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| 1 | Cytokine production in patients with cirrhosis and TLR4 polymorphisms显示文摘AIM:To analyze the cytokine production by peripheral blood cells from cirrhotic patients with and without TLR4 D299G and/or T399I polymorphisms.METHODS:The study included nine patients with cirrhosis and TLR4 D299G and/or T399I polymorphisms,and 10 wild-type patients matched for age,sex and degree of liver failure.TLR4 polymorphisms were determined by sequence-based genotyping.Cytokine production by peripheral blood cells was assessed spontaneously and also after lipopolysaccharide(LPS)and lipoteichoic acid(LTA)stimulation.RESULTS:Patients with TLR4 polymorphisms had a higher incidence of previous hepatic encephalopathy than wild-type patients(78%vs 20%,P=0.02).Spontaneous production of interleukin(IL)-6 and IL-10 was lower in patients with TLR4 polymorphisms than in wild-type patients[IL-6:888.7(172.0-2119.3)pg/m L vs 5540.4(1159.2-26053.9)pg/m L,P<0.001;IL-10:28.7(6.5-177.1)pg/m L vs 117.8(6.5-318.1)pg/m L,P=0.02].However,the production of tumor necrosis factor-α,IL-6 and IL-10 after LPS and LTA stimulation was similar in the two groups.CONCLUSION:TLR4 polymorphisms were associated with a distinctive pattern of cytokine production in cirrhotic patients,suggesting that they play a role in the development of cirrhosis complications. | Juan Camilo Nieto Elisabet Sánchez Eva Román Silvia Vidal Laia Oliva Carlos Guarner-Argente Maria Poca Xavier Torras Cándido Juárez Carlos Guarner German Soriano | 2014 | World Journal of Gastroenterology2014，20，46： | 5 |
| 2 | Toll-like receptor 4 polymorphisms and bacterial infections in patients with cirrhosis and ascites显示文摘AIM To assess the relationship between the presence of toll-like receptor 4(TLR4) polymorphisms and bacterial infections in cirrhotic patients with ascites. METHODS We prospectively included consecutive patients with cirrhosis and ascites hospitalized during a 6-year period. Patients with human immunodeficiency virus(HIV) infection or any other immunodeficiency, patients with advanced hepatocellular carcinoma(beyond Milan's criteria) or any other condition determining poor short-term prognosis, and patients with a permanent urinary catheter were excluded. The presence of D299 G and/or T399 I TLR4 polymorphisms was determined by sequencing and related to the incidence and probability of bacterial infections, other complications of cirrhosis, hepatocellular carcinoma, and mortality during follow-up. A multivariate analysis to identify predictive variables of mortality in the whole series was performed. RESULTS We included 258 patients: 28(10.8%) were carriers of D299G and/or T399I TLR4 polymorphisms(polymorphism group) and 230 patients were not(wildtype group). The probability of developing any bacterial infection at one-year follow-up was 78% in the polymorphism group and 69% in the wild-type group(P = 0.54). The one-year probability of presenting infections caused by gram-negative bacilli(51% vs 44%, P = 0.68), infections caused by gram-positive cocci(49% vs 40%, P = 0.53), and spontaneous bacterial peritonitis(29% vs 34%, respectively, P = 0.99) did not differ between the two groups. The oneyear probability of transplant-free survival was 55% in the polymorphism group and 66% in the wild-type group(P = 0.15). Multivariate analysis confirmed that age, Child-Pugh score, active alcohol intake, previous hepatic encephalopathy, hepatocellular carcinoma and serum creatinine were associated with a higher risk of death during follow-up. CONCLUSION Genetic polymorphisms D299 G and/or T399 I of TLR4 do not seem to play a relevant role in the predisposition of cirrhotic patients with ascites to bacterial infections. | Edilmar Alvarado-Tapias Carlos Guarner-Argente Elida Oblitas Elisabet Sánchez Silvia Vidal Eva Román Mar Concepción Maria Poca Cristina Gely Oana Pavel Juan Camilo Nieto Cándido Juárez Carlos Guarner Germán Soriano | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 3 | Influence of a nucleotide oligomerization domain 1 (NOD1) polymorphism and NOD2 mutant alleles on Crohn's disease phenotype显示文摘AIM: To examine genetic variation of nucleotide oligomerization domain 1 (NOD1 ) and NOD2 ,their respective influences on Crohn's disease phenotype and gene-gene interactions. METHODS: (ND1+326561 ) NOD1 polymorphism and SNP8,SNP12 and SNP13 of NOD2 were analyzed in 97 patients and 50 controls. NOD2 variants were determined by reaction restriction fragment length polymorphism analysis. NOD1 genotyping and NOD2 variant confirmation were performed by specific amplification and sequencing. RESULTS: The distribution of NOD1 polymorphism in patients was different from controls (P = 0.045) and not altered by existence of NOD2 mutations. In this cohort,30.92% patients and 6% controls carried at least one NOD2 variant (P < 0.001) with R702W being the most