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| 1 | Obesity is an important determinant of severity in newly defined metabolic dysfunction-associated fatty liver disease显示文摘Background: The recently proposed definition of metabolic dysfunction-associated fatty liver disease(MAFLD) is based on the co-existence of hepatic steatosis with other metabolic disorders, including obesity and metabolic risk abnormalities such as hyperglycemia, high blood pressure and dyslipidemia. This study aimed to assess MAFLD severity according to the presence of metabolic abnormalities and obesity. Methods: Using transient elastography, hepatic steatosis and fibrosis severity were assessed by measuring the controlled attenuation parameter and liver stiffness measurement. A total of 1163 patients with MAFLD were categorized into the following four groups according to metabolic risk abnormalities and obesity presence: non-obese without metabolic risk abnormality group(Group 1;reference group);nonobese with metabolic risk abnormality group(Group 2);obese without metabolic risk abnormality group(Group 3);and obese with metabolic risk abnormality group(Group 4). A multiple logistic regression analysis was performed to determine severe hepatic steatosis and fibrosis risk in each group in both unadjusted and adjusted models. Results: In the adjusted model, the odds ratios(ORs) [95% confidence interval(CI)] for severe hepatic steatosis in Groups 2, 3, and 4 were 1.07(0.61-1.88), 2.43(1.44-4.08), and 4.07(2.56-6.48), respectively( P trend < 0.001). For liver fibrosis, compared with Group 1, Group 2 showed no significant increases in OR, whereas Groups 3 and 4(obese groups) showed significant increases(OR = 4.70, 95% CI: 1.24-17.82 and OR = 6.43, 95% CI: 1.88-22.02, respectively). Conclusions: Obesity, rather than metabolic abnormality, is the principal determinant of severe hepatic steatosis and fibrosis in patients with MAFLD. | Ji Hye Huh Kwang Joon Kim Seung Up Kim Bong-Soo Cha Byung-Wan Lee | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，3： | 2 |
| 2 | Acute limb ischemia after minimally invasive cardiac surgery using the ProGlide:A case series显示文摘BACKGROUND We report two cases of acute femoral artery occlusion following the use of ProGlide in minimally invasive cardiac surgery and insertion of large-bore catheters through the common femoral artery.This will add to the existing body of literature by highlighting the possible complications associated with the use of ProGlide and reiterate that the use of the sono-guided ProGlide skill will reduce the incidence of these complications.CASE SUMMARY A 78-year-old man underwent minimally invasive cardiac surgery for severe aortic valve stenosis.After the operation,the puncture site of the common femoral artery was closed using ProGlide.The next morning,after regaining consciousness,he complained of pain,motor weakness(grade 2),and coldness in the right lower extremity.A 65-year-old man underwent minimally invasive cardiac surgery for a large secundum atrial septal defect(5 cm×5 cm).After the operation,the puncture site of the common femoral artery was closed using ProGlide.After extubation,the patient complained of paresthesia of the right thigh.Both the patients underwent emergency surgery for acute occlusion of the common femoral artery.CONCLUSION If the sono-guided ProGlide skill is used,complications can be prevented,and ProGlide can be safely used. | Jonggeun Lee Up Huh Seunghwan Song Chung Won Lee | 2022 | World Journal of Clinical Cases2022，10，35： | 1 |
| 3 | Venous adventitial cystic disease is a very rare disease that can cause deep vein thrombosis:A case report显示文摘BACKGROUND Venous adventitial cystic disease(VACD)is a rare disease characterized by cysts,filled with a gelatinous mucous substance similar to joint fluid,in the adventitia of blood vessels adjacent to the joints.It is often misdiagnosed as deep vein thrombosis(DVT),femoral varices,venous tumors,or lymphadenopathy.CASE SUMMARY A 69-year-old woman visited our hospital with a complaint of swelling in the right lower extremity.The patient was diagnosed with DVT and prescribed apixaban at an outpatient clinic.After 3 wk,the patient was hospitalized again because of sudden swelling in the right lower extremity.We diagnosed VACD and performed surgery for cyst removal as well as patch angioplasty and thrombectomy of the right common femoral vein.The patient received anticoagulants for 6 mo and has been doing well without recurrence for 1 year postoperatively.CONCLUSION Recurrent VACD requires complete removal of the connections to the joint cavity to prevent recurrence. | Miju Bae Up Huh Chung Won Lee Jong Won Kim | 2023 | World Journal of Clinical Cases2023，11，34： | 0 |
| 4 | Benefit in physical function and quality of life to nonsurgical treatment of varicose veins: Pilot study显示文摘BACKGROUND Studies on varicose veins have focused its effects on physical function;however,whether nonsurgical treatments alter muscle oxygenation or physical function remains unclear.Moreover,the differences in such functions between individuals with varicose veins and healthy individuals remain unclear.AIM To investigate changes in physical function and the quality of life(QOL)following nonsurgical treatment of patients with varicose veins and determine the changes in their muscle oxygenation during activity.METHODS We enrolled 37 participants(those with varicose veins,n=17;healthy individuals,n=20).We performed the following measurements pre-and post-nonsurgical treatment in the varicose vein patients and healthy individuals:Calf muscle oxygenation during the two-minute step test,open eyes one-leg stance,30 s sit-to-stand test,visual analog scale(VAS)for pain,Pittsburgh sleep quality index,physical activity assessment,and QOL assessment.RESULTS Varicose veins patients and healthy individuals differ in most variables(physical function,sleep quality,and QOL).Varicose veins patients showed significant differences between pre-and post-nonsurgical treatment—results in the 30 sit-to-stand test[14.41(2.45)to 16.35(4.11),P=0.018],two-minute step test[162.29(25.98)to 170.65(23.80),P=0.037],VAS for pain[5.35(1.90)to 3.88(1.73),P=0.004],and QOL[39.34(19.98)to 26.69(17.02),P=0.005];however,no significant difference was observed for muscle oxygenation.CONCLUSION Nonsurgical treatment improved lower extremity function and QOL in varicose veins patients,bringing their condition close to that of healthy individuals.Future studies should include patients with severe varicose veins requiring surgery to confirm our findings. | Gwon-Min Kim BoKun Kim Minwoo Jang Jong-Hwan Park Miju Bae Chung Won Lee Jong Won Kim Up Huh | 2024 | World Journal of Clinical Cases2024，12，3： | 0 |
| 5 | Central retinal artery occlusion in eosinophilic granulomatosis with polyangiitis(Churg-Strauss Syndrome):the first case report in South Korea显示文摘Dear Editor,I am Dr.Jungyul Park from the Department of Ophthalmology,Pusan National University Hospital,Busan,Korea.I am writing to present a case of eosinophilic granulomatosis with polyangiitis(EGPA)with central retinal artery occlusion(CRAO).It provides important information about the relationship between ANCA and CRAO in a patient who was diagnosed with EGPA who had ophthalmic symptoms.We believe that our study makes a significant contribution to the literature because to our knowledge,the literature of EGPA with CRAO are rare worldwide and this is even the first case of EGPA with CRAO in Republic of Korea. | Jungyul Park Up Huh Hee-young Choi Seunggeun Lee Miyeun Han Sungwoon Chung Hyerim Kim | 2021 | International Journal of Ophthalmology(English edition)2021，14，6： | 0 |
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