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| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | Phylogeny and diversificatoin of B-function MADS-box genes in angiosperms: Evolutionary and functional implications of a 260-million-year-old duplication显示文摘 | Kim S Yoo M J Albert V A | 2004 | Am J Bot2004，91，： | 1 |
| 3 | 显示文摘 | Nguyen V K Yoo Y | 2006 | Sensors and Actuators B2006，13，： | 1 |
| 4 | Contrast-induced nephropathy显示文摘 | RUNDBACK J H D NAHL V YOO | 2011 | J Vase Surg2011，54，2： | 1 |
| 5 | 查看详情显示文摘 | Fan W Snyder M A Kumar S Lee P S Yoo W C McCormick A V Penn R L Stein A Tsapatsis M | | 0，，： | 1 |
| 6 | The analgesic effect of remifentanil on prevention of withdrawal response associated with the injection of rocuronium in children: no evidence for a peripheral action显示文摘 | YOON J R JEON v YOO Y | 2010 | J Int Med Res2010，38，5： | 1 |
| 7 | In vivo structural character- istics of the femtoseeond LASIK-induced opaque bubble layers with ultrahigh-resolution SD-OCT 显示文摘 | Hurmeric V Yoo SH Fishler J | 2010 | Ophthalmic Surg Lasers Ima- ging2010，，： | 1 |
| 8 | Contrast-induced nephropathy显示文摘 | Rundblack JH Nahl D Yoo V | 2011 | J Vasc Surg2011，54，2： | 1 |
| 9 | Development of electroplated magnetic materials for MEMS 显示文摘 | MYUNG N V PARK D Y YOO B Y | 2003 | Journal of Magnetism and Magnetic Materials2003，265，： | 1 |
| 10 | 显示文摘 | Myung N V Park D Y Yoo B Y | 2003 | J Magn Magn Mater2003，265，： | 1 |
| 11 | A reusable dis- tributed arithmetic architecture for FIR Filtering 显示文摘 | Lo H J Yoo H J Anderson D V | 2008 | IEEE2008，，： | 1 |
| 12 | Ionic Liquid-catalyzed Alkylation of Isobutane with 2-Butene显示文摘 | Yoo K Namboodiri V V Varma R S | | 0，，02： | 1 |
| 13 | The arcuate NPY,POMC,and CART expressions responding to food deprivation are exaggerated in young female rats that experienced neonatal maternal separation显示文摘 | Yoo S B Ryu V | | 0，，： | 1 |
| 14 | Contrast-induced nephropathy显示文摘 | Rundback J H Nahl D Yoo V | 2011 | Vasc Surg2011，54，： | 1 |
| 15 | Quartzlike carbon dioxide: An optically nonlinear extended solid at high pressures and temperatures显示文摘 | Iota V Yoo C Cynn H | 1999 | Science1999，283，： | 1 |
| 16 | A model of neutral B2B intermediaries显示文摘 | Yoo B Choudhary V Mukhopadhyay T | 2002 | Journal of Management lnformation Systems2002，19，3： | 1 |
| 17 | Pressure-induced electronic spin transition of iron in magnesiowustite-(Mg, Fe)O显示文摘 | Lin J F Gavriliuk A G Struzhkin V V Jacobsen S D Sturhahn W Hu M Y Chow P Yoo C S | 2006 | Physical ReviewB2006，73，11： | 1 |
| 18 | Reducing door-to-puncture times for intra-arterial stroke therapy: a pilot quality improvement project 显示文摘 | Yoo Brijesh P Mehta Thabele M Leslie-Mazwi Ronil V | 2014 | Journal of the American Heart Association2014，3，6： | 1 |
| 19 | Amphiphilic hairy disks with branched hydrophilic tails and a hexa-peri-hexabenzocoronene core显示文摘 | Lee M Kim J-W Peleshanko S Larson K Yoo Y-S Vaknin D Markutsya S Tsukruk V V | | 0，，3： | 1 |
| 20 | Field enhancement factor for an array of MWNTs in CNT paste显示文摘 | Berdinsky A S Shaporin A V Yoo J B et ai | 2006 | Appl Phys A2006，83，3： | 1 |
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