frequent variant. Presence of at least one NOD2 mutation was inversely associated with colon involvement (9.09% with colon vs 36.4% with ileal or ileocolonic involvement,P = 0.04) and indicative of risk of penetrating disease (52.63% with penetrating vs 25.64% with non-penetrating or stricturing behavior,P = 0.02). L1007finsC and double NOD2 mutation conferred the highest risk for severity of disease (26.3% with penetrating disease vs 3.8% with non-penetrating or stricturing behavior presented L1007finsC,P = 0.01 and 21.0% with penetrating disease vs 2.5% with non-penentrating or stricturing behavior carried double NOD2 mutation,P = 0.007). Exclusion of patients with NOD2 mutations from phenotype/NOD1 -genotype analysis revealed higher prevalence of 11 genotype in groups of younger age at onset and colonic location. CONCLUSION: This study suggests population differences in the inheritance of risk NOD1 polymorphism and NOD2 mutations. Although no interaction between NOD1 -NOD2 was noticed,a relationship between disease location and Nod-like receptor molecules was established. | Elisabet Cantó Elena Ricart David Busquets David Monfort Esther García-Planella Dolors González Joaquim Balanzó José L Rodríguez-Sánchez Sílvia Vidal | 2007 | World Journal of Gastroenterology2007，13，41： | 2 |
| 4 | ECG after near-drowning mimicking acute coronary syndrome with left main coronary artery involvement显示文摘We present the case of a 74-year-old man with diabetes and hypertension who had to be rescued owing to a near-drowning syndrome at sea.When he was rescued,he complained of dyspnea and chest pain.An electrocardiogram(ECG)suggested acute coronary syndrome(ACS)affecting the left main coronary artery.Therefore,he was referred to our hospital for urgent coronary angiography. | Alfredo Vidal García Javier Lacunza Ruiz José María Lpez Ayala Mariano Valdés | 2013 | World Journal of Emergency Medicine2013，4，1： | 2 |
| 5 | Expression and distribution of vascular endothelial growth factor receptor Flk-1 in the rat pituitary显示文摘 | Vidal S Lloyd RV Moya L | 2002 | J Histochem Cytochem2002，50，4： | 1 |
| 6 | Effect of corticosteroids on the clinical course of community - acquired pneumonia: a randomized controlled trial显示文摘 | Fernandez - Serrano S Dorca J Garcia - Vidal C | 2011 | Crti Care2011，15，2： | 1 |
| 7 | Identification and characterization of a second mouse Nramp gene 显示文摘 | Gruenheid S Cellier M Vidal S | 1995 | Ge- nomics1995，25，2： | 1 |
| 8 | Efficacy and safety of aminoglycoside monotherapy: systematic review and meta- analysis of randomized controlled trial显示文摘 | Vidal L Gafter- Gvili A Borok S | 2007 | J Antimicrob Chcmother2007，60，2： | 1 |
| 9 | Licofelone,a balanced inhibitor of cyclooxygenase and 5-lipoxygenase,reduces inflammation in a rabbit model of atherosclerosis显示文摘 | Gómez-Hernández A Sánchez-Galán E | 2007 | J Pharmacol Exp Ther2007，320，1： | 1 |
| 10 | New large solar photocatalytic plant:set-up and preliminary results显示文摘 | Malato S Blanco J Vidal A | 2002 | Chemosphere2002，47，： | 1 |
| 11 | Efficient bleaching of non-wood high-quality paper pulp using laccase-mediator system显示文摘 | Camarero S Garcia O Vidal T | 2004 | Enzyme and Microbial Technology2004，35，2： | 1 |
| 12 | Effectivenessof continuous positive airway pressure in mild sleep apnea- hypopneasyndrome 显示文摘 | Monasterio C Vidal S Duran J | 2001 | Am J Respir Crit Care Med2001，164，7： | 1 |
| 13 | Interacting signal path- ways control defense gene expression in Arabidopsis in response to cell wall - degrading enzymes from Erwinia carotovora 显示文摘 | Norman -Setterblad C Vidal S Palva E T | 2000 | Mol Plant - Microbe Interact2000，13，： | 1 |
| 14 | On the Nature of Metal-carbon Bonding: AIM and ELF Analyses of MCH, ( n = 1-3) Compounds Containing Early Transition Metals 显示文摘 | VIDAL I MELCHOR S DOBADO J A | 2005 | J Phys Chem A2005，109，： | 1 |
| 15 | Serum cytokines and increased total serum IgE in alcoholics显示文摘 | Gonza'lez- Quintela A Vidal C Lojo S | 1999 | Ann A)Jergy Asthma Immunol1999，83，： | 1 |
| 16 | Differential regulation of luteinizing hormone and follicle- stimulating hormone expression during ovarian development and under sexual steroid feedback in the European eel显示文摘 | Schmitz M Aroua S Vidal B | 2005 | Neuroendocrinology2005，81，2： | 1 |
| 17 | Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg显示文摘 | Vidal S M Malo D Vogan K | 1993 | Cell1993，73，： | 1 |
| 18 | Modelling of wave loads and hydraulic performance of vertical permeable structures 显示文摘 | REQUEJO S VIDAL C LOSADA I | 2002 | Coastal Eng2002，46，4： | 1 |
| 19 | Treatment of intracerebral hemorrhage:the clinical evidences显示文摘 | Sterzi R Vidale S | 2004 | Neurol Sci2004，24，： | 1 |
| 20 | Changes in proanthocyani- dins chain in wine-like model solutions 显示文摘 | Vidal S Cartalade D Souquet J M | 2002 | Journal of Agricultural and Food Chemistry2002，50，： | 1 |
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