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| 1 | Mesenchymal stem cells: Molecular characteristics and clinical applications显示文摘Mesenchymal stem cells (MSCs) are non-hematopoietic stem cells with the capacity to differentiate into tissues of both mesenchymal and non-mesenchymal origin. MSCs can differentiate into osteoblastic, chondrogenic, and adipogenic lineages, although recent studies have demonstrated that MSCs are also able to differentiate into other lineages, including neuronal and cardiomyogenic lineages. Since their original isolation from the bone marrow, MSCs have been successfully harvested from many other tissues. Their ease of isolation and ex vivo expansion combined with their immunoprivileged nature has made these cells popular candidates for stem cell therapies. These cells have the potential to alter disease pathophysiology through many modalities including cytokine secretion, capacity to differentiate along various lineages, immune modulation and direct cell-cell interaction with diseased tissue. Here we first review basic features of MSC biology including MSC characteristics in culture, homing mechanisms, differentiation capabilities and immune modulation. We then highlight some in vivo and clinical evidence supporting the therapeutic roles of MSCs and their uses in orthopedic, autoimmune, and ischemic disorders. | Farbod Rastegar Deana Shenaq Eric R Wagner Stephanie H Kim Russell R Reid Hue H Luu Rex C Haydon | 2010 | World Journal of Stem Cells2010，2，4： | 35 |
| 2 | Use of shear wave elastography for the diagnosis and follow-up of biliary atresia: A meta-analysis显示文摘BACKGROUND Timely differentiation of biliary atresia(BA)from other infantile cholestatic diseases can impact patient outcomes.Additionally,non-invasive staging of fibrosis after Kasai hepatoportoenterostomy has not been widely standardized.Shear wave elastography is an ultrasound modality that detects changes in tissue stiffness.The authors propose that the utility of elastography in BA can be elucidated through meta-analysis of existing studies.AIM To assess the utility of elastography in:(1)BA diagnosis,and(2)post-Kasai fibrosis surveillance.METHODS A literature search identified articles that evaluated elastography for BA diagnosis and for post-Kasai follow-up.Twenty studies met criteria for meta-analysis:Eleven for diagnosis and nine for follow-up post-Kasai.Estimated diagnostic odds ratio(DOR),sensitivity,and specificity of elastography were calculated through a random-effects model using Meta-DiSc software.RESULTS Mean liver stiffness in BA infants at diagnosis was significantly higher than in non-BA,with overall DOR 24.61,sensitivity 83%,and specificity 79%.Post-Kasai,mean liver stiffness was significantly higher in BA patients with varices than in patients without,with DOR 16.36,sensitivity 85%,and specificity 76%.Elastography differentiated stage F4 fibrosis from F0-F3 with DOR of 70.03,sensitivity 96%,and specificity 89%.Elastography also differentiated F3-F4 fibrosis from F0-F2 with DOR of 24.68,sensitivity 85%,and specificity 81%.CONCLUSION Elastography has potential as a non-invasive modality for BA diagnosis and surveillance post-Kasai.This paper’s limitations include inter-study method heterogeneity and small sample sizes.Future,standardized,multi-center studies are recommended. | Ellen S Wagner Hussien Ahmed H Abdelgawad Meghan Landry Belal Asfour Mark B Slidell Ruba Azzam | 2022 | World Journal of Gastroenterology2022，28，32： | 5 |
| 3 | Stereochemistry of silybin 显示文摘 | Lotter H Wagner H | 1983 | Z Naturforsch C1983，38，56： | 3 |
