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| 1 | A randomized trial of iron depletion in patients with nonalcoholic fatty liver disease and hyperferritinemia显示文摘AIM:To compare iron depletion to lifestyle changes alone in patients with severe nonalcoholic fatty liver disease(NAFLD)and hyperferritinemia,a frequent feature associated with more severe liver damage,despite at least 6 mo of lifestyle changes.METHODS:Eligible subjects had to be 18-75 years old who underwent liver biopsy for ultrasonographically detected liver steatosis and hyperferritinemia,ferritin levels≥250 ng/mL,and NAFLD activity score>1.Iron depletion had to be achieved by removing 350 cc of blood every 10-15 d according to baseline hemoglobin values and venesection tolerance,until ferritin<30 ng/mL and/or transferrin saturation(TS)<25%.Thirty-eight patients were randomized 1:1 to phlebotomy(n=21)or lifestyle changes alone(n=17).The main outcome of the study was improvement in liver damage according to the NAFLD activity score at 2 years,secondary outcomes were improvements in liver enzymes[alanine aminotransferases(ALT),aspartate aminotransferase(AST),and gamma-glutamyl-transferases(GGT)].RESULTS:Phlebotomy was associated with normalization of iron parameters without adverse events.In the21 patients compliant to the study protocol,the rate of histological improvement was higher in iron depleted vs control subjects(8/12,67%vs 2/9,22%,P=0.039).There was a better improvement in steatosis grade in iron depleted vs control patients(P=0.02).In patients followed-up at two years(n=35),ALT,AST,and GGT levels were lower in iron-depleted than in control patients(P<0.05).The prevalence of subjects with improvement in histological damage or,in the absence of liver biopsy,ALT decrease≥20%(associated with histological improvement in biopsied patients)was higher in the phlebotomy than in the control arm(P=0.022).The effect of iron depletion on liver damage improvement as assessed by histology or ALT decrease≥20%was independent of baseline AST/ALT ratio and insulin resistance(P=0.0001).CONCLUSION:Iron depletion by phlebotomy is likely associated with a higher rate of improvement of histological liver damage than lifestyle changes alone in patients with NAFLD and hyperferritinemia,and with amelioration of liver enzymes. | Luca Valenti Anna Ludovica Fracanzani Paola Dongiovanni Serena Rovida Raffaela Rametta Erika Fatta Edoardo Alessandro Pulixi Marco Maggioni Silvia Fargion | 2014 | World Journal of Gastroenterology2014，20，11： | 8 |
| 2 | Sustained virologic response to direct-acting antiviral agents predicts better outcomes in hepatitis C virus-infected patients: A retrospective study显示文摘BACKGROUND Direct-acting antiviral agents(DAAs)are extremely effective in eradicating hepatitis C virus(HCV)in chronically infected patients.However,the protective role of the sustained virologic response(SVR)achieved by second-and thirdgeneration DAAs against the onset of hepatocellular carcinoma(HCC)and mortality is less well established.AIM To examine the occurrence of HCC or death from any cause in a retrospectiveprospective study of patients treated with DAAs.METHODS Patients were enrolled from a tertiary academic hospital center for liver disease management that collects subject data mainly from northeastern Italy.The study was conducted in 380 patients(age:60±13 years,224 males,32%with cirrhosis)treated with DAAs with or without SVR(95/5%),with a median follow up of 58 wk(interquartile range:38-117).The baseline anthropometric features,HCV viral load,severity of liver disease,presence of extra-hepatic complications,coinfection with HIV and/or HBV,alcohol consumption,previous interferon use,alphafetoprotein levels,and renal function were considered to be confounders.RESULTS The incidence rate of HCC in patients with and without SVR was 1.3 and 59 per 100 person-years,respectively(incidence rate ratio:44,95%CI:15-136,P<0.001).Considering the combined endpoint of HCC or death from any cause,the hazard ratio(HR)for the SVR patients was 0.070(95%CI:0.025-0.194,P<0.001).Other independent predictors of HCC or death were low HCV viremia(HR:0.808,P=0.030),low platelet count(HR:0.910,P=0.041),and presence of mixed cryoglobulinemia(HR:3.460,P=0.044).Considering SVR in a multi-state model,the independent predictors of SVR achievement were absence of cirrhosis(HR:0.521,P<0.001)and high platelet count(HR:1.019,P=0.026).Mixed cryoglobulinemia predicted the combined endpoint in patients with and without SVR(HR:5.982,P=0.028 and HR:5.633,P=0.047,respectively).CONCLUSION DAA treatment is effective in inducing SVR and protecting against HCC or death.A residual risk of HCC persists in patients with advanced liver disease or with complications,such as mixed cryoglobulinemia or renal failure. | Gian Luca Colussi Debora Donnini Rosario Francesco Brizzi Silvia Maier Luca Valenti Cristiana Catena Alessandro Cavarape Leonardo Alberto Sechi Giorgio Soardo | 2019 | World Journal of Gastroenterology2019，25，40： | 4 |
