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| 1 | Tumor targeted mesoporous silica-coated gold nanorods facilitate detection of pancreatic tumors using Multispectral optoacoustic tomography显示文摘Multispectral optoacoustic 断层摄影术(MSOT ) 是在传统的形式上提供几个优点的一种新兴的成像技术,特别地处于它解决在显微镜的规模上的深度的光对比的能力。当潜在的应用包括临床的阀值由当前的技术设置了的下面的肿瘤的早察觉时,肿瘤特定的对比代理人的缺乏限制 MSOT 成像的使用。因此,我们与 polyacrylic 酸(泛美航空公司) 或 aminefunctionalized mesoporous 硅石(MS ) 由涂层金牌 nanorods (GNR ) 构造了高度稳定的 nano 对比代理人。Syndecan-1,被显示了指向像胰岛素的生长因素 1 受体(IGF1-R )( 在胰腺的肿瘤的 upregulated ) ,在泛美航空公司涂的 GNR (PAA-GNRs ) 或 MS 涂的 GNR (MS-GNRs ) 的表面上被结合创造指向肿瘤的 nanoparticles。在 vitro, nanoparticles 指向的肿瘤与流动 cytometry 被估计。在 S2VP10L 房间(为 IGF1-R 积极) , syndecan-1 MS-GNRs (Syndecan-MS-GNRs ) 在 OA 信号表明了增加, 10x,与 syndecan-1 PAAGNR (Syndecan-PAA-GNRs ) 相比。最小的绑定在 MiaPaca-2 房间被观察(为 IGF1-R 否定) 。在 vivo,肿瘤 Syndecan-MS-GNRs 的特定的指向用鼠科的 orthotopic 被评估胰腺的癌症模型。Syndecan- MS-GNRs 比在象肝那样的离开目标机关在胰腺的肿瘤以内表明了显著地更大的累积。与 IGF1-R 否定 MiaPaca-2 房间植入的老鼠没表明指向的特定的肿瘤。在摘要,我们报导指向的 nano 对比代理人(Syndecan-MS-GNRs ) 能成功地检测 orthotopic 有在用 MSOT 的 vivo 有约束力的最小的离开目标的胰腺的肿瘤。 | Anil Khanal Christopher Ullum Charles W Kimbrough Nichola C. Garbett Joseph A. Burlison Molly W. McNally Phillip Chuong Ayman S. EI-Baz Jacek B. Jasinski Lacey R. McNally | 2015 | Nano Research2015，8，12： | 2 |
| 2 | Serum level of soluble urokinasetype plasminogen act ptor is a ivator rece strong and independent predictor of survival in human immunodeficiency virus infection 显示文摘 | Sidenius N Sier CF Ullum H | 2000 | Blood2000，96，13： | 1 |
| 3 | Bicycle exerciseenhances plasma IL-6 but does not change IL-1 alpha, IL-1 beta, IL-6, orTNF-alpha pre-mRNA in BMNC显示文摘 | ULLUM H HAAHR P M DIAMANT M | 1994 | J Appl Physiol1994，77，1： | 1 |
| 4 | Increased losses of CD4+ CD45RA+ cells in late stages of HIV infection is related to increased risk of death : evidence from a cohort of 347 HIV-infected individuals 显示文摘 | Ullum H Cozzi L A Victor J | 1997 | AIDS1997，11，： | 1 |
| 5 | Course and clinical significance of CD8+T-Cell counts in a large co- hort of HIV-infected individuals显示文摘 | Helleberg M Kronborg G Ullum H | 2015 | J Infect Dis2015，211，11： | 1 |
| 6 | Prognostic Value of Single Measurements of Beta-2-mieroglobulin,Immunoglobulin A in HIV Disease after Controlling for CD4 Lymphocyte Counts and Plasma HIV RNA Levels 显示文摘 | Ullum H Lepri AC Katzenstein TL | 2000 | Scand J Infect Dis2000，32，： | 1 |
| 7 | Plasma concentrations of soluble urokinase - type plasminogen activator receptor are in- creased in patients with malaria and are associated with a poor clinical or a fatal outcome显示文摘 | Ostrowski SR Ullum H Goka BQ | 2005 | J Infect Dis2005，191，8： | 1 |
| 8 | NK cell response to physical activity: possible mechanisms of action 显示文摘 | Pederson BK Ullum H | 1994 | Med Sci Sports Exerc1994，26，2： | 1 |
| 9 | Defective natural immunity: an early manifestation of human immunodeficiency virus infection显示文摘 | Ullum H Gotzsche PC Victor J | 1995 | J Exp Med1995，182，3： | 1 |
| 10 | Exercise-Induced Immunomodulation - Possible Roles of Neuroendocrine and Metabolic Factors显示文摘 | B. Pedersen H. Bruunsgaard M. Klokker M. Kappel D. MacLean H. Nielsen T. Rohde H. Ullum M. Zacho | 1997 | Int J Sports Med (S )1997，，1： | 1 |
| 11 | Infectivity of blood products from donors with occult hepatitis B virus infection显示文摘 | Jean‐Pierre Allain Ivanka Mihaljevic Maria Isabel Gonzalez‐Fraile Knut Gubbe Lene Holm‐Harritsh?j Jose Maria Garcia Ewa Brojer Christian Erikstrup Mona Saniewski Lorenz Wernish Lydia Bianco Henrik Ullum Daniel Candotti Nico Lelie Wolfram H. Gerlich Michae | 2013 | Transfusion2013，，7： | 1 |
| 12 | Leaching of glyphosate and amino-methylphosphonic acid from Danish agricultural field sites显示文摘 | Kjaer J Olsen P Ullum M | 2005 | J Environ Qual2005，34，： | 1 |
| 13 | Bicycle exercise enhances plasma IL-6 but does not change IL-1a, IL-1b, IL- 6, or TNF-a pre-mRNA in BMNC显示文摘 | ULLUM H HAAHR PM DIAMANT M | 1994 | J Appl Physiol1994，77，： | 1 |
| 14 | Epinephrine-induced mobilization of natural killer (NK) cells and NK-like T ceils in HIV-infected patients显示文摘 | Sondergaard SR Ullum H Skinhoj P | 1999 | Cell Immunol1999，197，： | 1 |
| 15 | Proliferative and eytotoxic capabilities of CD16+CD56 and CD16+/-CD56+natural killer cells显示文摘 | Sondergaard SR Ullum H Pedersen BK | 2001 | APMIS2001，108，： | 1 |
| 16 | NK Cell Response to Physical Activity:Possible Mechanisms of Action显示文摘 | Pedersen BK Ullum H | 1994 | Med Sci Sport Exercise1994，，26： | 1 |
| 17 | NK Cell Response to Physical Activity:Possible Mechanismos of Action显示文摘 | ULLUM H | 1994 | Med Sci Sports Exerc (S0195-9131)1994，26，： | 1 |
| 18 | Statistical analysis and accuracy of PIV data 显示文摘 | Ullum U Schmidt J J Larsen P S | 1998 | Visualization1998，1，2： | 1 |
| 19 | Processes of colloid mobilization and transport in macroporous soil monoliths显示文摘 | LAEGDSMAND M VILLHOLTh K G ULLUM M | 1999 | Genderma1999，93，： | 1 |
| 20 | NK cell response to physicalactivity : possible mechanisms of action 显示文摘 | Pedersen B K Ullum H | 1994 | Med SciSports Exerc1994，26，2： | 1 |
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