维普中文期刊产品整合服务
110篇 您的检索式:作者名="Uhal"
    题名 作者 年代 出处 被引量
1经气管灌注血管紧张素Ⅱ导致凋亡性急性肺损伤(英文)显示文摘为研究外源性血管紧张素Ⅱ(angiotensinⅡ,ANG)在急性肺损伤和肺泡上皮细胞凋亡中的作用,经气管分别给雄性Wistar大鼠(175~200g)灌注ANG、ANG加caspase抑制剂ZVAD-fmk、ANG加ANG受体1阻断剂losartan和仅灌注磷酸盐缓冲溶液(PBS)。6或20h后在体灌洗动物肺脏,测定灌洗液中血红蛋白(hemoglobin,Hb)和荧光物质(BODIPY)标定的白蛋白含量(在灌洗前15min静脉注入BODIPY-白蛋白)。TUNEL测定显示,灌注ANG6h后,支气管和肺泡上皮细胞内标定的DNA片断显著增加(P<0.05);ANG所致的DNA片断增加可被同时灌注ZVAD-fmk或losartan阻断。灌注ANG后免疫标定caspase3阳性细胞数量显著增多(P<0.01),ZVAD-fmk或losartan同样显著减少caspase3阳性细胞的数量。灌注ANG显著增加肺泡灌洗液中荧光标定的白蛋白(P<0.01)和Hb的含量(P<0.05);ZVAD-fmk或losartan亦显著抑制荧光白蛋白和Hb含量的变化。结果表明,肺泡上皮细胞在体暴露于外源性ANG足以引起ANG受体1介导的上皮细胞凋亡和肺泡屏障损伤。庄甲举 李小鹏 Bruce David Uhal Koh Rhun Yian 2008生理学报2008,60,6:7
2Persistent and pro- gressive pulmonary fibrotic changes in a model of fat embol- ism显示文摘Poisner A M Adler F Uhal B 2012J Trauma Acute Care Surg2012,72,4:1
3Alveolar epithelial cell death adjacent to underlying myofibroblasts in advanced fibrotic human lung显示文摘Uhal BD Joshi I Hughes WF 1998Am J Physiol1998,275,61:1
4Apoptosis in lung fibrosis and repair显示文摘Bruce D Uhal BD 2002Chest2002,,2:1
5Apoptosis in lung pathophysiology 显示文摘Fine A Janssen - Heininger Y Soultanakis RP Swisher SG Uhal BD 2000Am J Physiol Lung Cell Mol Physiol2000,279,:1
6Alveolar epithelial celldeath adjacent to underlying myofibroblasts in advanced fibrotichuman lung显示文摘Uhal BD Joshi I Hughes WF 1998Am J Physiol1998,275,6:1
7Fibroblasts isolated after fibrotic lung injury induce apoptosis of alveolar epithelial cells in vitro 显示文摘UHAL BD JOSHI I MUNDLE S 1995Am J Physiol1995,269,1:1
8Angiotensin-TGF-beta 1 crosstalk in hu- man idiopathic pulmonary fibrosis: autocfine mechanisms in myofibro- blasts and macrophages 显示文摘Uhal BD Kim JK Li X 2007Curr Pharm Des2007,13,12:1
9Fas and apoptosis in the alveolar epithelium:holes in the dike?显示文摘UHAL B D 2001Am J Physiol Lung Cell Mol Physiol2001,281,2:1
10Cell cycle kin cries in the alveolar epithelium显示文摘Uhal B D 1997AmJ Physiol1997,272,61:1
11Captopril inhibits apoptosis in human lung epithelial cells:a potential antifibrotic mechanism显示文摘Uhal BD Gidea C Bargout R 1998Am J Physiol1998,275,51:1
12Cell cycle kinetics in the alveolar epithelium显示文摘Uhal BD 1997Am J Physiol1997,272,61:1
13Angiotensin - TGF - beta 1 crosstalk in human idiopathic pulmonary fibrosis: autocrine mechanisms in myo- fibroblasts and macrophages 显示文摘Uhal BD Kim JK Li X 2007Curr Pharm Des2007,13,12:1
14Apoptosis in lung fibrosis and repair 显示文摘Uhal BD 2002Chest2002,22,6:1
15Inhibition of transforming growth factor-beta via the activin receptor-like kinase-5 inhib- itor attenuates pulmonary fibrosis显示文摘Koh R Y Lira C L Uhal B D 2015Mol Med Rep2015,11,5:1
16Protection of early phase hepatic ischemia-reperfusion injury by cholinergic agonists显示文摘Crockett E T Galligan J J Uhal B D Harkema J Roth R Pandya K 2006BMC Clin Pathol2006,6,:1
17Apoptosis in lung fibrosis and repair显示文摘Uhal 2002Chest2002,122,6:1
18Essential roles for angiotensin receptor ATla in Neomycin-induced apoptosis and lung fibrosis in mice显示文摘Li X Rayford H Uhal BD 2003Am J Patho12003,163,6:1
19Essential roles for angiotensin receptor ATla in bleomycin-induced apoptosis and lung ? brosis in mice 显示文摘Li X Rayford H Uhal BD 2003Am J Pathol2003,163,:1
20Cell death and lung cell histology in meconium aspirated newborn rabbit lung显示文摘Zagariya A Bhat R Uhal B 2000Eur J Pediatr2000,159,11:1
返回顶部 每页显示:
共6页 首页 上一页 第1页 下一页 末页 /6 跳转

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1 渝公网安备 50019002500403号 违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费