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| 1 | Plasma chitinase 3-like 1 is persistently elevated during first month after minimally invasive colorectal cancer resection显示文摘AIM: To assess blood chitinase 3-like 1(CHi3L1) levels for 2 mo after minimally invasive colorectal resection(MICR) for colorectal cancer(CRC). METHODS: CRC patients in an Institutional Review Board approved data/plasma bank who underwent elective MICR for whom preoperative(PreO p), early postoperative(PostO p), and 1 or more late PostO p samples [postoperative day(POD) 7-27] available were included. Plasma CHi3L1 levels(ng/m L) were determined in duplicate by enzyme linked immunosorbent assay. RESULTS: PreOp and PostOp plasma sample were available for 80 MICR cancer patients for the study. The median PreOp CHi3L1 level was 56.8 CI: 41.9-78.6 ng/mL(n = 80). Significantly elevated(P < 0.001) median plasma levels(ng/mL) over PreOp levels were detected on POD1(667.7 CI: 495.7, 771.7; n = 79), POD 3(132.6 CI: 95.5, 173.7; n = 76), POD7-13(96.4 CI: 67.7, 136.9; n = 62), POD14-20(101.4 CI: 80.7, 287.4; n = 22), and POD 21-27(98.1 CI: 66.8, 137.4; n = 20, P = 0.001). No significant difference in plasma levels were noted on POD27-41. CONCLUSION: Plasma CHi3L1 levels were significantly elevated for one month after MICR. Persistently elevated plasma CHi3L1 may support the growth of residual tumor and metastasis. | HMC Shantha Kumara David Gaita Hiromichi Miyagaki Xiaohong Yan Sonali AC Hearth Linda Njoh Vesna Cekic Richard L Whelan | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 4 |
| 2 | Plasma MMP-2 and MMP-7 levels are elevated first month after surgery and may promote growth of residual metastases显示文摘BACKGROUND MMP-2 also known as gelatinase A and MMP-7(matrilysin)are members of the zinc-dependent family of MMPs(Matrix metalloproteinase).MMP-2 and MMP-7 are remodeling enzymes that digest extracellular matrix;MMP-2 is extensively expressed during development and is upregulated at sites of tissue damage,inflammation,and in stromal cells of metastatic tumors.MMP-7 is expressed in the epithelial cells and in a variety of cancers including colon tumors.Plasma MMP-2 and MMP-7 levels were assessed before and after minimally invasive colorectal resection for cancer pathology.AIM To determine plasma MMP-2 and MMP-7 levels before and after minimally invasive colorectal resection for cancer pathology.METHODS Patients enrolled in a plasma bank for whom plasma was available were eligible.Plasma obtained from preoperative(Preop)and postoperative blood samples was used.Only colorectal cancer(CRC)patients who underwent elective minimally invasive cancer resection with preop,post-operative day(POD)1,3 and at least 1 late postop sample(POD 7-34)were included.Late samples were bundled into 7 d blocks(POD 7-13,14-20,etc.)and treated as single time points.Plasma MMP-2 and MMP-7 levels were determined via enzyme-linked immunosorbent assay in duplicate.RESULTS Total 88 minimally invasive CRC resection CRC patients were studied(right colectomy,37%;sigmoid,24%;and LAR/AR 18%).Cancer stages were:1,31%;2,30%;3,34%;and 4,5%.Mean Preop MMP-2 plasma level(ng/mL)was 179.3±40.9(n=88).Elevated mean levels were noted on POD1(214.3±51.2,n=87,P<0.001),POD3(258.0±63.9,n=80,P<0.001),POD7-13(229.9±62.3,n=65,P<0.001),POD 14-20(234.9±47.5,n=25,P<0.001),POD 21-27(237.0±63.5,n=17,P<0.001,)and POD 28-34(255.4±59.7,n=15,P<0.001).Mean Preop MMP-7 level was 3.9±1.9(n=88).No significant differences were noted on POD 1 or 3,however,significantly elevated levels were noted on POD 7-13(5.7±2.5,n=65,P<0.001),POD 14-20(5.9±2.5,n=25,P<0.001),POD 21-27(6.1±3.6,n=17,P=0.002)and on POD 28-34(6.8±3.3,n=15 P<0.001,)vs preop levels.CONCLUSION MMP-2 levels are elevated for 5 wk and MMP-7 levels elevated for weeks 2-6.The etiology of these changes in unclear,trauma and wound healing likely play a role.These changes may promote residual tumor growth and metastasis. | HMC Shantha Kumara Hiromichi Miyagaki Sajith A Herath Erica Pettke Xiaohong Yan Vesna Cekic Richard L Whelan | 2021 | World Journal of Gastrointestinal Oncology2021，13，8： | 3 |
| 3 | Physical properties of ultrasound treated soy proteins显示文摘 | ANET R J VESNA L TIMOTHY J M | 2009 | Journal of Food Engineering2009，93，4： | 1 |
| 4 | Theeffect of different levels of selenium in feed on eggproduction,egg quality and selenium content in yolk显示文摘 | GJORGOVSKA N KIRIL F VESNA L | 2012 | LucrSri Stiintifice- Universitatea de Stiinte Agri-cole si MedicinS Veterinary Seria Zootehnie2012，57，： | 1 |
