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| 1 | Studies on electroless Ni-P-Cr_2O_3 and Ni-P-SiO_2 composite coatings显示文摘本文对化学镀镍及化学镀镍磷基质中SiO2与Cr2O3的共沉积进行了研究。微粒在不断生长的膜层中共沉积引起了新的化学复合镀层的出现,这些复合镀层许多都具有优异的耐磨及耐蚀性能。通过选取镀层合金/复合微粒/金属基体的组分可改进镀层,获得所需的性能,以满足特别的需求。在对这些复合镀层的应用需求正在迫近与增长的同时,其市场正在迅速扩张。本文开发出了一种合适的复合化学镀镍液,并通过维氏硬度法对化学复合镀镍层进行了表征。采用动电位极化及交流阻抗法测定了镀层的Taber耐磨性能及耐蚀性能。采用SEM及XRD对复合镀层的表面形貌进行了分析。 | KARTHIKEYAN S SRINIVASAN K N VASUDEVAN T JOHN S | 2007 | 电镀与涂饰2007，26，1： | 15 |
| 2 | Abdominal tuberculosis of the gastrointestinal tract: Revisited显示文摘Abdominal tuberculosis is an increasingly common disease that poses diagnostic challenge,as the nonspecific features of the disease which may lead to diagnostic delays and development of complications.This condition is regarded as a great mimicker of other abdominal pathology.A high index of suspicion is an important factor in early diagnosis.Abdominal involvement mayoccur in the gastrointestinal tract,peritoneum,lymphnodes or solid viscera.Various investigative methods have been used to aid in the diagnosis of abdominal tuberculosis.Early diagnosis and initiation of antituberculous therapy and surgical treatment are essential to prevent morbidity and mortality.Most of the patients respond very well to standard antitubercular therapy and surgery is required only in a minority of cases.Imaging plays an important role in diagnosis of abdominal tuberculosis because early recognition of this condition is important.We reviewed our experience with the findings on various imaging modalities for diagnosis of this potentially treatable disease. | Uma Debi Vasudevan Ravisankar Kaushal Kishor Prasad Saroj Kant Sinha Arun Kumar Sharma | 2014 | World Journal of Gastroenterology2014，20，40： | 14 |
| 3 | 青少年及儿童近视进展及其危险因素显示文摘近视是全球重要的公共卫生问题。青少年及儿童近视患病率因在全球范围,尤其在亚洲地区,快速增长且影响因素复杂多样而受到广泛关注。尽管目前已有大量关于青少年及儿童近视进展及其危险因素的报道,然而由于人群、近视定义、睫状肌麻痹剂、验光方法等不同导致彼此间难以比较。本文就1990年至今关于青少年(〈18岁)和儿童近视进展及其与年龄、性别、屈光状态、近距工作、户外活动、父母近视或父母生育年龄等危险因素关系的报道进行总结。 | 林仲 梁远波 李晓霞 Balamurali Vasudevan Kenneth J Ciuffreda | 2015 | 中华实验眼科杂志2015，33，12： | 12 |
| 4 | Copy number variations are progressively associated with the pathogenesis of colorectal cancer in ulcerative colitis显示文摘AIM: To evaluate the association of known copy number variations(CNVs) in ulcerative colitis(UC) progressing to colorectal cancer.METHODS: Microsatellite instability analysis using the National Cancer Institute's panel of markers, and CNV association studies using Agilent 2 × 105 k arrays were done in tissue samples from four patient groups with UC: those at low risk(LR) or high risk of developing colorectal cancer, those with premalignant dysplastic lesions, and those with colitis-associated colorectal cancer(CAC). DNA from tissue samples of these groups were independently hybridized on arrays and analyzed. The data obtained were further subjected to downstream bioinformatics enrichment analysis to examine the correlation with CAC progression.RESULTS: Microarray analysis highlighted a progressive increase in the total number of CNVs [LR(n = 178) vs CAC(n = 958), 5.3-fold], gains and losses [LR(n = 37 and 141) vs CAC(n = 495 and 463), 13.4- and 3.3-fold, respectively], size [LR(964.2 kb) vs CAC(10540 kb), 10.9-fold] and the number of genes in such regions [LR(n = 119) vs CAC(n = 455), 3.8-fold]. Chromosomewise analysis of CNVs also showed an increase in the number of CNVs across each chromosome. There were 38 genes common to all four groups in the study; 13 of these were common to cancer genes from the Genetic Disease Association dataset. The gene set enrichment analysis and ontology analysis highlighted many cancerassociated genes. All the samples in the different groupswere microsatellite stable.CONCLUSION: Increasing numbers of CNVs are associated with the progression of UC to CAC, and warrant further detailed exploration. | Bhadravathi Marigowda Shivakumar Harish Rotti Thanvanthri Gururajan Vasudevan Aswath Balakrishnan Sanjiban Chakrabarty Ganesh Bhat Lakshmi Rao Cannanore Ganesh Pai Kapaettu Satyamoorthy | 2015 | World Journal of Gastroenterology2015，21，2： | 10 |
