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| 1 | Atrophy of the left dorsolateral prefrontal cortex is associated with poor performance in verbal fluency in elderly poststroke women显示文摘This study aimed to investigate the association between atrophy in the prefrontal cortex with executive function and verbal fluency in elderly male and female patients poststroke.Thirty elderly female patients with non-aphasic ischemic stroke aged ≥ 60 years and 30 age-matched non-aphasic male patients with ischemic stroke were recruited.Automatic magnetic resonance imaging segmentation was used to assess the volume of the whole prefrontal cortex,along with its subdivisions:anterior cingulate cortex,orbitofrontal cortex and dorsolateral prefrontal cortex.The Semantic Verbal Fluency Test was administered at 3 and 15 months poststroke.At 3 months poststroke,left dorsolateral prefrontal cortex volume was significantly correlated with Verbal Fluency Test score in female patients only(partial coefficient = 0.453,P = 0.045),after controlling for age,education,diabetes,neurological deficit,white matter lesions volume,as well as the location and volume of infarcts.At 15 months poststroke,there remained a significant association between the left dorsolateral prefrontal cortex volume and Verbal Fluency Test(partial coefficient = 0.661,P = 0.001) and between the left prefrontal cortex volume and Verbal Fluency Test(partial coefficient = 0.573,P = 0.004) in female patients after the same adjustments.These findings indicate that atrophy of the left dorsolateral prefrontal cortex contributes to the impairment of verbal fluency in elderly female patients with stroke.Sex differences may be present in the neuropsychological mechanisms of verbal fluency impairment in patients with stroke. | Yang-Kun Chen Wei-Min Xiao Defeng Wang Lin Shi Winnie CW Chu Vincent CT Mok Ka Sing Wong Gabor S Ungvari Wai Kwong Tang | 2013 | Neural Regeneration Research2013，8，4： | 2 |
| 2 | 深部脑刺激治疗帕金森病:下丘脑核团靶点定位的解剖与生理对比研究显示文摘目的 探讨脑深部STN刺激靶点时MRI直接定位法和MER术中导引定位法的解剖学偏差。方法 本组5例帕金森病患者,分别表现为运动迟缓、步态不稳及躯干症状,共安放6例次微电极。结果 采用MRI直接定位法和MER术中导引定位法,其定位靶点的平均偏差距离是1.25mm,尽管该偏差值较小,但是,基于影像学的立体定向法只能将刺激电极定位于距离靶点几毫米的范围内。结论 电生理学方法(MER)对于调整和确定靶点位置至关重要。MER术中导引定位法有助于手术的完全成功。 | Wai.S Poon Danny TM Chan XL Zhu Vincent CT Mok YL Chan | 2002 | 中华神经外科疾病研究杂志2002，1，2： | 2 |
| 3 | Sludge drying reedbed for septage treatment : towards design and operationrecommendations显示文摘 | VINCENT J’MOLLE P WISNIEWSKI Ct | 2011 | Bioresource Technology2011，102，17： | 1 |
| 4 | Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca^2+ sensitization of contraction in vascular smooth muscle显示文摘 | Vincent S Helene LJ Chrystelle CT | 2000 | J Biol Chem2000，275，21： | 1 |
| 5 | Dysregnlation of PAD4- mediated citrullination of nuclear GSK3β activates TGF-β signa- ling and indttees epithelial-to-mesenehymal transition in breast cancer cells显示文摘 | Stadler SC Vincent CT Fedorov VD | 2013 | Proe N ad Aead Sei USA2013，110，11： | 1 |
| 6 | A pilot- controlled study of a polymyxin B- immobilized hemoperfusion cartridgein patients with severe sepsis secondary to intra- abdominal infection显示文摘 | Vincent JL Laterre PF Cohen J ct al | 2005 | Shock2005，23，5： | 1 |
| 7 | Potassium channel anti- body-associated encephalopathy: a potentially immunothera- py-responsive form of limbic encephalitis显示文摘 | Vincent A Buckley C Schott JM ct al | 2004 | Brain2004，127，3： | 1 |
| 8 | Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca^2+ sensitization of contraction in vascular smooth muscle显示文摘 | Vincent S Helene LJ Chrystelle CT | 2000 | J Bio Chem2000，275，21： | 1 |
| 9 | Small cerebellopontine angle cisterns inpatients with trigeminal neuralgia显示文摘 | Parise M Ribeiro CT Vincent M | 2010 | J Neurosurg2010，112，90： | 1 |
| 10 | Dysreg- ulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epi- thelial-to-mesenchymal transition in breast cancer cells显示文摘 | Stadler SC1 Vincent CT Fedorov VD | 2013 | Proceedings of the National Academy of Sciences of the United States of America2013，110，11： | 1 |
| 11 | Dysregulation of PAD4-mediated citrullination of nuclear GSK313 acti- vates TGF-I~ signaling and induces epithelial-to-mes- enchymal transition in breast cancer cells显示文摘 | Stadler SC Vincent CT Fedorov VD | 2013 | Proc Natl Acad Sci U S A2013，110，11： | 1 |
| 12 | Effect of white matter changes on cognitive impairment in patients with lacunar infarcts显示文摘 | Hong MW Vincent CT Yu HF | 2004 | Stroke2004，35，： | 1 |
| 13 | Genome sequencing reveals the role of rare genomic variants in Chinese patients with symptomatic intracranial atherosclerotic disease显示文摘Objectives The predisposition of intracranial atherosclerotic disease(ICAD)to East Asians over Caucasians infers a genetic basis which,however,remains largely unknown.Higher prevalence of vascular risk factors(VRFs)in Chinese over Caucasian patients who had a stroke,and shared risk factors of ICAD with other stroke subtypes indicate genes related to VRFs and/or other stroke subtypes may also contribute to ICAD.Methods Unrelated symptomatic patients with ICAD were recruited for genome sequencing(GS,60-fold).Rare and potentially deleterious single-nucleotide variants(SNVs)and small insertions/deletions(InDels)were detected in genome-wide and correlated to genes related to VRFs and/or other stroke subtypes.Rare aneuploidies,copy number variants(CNVs)and chromosomal structural rearrangements were also investigated.Lastly,candidate genes were used for pathway and gene ontology enrichment analysis.Results Among 92 patients(mean age at stroke onset 61.0±9.3 years),GS identified likely ICAD-associated rare genomic variants in 54.3%(50/92)of patients.Forty-eight patients(52.2%,48/92)had 59 rare SNVs/InDels reported or predicted to be deleterious in genes related to VRFs and/or other stroke subtypes.None of the 59 rare variants were identified in local subjects without ICAD(n=126).31 SNVs/InDels were related to conventional VRFs,and 28 were discovered in genes related to other stroke subtypes.Our study also showed that rare CNVs(n=7)and structural rearrangement(a balanced translocation)were potentially related to ICAD in 8.7%(8/92)of patients.Lastly,candidate genes were significantly enriched in pathways related to lipoprotein metabolism and cellular lipid catabolic process.Conclusions Our GS study suggests a role of rare genomic variants with various variant types contributing to the development of ICAD in Chinese patients. | Mengmeng Shi Xinyi Leng Ying Li Zihan Chen Ye Cao Tiffany Chung Bonaventure YM Ip Vincent HL Ip Yannie OY Soo Florence SY Fan Sze Ho Ma Karen Ma Anne Y Y Chan Lisa WC Au Howan Leung Alexander Y Lau Vincent CT Mok Kwong Wai Choy Zirui Dong Thomas W Leung | 2022 | Stroke & Vascular Neurology2022，7，3： | 0 |
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