| 3 | Holmium laser enucleation of the prostate combined with mechanical morcellation in 155 patients with benign prostatic hyperplasia显示文摘 | Rodolfo Hurle Ivano Vavassori Alessandro Piccinelli Alberto Manzetti Sergio Valenti Alberto Vismara | 2002 | Urology2002，，3： | 1 |
| 4 | Liposomal incorporation of Artemisia arborescens L. essential oil and in vitro antiviral activity显示文摘 | Chiara Sinico Alessandro De Logu Francesco Lai Donatella Valenti Maria Manconi Giuseppe Loy Leonardo Bonsignore Anna Maria Fadda | 2004 | European Journal of Pharmaceutics and Biopharmaceutics2004，，1： | 1 |
| 5 | Power-Aware Routing and Wavelength Assignment in Multi-Fiber Optical Networks 显示文摘 | Coiro Angelo Listanti Marco Valenti Alessandro | 2011 | Optical Commu- nications and Networking2011，3，11： | 1 |
| 6 | MERTK rs4374383 polymorphism affects the severity of fibrosis in nonalcoholic fatty liver disease显示文摘 | Salvatore Petta Luca Valenti Fabio Marra Stefania Grimaudo Claudio Tripodo Elisabetta Bugianesi Calogero Cammà Andrea Cappon Vito Di Marco Giovanni Di Maira Paola Dongiovanni Raffaela Rametta Alessandro Gulino Enrico Mozzi Emanuele Orlando Marco Maggioni | 2015 | Journal of Hepatology2015，，： | 1 |
| 7 | Network performance investigation in a wide area gigabit ethernet test bed adopting all-optical wavelength conversion 显示文摘 | Francesco Matera Luea Rea Alessandro Valenti | 2008 | IEEE Pho- tonics Technology Letters2008，20，24： | 1 |
| 8 | Liposomal incorporation of Artemisia arborescens L. essential oil and in vitro antiviral activity显示文摘 | Chiara Sinico Alessandro De Logu Francesco Lai Donatella Valenti Maria Manconi Giuseppe Loy Leonardo Bonsignore Anna Maria Fadda | 2004 | European Journal of Pharmaceutics and Biopharmaceutics2004，，1： | 1 |
| 9 | Gallbladder hemorrhage–An uncommon surgical emergency:A case report显示文摘BACKGROUND Gallbladder hemorrhage is a life-threatening disorder.Trauma(accidental or iatrogenic such as a percutaneous biopsy or cholecystectomy surgery),cholelithiasis,biliary tract parasitosis,vasculitis,vascular malformations,autoimmune and neoplastic diseases and coagulopathies have been described as causes of hemorrhage within the lumen of the gallbladder.The use of nonsteroidal anti-inflammatory drugs and anticoagulants may represent a risk factor.CASE SUMMARY We report the case of a 76-year-old male patient.An urgent contrast computed tomography scan demonstrated relevant distension of the gallbladder filled with hyperdense non-homogeneous content.The gallbladder walls were of regular thickness.Near the anterior wall a focus of suspected active bleeding was observed.Due to the progressive decrease in hemoglobin despite three blood transfusions,this was an indication for urgent surgery.CONCLUSION Early diagnosis of this potentially fatal pathology is essential in order to plan a strategy and eventually proceed with urgent surgical treatment. | Maria Rosaria Valenti Andrea Cavallaro Maria Di Vita Antonio Zanghi Giovanni Longo Trischitta Alessandro Cappellani | 2022 | World Journal of Clinical Cases2022，10，27： | 0 |
| 10 | Digital literacy as a potential barrier to implementation of cardiology tele-visits after COVID-19 pandemic: the INFO-COVID survey显示文摘BACKGROUND During the COVID-19 pandemic,the implementation of telemedicine has represented a new potential option for outpatient care.The aim of our study was to evaluate digital literacy among cardiology outpatients.METHODS From March to June 2020,a survey on telehealth among cardiology outpatients was performed.Digital literacy was investigated through six main domains:age;sex;educational level;internet access;availability of internet sources;knowledge and use of teleconference software programs.RESULTS The study included 1067 patients,median age 70 years,41.3%females.The majority of the patients(58.0%)had a secondary school degree,but among patients aged≥75 years old the most represented educational level was primary school or none.Overall,for internet access,there was a splitting between'never'(42.1%)and'every day'(41.0%),while only 2.7%answered'at least 1/month'and 14.2%'at least 1/week'.In the total population,the most used devices for internet access were smartphones(59.0%),and WhatsApp represented the most used app(57.3%).Internet users were younger compared to non-internet users(63 vs.78 years old,respectively)and with a higher educational level.Age and educational level were associated with nonuse of internet(age-per 10-year increase odds ratio(OR)=3.07,95%CI:2.54-3.71,secondary school OR=0.18,95%CI:0.12-0.26,university OR=0.05,95%CI:0.02-0.10).CONCLUSIONS Telemedicine represents an appealing option to implement medical practice,and for its development it is important to address the gaps in patients’digital skills,with age and educational level being key factors in this setting. | Giuseppe Boriani Anna Maisano Niccolo Bonini Alessandro Albini Jacopo Francesco Imberti Andrea Venturelli Matteo Menozzi Valentina Ziveri Vernizia Morgante Giovanni Camaioni Matteo Passiatore Gerardo De Mitri Giulia Nanni Denise Girolami Riccardo Fontanesi Valerio Siena Daria Sgreccia Vincenzo Livio Malavasi Anna Chiara Valenti Marco Vitolo | 2021 | Journal of Geriatric Cardiology2021，18，9： | 0 |
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