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| 1 | Identification of pathologic features associated with “ulcerative colitis-like” Crohn's disease显示文摘AIM: To identify pathologic features associated with this 'ulcerative colitis(UC)-like' subgroup of Crohn's disease(CD).METHODS: Seventeen subjects diagnosed as having UC who underwent proctocolectomy(RPC) from 2003-2007 and subsequently developed CD of the ileal pouch were identified. UC was diagnosed based on preoperative clinical, endoscopic, and pathologic studies. Eighteen patients who underwent RPC for UC within the same time period without subsequently developing CD were randomly selected and used as controls. Pathology reports and histological slides were reviewed for a wide range of gross and microscopic pathological features, as well as extent of disease. The demographics, gross description and histopathology of the resection specimens were reviewed and compared between the two groups. RESULTS: Patients with 'UC-like' CD were on average 13 years younger than those with 'true' UC(P < 0.01). More severe disease in the proximal involved region and active ileitis with/without architectural distortion were observed in 6 of 17(35%) and 7 of 17(41%) 'UC-like' CD cases, respectively, but in none of the 'true' UC cases(P < 0.05). Active appendicitis occurred in 8 of 16(50%) 'UC-like' CD cases but in only two(11%) 'true' UC cases(P < 0.05). Conspicuous lamina propria neutrophils were more specific for 'UClike' CD(76% vs 22%, P < 0.05). In addition, prominent lymphoid aggregates tended to be more common in 'UC-like' CD(P = 0.07). The 'true' UC group contained a greater number of cases with severe activity(78% vs 47%). Therefore, the features more commonly seen in 'UC-like' CD were not due to a more severe disease process. Crohn's granulomas and transmural inflammation in non-ulcerated areas were absent in both groups.CONCLUSION: More severe disease in the proximal involved region, terminal ileum involvement, active appendicitis, and prominent lamina propria neutrophils may be morphological factors associated with 'UC-like' CD. | Samuel D James Paul E Wise Tania Zuluaga-Toro David A Schwartz M Kay Washington Chanjuan Shi | 2014 | World Journal of Gastroenterology2014，20，36： | 4 |
| 2 | Lymph node ratio and preoperative CA 19-9 levels predict overall survival and recurrence-free survival in patients with resected pancreatic adenocarcinoma显示文摘AIM:Clinicopathologic factors predicting overall survival (OS) would help identify a subset to benefit from adjuvant therapy. METHODS: One hundred and sixty-nine patients patients from 1984 to 2009 with curative resections for pancreatic adenocarcinoma were included. Tumors were staged by American Joint Committee on Cancer 7th edition criteria. Univariate and multivariable analyses were performed using Kaplan-Meier methodology or Cox proportional hazard models. Log-rank tests were performed. Statistical inferences were assessed by two-sided 5% significance level. RESULTS: Median age was 67.1 (57.2-73.0) years with equal gender distribution. Tumors were in the head (89.3%) or body/tail (10.7%). On univariate analysis, adjuvant therapy, lymph node (LN) ratio, histologic grade, negative margin status, absence of peripancreatic extension, and T stage were associated with improved OS. Adjuvant therapy, LN ratio, histologic grade, number of nodes examined, negative LN status, and absence of peripancreatic extension were associated with improved recurrence-free survival (RFS). On multivariable analysis, LN ratio and carbohydrate antigen (CA) 19-9 levels were associated with OS. LN ratio was associated with RFS. CONCLUSION: The LN ratio and CA 19-9 levels are independent prognostic factors following curative resections of pancreatic cancer. | Sabrina C Wentz Zhi-Guo Zhao Yu Shyr Chan-Juan Shi Kay Washington Nipun B Merchant Fen Xia A Bapsi Chakravarthy | 2012 | World Journal of Gastrointestinal Oncology2012，4，10： | 3 |
