|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 2 | Prospective real-time evaluation of diagnostic performance using endocytoscopy in differentiating neoplasia from nonneoplasia for colorectal diminutive polyps(≤ 5 mm)显示文摘AIM To clarify the diagnostic performance of endocytoscopy for differentiation between neoplastic and nonneoplastic colorectal diminutive polyps.METHODS Patients who underwent endocytoscopy between October and December 2016 at Sano Hospital were prospectively recruited. When diminutive polyps(≤5 mm) were detected, the lesions were evaluated by endocytoscopy after being stained with 0.05% crystal violet and 1% methylene blue. The diminutivepolyps were classified into five categories(EC 1 a, 1 b, 2, 3 a, and 3 b). Endoscopists were asked to take a biopsy from any lesion diagnosed as EC1 b(indicator of hyperplastic polyp) or EC2(indicator of adenoma). We have assessed the diagnostic performance of endocytoscopy for EC2 and EC1 b lesions by comparison with the histopathology of the biopsy specimen. RESULTS A total of 39 patients with 63 diminutive polyps were analyzed. All polyps were evaluated by endocytoscopy. The mean polyp size was 3.3 ± 0.9 mm. Among the 63 diminutive polyps, 60 were flat and 3 were pedunculated. The mean time required for EC observation, including the time for staining with crystal violet and methylene blue, was 3.0 ± 1.9 min. Histopathologic evaluation showed that 13 polyps were hyperplastic and 50 were adenomas. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of EC2 for adenoma compared with EC1 b for hyperplastic polyp were 98.0%, 92.3%, 96.8%, 98.0% and 92.3%, respectively. There were only two cases of disagreement between the endoscopic diagnosis made by endocytoscopy and the corresponding histopathological diagnosis.CONCLUSION Endocytoscopy showed a high diagnostic performance for differentiating between neoplastic and non-neoplastic colorectal diminutive polyps, and therefore has the potential to be used for 'real-time histopathology'. | Takahiro Utsumi Yasushi Sano Mineo Iwatate Hironori Sunakawa Akira Teramoto Daizen Hirata Santa Hattori Wataru Sano Noriaki Hasuike Kazuhito Ichikawa Takahiro Fujimori | 2018 | World Journal of Gastrointestinal Oncology2018，10，4： | 4 |
| 3 | CD14 upregulation as a distinct feature of non-alcoholic fatty liver disease after pancreatoduodenectomy显示文摘AIM:To investigate the pathogenesis of non-alcoholic fatty liver disease(NAFLD)after pancreatoduodenectomy(PD).METHODS:A cohort of 82 patients who underwent PD at Okayama University Hospital between 2003 and 2009 was enrolled and the clinicopathological features were compared between patients with and without NAFLD after PD.Computed tomography(CT)images were evaluated every 6 mo after PD for follow-up.Hepatic steatosis was diagnosed on CT when hepatic attenuation values were 40 Hounsfield units.Liver biopsy was performed for 4 of 30 patients with NAFLD after PD who consented to undergo biopsies.To compare NAFLD after PD with NAFLD associated with metabolic syndrome,liver samples were obtained from 10 patients with NAFLD associated with metabolic syndrome [fatty liver,n = 5;non-alcoholic steatohepatitis(NASH),n = 5] by percutaneous ultrasonography-guided liver biopsy.Double-fluorescence immunohistochemistry was applied to examine CD14 expression as a marker of lipopolysaccharide(LPS)-sensitized macrophage cells(Kupffer cells)in liver biopsy specimens.RESULTS:The incidence of postoperative NAFLD was 36.6%(30/82).Univariate analysis identified cancer of the pancreatic head,sex,diameter of the main pancreatic duct,and dissection of the nerve plexus as factors associated