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| 1 | Necrotizing enterocolitis: A multifactorial disease with no cure显示文摘Necrotizing enterocolitis is an inflammatory bowel disease of neonates with significant morbidity and mortality in preterm infants. Due to the multifactorial nature o the disease and limitations in disease models, early diagnosis remains challenging and the pathogenesis elusive. Although preterm birth, hypoxic-ischemic events formula feeding, and abnormal bacteria colonization are established risk factors, the role of genetics and vasoactive/inflammatory mediators is unclear Consequently, treatments do not target the specific underlying disease processes and are symptomatic and surgically invasive. Breast-feeding is the most effective preventative measure. Recent advances in the prevention of necrotizing enterocolitis have focused on bioactive nutrients and trophic factors in human milk. Developmen of new disease models including the aspect of prematurity that consistently predisposes neonates to the disease with multiple risk factors will improve our understanding of the pathogenesis and lead to discovery of innovative therapeutics. | Kareena L Schnabl John E Van Aerde Alan BR Thomson Michael T Clandinin | 2008 | World Journal of Gastroenterology2008，14，14： | 19 |
| 2 | [^11C]methionine PET, histopathology, and survival in primary brain tumors and recurrence显示文摘 | Ceyssens S Van Laere K de Groot T Goffin J Bormans G Mortelmans L | 2006 | 中国神经肿瘤杂志2006，4，3： | 13 |
| 3 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 4 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 5 | CD28/CTLA-4/B7 and CD40/CD40L costimulation and activation of regulatory T cells显示文摘Costimulatory signals are crucial for T cell activation. Attempts to block costimulatory pathways have been effective in preventing unwanted immune reactions. In particular, blocking the CD28/cytotoxic T lymphocyte antigen(CTLA)-4/B7 interaction(using CTLA-4Ig) and the CD40/CD40 L interaction(using anti-CD40 L antibodies) prevents T cell mediated autoimmune diseases, transplant rejection and graft vs host disease in experimental models. Moreover, CTLA-4Ig is in clinical use to treat rheumatoid arthritis(abatacept) and to prevent rejection of renal transplants(belatacept). Under certain experimental conditions, this treatment can even result in tolerance. Surprisingly, the underlying mechanisms of immune modulation are still not completely understood. We here discuss the evidence that costimulation blockade differentially affects effector T cells(Teff) and regulatory T cells(Treg). The latter are required to control inappropriate and unwanted immune responses, and their activity often contributes to tolerance induction and maintenance. Unfortunately, our knowledge on the costimulatory requirements of Treg cells is very limited. We therefore summarize the current understanding ofthe costimulatory requirements of Treg cells, and elaborate on the effect of anti-CD40 L antibody and CTLA-4Ig treatment on Treg cell activity. In this context, we point out that the outcome of a treatment aiming at blocking the CD28/CTLA-4/B7 costimulatory interaction can vary with dosing, timing and underlying immunopathology. | Isabel T Vogel Stefaan W Van Gool Jan L Ceuppens | 2014 | World Journal of Immunology2014，4，2： | 3 |
| 6 | Supercritical fluid chromatography of Ginkgolide A,B,C and J and bilobalide显示文摘 | Strode T B Taylor L T Van Beek T A | 1996 | J Chromatogr A1996，738，： | 2 |
| 7 | Flip PCR for DNA sequence motif invertion 显示文摘 | Schanke J T Quam L M Van Ness B G | 1994 | Bio Techniques1994，16，3： | 1 |
| 8 | Matching widely separated views based on affine invariant regions 显示文摘 | TUYTELAARS T Van GOOL L | 2004 | International Journal on Computer Vision2004，59，1： | 1 |
| 9 | Fas and Fas ligand: strong co-expression in human hepatceytes surrounding hepatoconular carcinoma; can cancer induce suicide in peritumoural cells? 显示文摘 | Roskams T Libbrecht L Van Damme B | 2000 | J Pathol2000，191，2： | 1 |
| 10 | A new technique of reversibly adsorbed phosphate显示文摘 | Fokkink L G J Van Reimsdijk W H | 1987 | Soil Sci Soc Am J1987，51，： | 1 |
| 11 | HMG-CoA reductase guides migrating primordial germ cells显示文摘 | van Doren M Broihier H T Moore L A | 1998 | Nature1998，396，6710： | 1 |
| 12 | Serum levels of CA125 and TPS during treatt ent of ovarian cancer 显示文摘 | VAN DALEN A FAVIER J BAUMGARTNER L t'al | 2000 | Anticancer Res2000，206，： | 1 |
| 13 | The effect of estrogen receptor genotype on litter size and placental traits at term in F2 crossbred gilts 显示文摘 | Van Rens B T de Groot P N Van Der L T | 2002 | Theriogenology2002，57，6： | 1 |
| 14 | The role of feed consumption and feed efficiency in copper-stimulated growth显示文摘 | ZHOU W KORNEGAY E T VAN L H | 1994 | J Ainm Sci1994，72，： | 1 |
| 15 | Gene expression profiling predicts clinical outcome of breast cancer 显示文摘 | van't Veer L J Dai H van de Vijver M J | 2002 | Nature2002，415，6871： | 1 |
| 16 | Risk indicators for pressure ulcers during surgery显示文摘 | Schoonhoven L Defloor T van der Tweel I | 2002 | Appl Nurs Res2002，15，3： | 1 |
| 17 | The osteogenic effect of electrosprayed nanoscale collagen/ calcium phosphate coatings on titanium显示文摘 | de Jonge L T Leeuwenburgh S C G van den Beucken J J J P | 2010 | Bioma?terials2010，31，9： | 1 |
| 18 | Determination o{ genetic structure of germplasm collections-Are traditional hierar- chical clustering methods appropriate for molecular marker data 显示文摘 | Odong T L van Heerwaarden J Jansen J | 2011 | TheorApplGenet2011，123，2： | 1 |
| 19 | Direct VUV photolysis of chlorinated methanes and their mixtures in a nitrogen stream 显示文摘 | Alapi T Van K C Van H L | 2007 | Chemosphere2007，66，1： | 1 |
| 20 | Effect of genetic variants of the heart fatty acid-binding protein gene on intramuscular fat and performan-ce traits in pigs显示文摘 | A J van Erp F L Hardem F J Verburg T H Meuwissen J HVeerkamp and M F te Pas | | 0，，04： | 1 |
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