|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pancreatic stellate cell: Pandora's box for pancreatic disease biology显示文摘Pancreatic stellate cells(PSCs) were identified in the early 1980 s, but received much attention after 1998 when the methods to isolate and culture them from murine and human sources were developed. PSCs contribute to a small proportion of all pancreatic cells under physiological condition, but are essential for maintaining the normal pancreatic architecture. Quiescent PSCs are characterized by the presence of vitamin A laden lipid droplets. Upon PSC activation, these perinuclear lipid droplets disappear from the cytosol, attain a myofibroblast like phenotype and expresses the activation marker, alpha smooth muscle actin. PSCs maintain their activated phenotype via an autocrine loop involving different cytokines and contribute to progressive fibrosis in chronic pancreatitis(CP) and pancreatic ductal adenocarcinoma(PDAC). Several pathways(e.g., JAK-STAT, Smad, Wnt signaling, Hedgehog etc.), transcription factors and mi RNAs have been implicated in the inflammatory and profibrogenic function of PSCs. The role of PSCs goes much beyond fibrosis/desmoplasia in PDAC. It is now shown that PSCs are involved in significant crosstalk between the pancreatic cancer cells and the cancer stroma. These interactions result in tumour progression, metastasis, tumour hypoxia, immune evasion and drug resistance. This is the rationale for therapeutic preclinical and clinical trials that have targeted PSCs and the cancer stroma. | Ratnakar R Bynigeri Aparna Jakkampudi Ramaiah Jangala Chivukula Subramanyam Mitnala Sasikala G Venkat Rao D Nageshwar Reddy Rupjyoti Talukdar | 2017 | World Journal of Gastroenterology2017，23，3： | 25 |
| 2 | Endoscopic mucosal resection of colorectal polyps in typical UK hospitals显示文摘AIM:To evaluate the outcomes of endoscopic mucosal resection(EMR) for colorectal polyps,with particular regard to procedural complications and recurrence rate,in typical United Kingdom(UK) hospitals that perform an average of about 25 colonic EMRs per year.METHODS:A total of 239 colorectal polyps(≥ 10 mm) resected from 199 patients referred to Rochdale Infirmary,Salford Royal Hospital and Royal Oldham Hospital for EMR between January 2003 and January 2009 were studied.RESULTS:The mean size of polyps resected was 19.6 ± 12.4 mm(range 10-80 mm).The overall major complication rate was 2.1%.Complications were less frequent with non-adenomas compared with the other groups(Pearson's χ 2 test,P < 0.0001).Resections of largersized polyps were more likely to result in complications(unpaired t-test,P = 0.021).Recurrence was associated with histology,with carcinoma-in-situ more likely to recur compared with low-grade dysplasia [hazard ratio(HR) 186.7,95% confidence interval(95% CI):8.81-3953.02,P = 0.001].Distal lesions were also more likely to recur compared with right-sided and transverse colon lesions(HR 5.93,95% CI:1.35-26.18,P = 0.019).CONCLUSION:EMR for colorectal polyps can be performed safely and effectively in typical UK hospitals.Stricter follow-up is required for histologically advanced lesions due to increased recurrence risk. | Teegan R Lim Venkat Mahesh Salil Singh Benjamin HL Tan Mohamed Elsadig Nerukav Radhakrishnan Phil Conlong Chris Babbs Regi George | 2010 | World Journal of Gastroenterology2010，16，42： | 11 |
| 3 | Preslaughter diet management in sheep and goats:effects on physiological responses and microbial loads on skin and carcass显示文摘Sixteen crossbred buck goats(Kiko x Spanish;BW = 32.8 kg) and wether sheep(Dorset x Suffolk;BW = 39.9 kg) were used to determine the effect of preslaughter diet and feed deprivation time(FDT) on physiological responses and microbial loads on skin and carcasses.Experimental animals were fed either a concentrate(CD) or a hay diet(HD)for 4 d and then deprived of feed for either 12-h or 24-h before slaughter.Blood samples were collected for plasma Cortisol and blood metabolite analyses.Longisimus muscle(LM) pH was measured.Skin and carcass swabs were obtained to assess microbial loads.Plasma creatine kinase activity(863.9 and 571.7 ± 95.21 IU) and non-esterified fatty acid concentrations(1,056.1 and 589.8 + 105.01 mEq/L) were different(P< 0.05) between sheep and goats.Species and diet treatments had significant