| 1 | Noni(Morinda citrifolia L.) fruit juice delays immunosenescence in the lymphocytes in lymph nodes of old F344 rats显示文摘Objective: Aging is associated with the development of diseases because of immunosuppression and altered functioning of the neuroendocrine system. The medicinal properties of Morinda citrifolia L. have been widely exploited for the treatment of age-associated diseases. This study aims to investigate the in vitro and in vivo effects of noni(M. citrifolia) fruit juice(NFJ) on neuro-immunomodulation in the lymph node lymphocytes of F344 rats.Methods: Lymphocytes isolated from axillary and inguinal lymph nodes of young(3–4 months) and old(18–21 months) rats were treated in vitro with different concentrations(0.0001%, 0.01%, and 1%) of NFJ for a period of 24 h. In the in vivo study, old(16–17 months) male F344 rats were treated with 5 mL/kg body weight of 5%, 10% and 20% of NFJ, twice a day, by oral gavage, and lymph node lymphocytes were isolated after 60 d. Concanavalin A(Con A)-induced lymphocyte proliferation, interleukin-2(IL-2)and interferon-γ(IFN-γ) production and expression of intracellular markers, such as phosphoextracellular signal-regulated kinase(p-ERK1/2), phospho-γ AMP response element-binding protein,phospho-protein kinase B(p-Akt), phospho-tyrosine hydroxylase(p-TH), phospho-nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor-α(p-IκB-α) and phospho-nuclear factor-κB(p-NF-κB p65 and p50) were examined in the lymphocytes of lymph nodes.Results: NFJ increased Con A-induced lymphocyte proliferation, IL-2 and IFN-γ production, and p-ERK1/2 expression both in vitro and in vivo. In in vivo NFJ-treated old rats, lymph node lymphocytes showed increased expression of p-TH and Akt, nitric oxide production and decreased expression of p-NF-κB p65 and p50.Conclusion: These results suggest that the immunostimulatory properties of NFJ are facilitated through intracellular signaling pathways involving ERK1/2, Akt and NF-κB. | Uday P.Pratap Hannah P.Priyanka Karthik R.Ramanathan Vishak Raman Lalgi Hima Srinivasan Thyagarajan | 2018 | Journal of Integrative Medicine2018，16，3： | 5 |
| 6 | Analysis of Heat Transfer of a Flat Plate Oscillating Heat Pipe, for Different Surfaces显示文摘对更大的力量密度和电子系统的更小的尺寸的最近、经常的要求刺激了象热管子那样的不同的被动的热转移方法的新图案的生长。特别地, OHP (震荡的热管子) 是相对新奇的设备,能够在长、短的距离上移开高热率与不温度落下。这研究专注于设计,造并且装配一个测试钻塔以便完全分析通过 5 拐弯的 deionised 水的流动模式板震荡在不同的热输入下面的热管子,它被二精力 M.Sc 在工程的学院和玛丽女王伦敦大学的材料科学里做。学生们。水的充满的比率是 40% 。而且, OHP 热表演上的试验性的研究被执行以便检验不同表面的效果湿条件:超级吸水的、吸水、清洗的黄铜。它被表明液体蛞蝓的形成和沿着隧道的水的蒸汽塞子。试验性的结果证明吸水的表面趋于是更多的精力有效。热转移表演超级吸水、吸水分别地比由 5-12% 和 15-20% 的黄铜高。 | Fraga De Cal Beatriz Vishak Jagadeesh Kumar | 2017 | Journal of Mechanics Engineering and Automation2017，7，7： | 0 |
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