| 5 | Transcranial magnetic stimulation for geriatric depression: Promises and pitfalls显示文摘As the global population gets older, depression in the elderly is emerging as an important health issue. A major challenge in treating geriatric depression is the lack of robust efficacy for many treatments that are of significant benefit to depressed working age adults. Repetitive transcranial magnetic stimulation(r TMS) is a novel physical treatment approach used mostly in working age adults with depression. Many TMS trials and clinics continue to exclude the elderly from treatment citing lack of evidence in this age group. In this review, we appraise the evidence regarding the safety and efficacy of rT MS in the elderly. A consistent observation supporting a high degree of tolerability and safety among the elderly patients emerged across the Randomised Controlled Trials and the uncontrolled trials. Further, there is no reliable evidence negating the utility of rT MS in the elderly with depression. We also identified several factors other than age that moderate the observed variations in the efficacy of rT MS in the elderly. These factors include but not limited to:(1) brain atrophy;(2) intensity and number of pulses(dose-response relationship); and(3) clinical profile of patients. On the basis of the current evidence, the practice of excluding elderly patients from TMS clinics and trials cannot be supported. | Priyadharshini Sabesan Sudheer Lankappa Najat Khalifa Vasudevan Krishnan Rahul Gandhi Lena Palaniyappan | 2015 | World Journal of Psychiatry2015，5，2： | 7 |
| 6 | 在以EDTA和柠檬酸为配位剂的酸性硫代硫酸盐–亚硫酸盐镀液中电沉积金(英文)显示文摘以乙二胺四乙酸或柠檬酸作配位剂,在无氰的硫代硫酸盐–亚硫酸盐体系中研究了金在镀镍铜基底上的电沉积。在温度为60°C,pH为6和电流密度为2A/dm2的条件下,研究了不同配位剂对电流效率、镀速、镀层硬度及镀液分散能力的影响。最佳的镀液组成为0.5mol/L硫代硫酸钠–亚硫酸钠+0.2mol/L乙二胺四乙酸(或0.3mol/L柠檬酸)。该镀液具有良好的分散能力及高达98%的电流效率。采用扫描电镜、原子力显微镜及X射线衍射分析了镀态金镀层的表面形貌和晶体结构。所得的金镀层几乎无孔(孔隙率〈2-4个/cm2),结合力良好,硬度适中(80-130HV)。 | AMUTHA K SHAKKTHIVEL P VASUDEVAN T | 2007 | 电镀与涂饰2007，26，8： | 6 |
| 7 | Role of nutrients in the utilization of polycyclic aromatic hydrocarbons by halotolerant bacterial strain显示文摘A halotolerant bacterial strain VA1 isolated from marine environment was studied for its ability to utilize polycylic aromatic hydrocarbons (PAHs) under saline condition.Anthracene and pyrene were used as representatives for the utilization of PAH by the bacterial strain.Glucose and sodium citrate were used as additional carbon sources to enhance the PAH utilization.The strain VA1 was able to utilize anthracene (73%) and pyrene (66%) without any additional substrate.In the presence of additional carbon sources (glucose/sodium citrate) the utilization of PAH was faster.PAH was utilized faster by VA1 in the presence of glucose than sodium citrate.The stain utilized 87% and 83% of anthracene and pyrene with glucose as carbon source and with sodium citrate the strain utilized 81% and 76% respectively in 4 days.Urea as an alternative source of nitrogen also enhanced the utilization of PAHs (anthracene and pyrene) by the bacterial strain up to 88% and 84% in 4 days.Sodium nitrate as nitrogen source was not able to enhance the PAH utilization rate.Phenotypic and phlyogenetic analysis proved that the PAHs utilizing halotolerant strain VA1 belongs to Ochrobactrum sp. | Pugazhendi Arulazhagan Namsivayam Vasudevan | 2011 | Journal of Environmental Sciences2011，23，2： | 6 |
