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| 1 | Role of non-steroidal anti-inflammatory drugs on intestinal permeability and nonalcoholic fatty liver disease显示文摘The use of non-steroidal anti-inflammatory drugs(NSAIDs) is widespread worldwide thanks to their analgesic, anti-inflammatory and antipyretic effects. However, even more attention is placed upon the recurrence of digestive system complications in the course of their use. Recent data suggests that the complications of the lower gastro-intestinal tract may be as frequent and severe as those of the upper tract. NSAIDs enteropathy is due to enterohepatic recycling of the drugs resulting in a prolonged and repeated exposure of the intestinal mucosa to the compound and its metabolites. Thus leading to so-called topical effects, which, in turn, lead to an impairment of the intestinal barrier. This process determines bacterial translocation and toxic substances of intestinal origin in the portal circulation, leading to an endotoxaemia. This condition could determine a liver inflammatory response and might promote the development of nonalcoholic steatohepatitis, mostly in patients with risk factors such as obesity, metabolic syndrome and a high fat diet, which may induce a small intestinal bacterial overgrowth and dysbiosis. This alteration of gut microbiota may contribute to nonalcoholic fatty liver disease and its related disorders in two ways: firstly causing a malfunction of the tight junctions that play a critical role in the increase of intestinal permeability, and then secondly leading to the development of insulin resistance, body weight gain, lipogenesis, fibrogenesis and hepatic oxidative stress. | erika utzeri paolo usai | 2017 | World Journal of Gastroenterology2017，23，22： | 12 |
| 2 | Nonalcoholic fatty liver disease in patients with inflammatory bowel disease: Beyond the natural history显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a frequently reported condition in patients with inflammatory bowel disease(IBD).Both intestinal inflammation and metabolic factors are believed to contribute to the pathogenesis of IBDassociated NAFLD.AIM To evaluate the prevalence of steatosis and liver fibrosis(LF)in a cohort of IBD patients and the identification of metabolic-and IBD-related risk factors for NAFLD and LF.METHODS IBD patients were consecutively enrolled from December 2016 to January 2018.Demographic,anthropometric and biochemical data were collected so as eating habits.Abdominal ultrasound and transient elastography were performed to evaluate the presence of NAFLD and LF respectively.RESULTS A total of 178 consecutive patients were enrolled and included in the analysis(95 Ulcerative colitis,83 Crohn’s disease).NAFLD was detected by imaging in 72(40.4%)patients.Comparison between patients with and without NAFLD showed no significant differences in terms of IBD severity,disease duration,location/extension,use of IBD-related medications(i.e.,steroids,anti-TNFs,and immunomodulators)and surgery.NAFLD was significantly associated with the presence of metabolic syndrome[MetS;odds ratio(OR):4.13,P=0.001]and obesity defined by body mass index(OR:9.21,P=0.0002).IBD patients with NAFLD showed higher caloric intake and lipid consumption than those without NAFLD,regardless disease activity.At the multivariate analysis,male sex,advanced age and high lipid consumption were independent risk factors for the development of NAFLD.An increased liver stiffness was detected in 21 patients(16%)and the presence of MetS was the only relevant factor associated to LF(OR:3.40,P=0.01).CONCLUSION In this study,we demonstrate that risk factors for NAFLD and LF in the IBD population do not differ from those in the general population. | Salvatore Magrì Danilo Paduano Fabio Chicco Arianna Cingolani Cristiana Farris Giovanna Delogu Francesca Tumbarello Mariantonia Lai Alessandro Melis Laura Casula Massimo C Fantini Paolo Usai | 2019 | World Journal of Gastroenterology2019，25，37： | 8 |
| 3 | Abscisic acid is an endogenous stimulator of insulin release from human pancreatic islets with cyclic ADP ribose as second messenger显示文摘 | BRUZZONE S BODRATO N USAI C | 2008 | J Biol Chem2008，283，32： | 1 |
| 4 | Design of a protein-targeting system for lactic acid bacteria显示文摘 | Dieye Y Usai S Clier F | 2001 | J Bacteriol2001，183，： | 1 |
| 5 | Prevalence of irritable bowel syndrome in Italian rural and urban areas显示文摘 | Usai P Manca R Lai MA | 2010 | Eur J Intern Med2010，21，4： | 1 |
| 6 | Spatial spillo vers and innovation activity in European regions显示文摘 | MORENO-SERRANO R PACI R USAI S | 2005 | Envi- ronment & Planning2005，37，1： | 1 |
| 7 | On Multi-input Chattering-free Second-order Sliding Mode Control 显示文摘 | Bartolini G Ferrara A Usai E | 2000 | IEEE Trans on Automatic Control (S0018-9286)2000，45，6： | 1 |
| 8 | Design of a protein-targeting system for lactic acid bacteria显示文摘 | Usai S Clier F | 2001 | J Bacteriol2001，183，14： | 1 |
| 9 | Network memory: The infl uence of past and current networks on perfor- mance显示文摘 | Soda G Usai A Zaheer A | 2004 | Academy of Management Journal2004，，47： | 1 |
| 10 | Homocysteine plasma levels in patients with migraine with aura显示文摘 | Moschiano F D’Amico D Usai S | 2008 | Neurol Sci2008，29，1： | 1 |
| 11 | Recent finding and new technologies in nephrolithiasisz a review of the recent literature 显示文摘 | ROSA M USAI P MIANO R | 2013 | BMC Urol2013，13，1： | 1 |
| 12 | Validating the Migraine-Specific Quality of Life Questionnaire v2.1 (MSQ) in Italian inpatients with chronic migraine with a history of medication overuse显示文摘 | Alberto Raggi Ambra Mara Giovannetti Silvia Schiavolin Matilde Leonardi Gennaro Bussone Licia Grazzi Susanna Usai Marcella Curone Paola Fiore Domenico D’Amico | 2014 | Quality of Life Research2014，，4： | 1 |
| 13 | Externalities, knowledge spillovers and the spa- tial distribution of innovation 显示文摘 | PACI R USAI S | 1999 | GeoJournal1999，，49： | 1 |
| 14 | Second order sliding mode control of container cranes 显示文摘 | Bartolini G Pisano A Usai E | 2002 | Automatica2002，38，10： | 1 |
| 15 | Network memory: the influence of past and current networks on performanee显示文摘 | SODA G USAI A ZAHEER A | 2004 | Academy of Management Journal2004，47，6： | 1 |
| 16 | Output tracking control ofuncertain nonlinear second-order systems 显示文摘 | Bartolinl G Ferrara A Usai E | 1997 | Automatica1997，33，12： | 1 |
| 17 | Spatial Spillovers and Innovation Activity in European Regions显示文摘 | Moreno R Paci R Usai S | 2005 | Environment and Planning2005，37，： | 1 |
| 18 | Spatial spillovers and inno-vation activity in European regions 显示文摘 | MORENO R PACI R USAI S | 2005 | Environment andPlanning A2005，37，10： | 1 |
| 19 | Design of a protein-targe- ting system for lactic acid bacteria 显示文摘 | DIEYE Y USAI S CLIER F | 2001 | J Bacteriol2001，183，14： | 1 |
| 20 | Treatment of severe intraventrieular hemorrange by intraventriclar infusion of urokinase显示文摘 | Todo T Usai M Takakura K | 1991 | J Neurosurg1991，74，1： | 1 |
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