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| 1 | High prevalence of viable Mycobacterium avium subspecies paratuberculosis in Crohn's disease显示文摘AIM:To examine the detection rate of viable Mycobacterium avium subspecies paratuberculosis(MAP) in patients with inflammatory bowel disease [Crohn's disease(CD) and ulcerative colitis(UC)].METHODS:Thirty patients with CD(15 with at least one NOD2/CARD15 mutation),29 with UC,and 10 with no inflammatory bowel disease(IBD).were tested for MAP by polymerase chain reaction(specific IS900 fragment) and blood culture.RESULTS:MAP DNA was detected in all original blood samples and 8-wk blood cultures(CD,UC and non-IBD).Positive MAP DNA status was confirmed by dot blot assays.All 69 cultures were negative by acid-fast Ziehl-Neelsen staining.Viable MAP,in spheroplast form,was isolated from the 18-mo blood cultures of all 30 CD patients,one UC patient,and none of the non-IBD controls.No association was found between positive MAP cultures and use of immunosuppressive drugs or CDassociated single nucleotide polymorphisms.CONCLUSION:MAP is widely present in our area and MAP DNA can be recovered from the blood of CD,UC and non-IBD patients.However,MAP spheroplasts were only found in CD patients. | Juan L Mendoza Amparo San-Pedro Esther Culebras Raquel Cíes Carlos Taxonera Raquel Lana Elena Urcelay Fernando de la Torre Juan J Picazo Manuel Díaz-Rubio | 2010 | World Journal of Gastroenterology2010，16，36： | 5 |
| 2 | IBD5 polymorphisms in inflammatory bowel disease: Association with response to infliximab显示文摘AIM: Inflammatory bowel diseases (IBD) are multifactorial pathologies of unknown etiology. One susceptibility locus,IBD5, has been mapped to chromosome 5q31. We analyzed our Spanish cohorts of Crohn's disease (CD)and ulcerative colitis (UC) patients to determine whether this locus is associated with IBD, and to ascertain the main clinical phenotype influenced by this risk factor. The kind of interaction, either genetic heterogeneity or epistasis, between this IBD5 susceptibility region and the NOD2/CARD15 gene mutations was studied as well.Finally, ve assessed whether this locus can predict response to infliximab therapy.METHODS: A case control study was performed with 274CD and 211 UC patients recruited from a single center and 511 healthy ethnically matched controls. Two polymorphisms were genotyped in the IBD5 locus and three in the CARD15/NOD2 gene.RESULTS: Our results evidence association only with CD especially with the fistulizing phenotype and in the absence of NOD2/CARD15 variants (mutant allele frequency in patients vscontrols: OR = 2.03, 95% CI = 1.35-3.06,P<0.01). The frequency of the IBD5 homozygous mutant genotype significantly increased in CD patients lacking response to infliximab (RR = 3.88, 95% CI = 1.18-12.0,P<0.05). UC patients overall do not show association with 5q31 polymorphisms, although a similar trend to the one observed in CD is found within the worse prognosis group.CONCLUSION: The IBD5 variants may enhance an individual carrier's risk for CD, mainly in the absence of the NOD2/CARD15 mutations and in fistulizing patients.The data presented suggest the potential role of the 5q31polymorphisms as markers of response to infiiximab. | Elena Urcelay Juan Luis Mendoza Alfonso Martínez Laura Fernández Carlos Taxonera Manuel Díaz-Rubio Emilio G.de la Concha | 2005 | World Journal of Gastroenterology2005，11，8： | 4 |
| 3 | Mycorrhizal status of Phlebopus bruchii (Boletaceae) : Does it form ectomycorrhizas with Fagara coco (Rutaceae) ? 显示文摘 | NOUHRA E URCELAY C BECERRA A | 2008 | Symbiosis2008，46，： | 1 |
| 4 | Ca2+/calmodulin-dependent modulation of cell cycle elements pRb and p27kip1 involved in the enhanced proliferation of lymphoblasts from patients with Alzheimer dementia显示文摘 | de las Cuevas N Urcelay E Hermida OG | 2003 | Neurobiol Dis2003，13，3： | 1 |
| 5 | Intermediate results acter complete repair of tetralogy of Failot in neonates显示文摘 | Hennein HA Mosca RS Urcelay G | 1995 | J Thorac Cardiovasc Surg1995，109，： | 1 |
| 6 | Mountain invasions on the way:are there climatic constraints for the expansion of alien woody species along an elevation gradient in Argentina?显示文摘Aims Increasing evidence worldwide indicates that high mountain regions are not immune to invasion by alien plants.Here,we aimed to address whether three major woody invaders of low-mountain areas are constrained to lower altitudes due to climatic restrictions or just by low propagule pressure.We hypothesize that the increasing climatic harshness towards higher altitudes restricts seedling establishment and survival of these woody invaders and thus their potential for altitudinal expansion.Methods The study was carried out in the Sierras Grandes Mountains,Córdoba,central Argentina(32°50′S,64°90′W).We addressed the hypothesis with an experimental approach,dissociating the effect of the environmental gradient from that of propagule pressure,by discarding the influence of seed sources.We translocated seeds of Gleditsia triacanthos L.,Ligustrum lucidum W.T.Aiton.and