| 5 | Plasma monocyte chemotactic protein-1 remains elevated after minimally invasive colorectal cancer resection显示文摘AIM: To investigate plasma Monocyte Chemotactic Protein-1 levels preoperatively in colorectal cancer(CRC) and benign patients and postoperatively after CRC resection.METHODS: A plasma bank was screened for minimally invasive colorectal cancer resection(MICR) for CRC and benign disease(BEN) patients for whom preoperative, early postoperative, and 1 or more late postoperative samples(postoperative day 7-27) were available. Monocyte chemotactic protein-1(MCP-1) levels(pg/mL) were determined via enzyme linked immuno-absorbent assay. RESULTS: One hundred and two CRC and 86 BEN patients were studied. The CRC patient's median preoperative MCP-1 level(283.1, CI: 256.0, 294.3) was higher than the BEN group level(227.5, CI: 200.2, 245.2; P = 0.0004). Vs CRC preoperative levels, elevated MCP-1 plasma levels were found on postoperative day 1(446.3, CI: 418.0, 520.1), postoperative day 3(342.7, CI: 320.4, 377.4), postoperative day 7-13(326.5, CI: 299.4, 354.1), postoperative day 14-20(361.6, CI: 287.8, 407.9), and postoperative day 21-27(318.1, CI: 287.2, 371.6; P < 0.001 for all). CONCLUSION: Preoperative MCP-1 levels were higher in CRC patients(vs BEN). After MICR for CRC, MCP-1 levels were elevated for 1 mo and may promote angiogenesis, cancer recurrence and metastasis. | HMC Shantha Kumara Elizabeth A Myers Sonali AC Herath Joon Ho Jang Linda Njoh Xiaohong Yan Daniel Kirchoff Vesna Cekic Martin Luchtefeld Richard L Whelan | 2014 | World Journal of Gastrointestinal Oncology2014，6，10： | 1 |
| 6 | Plasma from patients undergoing major open surgery stimulates in vitro tumor growth: Lower insulin-like growth factor binding protein 3 levels may, in part, account for this change显示文摘 | Irena Kirman Vesna Cekic Natalia Poltaratskaia Zishan Asi Marc Bessler Emina H Huang Kenneth A Forde Richard L Whelan | 2002 | Surgery2002，，2： | 1 |
| 7 | Europium-doped nanocrystalline Y203-La203 solid solutions with bixbyite structure 显示文摘 | VESNA D ZELJKA A VESNA L | 2014 | Journal of Physics and Chemistry of Solid2014，75，： | 1 |
| 8 | Genome shuffing of Lactoba- cillus for improved acid tolerance显示文摘 | RANJAN P SUSAN L VESNA G | 2002 | Nature Biotechnology2002，20，7： | 1 |
| 9 | Restoring enzyme activity in nonfunctional low erucic acid Brassica napus fatty acid elongase 1 hy a single amino acid substitution 显示文摘 | VESNA K ELZBIETA M DENNIS L | 2002 | Eur J Biochem2002，269，： | 1 |
| 10 | Improving erucic acid content in rapeseed through biotechnology, what can the Arabidopsis fae1 and the yeast slc1-1 genes contribute 显示文摘 | Vesna K Winnie F Dennis L B | 2001 | Crop Science2001，41，： | 1 |
| 11 | Improving erucic acid content in rapeseed through biotechnology, what can the Arabidopsis fael and the yeast slcl-1 genes contribute 显示文摘 | Vesna K Winnie F Dennis L B | 2001 | Crop Science2001，，41： | 1 |
| 12 | Genome shuffling of Lacto- bacillus for improved acid tolerance 显示文摘 | Ranjan P Susan L Vesna G | 2002 | Nature Biotech- nology2002，20，10： | 1 |
| 13 | Restoring enzyme activity in nonfunctional low erucic acid Brassica napus fatty acid elongase 1 by a single amino acid substitution 显示文摘 | Vesna K Elzbieta M Dennis L | 2002 | Eur J Biochem2002，269，22： | 1 |
| 14 | Physical properties of ultrasound treated soy proteins显示文摘 | Anet R J Vesna L Timothy J M | 2009 | Journal of Food Engineering2009，93，4： | 1 |
| 15 | Restoring enzyme activity in nonfunctional low erucic acid Brassica napus fatty acid elongase 1 by a single amino acid substitution 显示文摘 | Vesna K Elzbieta M Dennis L | 2002 | Eur J Biochem2002，，： | 1 |
| 16 | Decreasing of oil ab-sorption in potato strips during deep fat frying显示文摘 | Suzana R B Vesna L Desanka R | 2004 | Journal ofFood Engineering2004，64，： | 1 |
| 17 | The influence of temperature and solid matter content on the viscosity of whey protein concentrates and skim milk powder before and after tribomechanical treatment 显示文摘 | ZORAN H VESNA L | 2005 | Journal of Food Engineering2005，66，： | 1 |
| 18 | Improving erucic acid content in rape seed through biotechnology,what can the Arabidopsis FAE1 and the yeast SLC1-1 genes contribute显示文摘 | Vesna K Winnie F Dennis L B | 2001 | Crop Science2001，41，： | 1 |
| 19 | Physical properties of ultrasound treated soy proteins显示文摘 | ANET R J VESNA L TIMOTHY J | 2009 | Journal of Food Engineering2009，93，4： | 1 |
| 20 | Effect of ultrasound treatment on solubility and foaming properties of whey protein suspensions显示文摘 | ANET R J TIMOTHY J M VESNA L | 2008 | Journal of Food Engineering2008，86，2： | 1 |
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