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| 1 | Multidisciplinary approach for patients with esophageal cancer显示文摘Patients with esophageal cancer have a poor prognosis because they often have no symptoms until their disease is advanced. There are no screening recommendations for patients unless they have Barrett's esophagitis or a significant family history of this disease. Often, esophageal cancer is not diagnosed until patients present with dysphagia, odynophagia, anemia or weight loss. When symptoms occur, the stage is often stage Ⅲ or greater. Treatment of patients with very early stage disease is fairly straight forward using only local treatment with surgical resection or endoscopic mucosal resection. The treatment of patients who have locally advanced esophageal cancer is more complex and controversial. Despite multiple trials, treatment recommendations are still unclear due to conflicting data. Sadly, much of our data is difficult to interpret due to many of the trials done have included very heterogeneous groups of patients both histologically as well as anatomically. Additionally, studies have been underpowered or stopped early due to poor accrual. In the United States, concurrent chemoradiotherapy prior to surgical resection has been accepted by many as standard of care in the locally advanced patient. Patients who have metastatic disease are treated palliatively. The aim of this article is to describe the multidisciplinary approach used by an established team at a single high volume center for esophageal cancer, and to review the literature which guides our treatment recommendations. | Victoria M Villaflor Marco E Allaix Bruce Minsky Fernando A Herbella Marco G Patti | 2012 | World Journal of Gastroenterology2012，18，46： | 9 |
| 2 | Upper gastrointestinal tract capsule endoscopy using a nurse-led protocol: First reported experience显示文摘AIM To test the feasibility and performance of a novel upper gastrointestinal(GI) capsule endoscope using a nurse-led protocol. METHODS We conducted a prospective cohort analysis of patients who declined gastroscopy(oesophagogastroduodenoscopy, OGD) but who consented to upper GI capsule endoscopy. Patients swallowed the upper GI capsule following ingestion of 1 liter of water(containing simethicone). A series of positional changes were used to exploit the effects of water flow and move the upper GI capsule from one gravity-dependent area to another using a nurse-led protocol. Capsule transit time, video reading time, mucosal visualisation, pathology detection and patient tolerance was evaluated.RESULTS Fifty patients were included in the study. The mean capsule transit times in the oesophagus and stomach were 28 s and 68 min respectively. Visualisation of the following major anatomical landmarks was achieved(graded 1-5: Poor to excellent): Oesophagus, 4.8(± 0.5); gastro-oesophageal junction(GOJ), 4.8(± 0.8); cardia, 4.8(± 0.8); fundus, 3.8(± 1.2); body, 4.5(± 1); antrum, 4.5(± 1); pylorus, 4.7(± 0.8); duodenal bulb, 4.7(± 0.7); second part of the duodenum(D2), 4.7(± 1). The upper GI capsule reached D2 in 64% of patients. The mean video reading time was 48 min with standard playback mode and 20 min using Quickview(P = 0.0001). No pathology was missed using Quickview. Procedural tolerance was excellent. No complications were seen with the upper GI capsule. CONCLUSION The upper GI capsule achieved excellent views of the upper GI tract. Future studies should compare the diagnostic accuracy between upper GI capsule and OGD. | Hey-Long Ching Ailish Healy Victoria Thurston Melissa F Hale Reena Sidhu Mark E McAlindon | 2018 | World Journal of Gastroenterology2018，24，26： | 9 |