| 3 | Trends in the use and capacity of California's emergency departments, 1990- 1999显示文摘 | Lambe S Washington DL Fink A | 2002 | Ann Emerg Med2002，39，4： | 1 |
| 4 | Ectopic pregnancy in the United States: Economic consequences and payment source trends显示文摘 | Washington A E Katz P | 1993 | Obstet Gynecol1993，81，2： | 1 |
| 5 | Hyperh0m0cysteinemia leads to adverse cardiac remolding in hypertensive rats显示文摘 | Joseph J Washington A Joseph L | 2002 | Am J Physio Heart Circ Physiol2002，283，6： | 1 |
| 6 | South Asian summer monsoon variability in a model with doubled atmospheric carbon dioxide concentration显示文摘 | Meehl G A Washington W M | 1993 | Science1993，260，： | 1 |
| 7 | Climate change projections for the twenty-first century and climate change commitment in the CCSM3显示文摘 | MEEHL G A WASHINGTON W M | 2006 | J Climate2006，19，11： | 1 |
| 8 | Clinical practice:current approaches to cervical cancer screening显示文摘 | Sawaya G F Brown A D Washington A E | 2001 | N Engl J Med2001，344，21： | 1 |
| 9 | N-carboxyl chitosan inhi- bition of aflatoxin production-role of zinc显示文摘 | CUERA R G OSUJI G WASHINGTON A | 1991 | Biotechnology Letters1991，13，6： | 1 |
| 10 | Transforming growth factor beta receptor type Ⅱ inactivation promotes the establish- ment and progression of colon cancer显示文摘 | Biswas S Chytil A Washington K | 2004 | Cancer Res2004，64，14： | 1 |
| 11 | CO2 climate sensitivity and snow-sea-ice albedo parameterization in an atmospheric GCM coupled to a mixed layer ocean model显示文摘 | Meehl G A Washington W M | 1990 | Climate Change1990，16，： | 1 |
| 12 | Combi- nations of natural and anthropogenic forcings in twentieth-cen- tury climate 显示文摘 | Meehl G A Washington W M Ammann C M | 2004 | Journal of Climate2004，17，： | 1 |
| 13 | ARHI-induced auto- phagy enhances chemosensitivity to eisplatin in ovarian cancer cell lines and xenografts显示文摘 | Washington M N Suh G Orozco A F | 2013 | Cancer Research2013，73，8： | 1 |
| 14 | The impact of fish oil on the chemopreventive efficacy of tamoxifen against develop ment of N-methyl-N-nitrosourea induced rat mammary carcinogenesis显示文摘 | Manni A Xu H Washington S | | 0，，： | 1 |
| 15 | Patho- logy of rodent models of intestinal cancer: progress report and reco- mmendations显示文摘 | WASHINGTON M K POWELL A E SULLIVAN R | 2013 | Gastroenterology2013，144，4： | 1 |
| 16 | Modeling, Optimization, and Design of Efficient Initially Curved Piezoceramic Unimorphs for Energy Harvesting Application显示文摘 | Yoon H S Washington G Danak A | 2005 | Intelligent Material Systems and Structures2005，16，： | 1 |
| 17 | Gastric graft-versus-host disease:a blinded histologic study显示文摘 | Washington K Bentley RC Green A | 1997 | Am J Surg Pathol1997，21，： | 1 |
| 18 | Expression of beta - Catenin, alpha - Catenin, and E - cadherin in Barrett's e-sophagus and esophageal adenocarcinomas 显示文摘 | WASHINGTON K CHIAPPORI A HAMILTON K | 1998 | Mod Pathol1998，1，9： | 1 |
| 19 | General circulation model experiments on the climatic effects due to a doubling and quadrupling of carbon dioxide concentration显示文摘 | WASHINGTON W M MEEHL G A | 1983 | Journal of Geophysical Research1983，88，： | 1 |
| 20 | Modeling, Opti mization, and Design of Efficient Initially Curved Piezo- ceramic Unimorphs for Energy Harvesting Applications 显示文摘 | Yoon H S Washington G Danak A | 2005 | Journal of Intelligent Material Systems and Struc-tures2005，16，10： | 1 |
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