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| 1 | Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes显示文摘AIM To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts(TIPS) and compare outcomes with maximally dilated TIPS.METHODS Polytetrafluoroethylene covered TIPS(Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm(m TIPS), while 43 patients who were at increased risk for hepatic encephalopathy(HE), based on clinical evaluation or low pre-TIPS portosystemic gradient(PSG), had 10 mm TIPS sub-maximally dilated to 8 mm(sm TIPS). Group characteristics(age, gender, Model for End-Stage Liver Disease score, post-TIPS PSG and clinical outcomes were compared between groups, including clinical success(ascites or varices), primary patency,primary assisted patency, and severe post-TIPS HE. A subset of fourteen patients with sm TIPS underwent follow-up computed tomography imaging after TIPS creation, and were grouped based on time of imaging(< 6 mo and > 6 mo). Change in diameter and crosssectional area were measured with 3D imaging software to evaluate for passive expansion.RESULTS Patient characteristics were similar between the sm TIPS and m TIPS groups, except for pre-TIPS portosystemic gradient, which was lower in the sm TIPS group(19.4 mm Hg ± 6.8 vs 22.4 mm Hg ± 7.1, P = 0.01). Primary patency and primary assisted patency between sm TIPS and m TIPS was not significantly different(P = 0.64 and 0.55, respectively). Four of the 55 patients(7%) with sm TIPS required TIPS reduction for severe refractory HE, while this occurred in 6 of the 218 patients(3%) with m TIPS(P = 0.12). For the 14 patients with follow-up computed tomography(CT) imaging, the median imaging follow-up was 373 d. There was an increase in median TIPS diameter, median percent diameter change, median area, and median percent area change in patients with CT follow-up greater than 6 mo after TIPS placement compared to follow-up within 6 mo(8.45 mm, 5.58%, 56.04 mm^2, and 11.48%, respectively, P = 0.01).CONCLUSION Passive expansion of sm TIPS does occur but clinical outcomes of sm TIPS and m TIPS were similar. Sub-maximal dilation can prevent complications related to overshunting in select patients. | Michael C Hsu Charles N Weber S William Stavropoulos Timothy W Clark Scott O Trerotola Richard D Shlansky Goldberg Michael C Soulen Gregory J Nadolski | 2017 | World Journal of Hepatology2017，9，12： | 11 |
| 2 | 热应激和低营养摄入对猪肠道完整性和功能的影响显示文摘热应激会损害肠道完整性,并诱发肠渗漏。因此,本试验研究了直接或间接热应激(通过减少采食量)对生长猪肠道通透性的影响。选用体重(43±4)kg的杂交后备母猪(n=48),分别安置在以下控制环境中:热中性(TN)环境(20℃,湿度35%~50%,自由采食)、热应激(HS)环境(35℃,湿度20%~35%,自由采食)、热中性环境配对饲喂(PFTN,以消除不同采食量的交互影响)。第1、3、7天使猪只安乐死,采集的空肠样品被安装到尤式灌流室,测定跨膜电阻抗值(TER)和异硫氰基荧光标记的脂多糖(LPS)渗透性(APP,表示为表观渗透系数)。此外,评估肠道完整性以及应激基因和蛋白标志物。结果表明,不考虑热应激天数,HS组与TN组猪相比,血浆内毒素水平增加45%(P〈0.05),空肠TER降低30%(P〈0.05),LPS渗透率增加2倍(P〈0.01)。此外,与PFTN组相比,HS组第7天的猪LPS渗透性有增加的趋势(P=0.06)。整个试验阶段HS组溶菌酶和碱性磷酸酶活性下降,分别下降46%和59%(P〈0.05);然而,3 d和7 d空肠免疫细胞标记物——髓过氧化物酶活性增加(P〈0.05)。由此可见,热应激和减少采食量都会降低肠道完整性,并增加内毒素渗透性。推测这可能会导致炎症加重,在炎热的夏季可能是导致猪生长性能降低的原因。 | Pearce S C Mani V Weber T E Rhoads R P Patience J F Baumgard L H Gabler N K | 2016 | 中国饲料2016，，3： | 3 |
| 3 | Should antibiotics be administered before arthroscopic knee surgery? A systematic review of the literature显示文摘AIM To explore the current evidence surrounding the administration of prophylactic antibiotics for arthroscopic knee surgery. METHODS Databases were searched from inception through May of 2018 for studies examining prophylactic antibiotic use and efficacy in knee arthroscopy. Studies with patient data were further assessed for types of arthroscopic procedures performed,number of patients in the study,use of antibiotics,and outcomes with the intention of performing a pooled analysis. Data pertaining to 'deep tissue infection' or 'septic arthritis' were included in our analysis. Reported data on superficial infection were not included in our data analysis. For the pooled analysis,a relative risk ratio was calculated and χ~2 tests were used to assess for statistical significance between rates of infection amongst the various patient groups. Post hoc power analyses were performed to compute the statistical power obtained from our sample sizes. Number needed to treat analyses were performed for statistically significant differences by dividing 1 by the difference between the infection rates of the antibiotic and no antibiotic groups. An alpha value of 0.05 was used for our analysis. Study heterogeneity was assessed by Cochrane's Q test as well as calculation of the I^2 value.RESULTS A total of 49682 patients