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| 1 | Buttress plating for a rare case of comminuted medial condylar Hoffa fracture associated with patellar fracture显示文摘Hoffa 骨折是不平常的 injury.In 文学,侧面的 condylar Hoffa 骨折比中间的 condylar Hoffa 骨折作为一个更普通的损害模式被提及。损害的机制和处理的方法很好没在文学被描述。我们与 ipsilateral 正在介绍弄碎的中间的 condylar Hoffa 骨折的一个稀罕盒子膝盖骨的骨折。损害的机制没在文学被描述。落后螺丝钉固定,是处理的最可接受的方法,不由于粉碎是可能的。我们解释损害的可能的机制并且与 L-but-tress 板修理破裂。 | Ashwani Soni Ramesh K Sen Uttam Chand Saini Dajjit Singh Sushil Chaudhary | 2012 | Chinese Journal of Traumatology2012，15，4： | 9 |
| 2 | Applications of phototheranostic nanoagents in photodynamic therapy显示文摘Nanotherapeutics 在象癌症那样的疾病的治疗有一个增加的角色。在光力学的治疗(太平洋夏季时间) ,治疗学地不活跃的 photosensitizer 混合物被光有选择地激活生产能够杀死 diseased 房间和病原体的分子。一个 phototheranostic 代理人能为指向的交货,光成像和疾病的光力学的治疗与能力被定义为单个 nanoentity。恶意的房间,纸巾和微生物引起的 etiologic 代理人能被太平洋夏季时间有效地指向。光力学的治疗是 noninvasive,或最低限度地侵略,并且当健康织物的损坏被最小化,杀死的效果是局部性的,有很少副作用。癌症,粉刺和另外的疾病的各种各样的形式可以被对待。在里面 photosensitizers 的 vivo 功效被把他们纳入能够指向 diseased 地点的 nanostructures 进一步改进。如此的 photosensitizer-functionalized nanostructures,或 nanotherapeutics,为改进 phototheranostic 性能允许成像和治疗学的代理人的地点特定的交货。这评论在诊断和治疗探索 phototheranostic nanostructures 的潜在的应用。 | Jayeeta Bhaumik Amit Kumar Mittal Avik Banedee Yusuf Chisti Uttam Chand Banerjee | 2015 | Nano Research2015，8，5： | 8 |
| 3 | Adaptive immune response during hepatitis C virus infection显示文摘Hepatitis C virus(HCV)infection affects about 170 million people worldwide and it is a major cause of liver cirrhosis and hepatocellular carcinoma.HCV is a hepatotropic non-cytopathic virus able to persist in a great percentage of infected hosts due to its ability to escape from the immune control.Liver damage and disease progression during HCV infection are driven by both viral and host factors.Specifically,adaptive immune response carries out an essential task in controllingnon-cytopathic viruses because of its ability to recognize infected cells and to destroy them by cytopathic mechanisms and to eliminate the virus by non-cytolytic machinery.HCV is able to impair this response by several means such as developing escape mutations in neutralizing antibodies and in T cell receptor viral epitope recognition sites and inducing HCV-specific cytotoxic T cell anergy and deletion.To impair HCV-specific T cell reactivity,HCV affects effector T cell regulation by modulating T helper and Treg response and by impairing the balance between positive and negative co-stimulatory molecules and between pro-and antiapoptotic proteins.In this review,the role of adaptive immune response in controlling HCV infection and the HCV mechanisms to evade this response are reviewed. | Juan Ramon Larrubia Elia Moreno-Cubero Megha Uttam Lokhande Silvia Garcia-Garzon Alicia Lazaro Joaquin Miquel Cristian Perna Eduardo Sanz-de-Villalobos | 2014 | World Journal of Gastroenterology2014，20，13： | 7 |
