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| 1 | Post-partum reactivation of chronic hepatitis B virus infection among hepatitis B e-antigen-negative women显示文摘AIM: To investigate the frequency and timing of post-partum chronic hepatitis B virus(HBV) reactivation and identify its pre-partum predictors. METHODS: Forty-one hepatitis B e antigen(HBe Ag)-negative chronic HBV infected pregnant women were prospectively evaluated between the 28 th and the 32 nd week of gestation. Subjects were re-evaluated at 3-mo intervals during the first post-partum year and every 6 mo during the following years. HBV DNA was determined using real-time reverse transcription polymerase chain reaction(Cobas Taq Man HBV Test) with a lower detection limit of 8 IU/m L. Post-partum reactivation(PPR) was defined as abnormal alanine aminotransaminase(ALT) levels and HBV DNA above 2000 IU/m L. RESULTS: Fourteen out of 41 women(34.1%) had prepartum HBV DNA levels > 2000 IU/m L, 18(43.9%) had levels < 2000 IU/m L and 9(21.9%) had undetectable levels. Fourteen women were lost to follow-up(failure to return). PPR occurred in 8 of the 27(29.6%) women evaluated, all within the first 6 mo after delivery(5 at month 3; 3 at month 6). Five of the 6(83.3%) women with pre-partum HBV DNA > 10000 IU/m L exhibited PPR compared with 3 of the 21(14.3%) women with HBV DNA < 10000 IU/m L(two with HBV DNA > 2000 and the third with HBV DNA of 1850IU/m L), P = 0.004. An HBV DNA level ≥ 10000 IU/m L independently predicted post-partum HBV infection reactivation(OR = 57.02, P = 0.033). Mean pre-partum ALT levels presented a non-significant increase in PPR cases(47.3 IU/L vs 22.2 IU/L, respectively, P = 0.094).CONCLUSION: In the present study, PPR occurred in approximately 30% of HBe Ag-negative pregnant women; all events were observed during the first semester after delivery. Pre-partum HBV DNA level > 10000 IU/m L predicted PPR. | Ioannis Elefsiniotis Elena Vezali Dimitrios Vrachatis Sofia Hatzianastasiou Stefanos Pappas George Farmakidis Georgia Vrioni Athanasios Tsakris | 2015 | World Journal of Gastroenterology2015，21，4： | 7 |
| 2 | Relationship between serum b2-microglobulin levels and virological breakthrough in HBeAg-negative chronic hepatitis B patients,under long-term treatment schedules including lamivudine显示文摘AIM: Predictive value of serum b2-microglobulin (b2m)levels for virological breakthrough (VB) in HBeAg-negative chronic hepatitis B (CHB) patients under long-term treatment schedules including lamivudine (LAM).METHODS: Serum b2m levels were calculated during treatment in 25 CHB patients under long-term LAM monotherapy (group A) and 12 patients under initial interferon plus LAM treatment followed by LAM monotherapy (group B), using the MEIA technology. We used Cox proportional hazard models in order to investigate the association between serum b2m levels and VB.RESULTS: Seven of 25 patients (28%), 9/25 (36%) and 14/25 (56%) from group A and 0/12, 2/12 (16.6%) and 3/12 (25%) from group B exhibited VB at months 12, 24 and 36 of treatment, respectively. All patients, from both groups, who did not show VB exhibited b2m elevation in mo 3. The duration of b2m elevation was significantly longer in the virological responder's subgroup from group A than the non-responder's one (7.3±2.6 vs 3.8±3.4 mo,P = 0.02). In comparison to group A patients whose b2m levels were increased at 3 mo, patients whose b2m levels were decreased had 4.6 times higher risk of experiencing VB (RR = 4.6, P = 0.024). When baseline variables were simultaneously included in the same Cox model, decreased b2m status was still associated with increased risk of VB (RR = 12.2, P = 0.03).CONCLUSION: In HBeAg-negative CHB patients under either long-term LAM monotherapy or initial combination treatment, serum b2m levels at 3 mo of treatment,compared to baseline ones, might be a predictor of risk for VB. | Ioannis S.Elefsiniotis Antonios Moulakakis Konstantinos D.Pantazis Irene Glynou Ioannis Ketikoglou Elena Vezali Helen Kada Epameinondas Tsianos | 2005 | World Journal of Gastroenterology2005，11，13： | 4 |
