properties of heavily B-and N-doped grapheme with random distributions including aggregates显示文摘 | Milowska K Z Woi(n)ska M Wierzbowska M | 2013 | The Journal of Physical Chemistry C2013，117，20： | 1 |
| 3 | Hyperther- mia and body energy store effects on estrous behav ior, conception rate, and corpus luteum function in dairy cows 显示文摘 | Woi{enson D Flamenbaum I greman A | 1988 | Journal of Dairy Science1988，71，12： | 1 |
| 4 | Effects of seaweed Laminaria japonica extracts on skin moisturizing activity in vivo 显示文摘 | Choi Jae-Suk Moon Woi Sook Choi Ji Na | 2012 | Journal of cosmetic science2012，64，3： | 1 |
| 5 | Gaussian decomposition and Calibration of a Novel Small- footprint Full-waveform Digitizing Air- borne Laser Seanner显示文摘 | WOI FGANG W | 2006 | ISPI:IS Journal of Photogramme- try Remote Sensing2006，60，： | 1 |
| 6 | Analysis of carbendazim, benomyl, thiophanate methyl and 2, 4-dichlorophenoxyacetic acid in fruits and vegetables after supercritieal fluid extraction显示文摘 | MICHELANGELO A WOI FGANG S | 1998 | J Chromatogr: A1998，825，1： | 1 |
| 7 | Reexamination of the Determinants of Consumer Satisfaction 显示文摘 | Spreng Richard A Scott B MacKenzie Richard WOI shavsky | 2009 | Journal of Marketing2009，60，7： | 1 |
| 8 | Microstrip bandpass filter using degenerate mode> :1 : microslrip ring resonator 显示文摘 | WOI FI:' l | | Electron Left0，8，12： | 1 |
| 9 | Estimating within-group inlerrater reliability with and without response bias显示文摘 | JAMES L R I)EMAREE H G WOI F G | 1984 | J Appl Psychol1984，69，： | 1 |
| 10 | Determination of platinum and palladium in road dust after their separation on immobilized fungus by electrothermal atomic absorption spectrometry显示文摘 | Woińska S Godlewska-?y?kiewicz B | 2011 | Spectrochim Acta Part B Atomic Spectroscopy2011，66，7： | 1 |
| 11 | Blow-up versus global existence for a semilinear reaction diffusion system in a bounded do-main显示文摘 | ROSSI J D WOI ANSKI N | | 0，，11： | 1 |
| 12 | Evidence - based nursing practice for health pro- motion in adults with hypertension:A literature review 显示文摘 | Woi Hyun S | 2010 | A- sian Nursing Research2010，4，22： | 1 |
| 13 | Comparison of vergence mechanisms between university students with good and poor sleep quality显示文摘AIM:To compare the vergence mechanisms between good and poor sleepers in university students.METHODS:A total of 64 university students were recruited in this study.The validated Malay version of Pittsburgh Sleep Quality Index questionnaire(PSQI-M)was used to measure the participants’sleep quality over the past month.Participants were categorized as good sleepers(n=32)and poor sleepers(n=32)based on the PSQI-M scores.Heterophoria and fusional vergences were measured at distance and near.Mann-Whitney U test was used to compare heterophoria,negative fusional vergence(NFV),and positive fusional vergence(PFV)at distance and near between good and poor sleepers.Spearman correlation analysis was used to study the relationship between PSQI-M score and PFV at distance.RESULTS:Both distance and near heterophorias were not significantly different between good and poor sleepers(P>0.05).There was a difference in distance PFV(P<0.05)between good and poor sleepers,but not in distance NFV,near NFV,and near PFV(P>0.05).Distance PFV was negatively correlated with PSQI-M score(rs=-0.33,P<0.05).CONCLUSION:University students with poor sleep quality demonstrates a reduced ability to maintain fusion with increasing convergence demand at distance.Sleep quality assessment during binocular vision examination in university students is recommended. | Pui Juan Woi Joyce Yi Ling Lu Mohd Izzuddin Hairol Wan Nur Amirah Ibrahim | 2024 | International Journal of Ophthalmology(English edition)2024，17，2： | 0 |
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