| 8 | The genetic framework for development of nephrolithiasis显示文摘Over 1%-15% of the population worldwide is affected by nephrolithiasis,which remains the most common and costly disease that urologists manage today.Identification of atrisk individuals remains a theoretical and technological challenge.The search for monogenic causes of stone disease has been largely unfruitful and a technological challenge;however,several candidate genes have been implicated in the development of nephrolithiasis.In this review,we will review current data on the genetic inheritance of stone disease,as well as investigate the evolving role of genetic analysis and counseling in the management of nephrolithiasis. | Vinaya Vasudevan Patrick Samson Arthur D.Smith Zeph Okeke | 2017 | Asian Journal of Urology2017，4，1： | 5 |
| 9 | Approach to medical therapy in perianal Crohn’s disease显示文摘Perianal Crohn’s disease remains a challenging condition to treat and can have a substantial negative impact on quality of life.It often requires combined surgical and medical interventions.Anti-tumor necrosis factor(anti-TNF)therapy,including infliximab and adalimumab,remain preferred medical therapies for perianal Crohn’s disease.Infliximab has been shown to be efficacious in improving fistula closure rates in randomized controlled trials.Clinicians can be faced with a number of questions relating to the optimal use of anti-TNF therapy in perianal Crohn’s disease.Specific issues include evaluation for the presence of perianal sepsis,the treatment target of therapy,the ideal time to commence treatment,whether additional medical therapy should be used in conjunction with anti-TNF therapy,and the duration of treatment.This article will discuss key studies which can assist clinicians in addressing these matters when they are considering or have already commenced anti-TNF therapy for the treatment of perianal Crohn’s disease.It will also discuss current evidence regarding the use of vedolizumab and ustekinumab in patients who are failing to achieve a response to anti-TNF therapy for perianal Crohn’s disease.Lastly,new therapies such as local injection of mesenchymal stem cell therapy will be discussed. | Abhinav Vasudevan David H Bruining Edward V Loftus Jr William Faubion Eric C Ehman Laura Raffals | 2021 | World Journal of Gastroenterology2021，27，25： | 4 |
| 10 | Time to clinical response and remission for therapeutics in inflammatory bowel diseases: what should the clinician expect, what should patients be told?显示文摘An awareness of the expected time for therapies to induce symptomatic improvement and remission is necessary for determining the timing of follow-up, disease(re)assessment, and the duration to persist with therapies, yet this is seldom reported as an outcome in clinical trials. In this review, we explore the time to clinical response and remission of current therapies for inflammatory bowel disease(IBD) as well as medication, patient and disease related factors that may influence the time to clinical response. It appears that the time to therapeutic response varies depending on the indication for therapy(Crohn's disease or ulcerative colitis). Agents with the most rapid time to clinical response included corticosteroids, calcineurin inhibitors, exclusive enteral nutrition, aminosalicylates and anti-tumor necrosis factor therapy which will work in most patients within the first 2 mo. Vedolizumab,methotrexate and thiopurines had a longer time to clinical response and can take several months to achieve maximal efficacy. Factors affecting the time to clinical response of therapies included use of concomitant therapy, disease duration, smoking status, disease phenotype and advanced age. There appears to be marked variation in time to clinical response for therapies used in IBD which is further influenced by disease and patient related factors. Understanding the expected time to therapeutic response is integral to inform further decision making, maintain a patientcentered approach and ensure treatment is given an appropriate timeframe to achieve maximal benefit prior to cessation. | Abhinav Vasudevan Peter R Gibson Daniel R van Langenberg | 2017 | World Journal of Gastroenterology2017，23，35： | 4 |