| 3 | The role of antioxidants and pro-oxidants in colon cancer显示文摘This review focuses on the roles antioxidants and prooxidants in colorectal cancer(CRC).Considerable evidence suggests that environmental factors play key roles in the incidence of sporadic CRC.If pro-oxidant factors play an etiological role in CRC it is reasonable to expect causal interconnections between the wellcharacterized risk factors for CRC,oxidative stress and genotoxicity.Cigarette smoking,a high dietary consumption of n-6 polyunsaturated fatty acids and alcohol intake are all associated with increased CRC risk.These risk factors are all pro-oxidant stressors and their connections to oxidative stress,the intestinal microbiome,intestinal microfold cells,cyclooxygenase-2 and CRCare detailed in this review.While a strong case can be made for pro-oxidant stressors in causing CRC,the role of food antioxidants in preventing CRC is less certain.It is clear that not every micronutrient with antioxidant activity can prevent CRC.It is plausible,however,that the optimal food antioxidants for preventing CRC have not yet been critically evaluated.Increasing evidence suggests that RRR-gamma-tocopherol(the primary dietary form of vitamin E)or other'non-alpha-tocopherol'forms of vitamin E(e.g.,tocotrienols)might be effective.Aspirin is an antioxidant and its consumption is linked to a decreased risk of CRC. | William L Stone Koyamangalath Krishnan Sharon E Campbell Victoria E Palau | 2014 | World Journal of Gastrointestinal Oncology2014，6，3： | 4 |
| 4 | Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression显示文摘 | Victoria G Weis Josane F Sousa Bonnie J LaFleur Ki Taek Nam Jared A Weis Paul E Finke Nadia A Ameen James G Fox James R Goldenring | 2013 | Gut2013，，9： | 3 |
| 5 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 6 | Technique for escape from geosynehronous transfer orbit using a solar sail显示文摘 | Victoria L Coverstone John E Prussing | 2003 | Journal of Guid- ance Control and Dynamics2003，26，4： | 1 |
| 7 | Atomic force microscopy investigation of human immunodeficiency virus (HIV) and HIV-infected lymphocytes显示文摘 | Kuznetsov Y G Victoria J G Robinson W E | 2003 | J Virol2003，77，11： | 1 |
| 8 | WooMapping of deletion and translocation breakpoints in 1@4 implicates the serine/ threonine kinase Akt3 in postnatal microcephaly and agenesis of the corpus callosum显示文摘 | Boland E Jill C S Victoria G | 2007 | Am J Hum Genet2007，81，2： | 1 |
| 9 | Enzymes of phospholipids metabolism in the plasma of Acanthamoeba castellanii显示文摘 | Victoria E J Korn ED | 1975 | J Lipid Res1975，16，1： | 1 |
| 10 | Comparison of convention and miniemulsion copolymerizations of acyrlic monomers using poly (vinyl alcohol) as the sole stabilizer 显示文摘 | Noma K Sudol E D Victoria L | 2004 | Macromolecules2004，，37： | 1 |
| 11 | Role of Fas/Fas-L in vascular cell apoptosis显示文摘 | Victoria E Stoneman A PhD | 2009 | J Cardiovasc PharmacolTM2009，53，2： | 1 |
| 12 | Technique for Escape from Geosynchronous Transfer Orbit Using a Solar Sail 显示文摘 | Victoria L Coverstone John E Prussing | 2003 | Journal of Guidance Control and Dynamics2003，26，4： | 1 |
| 13 | Ca^2+ influx through AMPA or Kainate receptors alone is sufficient to initiate excitotoxicity in cultured aligodendrocytes 显示文摘 | Alberdi E Victoria MS Marino A | 2002 | Neurobiol Dis2002，9，2： | 1 |
| 14 | Role played by Protein Phosphatase 2A in insulin secretion显示文摘 | Vinay KP Aditi JS Victoria E | 2005 | Pancreas2005，6，4： | 1 |
| 15 | The timecourse of induction of brain - drived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise 显示文摘 | Paul A A Victoria M P Christie E C | 2004 | Neurosci2004，363，1： | 1 |
| 16 | Synthesis and characterization of amino-terminated telechelic polybutadiene显示文摘 | Jiangtian Xu Victoria L E David Sudol | 1995 | Journal ofPolymer Science Part A: Polymer Chemistry1995，33，8： | 1 |
| 17 | Use of ultrasound and MRIfor evaluation of lung volumes in fetuses with isolated leftcongenital diaphragmatic hernia显示文摘 | Victoria T Danzer E Adzick NS | 2013 | Semin Pediatr Surg2013，22，： | 1 |
| 18 | Use of ultrasound and MRI for evaluation of lung volumes in fetuses with isolated left congenital diaphragmatic hernia显示文摘 | Victoria T Danzer E Adzick NS | 2013 | Semin Pediatr Surg2013，22，： | 1 |
| 19 | Improvement of fermentation conditions for the production of X-prolyl-dipeptidyl aminopeptidase from Lactococcus lactis 显示文摘 | Prrez-Guzmfin A E Victoria T C Y Cruz-Camarillo | 2004 | World Journal of Microbiology & Biotechnology2004，20，4： | 1 |
| 20 | Pemphigus: A treatment update 显示文摘 | Dick Sarah E Werth Victoria P | 2006 | Autoimmunity2006，39，7： | 1 |
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