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| 1 | Acceptability of an acupuncture intervention for geriatric chronic pain: an open pilot study显示文摘OBJECTIVE: This study investigated the acceptability and effectiveness of acupuncture for persistent musculoskeletal pain in the elderly and assessed the conditions for a future controlled trial. METHODS: A total of 60 patients, hospitalized in a geriatric hospital were enrolled. The intervention consisted of eight acupuncture sessions. The main outcome was the patient's participation rate. Regarding pain, the evaluation was based on pre- and post-treatment variations. As a high proportion of the patients had cognitive impairment, the behavioral pain scale DOLOPLUS-2 was chosen although self evaluation was used wherever possible. RESULTS: The mean age of the patients was 83 years. The acceptance rate was very high (89.6%) and 90% of the patients completed the entire course of treatment. After five weeks, the mean DOLOPLUS score had decreased significantly (P<0.01). The patients reported improved sleep quality and a reduction in their anxiety symptoms. Furthermore, caregivers noticed a decrease in patient aggressiveness making care easier. CONCLUSION: Our results suggest that acupuncture is highly acceptable and could be very useful in the management of chronic pain when performed in very old frail people with chronic physical and mental disability. | Marie-France Couilliot Veronique Dareest Bruno.Tenenbaum Gerard Delahaye Philippe Ercolano Maud Carcaille Pavia Vytopilova Bruno Tenenbaum Eric Vicaut | 2013 | Journal of Integrative Medicine2013，11，1： | 5 |
| 2 | Magnetic Resonance Elastography for the Noninvasive Staging of Liver Fibrosis显示文摘 | Laurent Huwart Christine Sempoux Eric Vicaut Najat Salameh Laurence Annet Etienne Danse Frank Peeters Leon C. ter Beek Jacques Rahier Ralph Sinkus Yves Horsmans Bernard E. Van Beers | 2008 | Gastroenterology2008，，1： | 4 |
| 3 | Impact of Metformin on the Prognosis of Cirrhosis Induced by Viral Hepatitis C in Diabetic Patients显示文摘 | Gisèle Nkontchou Emmanuel Cosson Mounir Aout Amel Mahmoudi Valérie Bourcier Iliass Charif Nathalie Ganne-Carrie Véronique Grando-Lemaire Eric Vicaut Jean-Claude Trinchet Michel Beaugrand | 2011 | The Journal of Clinical Endocrinology & Metabolism2011，，8： | 3 |
| 4 | 低剂量白细胞介素-2在11种自身免疫疾病中的免疫学和临床疗效:单中心开放临床试验显示文摘背景调节性T(Tregs)细胞可以预防自身免疫并控制炎症,在各种自身免疫性或自身炎症性疾病中的研究都表明Treg细胞不足。由于低剂量白细胞介素-2(low-dose interleukin-2,ld-IL2)能够扩增并激活Tregs细胞,因此ld-IL2具有广泛的治疗潜力。目的我们通过一项临床试验观察ld-IL2治疗11种自身免疫性疾病中1种的效果,旨在评估ld-IL2的治疗潜力并选择疾病,以用于进一步的临床开发。方法本研究为前瞻开放性Ⅰ~Ⅱa期临床观察,入选了46例轻中度患者,诊断分别为类风湿关节炎、强直性脊柱炎、系统性红斑狼疮、牛皮癣、白塞病、肉芽肿性多血管炎、大动脉炎、克罗恩病、溃疡性结肠炎、自身免疫性肝炎或硬化性胆管炎。所有患者都接受了ld-IL2(100万IU/天)5天,然后每两周注射一次,维持6个月。所有患者均接受了深入的免疫监测和临床评估。结果在任何疾病类型以及任何合并药物治疗的患者中,ld-IL2都显示出了良好的耐受性。通过经典的免疫表型分析和广泛的免疫表型分析发现所有患者的Tregs细胞均被特异性地扩增激活,而效应T细胞没有被活化,提示ld-IL2具有临床疗效的前景。结论本研究中所采用的IL-2剂量和治疗方案可以选择性地激活和扩增Tregs细胞,并且对于不同的疾病种类以及不同的合并用药都是安全的。这一临床疗效以及初步结果可以为ld-IL2在各种自身免疫和自身炎症性疾病中开展Ⅱ期临床试验观察疗效提供了依据。试验注册号NCT01988506. | Michelle Rosenzwajg Roberta Lorenzon Patrice Cacoub Hang Phuong Pham Fabien Pitoiset Karim El Soufi Claire RIbet Claude Bernard Selim Aractingi Beatrice Banneville Laurent Beaugerie Francis Berenbaum Julien Champey Olivier Chazouilleres Christophe Corpechot Bruno Fautrel Arsfene Mekinian Elodie Regnier David Saadoun Joe-Elie Salem Jeremie Sellam Philippe Seksik Anne Daguenel-Nguyen Valene Doppler Jeremie Mariau Eric Vicaut David Klatzmann 杨新蕾(译) 张卓莉(校) | 2019 | 英国医学杂志中文版2019，22，2： | 2 |
