|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Peritoneal seeding from appendiceal carcinoma:A case report and review of the literature显示文摘Non-carcinoid appendiceal malignancies are rare entities,representing less than 0.5% of all gastrointestinal malignancies.Because of their rarity and particular biological behavior,a substantial number of patients affected by these neoplasms do not receive appropriate surgical resection.In this report,we describe a rare case of primary signetring cell carcinoma of the appendix with peritoneal seeding which occurred in a 40-year old man admitted at the Emergency Surgery Department with the clinical suspicion of acute appendicitis.After a surgical debulking and right hemicolectomy,the patient had systemic chemotherapy according to FOLFOX protocol.After completion of the latter,the patient underwent cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy.This report offers a brief review of the literature and suggests an algorithm for the management of non-carci-noid appendiceal tumors with peritoneal dissemination. | Valentina R Bertuzzo Federico Coccolini Antonio D Pinna | 2010 | World Journal of Gastrointestinal Surgery2010，2，8： | 6 |
| 2 | Anti-tumor necrosis factor α therapy associates to type 17 helper T lymphocytes immunological shift and significant microbial changes in dextran sodium sulphate colitis显示文摘BACKGROUND Anti-tumor necrosis factor α(TNFα) represents the best therapeutic option to induce mucosal healing and clinical remission in patients with moderate-severe ulcerative colitis. On the other side gut microbiota plays a crucial role in pathogenesis of ulcerative colitis but few information exists on how microbiota changes following anti-TNFα therapy and on microbiota role in mucosal healing.AIM To elucidate whether gut microbiota and immune system changes appear following anti TNFα therapy during dextran sulfate sodium(DSS) colitis.METHODS Eighty C57 BL/6 mice were divided into four groups: 'No DSS', 'No DSS + antiTNFα', 'DSS' and 'DSS + anti-TNFα'. 'DSS' and 'DSS + anti-TNFα' were treated for 5 d with 3% DSS. At day 3, mice whithin 'No DSS+anti-TNFα' and'DSS+anti-TNFα' group received 5 mg/kg of an anti-TNFα agent. Forty mice were sacrificed at day 5, forty at day 12, after one week of recovery post DSS. The severity of colitis was assessed by a clinical score(Disease Activity Index), colon length and histology. Bacteria such as Bacteroides, Clostridiaceae, Enterococcaceae and Fecalibacterium prausnitzii(F. prausnitzii) were evaluated by quantitative PCR.Type 1 helper T lymphocytes(Th1), type 17 helper T lymphocytes(Th17) and CD4+ regulatory T lymphocytes(Treg) distributions in the mesenteric lymph node(MLN) were studied by flow cytometry.RESULTS Bacteria associated with a healthy state(i.e., such as Bacteroides, Clostridiaceae and F. prausnitzii) decreased during colitis and increased in course of anti-TNFαtreatment. Conversely, microorganisms belonging to Enterococcaceae genera,which are linked to inflammatory processes, showed an opposite trend.Furthermore, in colitic mice treated with anti-TNFα microbial changes were associated with an initial increase(day 5 of the colitis) in Treg cells and a consequent decrease(day 12 post DSS) in Th1 and Th17 frequency cells. Healthy mice treated with anti-TNFα showed the same histological, microbial and immune features of untreated colitic mice. 'No DSS + anti-TNFα' group showed a lymphomononuclear infiltrate both at 5 th and 12 th d at hematoxylin and eosin staining, an increase of in Th1 and Th17 frequency at day 12, an increase of Enterococcaceae at day 5, a decrease of Bacteroides and Clostridiaceae at day 12.CONCLUSION Anti-TNFα treatment in experimental model of colitis improves disease activity but it is associated to an increase in Th17 pathway together with gut microbiota alteration. | Valentina Petito Cristina Graziani Loris R Lopetuso Marco Fossati Alessandra Battaglia Vincenzo Arena Domenico Scannone Gianluca Quaranta Andrea Quagliariello Federica Del Chierico Lorenza Putignani Luca Masucci Maurizio Sanguinetti Alessandro Sgambato Antonio Gasbarrini Franco Scaldaferri | 2019 | World Journal of Gastroenterology2019，25，12： | 2 |