with the development of NAFLD after PD.Those patients who developed NAFLD after PD demonstrated significantly decreased levels of serum albumin,total protein,cholesterol and triglycerides compared to patients without NAFLD after PD,but no glucose intolerance or insulin resistance.Liver biopsy was performed in four patients with NAFLD after PD.All four patients showed moderate-to-severe steatosis and NASH was diagnosed in two.Numbers of cells positive for CD68(a marker of Kupffer cells)and CD14(a marker of LPSsensitized Kupffer cells)were counted in all biopsy specimens.The number of CD68+ cells in specimens of NAFLD after PD was significantly increased from that in specimens of NAFLD associated with metabolic syndrome specimens,which indicated the presence of significantly more Kupffer cells in NAFLD after PD than in NAFLD associated with metabolic syndrome.Similarly,more CD14+ cells,namely,LPS-sensitized Kupffer cells,were observed in NAFLD after PD than in NAFLD associated with metabolic syndrome.Regarding NASH,more CD68+ cells and CD14+ cells were observed in NASH after PD specimens than in NASH associated with metabolic syndrome.This showed that more Kupffer cells and more LPS-sensitized Kupffer cells were present in NASH after PD than in NASH associated with metabolic syndrome.These observations suggest that after PD,Kupffer cells and LPS-sensitized Kupffer cells were significantly upregulated,not only in NASH,but also in simple fatty liver.CONCLUSION:NAFLD after PD is characterized by both malnutrition and the up-regulation of CD14 on Kupffer cells.Gut-derived endotoxin appears central to the development of NAFLD after PD. | Daisuke Satoh Takahito Yagi Takeshi Nagasaka Susumu Shinoura Yuzo Umeda Ryuichi Yoshida Masashi Utsumi Takehiro Tanaka Hiroshi Sadamori Toshiyoshi Fujiwara | 2013 | World Journal of Hepatology2013，5，4： | 3 |
| 4 | Phase transition in Pd_(40)Ni_(10)Cu_(30)P_(20) bulk metallic glass under HP & HT显示文摘The phase transitions in Pd40Ni10Cu30P20 bulk metallic glass (BMG) have been studied under high pressure and high temperature (HP & HT) by X-ray diffraction measurements with synchrotron radiation source. We found that the BMG underwent a phase transitions of amorphous-crystalline-amorphous at 10 GPa upon heating. The parallel experiments were carried out at 7 GPa, while we did not observe the amorphous-crystalline-amorphous transitions by increasing temperature. Quenching the melted BMG at 7 GPa, it was found that the phase crystallized from the melt differed from the primary phase crystallized from the starting amorphous solid upon heating, suggesting there existed a distinct mechanism in two cases. | Utsumi Wataru Okada Taku | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，6： | 2 |
| 5 | Viral hepatitis and human immunodeficiency virus coinfections in Asia显示文摘Hepatitis B virus(HBV), hepatitis C virus(HCV),and human immunodeficiency virus(HIV) affect many people in Asian countries, although there are geographic differences. Both HBV and HIV(HBV/HIV) and HCV/HIV co-infections are highly prevalent in Asia. Hetero- and homosexual, injection drug use, and geographic area are strong predictors of HBV, HCV, and HIV serostatus. In HBV endemic regions, the prevalence and genotype distribution of HBV/HIV coinfection is almost comparable with that in the general population. In Japan, where HBV has low endemicity, the prevalence of HBV/HIV co-infection is approximately 10-fold higher than that in the general population, and HBV Ae is the most common subgenotype among HIV infected individuals. Highly active antiretroviral therapy(HAART) is an effective treatment for HIV/Acquired