| 11 | Addressing quality of life in the patient with interstitial cystitis/bladder pain syndrome显示文摘Interstitial cystitis/bladder pain syndrome(IC/BPS)is a debilitating,chronic condition characterized by chronic pelvic pain,urinary urgency,and frequency and is well-known to be associated with a decrease in work productivity,emotional changes,sleep,sexual dysfunction,and mobility.Many metrics of quality of life(QoL)in this patient population have been developed;however,a unified,standardized approach to QoL in these patients has not been determined.The effects of IC/BPS and co-morbid conditions on QoL are described using current validated metrics.Next,data regarding successful treatment of IC/BPS in terms of QoL improvement are reviewed.While QoL is the single most important clinical measure of success in the treatment of patients suffering from IC/BPS,addressing QoL in this patient population remains a significant challenge,as its effects on QoL are highly variable and unable to be differentiated from the effects of comorbid conditions on QoL,including depression,poor sleep,and inability to work.Future studies will need to address treatment efficacy on the basis of IC/BPS specific QoL metrics,and multi-modal assessment and therapy to address comorbid disease will also play an important role in the future to ensure comprehensive management of these patients. | Vinaya Vasudevan Robert Moldwin | 2017 | Asian Journal of Urology2017，4，1： | 4 |
| 12 | 印度南部2型糖尿病患者糖尿病视网膜病变相关危险因素的研究(英文)显示文摘目的:探究2型糖尿病患者糖尿病视网膜病变(DR)的严重度及受试者中糖尿病视网膜病变严重程度与其病程、糖化血红蛋白水平、高血压史、年龄和性别的相关性。方法:横断面研究。2012-05/06,采取简单随机抽样方法进行结构化问卷调查,收集100例年龄≥35岁糖尿病视网膜病变患者。进行描述性统计、单变量和多变量有序逻辑回归分析。用excel表进行数据录入,并用SPSS 21.0进行数据分析(P<0.05)。结果:100例患者,平均年龄53.16±10.81(35~78)岁。通过单因素分析发现,糖尿病视网膜病变严重度与年龄(P<0.01),糖尿病病程(P<0.001),糖化血红蛋白水平(P<0.001),糖尿病家族史(P<0.01),高血压病史(P<0.05),均呈正相关,高密度脂蛋白(HDL)及年龄与DR严重程度无相关性。除年龄因素外,上述所有因素均为影响糖尿病视网膜病变严重度的独立风险因素。结论:研究表明,糖尿病病程、糖化血红蛋白水平、糖尿病家族史、高血压病史以及性别与糖尿病视网膜病变严重程度密切相关。但多因素分析中,年龄、HDL因素与DR严重程度无关。因此,利用现有治疗手段的有效性和及时控制,可以预防和消除视力威胁性疾病,延缓DR的发生。 | Senthilvel Vasudevan Sumathi Senthilvel Jayanthi Sureshbabu | 2017 | 国际眼科杂志2017，17，9： | 4 |
| 13 | Comparison of ocular modulation transfer function determined by a ray-tracing aberrometer and a double-pass system in early cataract patients显示文摘 | Qiao Liya Wan Xiuhua Cai Xiaogu Balamurali Vasudevan Xiong Ying Tan Jiaxuan Guan Zheng David A Atchison Wang Ningli | 2014 | Chinese Medical Journal2014，，19： | 3 |
| 14 | Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior显示文摘服的外皮为集成是必要的并且为大多数行为被要求的信息处理。当神经原从室的地区连续地移居联合进特定的外皮的层时,服的外皮的精致地精确的 laminar 组织在胚胎的开发期间产生。当时指南为设计神经原移植责骂的光线的神经胶质行为, pre-formed 脉管的网络为 GABAergic interneuron 移植提供支持和指导暗示。这研究提供新奇概念、机械学的卓见进 vascular-neuronal 相互作用的这个范例,揭示伽马氨基丁酸并且它经由胚胎的前脑 endothelial 房间的调停受体的发信号的新机制。与二个新 endothelial 房间的使用,特定的有条件的老鼠 GABA 小径当模特儿(Gabrb3 Tie2-Cre 和 Vgat 我们显示出的 Tie2-Cre ), 从 endothelial 房间的伽马氨基丁酸版本的那部分或完全的损失在 embryogenesis 期间导致脉管的缺点并且损害长途的移植并且外皮的 interneurons 放。使不安的 endothelial 的下游的效果导出房间的伽马氨基丁酸发信号是批评的,导致上次修改到外皮的电路和坚持的行为的赤字。而且,我们说明在支持他们血大脑障碍性质的迁居, angiogenesis 和获得的前脑 endothelial 房间发信号的伽马氨基丁酸的激活的新机制。我们的调查结果揭开并且阐明在从表明小径的古典 neuronal 伽马氨基丁酸是不同的并且在 neuropsychiatric 疾病的病原学和 pathophysiology 上打开新灯的 CNS 表明小径的新奇 endothelial 伽马氨基丁酸例如孤独性光谱混乱,癫痫,焦虑,消沉和精神分裂症。 | Suyan Li Peeyush Kumar Sampada Joshee Timo Kirschstein Sivan Subburaju Jahan S Khalili Jonas Kloepper Chuang Du Abdallah Elkhal Gabor Szabo Rakesh K Jain Rudiger Kohling Anju Vasudevan | 2018 | Cell Research2018，28，2： | 3 |
