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| 1 | Targeting Wnt/β-catenin pathway in hepatocellularcarcinoma treatment显示文摘Hepatocellular carcinoma(HCC) is one of the most common causes of cancer-related death worldwide. Liver cancer is generally related to hepatitis B or Cinfection and cirrhosis. Usually, patients with HCC are asymptomatic and are diagnosed at late stages when surgical treatment is no longer suitable. Limited treatment options for patients with advanced HCC are a major concern. Therefore, there is an urge for finding novel therapies to treat HCC. Liver cancer is highly heterogeneous and involved deregulation of several signaling pathways. Wnt/β-catenin pathway is frequently upregulated in HCC and it is implicated in maintenance of tumor initiating cells, drug resistance, tumor progression, and metastasis. A great effort in developing selective drugs to target components of the β-catenin pathway with anticancer activity is underway but only a few of them have reached phase Ⅰ clinical trials. We aim to review the role of β-catenin pathway on hepatocarcinogenesis and liver cancer stem cell maintenance. We also evaluated the use of small molecules targeting the Wnt/β-catenin pathway with potential application for treatment of HCC. | valery vilchez lilia turcios francesc marti roberto gedaly | 2016 | World Journal of Gastroenterology2016，22，2： | 51 |
| 2 | Induced pluripotent stem cells from Huntington's disease patients:a promising approach to define and correct disease-related alterations显示文摘Adult somatic cells such as skin or blood cells from either health donors or patients can be reprogrammed into induced pluripotent stem cells(iPSCs).Given their unlimited self-renewal and differentiation capacities,iPSCs are an invaluable resource to generate terminally differentiated cells.Thus,iPSCs can facilitate the study of human diseases and drug screening,holding great promise for regenerative medicine.Another significant advantage of iPSC disease-modeling is that normal and mutant proteins are expressed at endogenous levels.In addition,subtle phenotypes and the effects of genetic background variations can be assessed by comparison between iPSC lines obtained from different patients and healthy donors as well as isogenic lines,in which disease-related mutations are corrected. | Azra Fatima Ricardo Gutiérrez-Garcia David Vilchez | 2019 | Neural Regeneration Research2019，14，5： | 3 |
| 3 | An Interferon-free Antiviral Regimen for HCV after Liver Transplantation显示文摘 | Paul Y. Kwo Parvez S. Mantry Eoin Coakley Helen S. Te Hugo E. Vargas Robert Brown Fredric Gordon Josh Levitsky Norah A. Terrault James R. Burton Wangang Xie Carolyn Setze Prajakta Badri Tami Pilot-Matias Regis A. Vilchez Xavier Forns | 2014 | The New England Journal of Medicine2014，，25： | 2 |
| 4 | The impact of clinician education on IUD uptake, knowledge and attitudes: results of a randomized trial显示文摘 | David Hubacher Rosa Vilchez Rebecca Gmach Carlos Jarquin Jose Medrano Auxiliadora Gadea Tom Grey Bosny Pierre-Louis | 2006 | Contraception2006，，6： | 1 |
| 5 | Infectious spondylitis in the Balearic Islands:An analysis of 51cases显示文摘 | Raya Cruza M Vilchez Rueda HH Marinescu CI | 2015 | Rev Clin Esp2015，215，5： | 1 |
| 6 | Determination of fipronil by solid-phase microextraction and gas chromatography-mass spectrometry 显示文摘 | Vilchez J L Prieto A Araujo L | 2001 | Journal of Chromatography A2001，919，1： | 1 |
| 7 | Differential-pulse adsorptive stripping voltammetric determination of the antibacterial lomefloxzcin显示文摘 | ARAUJO L PRIETO A | 2001 | J Phar and Biome Anal2001，26，1： | 1 |
| 8 | Cost-benefit analysis of spironolactone use in the treatment of chronic heart failure显示文摘 | Alvarez JS Vilchez FG | 2001 | Rev Esp Cardiol2001，54，： | 1 |
| 9 | Azacitidine adverse effects in patients with myelodysplastic syndromes 显示文摘 | San Miguel Amigo L Franco Osorio R Mercadal Vilchez S | 2011 | AdvTher2011，28，14： | 1 |
| 10 | Effect of low-temperature plasma and chitosan treatment on wool dyeing with acid red 27 显示文摘 | JOCIC D VILCHEZ S TOPALOVIC T | 2005 | Journal of Applied Polymer Science2005，97，6： | 1 |
| 11 | HCV RNA viral load assessments in the era of direct-acting antivirals 显示文摘 | Cobb B Pockros PJ Vilchez RA | 2013 | Am J Gastroenterol2013，108，4： | 1 |
| 12 | Determination of trace amounts of bisphenol F,bisphenol A and their diglycidyl ethers in wastewater by gas chromatography-mass spectrometry显示文摘 | Jose Luis Vilchez Alberto Zafra Antonio Gonza lez-Casado | 2001 | Analytica Chimica Acta2001，431，： | 1 |
| 13 | Mathematical modeling of accidental gas releases显示文摘 | Montiel H Vilchez J A Casal J | 1998 | Journal of Hazardous Materials1998，59，2： | 1 |
| 14 | An integrated approach to the quardifieation of aortic regurgitation by Doppler eehoeardiography 显示文摘 | Zaranza J Arcs M vilchez F G | 1998 | Am Heart J1998，136，6： | 1 |
| 15 | Plasma levels of yon Willebrand factor are increased in patients with hyper- trophiccardiomyopathy 显示文摘 | Cambronero F Vilchez JA Garcia-Honrubia A | 2010 | ThrombRes2010，126，： | 1 |
| 16 | Analysing traces of autoinducer-2 requires standardization of the Vibrio harveyibioassay显示文摘 | VILCHEZ R LEMME A THIEL V | | 0，，02： | 1 |
| 17 | Gas chromatographic-mass spectrometric method for the determination of bisphenol A and its chlorinated derivatives in urban wastewater 显示文摘 | Zafra A del Olmo M Suarez B Hontoria E Navalon A O Vilchez J L | 2003 | Water Research2003，37，： | 1 |
| 18 | Evaluation of lisianthus cuhivars for resistance to Botrytis cinerea 显示文摘 | WEGULO S N VILCHEZ M | 2007 | Plant Disease2007，91，8： | 1 |
| 19 | Influenza virus infection in adult solid organ transplant re- cipients显示文摘 | VILCHEZ R A MCCURRY K DAUBER J | 2002 | Am J Transplant2002，2，3： | 1 |
| 20 | Effect of the concentration of suspended solids on the enzymatic activities and biodiversity of a submerged membrane bioreactor for aerobic treatment of domestic wastewater显示文摘 | M Molina-Munoz J M Poyatos R Vilchez | 2007 | Appl MicrobiolBiotechnol2007，73，6： | 1 |
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