| 3 | T cell responses to allogeneic human mesenchymal stem cells: immunogenicity, tolerance, and suppression显示文摘 | Elena Klyushnenkova Joseph D Mosca Valentina Zernetkina Manas K Majumdar Kirstin J Beggs Donald W Simonetti Robert J Deans Kevin R McIntosh | 2005 | Journal of Biomedical Science2005，，1： | 2 |
| 4 | Benfotiamine counteracts glutoxicity effects on endothelial progenitor cell differentiation via Akf O signaling显示文摘 | Valentina M Rossella M Stefano R | 2006 | Diabetes2006，55，8： | 1 |
| 5 | Antisense locked nucleic acids efficiently suppress BCR/ABL and induce cell growth decline and apoptosis in leukemic cells显示文摘 | Valentina R Susanna C Luigi EX | 2006 | Mol Cancer Ther2006，5，7： | 1 |
| 6 | Agricultural market inte-gration in the OECD:a gravity-border effect approach显示文摘 | ALESSANDRO O VALENTINA R | 2008 | Food Policy2008，33，2： | 1 |
| 7 | Chemistry and pharmacology of Gynostemma pentaphyllum显示文摘 | Valentina R N Tom H H Van H T | | 0，，： | 1 |
| 8 | Selective dehydrolinalool hydrogenation with poly(ethylene oxide)- block -poly-2-vinylpyridine micelles filled with Pd nanoparticles显示文摘 | Natalia V Semagina Alexei V Bykov Esther M Sulman Valentina G Matveeva Stanislav N Sidorov Lidia V Dubrovina Peter M Valetsky Olga I Kiselyova Alexei R Khokhlov Barry Stein Lyudmila M Bronstein | 2003 | Journal of Molecular Catalysis A Chemical2003，，1： | 1 |
| 9 | Gas permeability and thermal behavior of polypropylene films used for packaging minimally processed fresh-cut potato:A case study显示文摘 | Valentina S Ignazio B Santina R | 2012 | Journal of Food Science2012，77，10： | 1 |
| 10 | Sleep loss, circadian mismatch, and abnormalities in reorienting of attention in night workers with shift work disorder 显示文摘 | Valentina G Ryan H Thomas R | 2014 | Sleep2014，37，3： | 1 |
| 11 | A novel LXR-α activator identified from the natural product Gynostemma pentaphyllum显示文摘 | Tom H H Valentina R N Noeris K S | | 0，，09： | 1 |
| 12 | Mass spectrometric characterization of flavonoids in extracts from Passiflora incarnata 显示文摘 | Andrea R Gloriano M Valentina M | 1997 | J Chromatogr1997，777，： | 1 |
| 13 | A novel LXR - a activator identified from the natural product gynostemma pentaphyllum 显示文摘 | Tom H - W H Valentina R - N Noeris K S | 2005 | Biochemical Pharmacology2005，70，9： | 1 |
| 14 | Hepatitis E virus in Italy: molecular analysis of travel related and autochthonous cases显示文摘 | Giuseppina L R Michele M Valentina S V | 2011 | J Gen Virol2011，92，7： | 1 |
| 15 | DOE applied to optimization of aluminum alloy die cast- ings显示文摘 | VERRAN G O MENDES R P K DALLA VALENTINA L V O | 2008 | Journal of Materials Processing Technology2008，200，1： | 1 |
| 16 | Echocardiographic findings in left ventricular septal aneurysm显示文摘 | Fasoli G Della Valentina P Scognamiglio R | 1988 | Int J Cardiol1988，18，3： | 1 |
| 17 | Increased absorption rate of diclofenac from fast acting formulations containing its potassium salt 显示文摘 | Valentina R Alberto R Giorgio R | 2001 | Arzeim-Forsch Drug Res2001，51，： | 1 |
| 18 | Roufogalis chemistry and pharmacology of Gynostemma pentaphyllum显示文摘 | VALENTINA R N TOM H W H VAN HOAN T | 2005 | Phytochemistry Reviews2005，，4： | 1 |
| 19 | Akt-Mediated YB-1 Phosphorylation activates Translation of Silent mRNa Species 显示文摘 | Valentina E Peter R Michael S | 2006 | Mol Cell Biol2006，26，1： | 1 |
| 20 | DOE applied to optimization of aluminum alloy die castings显示文摘 | VERRAN G O MENDES R P K VALENTINA L V O D | 2008 | Journal of Materials Processing Technology2008，200，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员