Immune Deficiency Syndrome. Lamivudine, a component of HAART, is an effective treatment for HBV, HIV, and HBV/HIV co-infection; however, cost, emerging drug resistance, antiretroviral-associated liver toxicity and liver-related morbidity due to HCV progression are particular concerns. HCV/HIV co-infection may accelerate the clinical progression of both HCV and HIV. The high prevalence of HBV/HIV and HCV/HIV co-infections in Asia underscores the need to improve prevention and control measures, as fewer evidencebased prevention strategies are available(compared with Western countries). In this review, the most recent publications on the prevalence of HBV/HIV and HCV/HIV co-infections and related issues, such as therapy and problems in Asia, are updated and summarized. | Takako Utsumi Maria I Lusida | 2015 | World Journal of Virology2015，4，2： | 2 |
| 6 | Prostaglandin H synthase 2 expression in airway cells from patients with asthma and chronic ob-structive pulmonary disease显示文摘 | Taha R Olivenstein R Utsumi T | 2000 | Am J Respir Crit Care Med2000，161，21： | 1 |
| 7 | Low-g propellant slosh analysis using spherical coordinates 显示文摘 | Utsumi M | 1998 | Journal of Fluids and Structures1998，12，： | 1 |
| 8 | 显示文摘 | Utsumi T TakeST TanakaK etal | 2001 | FEBSLett2001，500，12： | 1 |
| 9 | Verbal irony as implicit display of ironic environment:Distinguishing ironic utterances from nonirony显示文摘 | Utsumi A | 2000 | Journal of Pragmatics2000，，32： | 1 |
| 10 | Vertical division of the rectum by endostapler in very low colorectal anastomosis with a double-stapling technique 显示文摘 | Maeda K Maruta M Utsumi T | 1999 | Minim Invasive Ther Allied Technol1999，8，： | 1 |
| 11 | Involvement of lysosomal eysteine proteases in hydrogen peroxide-induced apoptosis in HL- 60 cells 显示文摘 | ISHISAKA R UTSUMI K UTSUMI T | 2002 | Biosci Biotechnol Biochem2002，66，9： | 1 |
| 12 | Prepulse effects on the interaction of intense femtosecond laser pulses with high-Z solids显示文摘 | Zhidkov A Sasaki A Utsumi T | 2000 | Phys Rev E2000，62，5： | 1 |
| 13 | Crossed cerebellar diaschisis in patients with cortical infarction: logistic regression analysis to control for confounding effects显示文摘 | Komaba Y Mishina M Utsumi K | 2004 | Stroke2004，35，2： | 1 |
| 14 | Quantitative analysis of brain perfusion SPECT in Alzheimer's disease using a fully automated regional cerebral blood flow quantification software,3DSRT显示文摘 | Seiju Kobayashi Masaru Tateno Kumiko Utsumi | | 0，，01： | 1 |
| 15 | Changes in Scoliotic Curvature and Lordotic Angle During the Early Phase of Degenerative Lumbar Scoliosis显示文摘 | Yasuaki Murata Kazuhisa Takahashi Eiji Hanaoka Takehiko Utsumi Masatsune Yamagata Hideshige Moriya | 2002 | Spine2002，，20： | 1 |
| 16 | Neutron powder diffraction under high pressure at J-PARC 显示文摘 | Utsumi W Kagi H Komatsu K | 2009 | Nucl Instrum Meth Phys Res Sect A:Aecel Spectrom Detect Assoc Equipm2009，600，1： | 1 |
| 17 | Mechanism of apoptosis in HL-60 cells induced by n-3 and n-6 polyunsaturated fatty acids显示文摘 | Arita K Kobuchi H Utsumi T | 2001 | Biochem Pharmacol2001，62，7： | 1 |
| 18 | Predominance of precore mutations and clinical significance of basal core promoter mutations in chronic hepatitis B virus infection in Indonesia显示文摘 | Juniastuti I Utsumi T Aksono EB | 2013 | Biomed Rep2013，1，4： | 1 |
| 19 | Mechanism of dibucaine- induced apoptosis in promyelocytic leukemia cells (HL- 60) 显示文摘 | Arita K Utsumi T Kato A | 2000 | Biochem Phanaaacol2000，60，7： | 1 |
| 20 | Thermal expansivity of MgSiO3 perovskite under high pressures up to 20 GPa 显示文摘 | UTSUMI W FUNAMORI N | 1995 | Geophys Res Lett1995，22，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员