| 3 | A review of the treatment of chronic hepatitis C virus infection in cirrhosis显示文摘 | Elena Vezali Alessio Aghemo Massimo Colombo | 2010 | Clinical Therapeutics2010，，13： | 2 |
| 4 | A review of the treatm ent of chronic hepatitis C virus infection in cirrhosis显示文摘 | Vezali E Aghem o A Colom bo M | 2010 | Clin Ther2010，32，13： | 1 |
| 5 | Clinical significance of serum proealcitonin levels in patients with acute or chronic liver disease显示文摘 | Elefsiniotis IS Skounakis M Vezali E | 2006 | Eur J Gastroenterol Hepatol2006，18，5： | 1 |
| 6 | Spontaneous preterm birth in women with chronic hepatitis B virus infection 显示文摘 | Elefsiniotis I Tsoumakas K Vezali E | 2010 | Int J Gynaecol Obstet2010，3，10： | 1 |
| 7 | Thyroid dysfunction in patients with chronic hepatitis C:Virus-or therapyrelated?显示文摘 | Vezali E Elefsiniotis I Mihas C | 2009 | J Gastroenterol Hepatol2009，24，6： | 1 |
| 8 | Presence of HBV-DNA in Cord Blood Is Associated with Spontaneous Preterm Birth in Pregnant Women with HBeAg-Negative Chronic Hepatitis B Virus Infection显示文摘 | Elefsiniotis Ioannis S Papadakis Miltos Vlachos George Vezali Elena Tsoumakas Konstantinos Saroglou George Antsaklis Aristidis | 2011 | EN2011，，5： | 1 |
| 9 | Thy- roid dysfunction in patients with chronic hepatitis C: Virus- or therapy-related 显示文摘 | Elena Vezali loannis Elefsiniotis Constantinos Mihas | 2009 | Journal of Gastroenterology and Hepatology2009，24，： | 1 |
| 10 | Left ventricular hypertrophy versus chronic kidney disease as predictors of cardiovascular events in hypertension:a Greek 6-year-follow-up study显示文摘 | Tsioufis C Vezali E Tsiachris D | 2009 | J Hypertens2009，27，4： | 1 |
| 11 | Spontaneous preterm birth in women with chronic hepatitis B virus infection 显示文摘 | Elefsiniotis I Tsoumakas K Vezali E | 2010 | Int J Gynecol Obstet2010，110，3： | 1 |
| 12 | Clinical signifi- cance of serum procalcitonin levels in patients with acute or chronic liver disease 显示文摘 | Elefsiniotis IS Skounakis M Vezali E | 2006 | Eur J Gastroenterol Hepatol2006，18，5： | 1 |
| 13 | A review of the treatment of chronic hepatitis c virus infection in cirrhosis 显示文摘 | Vezali E Aghemo A Colombo M | 2010 | Clin Ther2010，32，13： | 1 |
| 14 | Spontaneous preterm birth in women with chronic hepatitis B virus infection 显示文摘 | Elefsiniotis I Tsoumakas K Vezali E | 2010 | International Journal of Gynecology & Obstetrics2010，110，3： | 1 |
| 15 | Clinical significance of serum procalcitonin levels in patients with acute or chronic liver dis?ease显示文摘 | Elefsiniotis IS Skounakis M Vezali E | 2006 | Eur J Gastroenterol Hepatol2006，18，5： | 1 |
| 16 | Clinical significance of serum procalcitonin levels in patients with acute or chronic liver disease 显示文摘 | Elefsiniotis IS Skounakis M Vezali E | 2006 | Eur J Gastroenterol Hepatoh2006，18，5： | 1 |
| 17 | Left ventricular hypertrophy versus chronic kidney disease as predictors of cardiovascular events in hypertension:a Greek 6-year-follow-up study显示文摘 | Tsioufis C Vezali E Tsiachris D | | 0，，04： | 1 |
| 18 | A review of the treatment of chronic hepatitis C virus infection in cirrhosis显示文摘 | Elena Vezali Alessio Aghemo Massimo Colombo | 2010 | Clinical Therapeutics2010，，13： | 1 |
| 19 | Thyroiddys function inpatients with chronic hepatitis C:virus or therapy-related显示文摘 | Vezali E Elefsiniot is I Mihas C | | 0，，： | 1 |
| 20 | The controversial role of serum uric acid in essential hypertension: relationships with indices of target organ danmge 显示文摘 | TSIOUFIS C CHATZIS D VEZALI E | 2005 | J Hmn HyPertens2005，19，3： | 1 |
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