| 4 | Beta-7 integrin controls enterocyte migration in the small intestine显示文摘AIM:To hypothesize that beta-7 integrin affects cellularmigration of both,lymphocytes and enterocytes.METHODS:The nucleoside analog Brd U was ip injected in beta-7-deficient mice(C57BL/6-Itgbtmlcgn/J)of male gender and age-matched male C57BL/J J mice(wild type)4,20,or 40 h before analysis.The total small intestine was isolated,dissected,and used for morphometrical studies.Brd U-positive epithelial cells were numbered in at least 15 hemi-crypts per duodenum,jejunum,and ileum of each animal.The outer most Brd U-positive cell(cellmax)was determined per hemi-crypt,numerically documented,and statistically analysed.RESULTS:Integrins containing the beta-7-chain were exclusively expressed on leukocytes.In the small intestinal mucosa of beta-7 integrin-deficient mice the number of intraepithelial lymphocytes was drastically decreased.Moreover,the Peyer’s patches of beta-7integrin-deficient mice appeared hypoplastic.In beta-7integrin-deficient mice the location of cellmax was found in a higher position than it was the case for the controls.The difference was already detected at 4 h after Brd U application,but significantly increased with time(40 h after Brd U injection)in all small intestinal segments investigated,i.e.,duodenum,jejunum,and ileum.Migration of small intestinal enterocytes was different between the experimental groups measured by cellmax locations.CONCLUSION:The E-cadherin beta-7 integrin pathway probably controls migration of enterocytes within the small intestinal surface lining epithelial layer. | Elke Kaemmerer Paula Kuhn Ursula Schneider Thomas Clahsen Min Kyung Jeon Christina Klaus Julia Andruszkow Michael Hrer Sabine Ernst Angela Schippers Norbert Wagner Nikolaus Gassler | 2015 | World Journal of Gastroenterology2015，21，6： | 3 |
| 5 | Studies on processing, particle formation and immunogenicity of the HIV-1gag gene product: A possible component of a HIV vaccine显示文摘 | Wagner R Fliessbach H Wanner G | 1992 | Arch Virol1992，127，14： | 2 |
| 6 | the barrier discharge:basic properties and applications to surface treatment显示文摘 | Wagner H E brandenburg R Kozlov K V | 2003 | Vacuum2003，71，3： | 2 |
| 7 | On a class of capacitated transportation problems 显示文摘 | Wagner H M | 1959 | Management Science1959，5，： | 2 |
| 8 | DNA activates human im mune cells through a CpG sequence-dependent manner显示文摘 | Bauer M Heeg K Wagner H | 1999 | Immunology1999，97，4： | 2 |
| 9 | Radiation therapy in the management of patients with Unresctable stage Ⅲ A and Ⅲ B non-small cell lung cancer显示文摘 | Wagner H J | 1997 | Semin Oncol1997，24，4： | 1 |
| 10 | NF-kappaB/Rel activication in cerulean pancreatitis显示文摘 | Steinle AU Weidenbach H Wagner M | 1999 | Gastroenterology1999，116，2： | 1 |
| 11 | Auger and photoelection line energy erlation ships in aluminum-oxygen and Silicon-oxygen compounds显示文摘 | Wagner C D Passoja D E Hillery H F | 1982 | J Vac Sci Technol1982，21，： | 1 |
| 12 | Evidence of stress transfer and formation of fracture cluster in carbon nanotube-based composites显示文摘 | Lourie O Wagner H D | 1999 | Composites Science and Technology1999，59，： | 1 |
| 13 | Mammalian genotoxicity assessment of methylene blue in plasma: implications for virus inactivation 显示文摘 | Wagner SJ Cifone MA Murli H | 1995 | Transfusion1995，35，4： | 1 |
| 14 | Nanoscale shear and indentation measurement in tran-scrystallineα-isotacitc polypropylene显示文摘 | Amitay-Sadovsky E Cohen S R Wagner H D | 2001 | Macro-molecules2001，34，： | 1 |
| 15 | An aluminium heat switch made from cold-pressed Cu/A1 composite显示文摘 | Wang H L Wagner Th Eska G | 2000 | Physica B2000，28，4288： | 1 |
| 16 | , Development of a quantitative method for the analysis of tobaccospecific nitrosamines in mainstream cigarette smoke using isotope dilution liquid ehromatography/eleetrospray ionization tandem mass spectrometry 显示文摘 | Wagner K A Finkel N H Fossett J E | 2005 | Analytical Chemistry2005，77，4： | 1 |
| 17 | Association of four different calcium crystals in the antherconnective tissue and hypodermal stomium of Capsicum annuurn (Solanaceae) during microsporogenesis显示文摘 | HORNER H T WAGNER B L | 1992 | American Journal of Botany1992，79，5： | 1 |
| 18 | Pancreatic fistula after pancreatic head resection 显示文摘 | Buchler MW Friess H Wagner M | 2000 | Br J Surg2000，87，7： | 1 |
| 19 | Mediastinal lymph node dissertion improves survival in patients with stagea ii and iii non-small cell lung cancer显示文摘 | Keller SM Adak S Wagner H | 2000 | Ann thorac Surg2000，70，： | 1 |
| 20 | Sustained activation of nuclear factor kappa B and activator protein 1 in chronic heart failure显示文摘 | Frantz S Fraccarollo D Wagner H | | 0，，03： | 1 |
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