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| 1 | Modulation of protein tyrosine phosphorylation in gastric mucosa during re-epithelization processes显示文摘AIM:To investigate the role of protein tyrosine phosphorylation in gastric wound formation and repair following ulceration. METHODS:Gastric lesions were induced in rats using restraint cold stress.To investigate the effect of oxidative and nitrosative cell stress on tyrosine phosphorylation during wound repair,total activity of protein tyrosine kinase(PTK),protein tyrosine phosphatase (PTP),antioxidant enzymes,nitric oxide synthase (NOS), 2',5'-oligoadenylate synthetase,hydroxyl radical and zinc levels were assayed in parallel. RESULTS:Ulcer provocation induced an immediate decrease in tyrosine kinase(40% in plasma membranes and 56% in cytosol,(P<0.05) and phosphatase activity (threefold in plasma membranes and 3.3-fold in cytosol),followed by 2.3-2.4-fold decrease (P<0.05) in protein phosphotyrosine content in the gastric mucosa. Ulceration induced no immediate change in superoxide dismutase (SOD) activity,30% increase (P<0.05) in catalase activity,2.3-fold inhibition (P<0.05) of glutathione peroxidase,3.3-fold increase (P<0.05) in hydroxyl radical content,and 2.3-fold decrease (P<0.05) in zinc level in gastric mucosa.NOS activity was three times higher in gastric mucosa cells after cold stress. Following ulceration,PTK activity increased in plasma membranes and reached a maximum on day 4 after stress (twofold increase,P<0.05),but remained inhibited(1.6-3-fold decrease on days 3,4 and 5,P<0.05) in the cytosol.Tyrosine phosphatases remained inhibited both in membranes and cytosol(1.5-2.4-fold,P< 0.05).NOS activity remained increased on days 1,2 and 3(3.8-,2.6-,2.2-fold,respectively,P<0.05).Activity of SOD increased 1.6 times(P<0.05)days 4 and 5 after stress.Catalase activity normalized after day 2. Glutathione peroxidase activity and zinc level decreased (3.3-and 2-fold,respectively,P<0.05)on the last day. Activity of 2',5'-oligoadenylate synthethase increased 2.8-fold (P<0.05) at the beginning,and 1.6-2.3-fold (P<0.05) during ulcer recuperation,and normalized on day 5,consistent with slowing of inflammation processes. CONCLUSION:These studies show diverse changes in total tyrosine kinase activity in gastric mucosa during the recovery process.Oxidative and nitrosative stress during lesion formation might lead to the observed reduction in tyrosine phosphorylation during ulceration. | Olena V Bogdanova Larysa I Kot Kateryna V Lavrova Volodymyr B Bogdanov Erica K Sloan Tetyana V Beregova Ludmyla I Ostapchenko | 2010 | World Journal of Biological Chemistry2010，1，11： | 2 |
| 2 | 显示文摘 | Julian S Taurozzi Christopher A Crock Volodymyr V | 2011 | De- salination2011，269，： | 1 |
| 3 | Hypoxia induces oxidative stress in tissues of a goby, the rotan Perccottus glenii显示文摘 | Volodymyr I L Tetyana V B | 2007 | Comp Bio- chem Physiol2007，，148： | 1 |
| 4 | Improving the performance of root-MUSIC via pseudo-noise resamplingand conventional beamformer显示文摘 | V Volodymyr | 2011 | Microwaves Radar and Remote Sensing Symposium (MRRS)2011，25，8： | 1 |
| 5 | Pore blocking mechanisms during early stages of membrane fouling by colloids显示文摘 | Wang F L Volodymyr V T | 2008 | Colloid Interface Sci2008，328，2： | 1 |
| 6 | The Impacts of Farm Fi- nancial Structure on Production Efficiency显示文摘 | Bayda Volodymyr V Lambert | 2005 | Journal of Agricultural and Applied Economics2005，37，27： | 1 |
| 7 | Temperature increase results in oxidative stress in goldfish tissues 显示文摘 | Volodymyr I L Tetyana V B | 2006 | Comparative 13iocbemistry and Physiology2006，14，： | 1 |
| 8 | (2007) Retrieving 3-D topography by using a single-antenna squint-mode airborne SAR显示文摘 | Oleksandr O B levgeniia V D Volodymyr V V | 2007 | IEEE Transactions on Geoscience and Remote Sensing2007，45，11： | 1 |
| 9 | Microwave-mediated reactions of 3-aminomethylpyridines with acetylenedicarboxylates:A novel synthetic route to dihydronaphthyridines and naphthyridine-1-ones显示文摘 | Vvedensky V Y Ivanov Y V Volodymyr K | 2005 | Tetrahedron Letters2005，46，23： | 1 |
| 10 | Coupled effects of colloidal deposition and salt concentration polarization on reverse osmosis membrane performance 显示文摘 | FULIN WANG VOLODYMYR V TARABARA | 2007 | J Membr Sci2007，293，： | 1 |
| 11 | Coupled effects of colloidal deposition and salt concentration polarization on reverse osmosis membrane performance显示文摘 | Wang Fulin Volodymyr V Tarabara | | 0，，： | 1 |
| 12 | StoreyRegulation of AMP -deaminase activity from white muscleofcommon carp Cyprinuscarpio 显示文摘 | Volodymyr I Lushchak Viktor V Husak Kenneth B | 2008 | Comparative Biochemistry andPhysiology2008，149，： | 1 |
| 13 | Advanced nanostructured anode materials for lithium-ion batteries显示文摘 | Volodymyr G Khomenko Ilona V Senyk Viacheslav Z Barsukov | 2011 | Nanomater: Appl Properties2011，2，： | 1 |
| 14 | Morphology of deposits formed from chemically heterogeneous suspensions:Application to membrane filtration显示文摘 | VOLODYMYR V A FRANCOISE P | 2002 | Journal of Colloid and Interface Science2002，256，： | 1 |
| 15 | Management of residual penile curvature after penile prosthesis placement显示文摘Residual penile curvature is a common situation following the implantation of a penile prosthesis in patients with Peyronie’s disease.Currently,there is a variety of options for the correction of residual curvature,including penile modeling,plication techniques,as well as tunical incision/excision with or without grafting.A literature search of PubMed and Medline databases was conducted from 1964 until 2020,using search terms for all articles in the English language.In this article,we provide a review of the techniques and the outcomes,according to the published literature. | Denis V Krakhotkin David J Ralph Gideon A Blecher Volodymyr A Chernylovskyi Francesco Greco Evgeny E Bakurov Ruslan A Bugaev | 2021 | Asian Journal of Andrology2021，23，2： | 0 |
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