| 4 | Selection of appropriate analytical tools to determine the potency and bioactivity of antibiotics and antibiotic resistance显示文摘Antibiotics are the chemotherapeutic agents that kill or inhibit the pathogenic microorganisms.Resistance of microorganism to antibiotics is a growing problem around the world due to indiscriminate and irrational use of antibiotics.In order to overcome the resistance problem and to safely use antibiotics,the correct measurement of potency and bioactivity of antibiotics is essential.Microbiological assay and high performance liquid chromatography(HPLC) method are used to quantify the potency of antibiotics.HPLC method is commonly used for the quantification of potency of antibiotics,but unable to determine the bioactivity;whereas microbiological assay estimates both potency and bioactivity of antibiotics.Additionally,bioassay is used to estimate the effective dose against antibiotic resistant microbes.Simultaneously,microbiological assay addresses the several parameters such as minimal inhibitory concentration(MIC),minimum bactericidal concentration(MBC),mutation prevention concentration(MPC) and critical concentration(Ccr) which are used to describe the potency in a more informative way.Microbiological assay is a simple,sensitive,precise and cost effective method which gives reproducible results similar to HPLC.However,the HPLC cannot be a complete substitute for microbiological assay and both methods have their own significance to obtain more realistic and precise results. | Nishant A.Dafale Uttam P.Semwal Rupak K.Rajput G.N.Singh | 2016 | Journal of Pharmaceutical Analysis2016，6，4： | 5 |
| 5 | Use of gentamicin-loaded collagen sponge in internal fixation of open fractures显示文摘ObjectiveTo 经由逐渐地在介绍给我们的开的破裂的外科的治疗局部地释放抗菌素的使妊娠的骨胶原敲诈的抗菌素(gentamicin骨胶原和抗菌素海绵)的申请估计立即的板 osteosynthesis 的结果在 injury.MethodsAll 盒子以后的 6 个小时包括 35 个病人在我们的第三级的水平损伤中心和教学医院被对待与开的破裂被立即的开的减小和板固定从2008年1月对待到 Augu 在他们之中, 31 个病人为足够的后续和评价是可得到的。所有破裂被灌溉对待,与释放抗菌素的骨胶原的放置一起的清创术,立即的开的减小和板固定就在创伤的闭合前在板附近敲诈。病人们被估计决定手术后的感染,推迟的联合或不属于工会并且另外的手术后的复杂并发症的开发。在彻底的清创术和本地抗菌素以后的立即的板 osteosynthesis 将在开的 fractures.ResultsThe 的治疗给安全、可接受的临床的结果,这被假设有足够的最后的后续的 31 个病人在 40 个星期(15-160 星期) 的一吝啬的时间被估计。大多数破裂根据参与的区域首先在一个可接受的时间时期联合起来。本地创伤复杂并发症(表面的感染和皮损失) 在 3 个病人(9.67%) 被发现。深感染在 2 个病人(6.45%) 被注意。任何一个都需要不这些病人植入在到期的时间统一的移动和两个破裂。推迟的联合在 5 个病人(16.13%) 被注意。没有病人进行了到不属于工会或在长期的后续植入失败。过多的结疤在 2 被开发在骨胶原电影 elut-ing 抗菌素的足够的清创术和放置以后的病人(6.45%).ConclusionsImmediate 板 osteosynthesis 局部地关于骨头联合和深感染的缺席生产优秀结果并且是在开的骨头损害的管理的一种安全技术。这些海绵能与内部固定的任何形式容易被使用,自从他们是 bioabsorbable,没有为这些抗菌素搬运人的移动的第二个手术的需要。与为 3 ~ 5 天的全身的抗菌素一起的本地使抗菌素妊娠的骨胶原海绵在开的破裂管理提供有希望的结果。 | Chaudhary Susheel Sen Ramesh Saini Uttam Chand Soni Ashwani Gahlot Nitesh Singh Daljit | 2011 | Chinese Journal of Traumatology2011，14，4： | 4 |
| 6 | Internal fixation and bone grafting for intraarticular nonunion of tibial plateau: a report of four cases显示文摘胫骨的高原不属于工会的 Intraarticular 是稀罕的。在文学,仅仅 9 个病人被发现为不属于工会的胫骨的高原和他们得到了改变结果的 intraarticular 被对待。与骨头 grafting 一起的内部固定在所有情况中作为标准治疗被做。我们对待 intraarticular 的 4 个不同侧面案例在我们由 4 个不同方法的机构不属于工会的胫骨的高原。我们与骨头接枝,有 K 钉子的 arthrodesis 和全部的膝代替一起与巴黎扔的、内部固定的灰浆对待这些案例。大小写 1 与当病人拒绝了外科,扔的巴黎(流行音乐) 的灰浆被对待。破裂被统一,尽管有外翻足 malalignment,病人充分对运动的完整的范围满意。大小写 2 与开的减小被管理与骨头 grafting 一起的内部固定。病人有一个好工会并且在膝关节得到了运动的完整的范围。大小写 3 由于她的老年与全部的膝关节造形术被对待并且得到了令人满意的结果。大小写 4 是一感染不属于工会。Arthrodesis 被做,病人能与忍受 independently.We 的完整的重量走断定与骨头 grafting 一起的那内部固定不能在胫骨的高原不属于工会的 intraarticular 的所有情况中是合适的。不属于工会的、现在的状况的原因和膝关节的运动的范围都应该被考虑,治疗应该根据每种 patient’s 状况是 individualised。 | Ramesh K Sen Ashwani Soni Uttam Chand Saini Daljit Singh | 2011 | Chinese Journal of Traumatology2011，14，6： | 4 |