| 5 | Prospective study of symptomatic atherothrombotic intracranial stenoses: The GESICA Study显示文摘 | M Mazighi R Tanasescu X Ducrocq E Vicaut S Bracard E Houdart F Woimant | 2006 | Neurology2006，，8： | 2 |
| 6 | Helical CT-enteroclysis in the detection of small-bowel tumours: a meta-analysis显示文摘 | Philippe Soyer Mounir Aout Christine Hoeffel Eric Vicaut Vinciane Placé Mourad Boudiaf | 2013 | European Radiology2013，，2： | 2 |
| 7 | Sequential-design,multicenter,randomized,controlled trial of early decompressive craniectomy in malignant middle cerebral artery infarction(DECIMAL Trial)显示文摘 | Vahedi K Vicaut E Mateo J | 2007 | Stroke2007，38，9： | 1 |
| 8 | Predictive factors for failure of percutaneous drainage of postoperative abscess after abdominal surgery显示文摘 | Fulgence Kassi Anthony Dohan Philippe Soyer Eric Vicaut Mourad Boudiaf Patrice Valleur Marc Pocard | 2013 | The American Journal of Surgery2013，，： | 1 |
| 9 | Differences between eytokine effects in the mierocirculation of the rat显示文摘 | Baudry N Rasetti C Vicaut E | 1996 | Am J Physiol1996，271，32： | 1 |
| 10 | Acute release of plasmi-nogen activator inhibitor-1 in ST-segment elevation myocardial infarction predicts mortality显示文摘 | Collet JP Montalescot G Vicaut E | 2003 | Circulation2003，108，： | 1 |
| 11 | Sequential-design, multicenter, randomized, controlled trial of early decompressive craniectomy in malignant middle cerebral artery infarction (decimal trial)显示文摘 | Vahedi K Vicaut E Mateo J | 2007 | Stroke2007，38，9： | 1 |
| 12 | Inflammatory cytokines,C-reactive protein,and procalcition as early predictors of necrosis infection in acute necrotizing pancreatitis显示文摘 | Riche FC Cholley BP Lasine MJ Vicaut E Panis YH Lajeunie E J | 2003 | Surgery2003，133，3： | 1 |
| 13 | Meta-analysis of randomized trials of colorectal surgery with or without mechanical bowel preparation 显示文摘 | Slim K Vicaut E Panis Y | 2004 | Br J Surg2004，91，9： | 1 |
| 14 | Meta - analysis of randomized clin- ical trials of colorectal surgery with or without mechanical bowel preparation 显示文摘 | Slim K Vicaut E Panis Y | 2004 | Br J Surg2004，91，9： | 1 |
| 15 | Meta - analysis of ran- domized clinical trials of colorectal surgery with or with- out mechanical bowel preparation 显示文摘 | Slim K Vicaut E Panis Y | 2004 | Br J Surg2004，91，9： | 1 |
| 16 | A high interleukin 1 receptor antagonist/IL-1beta ratio occurs naturally in knee osteoarthritis显示文摘 | Richette P Francois M Vicaut E | 2008 | J Rheumatol2008，35，8： | 1 |
| 17 | Endovascular treatment of basilar tip aneurysms with GDC : predictors of immediate and long term results with multivariate analysis -6 - year experience 显示文摘 | Vallee JN Aymard A Vicaut E | 2003 | Radiology2003，226，3： | 1 |
| 18 | Endovaseular Treatment of Basilar Tip Aneurysms with Gugliei I Detachable Coils Predictors of in Mediate and Long-tern Results with Multivariate Analysis 6-year Experience 显示文摘 | Vallee J N Aymartl A Vicaut E | 2003 | Radiology ( S0033 -- 8419 )2003，226，4： | 1 |
| 19 | Meta-analysis of randomized clinical trials of colorectal surgery with or without mechanical bowel preparation显示文摘 | Slim K Vicaut E Panis Y | 2004 | Br J Surg2004，91，9： | 1 |
| 20 | Risk Factors for A- cute Postoperative Renal Failure in Thoraci or Thoracoabd0minal Aortic Surgery : A Prospective Study 显示文摘 | Gilles G Marie-H&ne F1Qon Eric Vicaut | 1997 | Anesth analg1997，85，： | 1 |
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