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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | Bacterial carbonate precipitation as an alternative surface treatment for concrete显示文摘 | Willem D M Kathelijn C Nele D B | 2008 | Construction and Building Materials2008，22，5： | 1 |
| 3 | Solitary waves with prescribed speed on infinite lattices 显示文摘 | Smets D Willem M | 1977 | Journal of Functional Analysis1977，149，1： | 1 |
| 4 | Dislocation distributions in brown diamond显示文摘 | WILLEMS B MARTINEAU P M FISHER D | 2006 | Physical Status Solid2006，12，： | 1 |
| 5 | Non-radial ground states for the Hénon equation显示文摘 | Smets D SU Jiabao Willem M | | 0，，： | 1 |
| 6 | The phylogeny of the genus Clostridium: proposal of five new genera and eleven new species eombinations显示文摘 | COLLINS M D LAWSON P A WILLEMS A | 1994 | Int J Syst Baeteriol1994，44，4： | 1 |
| 7 | 显示文摘 | Tourwe D G Biesemans M Willem R | 2008 | Progress in Organic Coatings2008，63，： | 1 |
| 8 | Neurokinin 1 receptor expression and substance P physiological actions are developmentally regulated in the rabbit retina显示文摘 | Casini G Dal Monte M Fornai F Bosco L Willems D Yang Q | 2004 | Neuroscience2004，124，1： | 1 |
| 9 | Outcome of Pregnancy in Women With Congenital Heart Disease显示文摘 | Willem Drenthen M D Petronella G | 2007 | J Am Coll Cardiol2007，49，： | 1 |
| 10 | Lactic Acid Bacteria: Life af- ter Genomics显示文摘 | KLEEREBEZEM M WILLEM M D V | 2011 | Microbial Biotechnology2011，4，3： | 1 |
| 11 | Temporal characteristics of foot rollover during barefoot jogging reference data for young adults 显示文摘 | DE C A DE C D WILLEMS T M | 2005 | Gait Posture2005，，21： | 1 |
| 12 | An optimized procedure for whole-mount in situ hybridization on mouse embryos and embryoid bodies显示文摘 | PIETTE D HENDRICKX M WILLEMS E | 2008 | Nat Protoc2008，3，7： | 1 |
| 13 | An optimized procedure for whole-mount in situ hybridization on mouse embryos and embryold bodies显示文摘 | Piette D Hendrickx M Willems E | 2008 | Nat Protoe2008，3，： | 1 |
| 14 | The phylogeny of the genus Clostridium: proposal of five new genera and eleven new species combinations显示文摘 | Collins M D Lawson P A Willems A | 1994 | International Journal of Systematic Bacteriology1994，44，4： | 1 |
| 15 | Ventricular high-rate episodes in pacemaker diagnostics identify a high risk subgroup of patients with tachy-brady syndrome显示文摘 | Willems R Morck M L Exner D V | 2004 | Heart Rhythm2004，4，： | 1 |
| 16 | Patient education for preventing diabetic foot ulceration, A systematic review 显示文摘 | Gerlof D V Didi M W Willem J J | 2002 | Endocrionol Metab Clin N AM2002，31，3： | 1 |
| 17 | Analysis of the entire nucleotide sequence of the cryptic plasmid QpH1 from Coxiella burnetii显示文摘 | Willems H Haas M | 1994 | Eur J Epidemiol1994，10，4： | 1 |
| 18 | Risk scores of common ge- netic variants for lipid levels influence atherosclerosis and incident coronary heart disease 显示文摘 | Isaacs A Willems S M Bos D | 2013 | Arterioscler Thromb Vasc Biol2013，33，9： | 1 |
| 19 | Searching for predominant soil bacteria- 16S rDNA cloning versus strain cultivation显示文摘 | WILLEM M ANTOON D WILLEM M | 1999 | FEMS Microbiology Ecology1999，30，： | 1 |
| 20 | Randomised comparison of primary stent placement versus primary angioplasty followed by selective stent placement in patients with iliac-artery occlusive disease显示文摘 | Eric Tetteroo Yolanda van der Graaf Johanna L Bosch Andries D van Engelen Maria GM Hunink Bert C Eikelboom Willem P Th M Mali | 1998 | The Lancet . 1998 (9110)1998，，： | 1 |
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