| 15 | A New Species of the Genus Tylototriton(Amphibia: Urodela: Salamandridae) from Eastern Himalaya显示文摘A new species of the genus Tylototriton is described from eastern Himalaya based on molecular and morphological comparisons. The new species is diagnosable from the closely-related species by having light brown colouration in dorsal region in life, flat and blunt snout, greatly separated dorsolateral bony ridges on head and straightthick tailfin. In addition to head morphology, the new species is also morphologically distinguishable from its closelyrelated species Tylototriton shanorum by having 16 dorsal warts and average smaller Snout Vent Length(SVL). | Janak Raj KHATIWADA Bin WANG Subarna GHIMIRE Karthikeyan VASUDEVAN Shanta PAUDEL Jianping JIANG | 2015 | Asian Herpetological Research2015，6，4： | 3 |
| 16 | 稳定性冠状动脉疾病患者的尿11-脱氢血栓素B_2与死亡率的关系显示文摘已有研究证明,应用阿司匹林抗血小板治疗可减少冠状动脉疾病(coronary artery disease,CAD)患者的不良预后。阿司匹林不可逆地抑制血小板环加氧酶1(cyclooxygenase-1,COX-1)并减弱血栓烷A2(thromboxane A2,TXA2)介导的血小板聚集, | 刘莉 叶鹏 McCullough PA Vasudevan A Sathyamoorthy M Schussler JM Velasco CE Lopez LR Swift C Peterson M Bennett-Firmin J Schiffmann R Bottiglieri T | 2017 | 中华高血压杂志2017，25，1： | 3 |
| 17 | Occurrence of Clostridium perfringens contamination in poultry feed ingredients:Isolation, identification and its antibiotic sensitivity pattern显示文摘This work has been undertaken to study the occurrence of Clostridium perfringens contamination in the poultry feed ingredients and find out its in-vitro antibiotic sensitivity pattern to various antimicrobial drugs. Two hundred and ninety-eight poultry feed ingredient samples received at Poultry Disease Diagnosis and Surveillance Laboratory, Namakkal, Tamil Nadu in South India were screened for the presence of C. perfringens. The organisms were isolated in Perfringens agar under anaerobic condition and subjected to standard biochemical tests for confirmation. In vitro antibiogram assay has been carried out to determine the sensitivity pattern of the isolates to various antimicrobial drugs. One hundred and one isolates of C. perfringens were obtained from a total of 298 poultry feed ingredient samples. Overall positivity of 33.89% could be made from the poultry feed ingredients. Highest level of C. perfringens contamination was detected in fish meal followed by bone meal, meat and bone meal and dry fish.Antibiogram assay indicated that the organisms are highly sensitive to gentamicin(100%), chlortetracycline(96.67%), gatifloxacin(93.33%), ciprofloxacin(86.67%), ofloxacin(86.67%) and lincomycin(86.67%). All the isolates were resistant to penicillin-G. Feed ingredients rich in animal proteins are the major source of C. perfringens contamination. | Shanmugasundaram Udhayavel Gopalakrishnamurthy Thippichettypalayam Ramasamy Vasudevan Gowthaman Shanmugasamy Malmarugan Kandasamy Senthilvel | 2017 | Animal Nutrition2017，，3： | 2 |
| 18 | Deep learning vs conventional learning algorithms for clinical prediction in Crohn's disease: A proof-of-concept study显示文摘BACKGROUND Traditional methods of developing predictive models in inflammatory bowel diseases(IBD)rely on using statistical regression approaches to deriving clinical scores such as the Crohn's disease(CD)activity index.However,traditional approaches are unable to take advantage of more complex data structures such as repeated measurements.Deep learning methods have the potential ability to automatically find and learn complex,hidden relationships between predictive markers and outcomes,but their application to clinical prediction in CD and IBD has not been explored previously.AIM To determine and compare the utility of deep learning with conventional algorithms in predicting response to anti-tumor necrosis factor(anti-TNF)therapy in CD.METHODS This was a retrospective single-center