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6篇 您的检索式：作者名="Vogel WM"

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		题名	作者	年代	出处	被引量
	1	ATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes of Crohn's disease patients显示文摘AIM:To investigate if the presence of relevant genetic polymorphisms has effect on the effectual clearance of bacteria by monocytes and granulocytes in patients with Crohn’s disease(CD).METHODS:In this study,we assessed the differential responses in phagocytosis by measuring the phagocytic activity and the percentage of active phagocytic monocytes and granulocytes in inflammatory bowel disease patients as well as healthy controls.As both autophagy related like 1(ATG16L1)and immunityrelated guanosine triphosphatase gene are autophagy genes associated with CD and more recently nucleo-tide-binding ligomerization domain-containing protein2(NOD2)has been identified as a potent inducer of autophagy we genotyped the patients for these variants and correlated this to the phagocytic reaction.The genotyping was done with restriction fragment length polymorphisms analysis and the phagocytosis was determined with the pHrodo?Escherichia coli Bioparticles Phagocytosis kit for flowcytometry.RESULTS:In this study,we demonstrate that analysis of the monocyte and granulocyte populations of patients with CD and ulcerative colitis showed a comparable phagocytic activity(ratio of mean fluorescence intensity)between the patient groups and the healthy controls.CD patients show a significantly higher phagocytic capacity(ratio mean percentage of phagocytic cells)compared to healthy controls(51.91%±2.85%vs 37.67%±7.06%,P=0.05).The extend of disease was not of influence.However,variants of ATG16L1(WT:2.03±0.19 vs homozygoot variant:4.38±0.37,P<0.009)as well as NOD2(C-ins)(heterozygous variant:42.08±2.94 vs homozygous variant:75.58±4.34(P=0.05)are associated with the phagocytic activity in patients with CD.CONCLUSION:Monocytes of CD patients show enhanced phagocytosis associated with the presence of ATG16L1 and NOD2 variants.This could be part of the pathophysiological mechanism resulting in the disease.	Simone CS Wolfkamp Caroline Verseyden Esther WM Vogels Sander Meisner Kirsten Boonstra Charlotte P Peters Pieter CF Stokkers Anje A te Velde	2014	World Journal of Gastroenterology2014，20，10：	2
	2	p63 deficiency activates a program of cellular senescence and leads to accelerated aging显示文摘	Keyes WM Wu Y Vogel H	2008	Genes Dev2008，，19：	1
	3	Brain magnetic resonance imaging abnormalities in patients with heart failure 显示文摘	Vogels RL van der Flier WM van Harten B	2007	Eur J Heart Fail2007，9，10：	1
	4	p63 Deficiency activates a program of cellular senescence and leads to accelerated aging显示文摘	Keyes WM Wu Y Vogel H Guo X Lowe SW Mills AA	2005	Genes Dev2005，19，17：	1
	5	Acute alterations in left ventricular diastolic chamber stiffness:role of the 'erectile' effect of coronary arterial pressure and flow in normal and damaged hearts显示文摘	Vogel WM Apstein CS Brigs LL	1982	Circ Res1982，51，：	1
	6	Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes:the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial显示文摘	Vogel VG Costantino JP Wickerham DL Cronin WM Cecchini RS Atkins JN		0，，：	1

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