| 7 | Multi-spectroscopic investigation of the binding interaction of fosfomycin with bovine serum albumin显示文摘The interaction between fosfomycin(FOS) and bovine serum albumin(BSA) has been investigated effectively by multi-spectroscopic techniques under physiological p H 7.4. FOS quenched the intrinsic fl uorescence of BSA via static quenching. The number of binding sites n and observed binding constant K A were measured by the fl uorescence quenching method. The thermodynamic parameters ΔG0, ΔH0andΔS0were calculated at different temperatures according to the van't Hoff equation. The site of binding of FOS in the protein was proposed to be Sudlow's site I based on displacement experiments using site markers viz. warfarin, ibuprofen and digitoxin. The distance r between the donor(BSA) and acceptor(FOS) molecules was obtained according to the F?rster theory. The effect of FOS on the conformation of BSA was analyzed using synchronous fl uorescence spectra(SFS), circular dichroism(CD) and 3D fl uorescence spectra. A molecular modeling study further con fi rmed the binding mode obtained by the experimental studies. | Manjunath D.Meti Sharanappa T.Nandibewoor Shrinivas D.Joshi Uttam A.More Shivamurti A.Chimatadar | 2015 | Journal of Pharmaceutical Analysis2015，5，4： | 3 |
| 8 | Gastro-retentive drug delivery systems and their in vivo success:A recent update显示文摘Gastro-retentive drug delivery system(GRDDS) has gained immense popularity in the field of oral drug delivery recently. It is a widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many challenges associated with conventional oral delivery, including poor bioavailability.Different innovative approaches like magnetic field assisted gastro-retention, plug type swelling system, muco-adhesion technique, floating system with or without effervescence are being applied to fabricate GRDDS. Apart from in vitro characterization, successful GRDDS development demands well designed in vivo study to establish enhanced gastro-retention and prolonged drug release. Gama scintigraphy and MRI are popular techniques to evaluate in vivo gastric residence time. However, checking of their overall in-vivo efficacy still remains a major challenge for this kind of dosage form, especially in small animals like mice or rat.Reported in vivo studies with beagle dogs, rabbits, and human subjects are only a handful in spite of a large number of encouraging in vitro results. In spite of the many advantages,high subject variations in gastrointestinal physiological condition, effect of food, and variable rate of gastric emptying time are the challenges that limit the number of available GRDDS in the market. This review article highlights the in vivo works of GRDDS carried out in the recent past, including their limitations and challenges that need to be overcome in the near future. | Uttam Kumar Mandal Bappaditya Chatterjee Faria Gias Senjoti | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，5： | 3 |
| 9 | First-principles study on the mechanical and thermodynamic properties of MoNbTaTiW显示文摘Refractory high-entropy alloys(RHEAs)are emerging as new materials for high temperature structural applications because of their stable mechanical and thermal properties at temperatures higher than 2273 K.In this study,the mechanical properties of MoNbTaTiW RHEA are examined by applying calculations based on first-principles density functional theory(DFT)and using a large unit cell with 100 randomized atoms.The phase calculation