cohort study of all CD patients who commenced anti-TNF therapy(either adalimumab or infliximab)from January 1,2010 to December 31,2015.Remission was defined as a C-reactive protein(CRP)<5 mg/L at 12 mo after anti-TNF commencement.Three supervised learning algorithms were compared:(1)A conventional statistical learning algorithm using multivariable logistic regression on baseline data only;(2)A deep learning algorithm using a feed-forward artificial neural network on baseline data only;and(3)A deep learning algorithm using a recurrent neural network on repeated data.Predictive performance was assessed using area under the receiver operator characteristic curve(AUC)after 10×repeated 5-fold cross-validation.RESULTS A total of 146 patients were included(median age 36 years,48%male).Concomitant therapy at anti-TNF commencement included thiopurines(68%),methotrexate(18%),corticosteroids(44%)and aminosalicylates(33%).After 12 mo,64%had CRP<5 mg/L.The conventional learning algorithm selected the following baseline variables for the predictive model:Complex disease behavior,albumin,monocytes,lymphocytes,mean corpuscular hemoglobin concentration and gamma-glutamyl transferase,and had a cross-validated AUC of 0.659,95%confidence interval(CI):0.562-0.756.A feed-forward artificial neural network using only baseline data demonstrated an AUC of 0.710(95%CI:0.622-0.799;P=0.25 vs conventional).A recurrent neural network using repeated biomarker measurements demonstrated significantly higher AUC compared to the conventional algorithm(0.754,95%CI:0.674-0.834;P=0.036).CONCLUSION Deep learning methods are feasible and have the potential for stronger predictive performance compared to conventional model building methods when applied to predicting remission after anti-TNF therapy in CD. | Danny Con Daniel R van Langenberg Abhinav Vasudevan | 2021 | World Journal of Gastroenterology2021，27，38： | 2 |
| 19 | Microstructure of Long-Term Aged IN617 Ni-Base Superalloy显示文摘 | Quanyan Wu Hyojin Song Robert W. Swindeman John P. Shingledecker Vijay K. Vasudevan | 2008 | Metallurgical and Materials Transactions A2008，，11： | 2 |
| 20 | Structural and luminescence enhancement properties of Eu^(3+)/Ag nanocrystallites doped SiO_2-TiO_2 matrices显示文摘We reported here the structural and optical characterisation of silver nanocrystallites/Eu3+ :SiO2-TiO2 matrices synthesised through sol-gel route. Structural characterisations were done by using energy dispersive spectroscopy (EDX), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), atomic force microscope (AFM) and transmission electron microscopy (TEM) measurements and optical characterisations were performed by absorption and emission spectroscopy. The TEM and XRD measurements confirmed the presence of nanocrystals. A broad absorption band was observed due to surface plasmon resonance of silver nanocrystals. The effect of silver nanocrystals on the emission spectrum of Eu3+ doped SiO2-TiO2 matrices was discussed. An attempt was made to explain this fluorescence enhancement by invoking phenomena such as energy transfer, asymmetry ratio, surface plasmon, surface roughness, crystallinity and grain boundary. Our analysis, based on the experimental results, suggested that all the phenomena except crystallinity and grain boundary had favourable effects on fluorescence enhancement. We also estimated the relevant parameters associated with the phenomena that affected the fluorescence emission from the Eu3+ ions in the matrix. It was seen that the theoretical estimate of fluorescence enhancement agreed well with the experimental estimate. | Arun Kumar K V Revathy K P Prathibha Vasudevan Sunil Thomas Biju P R Unnikrishnan N V | 2013 | Journal of Rare Earths2013，31，5： | 2 |
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