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| 1 | Role of E3 ubiquitin ligases in lung cancer显示文摘E3 ubiquitin ligases are a large family of proteins that catalyze the ubiquitination of many protein substrates for targeted degradation by the 26S proteasome.Therefore,E3 ubiquitin ligases play an essential role in a variety of biological processes including cell cycle regulation,proliferation and apoptosis.E3 ubiquitin ligases are often found overexpressed in human cancers,including lung cancer,and their deregulation has been shown to contribute to cancer development.However,the lack of specific inhibitors in clinical trials is a major issue in targeting E3 ubiquitin ligases with currently only one E3 ubiquitin ligase inhibitor being tested in the clinical setting.In this review,we focus on E3 ubiquitin ligases that have been found deregulated in lung cancer.Furthermore,we discuss the processes in which they are involved and evaluate them as potential anti-cancer targets.By better understanding the mechanisms by which E3 ubiquitin ligases regulate biological processes and their exact role in carcinogenesis,we can improve the development of specific E3 ubiquitin ligase inhibitors and pave the way for novel treatment strategies for cancer patients. | Barbara C Snoek Leonie HAM de Wilt Gerrit Jansen Godefridus J Peters | 2013 | World Journal of Clinical Oncology2013，4，3： | 5 |
| 2 | Binaphthol-based diphosphite ligands in asymmetric nickel-catalyzed hydro-cyanation of styrene and 1,3-cyclohexadiene : influence of stericproperties 显示文摘 | Wilting J Janssen M Mueller C Lutz | 2007 | Advanced Synthesis &- Catalysis2007，349，3： | 1 |
| 3 | Long-term corn residue effects: Harvest alternatives, soil carbon turnover and root-derived carbon显示文摘 | WILTS A R REICOSKY D C ALLMARAS R R | 2004 | Soil Sci Soc Am J2004，68，： | 1 |
| 4 | Highly selective hydroeyanation of butadiene toward 3-pentenenitrile显示文摘 | Bini L Muller C Wilting J | 2007 | Journal of the American Chemical Society2007，129，12： | 1 |
| 5 | Device-to-Device Communication as an Underlay to LTE-Advanced Networks 显示文摘 | DOPPLER K RINNE M WILTING C | 2009 | IEEE Communications Magzine2009，47，12： | 1 |
| 6 | Gene expression profiling to identify markers associated with deregulated hTERT in HPV-transformed keratinocytes and cervical cancer显示文摘 | de Wilde J Wilting S M Meijer C J | 2008 | Int J Cancer2008，122，4： | 1 |
| 7 | Gene expression profiling to identify markers associated with deregulated hTERT in HPV-transformed keratinocytes and cervical cancer显示文摘 | De Wilde J Wilting S M Meijer C J | 2008 | Int J Cancer2008，122，4： | 1 |
| 8 | Metastatic pattern in eolorectal cancer is strongly influenced by histological subtype 显示文摘 | Hugen N van de Velde C J de Wilt JH | 2014 | Ann Oncol2014，25，3： | 1 |
| 9 | Long-term corn residue effects: Harvest alternatives,soil carbon turnover and root-derived carbon显示文摘 | Wilts A R Reicosly D C Allmaras R R | 2004 | Soil Science Society of America Journal2004，68，： | 1 |
| 10 | Charcoal carbon in US agricultural soils 显示文摘 | Skjemstad J O Reicosky D C Wilts A R etal | 2002 | Soil Science Society of America Journal2002，66，4： | 1 |
| 11 | Managing Complex Adaptive Systems-A Co-evolutionary Perspective on Natural Resource Management显示文摘 | Rammel C Stag1 S Wilting H | 2007 | Ecological Economics2007，63，： | 1 |
| 12 | Species differences in the generation of reactive oxygen species by microglia 显示文摘 | Cohen C Wilt S Gilbert D | 1996 | Mol Chem Neuropathol1996，28，13： | 1 |
| 13 | The isomerization of D-glucose into D-fructose in aqueous alkaline solutions显示文摘 | KOOYMAN C VELLENGA K WILT H G J | 1977 | Carbohydrate Research1977，54，1： | 1 |
| 14 | High refractive index of melanin in shiny occipital feathers of a bird of paradise显示文摘Male Lawes’s Parotia,a bird of paradise,use the highly directional reflection of the structurally colored,brilliant-silvery occipital feathers in their courtship display.As in other birds,the structural coloration is produced by ordered melanin pigmentation.The barbules of the Parotia’s occipital feathers,with thickness,3 μm,contain 6–7 layers of densely packed melanin rodlets(diameter,0.25 μm,length,2 μm).The effectively,0.2 μm thick melanin layers separated by,0.2 μm thick keratin layers create a multilayer interference reflector.Reflectance measurements yielded peak wavelengths in the near-infrared at,1.3 μm,i.e.,far outside the visible wavelength range.With the Jamin-Lebedeff interference microscopy method recently developed for pigmented media,we here determined the refractive index of the intact barbules.We thus derived the wavelength dependence of the refractive index of the barbules’melanin to be 1.7–1.8 in the visible wavelength range.Implementing the anatomical and refractive index data in an optical multilayer model,we calculated the barbules’reflectance,transmittance and absorptance spectra,thereby confirming measured spectra. | Doekele G Stavenga Hein L Leertouwer Daniel C Osorio Bodo D Wilts | 2015 | Light(Science & Applications)2015，4，1： | 1 |
| 15 | Gene expression profiling to identify markers associated with deregulated hTERT in HPV- transformed keratinocytes and cervical cancer 显示文摘 | De Wilde J Wilting SM Meijer C J | 2008 | Int J Cancer2008，122，4： | 1 |
| 16 | Isolated hypoxic hepatic perfusion with retrograde outflow in patients with irresectable liver metastases; a new simplified technique in isolated hepatic perfusion显示文摘 | Verhoef C de Wilt JH Brunstein F | 2008 | Ann Surg Oncol2008，15，5： | 1 |
| 17 | Im munotherapy for advanced renal cell cancer 显示文摘 | Coppin C Porzsolt F Awa A Kumpf J Coldman A Wilt T | 2005 | Cochrane Data- base Syst Rev2005，，00： | 1 |
| 18 | Angiogenesis inhibitors: perspectives for medical,surgical and radiation oncology显示文摘 | VERHOEF C DE WILT JH VERHEUL HM | 2006 | Curt Pharm Des2006，12，21： | 1 |
| 19 | Use of spirometry for case finding, diagnosis, and management of chronic obstructive pulmonary disease (COPD) 显示文摘 | Wilt TJ Niewoehner D Kim C | 2005 | Evid Rep Technol Assess2005，，121： | 1 |
| 20 | Isolated hepatic perfusion:experimental evidence and clinical utility显示文摘 | De Wilt JHW van Etten B Verhoef C | 2004 | Surg Clin North Am2004，84，： | 1 |
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