of MoNbTaTiW with CALPHAD method shows the existence of a stable body-centered cubic structure at a high temperature and a hexagonal closely packed phase at a low temperature.The predicted phase,shear modulus,Young’s modulus,Poisson’s ratio,and hardness values are consistent with available experimental results.The linear thermal expansion coefficient,vibrational entropy,and vibrational heat capacity of MoNbTaTiW RHEA are investigated in accordance with Debye-Grüneisen theory.These results may provide a basis for future research related to the application of RHEAs. | Uttam Bhandari Congyan Zhang Shengmin Guo Shizhong Yang | 2020 | International Journal of Minerals,Metallurgy and Materials2020，27，10： | 3 |
| 10 | Role of T cell death in maintaining immune tolerance during persistent viral hepatitis显示文摘Virus-specific T cells play an important role in the resolution of hepatic infection. However, during chronic hepatitis infection these cells lack their effector functions and fail to control the virus. Hepatitis B virus and hepatitis C virus have developed several mechanisms to generate immune tolerance. One of these strategies is the depletion of virus-specific T cells by apoptosis. The immunotolerogenic liver has unique property to retain and activate na ve T cell to avoid the over reactivation of immune response against antigens which is exploited by hepatotropic viruses to persist. The deletion of the virus-specific T cells occurs by intrinsic (passive) apoptotic mechanism. The pro-apoptotic molecule Bcl-2 interacting mediator (Bim) has attracted increasing attention as a pivotal involvement in apoptosis, as a regulator of tissue homeostasis and an enhancer for the viral persistence. Here, we reviewed our current knowledge on the evidence showing critical role of Bim in viral-specific T cell death by apoptotic pathways and helps in the immune tolerance. | Juan Ramón Larrubia Megha Uttam Lokhande Silvia García-Garzón Joaquín Miquel Dolores Subirá Eduardo Sanz-de-Villalobos | 2013 | World Journal of Gastroenterology2013，19，12： | 2 |
| 11 | Effect of tool rotational speed on the particle distribution in friction stir welding of AA6092/17.5 SiCp-T6 composite plates and its consequences on the mechanical property of the joint显示文摘This study investigates the effect of tool rotational speed(TRS)on particle distribution in nugget zone(NZ)through quantitative approach and its consequences on the mechanical property of friction stir welded joints of AA6092/17.5 SiCp-T6 composite.6 mm thick plates are welded at a constant tool tilt angle of 2°and tool traverse speed of 1 mm/s by varying the TRS at 1000 rpm,1500 rpm and 2000 rpm with a taper pin profiled tool.Microstructure analysis shows large quantity of uniformly shaped smaller size SiC particle with lower average particle area which are homogeneously distributed in the NZ.The fragmentation of bigger size particles has been observed because of abrading action of the hard tool and resulting shearing effect and severe stress generation due to the rotation of tool.The particles occupy maximum area in the matrix compared to that of the base material(BM)due to the redistribution of broken particles as an effect of TRS.The migration of particles towards the TMAZ-NZ transition zone has been also encountered at higher TRS(2000 