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| 1 | Molecular diagnosis in cat allergy显示文摘Domestic cats represent one of the most common sources of indoor allergens.All over the world,many households own cats,whose allergens are persistent and widespread.Cat allergy itself is frequent,and its symptoms vary from rhinoconjunctivitis to life-threatening asthma.In vitro diagnosis using precision medicine allergy immunoassays is important because natural cat dander extracts may differ in quality and quantity of some of the individual allergen components and other molecules.In the component-resolved diagnosis of cat allergy,singleplex and multiplex specific immunoglobulin(Ig)E assays include use of the cat-specific major allergen,secretoglobin Fel d 1(as a species-specific molecule),other allergen components(such as lipocalins Fel d 4,cross-reacting with other animal similar molecules,and Fel d 7,present in small quantities in natural extracts),and serum albumin Fel d 2(related to the cat-pork syndrome).IgA Fel d 5 and IgM Fel d 6 are not available as allergen components in the current commercial IgE immunoassays,but they may impair the in vitro diagnostic evaluation of cat allergy because galactose-α1,3-galactose is an IgE-binding epitope of these native feline allergens.The benefits of molecular-based cat allergy diagnosis are continually evaluated,as the role of recombinant allergen components already known is detailed and new other molecules of interest may be discovered in the future. | Florin-Dan Popescu Carmen Saviana Ganea Carmen Panaitescu Mariana Vieru | 2021 | World Journal of Methodology2021，11，3： | 3 |
| 2 | Precision medicine allergy immunoassay methods for assessing immunoglobulin E sensitization to aeroallergen molecules显示文摘Molecular-based allergy diagnosis for the in vitro assessment of a patient immunoglobulin E(IgE) sensitization profile at the molecular level uses allergen molecules(also referred to as allergen components), which may be well-defined, highly purified, natural allergen components or recombinant allergens. Modern immunoassay methods used for the detection of specific Ig E against aeroallergen components are either singleplex(such as the fluorescence enzyme immunoassay with capsulated cellulose polymer solid-phase coupled allergens, the enzyme-enhanced chemiluminescence immunoassay and the reversed enzyme allergosorbent test, with liquid-phase allergens), multiparameter(such as the line blot immunoassay for defined partial allergen diagnostics with allergen components coating membrane strips) or multiplex(such as the microarraybased immunoassay on immuno solid-phase allergen chip, and the two new multiplex nanotechnology-based immunoassays: the patient-friendly allergen nanobead array, and the macroarray nanotechnology-based immunoassay used as a molecular allergy explorer). The precision medicine diagnostic work-up may be organized as an integrated 'U-shape' approach, with a 'top-down' approach(from symptoms to molecules) and a 'bottomup' approach(from molecules to clinical implications), as needed in selected patients. The comprehensive and accurate Ig E sensitization molecular profiling, with identification of the relevant allergens, is indicated within the framework of a detailed patient's clinical history to distinguish genuine Ig E sensitization from sensitization due to cross-reactivity(especially in polysensitized patients), to assess unclear symptoms and unsatisfactory response to treatment, to reveal unexpected sensitizations, and to improve assessment of severity and risk aspects in some patients. Practical approaches, such as anamnesis molecular thinking, laboratory molecular thinking and postmolecular anamnesis, are sometimes applied. The component-resolved diagnosis of the specific IgE repertoire has a key impact on optimal decisions making for prophylactic and specific immunotherapeutic strategies tailored for the individual patient. | Florin-Dan Popescu Mariana Vieru | 2018 | World Journal of Methodology2018，8，3： | 2 |
| 3 | Tuberculous meningitis - clinical and epidemiological considerations ( a retrospective study 2008 - 2011 ) 显示文摘 | Luea MC Vieru A VA | 2012 | Rev Med Chir Soc Med Nat Iasi2012，116，3： | 1 |
| 4 | Starting solutions for the oscillating motion of a Maxwell fluid in cylindrical domains显示文摘 | D. Vieru W. Akhtar Corina Fetecau C. Fetecau | 2007 | Meccanica2007，，6： | 1 |
| 5 | New exact solutions corresponding to the first problem of Stokes for Oldroyd-B fluids显示文摘 | Vieru D Nazar M Fetecau Corina Fetecau C | 2008 | Int J Computers and Mathematics With Appl2008，55，8： | 1 |
| 6 | Decay of a potential vortex in a generalized Oldroyd-B fluid显示文摘 | Fetecau C Fetecau C Khan M Vieru D | 2008 | Appl Math Computation2008，205，1： | 1 |
| 7 | On the oscillating motion of an Oldroyd-B fluid betweentwo infinite circular cylinders显示文摘 | Fetecau C Akhtar W Imran M A Vieru D | 2010 | Computers&Mathematics With Applications2010，59，8： | 1 |
| 8 | General Solutions for Hydromagnetic Free Convection Flow over an Infinite Plate with Newtonian Heating, Mass Diffusion and Chemical Reaction显示文摘The problem of hydromagnetic free convection flow over a moving infinite vertical plate with Newtonian heating, mass diffusion and chemical reaction in the presence of a heat source is completely solved. Radiative and porous effects are not taken into consideration but they can be immediately included by a simple rescaling of Prandtl number and magnetic parameter. Exact general solutions for the dimensionless velocity and concentration fields and the corresponding Sherwood number and skin friction coefficient are determined under integral form in terms of error function or complementary error function of Gauss. They satisfy all imposed initial and boundary conditions and can generate exact solutions for any problem with technical relevance of this type. As an interesting completion, uncommon in the literature, the differential equations which describe the thermal, concentration and momentum boundary layer, as well as the exact expressions for the thicknesses of thermal, concentration or velocity boundary layers were determined.Numerical results have shown that the thermal boundary layer thickness decreases for increasing values of Prandtl number and the concentration boundary layer thickness is decreasing with Schmidt number. Finally, for illustration,three special cases are considered and the influence of physical parameters on some fundamental motions is graphically underlined and discussed. The required time to reach the flow according with post-transient solution(the steady-state),for cosine/sine oscillating concentrations on the boundary is graphically determined. It is found that, the presence of destructive chemical reaction improves this time for increasing values of chemical reaction parameter. | Constatin Fetecau Nehad Ali Shah Dumitru Vieru | 2017 | Communications in Theoretical Physics2017，67，12： | 0 |
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