Pyracantha angustifolia(Franch.)C.K.Schneid.along the altitudinal gradient(from 900 to 2700 m asl).Seven sites were selected along the altitudinal gradient,spaced every 200-400 m.Three plots(4×4 m)were selected within each altitudinal site and excluded from livestock;100 seeds of each species were sown within each plot(6300 seeds in total).Seedling emergence and survival was monitored during two growing seasons and soil temperature and moisture was recorded as well.The field experiment was complemented with lab assays.Important Findings Climate along this altitudinal gradient might be least restrictive at mid elevations,as a result of the intersection between opposite soil temperature and moisture gradients.Sown seeds germinated along the whole altitudinal gradient and seedlings successfully established and over-wintered well above their current altitudinal distribution(up to 2200 m for Ligustrum and 2400 m for Gleditsia and Pyracantha).Additional lab assays confirmed field patterns and gave some insights into contrasting regeneration strategies between these invaders that might help to overcome stochastic environmental constraints in the germination stage.Overall,seedlings of three major woody invaders of low-mountain woodlands can establish and survive at higher elevations than their current distribution.In contrast to natives,they seem to be broad climate tolerators,rather than specialized stress tolerators,capable of germinating and growing across a wide elevational range.While long-term experiments might be necessary to fully address the potentials for altitudinal expansion,out results on early lifecycle stage suggest that the invaders studied here would have mostly a dispersal barrier rather than a climate barrier to establish in the upper belt of the Sierras Grandes. | Paula A.Tecco Ana I.Pais-Bosch Guillermo Funes Paula I.Marcora Sebastián R.Zeballos Marcelo Cabido Carlos Urcelay | 2016 | Journal of Plant Ecology2016，9，4： | 1 |
| 7 | MDR1 gene: susceptibility in Spanish Crohn's disease and ulcerative colitis patients 显示文摘 | URCELAY E MENDOZA J L MARTIN M C | 2006 | Inflamm Bowel Dis2006，12，1： | 1 |
| 8 | Osteopontin gene polymorphisms in Spanish patients with rheumatoid arthritis显示文摘 | Martinez A Mas-Fontao A | 2005 | J Rheumatol2005，32，3： | 1 |
| 9 | Intermediate results after repair of tetralogy of Fallot in neonates显示文摘 | Hennein HA Mosca RS Urcelay Q | 1995 | J Thorac Cardiovasc Surg1995，109，2： | 1 |
| 10 | Autoinflammatory diseases, more frequent than it seems? 显示文摘 | Urcelay RM Aramburu de la Puerta FJ Villarreal Baiza de Vallejo JJ | 2013 | Rev Clin Esp2013，213，： | 1 |
| 11 | Intermediate resulst after repair of tetralogy of Fallot in neonates显示文摘 | Mosca RS Urcelay Q | 1995 | J Thorac Cardiovasc Surg1995，109，： | 1 |
| 12 | Origin of both coronary arteries from the pulmonary artery显示文摘 | Urcelay GE Iannettoni MD Ludomirsky A | 1994 | Circulation1994，90，5： | 1 |
| 13 | Transdermal glyceryl trinitrate for prevention of post-ERCP pancreatitis: A randomized double-blind trial显示文摘 | Manuel Moretó Manuel Zaballa Ignacio Casado Olga Merino Miguel Rueda Kléber Ramírez Raquel Urcelay Amaia Baranda | 2003 | Gastrointestinal Endoscopy2003，，1： | 1 |
| 14 | Influence of the inducible nitric oxide synthase gene ( NOS2A ) on inflammatory bowel disease susceptibility显示文摘 | M. Carmen Martín Alfonso Martinez J. Luis Mendoza Carlos Taxonera Manuel Díaz-Rubio Miguel Fernández-Arquero Emilio G. Concha Elena Urcelay | 2007 | Immunogenetics2007，，： | 1 |
| 15 | Influence of the inducible nitric oxide synthase gene (NOS2A) on inflammatory bowel disease susceptibility显示文摘 | M. Carmen Martín Alfonso Martinez J. Luis Mendoza Carlos Taxonera Manuel Díaz-Rubio Miguel Fernández-Arquero Emilio G. Concha Elena Urcelay | 2007 | Immunogenetics2007，，11： | 1 |
| 16 | Enhanced proliferation of lymphoblasts from patients with Alzheimer dementia associated with calmodulin-dependent activation of the Na^ +/H^+ exchanger显示文摘 | Urcelay E Ibarreta D Parrilla R | 2001 | Neumbiol Dis2001，8，2： | 1 |
| 17 | TNF-376A marks susceptibility to MS in the Spanish population:A replication study显示文摘 | MARTINEZ A RUBIO A URCELAY E | 2004 | Neurology2004，62，5： | 1 |
| 18 | TNF-376A marks susceptibility to MS in the Spanish population:a replication study显示文摘 | Martinez A Rubio E Urcelay M | 2004 | Neurology2004，62，5： | 1 |
| 19 | Influence of the inducible nitric oxide synthase gene (NOS2A) on inflammatory bowel disease susceptibility显示文摘 | M. Carmen Martín Alfonso Martinez J. Luis Mendoza Carlos Taxonera Manuel Díaz-Rubio Miguel Fernández-Arquero Emilio G. Concha Elena Urcelay | 2007 | Immunogenetics2007，，11： | 1 |
| 20 | Prevalence of mutations of the NOD2/CARD15 gene and relation to phenotype in Spanish patients with Crohn disease显示文摘 | J. L. Mendoza L. S. Murillo L. Ferná ndez A. S. Pe? a R. Lana E. Urcelay D. M. Cruz&hyphen Santamarí a E. G. de la Concha M. Dí az&hyphen Rubio J. Garcí a&hyphen Paredes | 2003 | Scandinavian Journal of Gastroenterology2003，，12： | 1 |
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