rpm).The microhardness analysis depicts variation in average hardness from top to bottom of the NZ,minimum for 1500 rpm and maximum for 2000 rpm.The impact strength at 1000 rpm and 1500 rpm remains close to that of BM(21.6 J)while 2000 rpm shows the accountable reduction.The maximum joint efficiency has been achieved at 1500 rpm(84%)and minimum at 1000 rpm(68%)under tensile loading.Fractographic analysis shows mixed mode of failure for BM,1000 rpm and 1500 rpm,whereas 2000 rpm shows the brittle mode of failure. | Uttam Acharya Barnik Saha Roy Subhash Chandra Saha | 2020 | Defence Technology(防务技术)2020，16，2： | 2 |
| 12 | Failure of intramedullary femoral nail with segmental breakage of distal locking bolts: a case report and review of the literature显示文摘锁螺栓的破裂是联锁的一个重要原因在大腿骨的破裂的钉子失败。它通常在远侧的锁住洞附近在钉子或钉子破裂的远侧的螺栓之一发生在单个破裂形式。这里,我们报导 intramedullary 的一个不平常的案例有两个的部分破裂的大腿骨的钉子失败远侧的锁住螺栓。如此的一种情形通常复杂化进一步的管理。我们成功地管理了这个案例,没有骨头 grafting,交换钉。这里,我们简短关于如此的一个不平常的演讲考察了文学并且当面对如此的一种复杂状况时,详细讨论了如此的一个演讲和管理选择的可能的病原学。 | Sameer Aggerwal Nitesh Gahlot Uttam C. Saini Kamal Bail | 2011 | Chinese Journal of Traumatology2011，14，3： | 2 |
| 13 | Cobaltaelectro-Catalyzed C—H Acyloxylation显示文摘Cobaltaelectrocatalysis set the stage for sustainable C—H acyloxylations in biomass-derived γ-valerolactone as a renewable solvent. The sustainable electrocatalysis regime featured ample scope, along with high levels of chemo- and position-selectivity. | Cong Tian Uttam Dhawa Julia Struwe Lutz Ackermann | 2019 | Chinese Journal of Chemistry2019，37，6： | 2 |
| 14 | Production, purification, characterization, and applications of lipases显示文摘 | Rohit Sharma Yusuf Chisti Uttam Chand Banerjee | 2001 | Biotechnology Advances2001，，8： | 2 |
| 15 | Superresolution of Coherent Sources in Real-Beam Data 显示文摘 | Uttam S Goodman N A | 2010 | Aerospace and Electronic Systems IEEE Transactions on2010，46，3： | 1 |
| 16 | Arsenic transformation in the growth media and biomass of hyperaccumulator Pteris vittata L.显示文摘 | Shiny Mathews Lena Q. Ma Bala Rathinasabapathi Seenivasan Natarajan Uttam K. Saha | 2010 | Bioresource Technology2010，，21： | 1 |
| 17 | Long-term soil management effects on crop yields and soil quality in a dryland Alfisol显示文摘 | Sharma K L Uttam Kumar Mandal Srinivas K | 2005 | Soil and Tillage Research2005，83，： | 1 |
| 18 | The Association Between Elevaed EphB4 Expression ,Smoking Status,and Advanced-Stage Disease in Patients With Head and Neck Squamous Cell Carcinoma显示文摘 | Uttam K Sinha MD Kashif Mazhar MD | 2006 | Arch otolaryngol head neck sury2006，132，10： | 1 |
| 19 | 闪光对于减轻静脉置管痛的作用:一项前瞻性随机安慰剂对照研究显示文摘背景尽管静脉置管时的疼痛经常让人备受困扰,但通常都是在没有任何镇痛措施下进行静脉置管的。临床上曾尝试用一些药物和非药物方法来减轻静脉置管的疼痛,但结果各异。本研究拟评价一次闪光对于减轻静脉置管痛的效果。方法90例拟择期行腹腔镜胆囊切除术的ASAⅠ~Ⅱ级的成年患者(15~60岁),随机分为3组,每组30例,组1为对照组;组2为分散注意力组,即在非优势手的手背静脉进行置管前给患者照相而不使用闪光;组3为闪光组,静脉置管前照相并且使用闪光;在照相后立即使用18G的穿刺针进行静脉置管。结果每组均有2例患者首次静脉穿刺失败,在数据分析中即予以剔除,闪光组疼痛的发生率为50%(28例中14例发生),其他2组为100%(28例全部发生),通过视觉模拟评分评估的疼痛严重程度分散注意力组和闪光组显著低于对照组,而闪光组也显著低于分散注意力组。结论静脉置管前使用闪光是一种减轻疼痛的安全而简单有效的方法。 | Anil Agarwal GhanshvamYadav Devendra Gupta Manish Tandon Prabhat Kumar Singh Uttam Singh 吴志林(译) | 2009 | 麻醉与镇痛2009，，3： | 1 |
| 20 | Production, purification, characterization, and application of lipases显示文摘 | Rohit S Yusuf C Uttam C B | 2001 | Biotechnology Advances2001，19，8： | 1 |
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