who underwent knee ar-throscopy for a diverse set of procedures across 19 studies met inclusion critera for pooled analysis. For those not undergoing graft procedures,there were 27 cases of post-operative septic arthritis in 34487 patients(0.08%) who received prophylactic antibiotics and 16 cases in 10911(0.15%) who received none [risk ratio(RR) = 0.53,95% confidence interval(CI): 0.29-0.99,P = 0.05]. A sub-group analysis in which bony procedures were excluded was performed which found no significant difference in infection rates between patients that received prophylactic antibiotics and patients that did not(P > 0.05). All anterior cruciate ligament reconstruction studies used prophylactic antibiotics,but two studies investigating the effect of soaking the graft in vancomycin in addition to standard intravenous(IV) prophylaxis were combined for analysis. There were 19 cases in 1095 patients(1.74%) who received IV antibioitics alone and no infections in 2034 patients who received IV antibiotics and had a vancomycin soaked graft(RR = 0.01,95%CI: 0.001-0.229,P < 0.01).CONCLUSION Prophylactic antibiotics are effective in preventing septic arthritis following simple knee arthroscopy. In procedures involving graft implantation,graft soaking reduces the rate of infection. | John Carney Nathanael Heckmann Erik N Mayer Ram K Alluri Carleton Thomas Vangsness George F Hatch Ⅲ Alexander E Weber | 2018 | World Journal of Orthopedics2018，9，11： | 2 |
| 4 | Identifying organizational culture clash in MIS implementation显示文摘 | Pliskin N Weber Y | 1991 | Information and Management1991，21，2： | 1 |
| 5 | Mosaic genes and mosaic chromosomes: intra - and interspecies genomic variation of Streptococcus pneumoniae显示文摘 | Hakenbeck R Balmelle N Weber B | 2001 | Infect Immun2001，69，4： | 1 |
| 6 | Visusrelevante physikalischchemische parameter von Viskoelastika bei kataraktoperationen 显示文摘 | Weber U Holak N | 2001 | Ophthalmologe2001，98，5： | 1 |
| 7 | Hyperglycaemiablocks sevofluraneinduced postconditioning in the rat heart invivo:cardioprotection can be restored by blocking the mito-chondrial permeability transition pore显示文摘 | Hunu R Heinen A Weber N C | 2008 | Br J Anaesth2008，100，4： | 1 |
| 8 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 9 | Bonding properties of metals anodically bonded to glass 显示文摘 | Briand D Weber P Derooij N F | 2004 | Sensors and Actuators A:Physieal2004，114，23： | 1 |
| 10 | A sulfonated polyphenylene- sulfone (sPPSU) as the supporting substrate in thin film composite (TFC) membranes with enhanced performance for forward osmosis (FO)显示文摘 | Widjojo N Chung T-S Weber M | 2013 | Chem Eng J2013，220，： | 1 |
| 11 | Long-term land use changes in a mesoscale watershed due to socio-economic factors-effects on landscape structures and functions显示文摘 | Weber A Fohrer N Moller D | 2001 | Ecological Modelling2001，140，12： | 1 |
| 12 | Evaluation of different markers in non-small cell lung cancer:prognostic value of clinical staging,tumour cell detection and tumor marker analysis for tumor progression and overall survival显示文摘 | Kasimir-Bauer S Schleucher N Weber R | 2003 | Oncol Rep2003，10，2： | 1 |
| 13 | Experiments on flow at a 90 open-ehanneljunction显示文摘 | Weber L J Schumate E D Mawer N | 2001 | JournalofHydranlicEngineering2001，127，5： | 1 |
| 14 | Host-induced gene silen- cing of eytochrome P450 lanostero显示文摘 | Koch A Kumar N Weber L | 2013 | Pro- ceedings of the National Academy of Sciences of the United States of America2013，110，19： | 1 |
| 15 | Carbon and oxygen isotopic composi tion of selected limestones and fossils显示文摘 | Keith M L Weber J N | 1964 | Geochimica et Cos- mochimica Acta1964，28，10： | 1 |
| 16 | Ozone column classified climatology of ozone and temperature profiles based on ozonesonde and satellite data显示文摘 | Lamsal L N Weber M Telhnann S | 2004 | Journal of Geophysical Research2004，109，20： | 1 |
| 17 | Subchronic exposure to dibromoacetic acid, a water disinfection by-product, does not affect gametogenic potential in mice显示文摘 | WEBER N M SAWYER H R LEGARE M E | 2006 | Toxicol Sci2006，89，1： | 1 |
| 18 | Carbon and oxygen stable isotopic composi- tion of selected limestones and fossils显示文摘 | Keitht M H Weber J N | 1964 | Geochimica et Cosmochimi- ca Acta1964，28，11： | 1 |
| 19 | Kidney transplantation from donors without a heartbeat显示文摘 | Weber M Dindo D Demartines N | | 0，，： | 1 |
| 20 | The expression of VEGF and its receptors in the human ductus arteriosus显示文摘 | Weber SC Rheinlaender C Sarioglu N | | 0，，04： | 1 |
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