effects on the ultimate pH of LM.Pre-holding total coliform(TCC) and aerobic plate counts(APC) of skin were significantly different between species.Goats had lower(P < 0.05) TCC(2.1 vs.3.0 log_(10) CFU/cm^2) and APC(8.2 vs.8.5 log_(10) CFU/cm^2) counts in the skin compared to sheep.Preslaughter skin E.coli counts and TCC were different(P < 0.05) between species.Goats had lower(P < 0.05) counts of E.coli(2.2 vs.2.9 log_(10) CFU/cm^2) and TCC(2.3 vs.3.0 log_(10) CFU/cm^2) in the skin compared with those in sheep.Diet,species,and FDT had no effect(P> 0.05) on E.coli and TCC in carcass swab samples.The APC of carcass swab samples were only affected(P < 0.05) by the FDT.The results indicated that preslaughter dietary management had no significant changes on hormone and blood metabolite concentrations and sheep might be more prone for fecal contamination than goats in the holding pens at abattoir. | Govind Kannan Venkat R Gutta Jung Hoon Lee Brou Kouakou Will R Getz George W McCommon | 2015 | Journal of Animal Science and Biotechnology2015，6，1： | 2 |
| 4 | Alkylation of aromatics with ethylene and propylene: Recent developments in commercial processes显示文摘 | DEGNAN T F Jr SMITH M C VENKAT C R | 2001 | Appl Catal A2001，221，12： | 1 |
| 5 | Characterisation of CFR- P through enhanced ultrasonic testing methods显示文摘 | Helfen T Venkat R Rabe U | 2012 | Applied Composite Materials2012，19，6： | 1 |
| 6 | Alkylation of aromaticswith ethylene and propylene: recent developments in commercial processes显示文摘 | Thomas F Degnan Jr C Morris Smith Chaya R Venkat | 2001 | Appl CatalA2001，221，： | 1 |
| 7 | Statistical methods to compare the texture features of machined surfaces显示文摘 | Venkat R K Ramamoorthy B | 1996 | Pattern Recognition1996，29，9： | 1 |
| 8 | Laparoscopic distal pancreatectomy is associated with significantly less overall morbidity compared to the open technique: a systematic review and meta- analysis显示文摘 | Venkat R Edil BH Schulick RD | 2012 | Ann Surg2012，255，6： | 1 |
| 9 | Effect of Pt and Ru promoters on deactivation of Co cata- lysts by C deposition during Fischer-Tropsch synthesis: a DFT study 显示文摘 | Balakrishnan Nianthrini Joseph Babu Bhethanabotla Venkat R | 2013 | Applied Catalysis A : General2013，，10： | 1 |
| 10 | DNA fingerprinting by infrequent-restriction-site amplification显示文摘 | Gerald H Mazurek Venkat R | 1996 | J Clin Microbio1996，34，： | 1 |
| 11 | Global (50 degrees S-50 degrees N) Distribution of Water Vapor Observed by COSMIC GPS RO Comparison with GPS Radiosonde,NCEP,ERA-Interim,and JRA-25 Reanalysis Data Sets显示文摘 | Kishore P Venkat M R Namboothiri S P | | 0，，4： | 1 |
| 12 | A simple and convenient method for the reduction of nitroacenes显示文摘 | Venkat R G Rama Rao V V V N S | 2002 | Synth Commun2002，32，18： | 1 |
| 13 | Enatioselectire total synthesis of the antihypertensive agent (S,R,R,R)-nebivolol显示文摘 | Chandrasekhar S Venkat R M | 2000 | Tetrahedron2000，56，： | 1 |
| 14 | Alkylation of aromatics with ethylene and propylene: recent developments in commercial processes显示文摘 | Degnan T F Smith M C Venkat R V | 2001 | Applied Catalysis A: General2001，221，12： | 1 |
| 15 | Identification of complex nonlinear processes based on fuzzy decomposition of the steady state space显示文摘 | Venkat A N Vijaysai P Gudi R D | 2003 | Journal of Process Control2003，13，6： | 1 |
| 16 | Laparoscopic distal pancreatectomy is associated with significantly less overall morbidity compared to the open technique:a systematic review and meta-analysis显示文摘 | Venkat R Edil BH Schulick RD | | 0，，06： | 1 |
| 17 | Spontaneous Emergence of Complex Optimal Networks Through Evolutionary Adaptation 显示文摘 | Venkat Venkatasubramanian Santhoji Katare Priyan R Patkar Fang-ping Mu | 2004 | Computers & Chemical Engineering (S0098-1354)2004，28，9： | 1 |
| 18 | Growth dynamics of InGaAs by MBE:process simulation and theoretical analysis显示文摘 | COLAYNI G VENKAT R | 2000 | Journal of Crystal Growth2000，211，1234： | 1 |
| 19 | Dynamic recuurent radial basis function network model predictive control of unstable nonlinear processes显示文摘 | VENKATESWARLU K VENKAT R | 2005 | Chemical Engineering Science2005，60，： | 1 |
| 20 | Alkylation of aromatics with ethylene and propylene:recent developments in commercial processes显示文摘 | Degnan T F Smith M C Venkat R V | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员