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| 1 | Function and regulation of self-reactive marginal zone B cells in autoimmune arthritis显示文摘Polyreactive 天生类型的 B 房间说明在圆周表示自我反应的许多 B 房间。这些 B 房间的不适当的规定可以是位于自体免疫的疾病下面的一个重要因素。这里,我们在导致骨胶原的关节炎(中央情报局) 的开发探索了自我反应的天生的 B 房间的影响,风湿性关节炎的一个鼠标模型。我们显示出那个脾的边缘的地区(MZ ) ,然而并非 B-1 B 房间在 naı 展出自发的 IgM 反应到自体同源的骨胶原 II; ¨ ve 老鼠。在有在完全的 Freund’ 的 heterologous 骨胶原 II 的免疫之上;骨胶原反应的 MZ B 房间很快扩展了的 s 助手,当 B-1 B 房间显示出谦虚反骨胶原回答时。MZ B 房间被像使用费的受体(TLR ) 容易激活 4 并且在 vitro,导致的增长和 cytokine 分泌物的 9-ligands,暗示 B 房间受体和 TLR 的那个双约会可以把有免疫力的反应提升到自我抗原。而且,告知骨胶原的 MZ B 房间显示出在 vivo 在 IgG 反骨胶原抗体的 vitro 和正式就职由血缘的 T 房间增长思考了的重要介绍抗原的能力。在 1 和 2 表明了的补充受体是缺乏的 MZ B 房间增加了增长和 cytokine 生产,当时 Fcγ房间的受体 IIb 缺乏导致增加的 cytokine 生产和抗原表示。在结论,我们的数据在中央情报局作为自体免疫的反应的开始者加亮自我反应的 MZ B 房间,在补充和 Fc 受体在在房间控制自我反应是相关的的地方。 | Anna-Karin E Palm Heike C Friedrich Anja Mezger Maya Salomonsson Linda K Myers Sandra Kleinau | 2015 | Cellular & Molecular Immunology2015，12，4： | 3 |
| 2 | Marginal zone B cells are naturally reactive to collagen type II and are involved in the initiation of the immune response in collagen-induced arthritis显示文摘Antibodies against type II collagen(CII)are essential for development of collagen-induced arthritis(CIA),but how and where the B-cell response to CII is initiated is not fully known.We show here that naive DBA/1 mice display naturally reactive IgM and IgG anti-CII producing B cells prior to immunization.The CII-reactive B cells were observed in the spleen and recognized as marginal zone(MZ)B cells.After CII immunization,CII-specific B cells expanded rapidly in the spleen,in contrast to the lymph nodes,with the initial response derived from MZ B cells and later by follicular(FO)B cells.This was evident despite that the MZ B cells were subject to stringent tolerance mechanisms by having a greater Fc gamma receptor IIb expression than the FO B cells.Further,the MZ B cells migrated to the FO areas upon immunization,possibly providing antigen and activating FO T cells and subsequently FO B cells.Thus,around CIA onset increased numbers of IgG anti-CII producing FO B cells was seen in the spleen,which was dominated by IgG2a-and IgG2b-positive cells.These data demonstrate that CII-reactive MZ B cells are present before and expand after CII immunization,suggesting an initiating role of MZ B cells in the development of CIA. | Cecilia Carnrot Kajsa E Prokopec Kristina Rasbo Mikael CI Karlsson Sandra Kleinau | 2011 | Cellular & Molecular Immunology2011，8，4： | 3 |
| 3 | Biliary pneumonitis after proximal stent migration显示文摘 | Lutz Liebich-Bartholain Ulrich Kleinau Harry Elsbernd Reinhard Büchsel | 2001 | Gastrointestinal Endoscopy2001，，3： | 1 |
| 4 | Induction and suppression of collagen-induced arthritis is dependent on distinct Fcgamma receptors 显示文摘 | KLEINAU S MARTINS SON P HEYMAN B | 2000 | J Exp Med2000，191，9： | 1 |
| 5 | Homologous type Ⅱ collagen-induced arthritis in rats显示文摘 | Larson P Kleinau S Holmdahl R | 1990 | Arthritis Rheum1990，33，5： | 1 |
| 6 | Thermal duty cycle requirement development and enforcement in an electric power steering system 显示文摘 | Julie A Kleinau | 2000 | Society of Automotive Engineers2000，33，6： | 1 |
| 7 | A low-molecu-lar-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism显示文摘 | Neumann S Kleinau G Costanzi S | 2008 | Endocrinology2008，149，12： | 1 |
| 8 | Homologous type Ⅱ collagen-induced arthritis in rats显示文摘 | Larsson P Kleinau S Holmdahl R | 1990 | Arthritis Rheum1990，33，： | 1 |
| 9 | Evaluation of small-molecule modulators of the luteinizing hor- mone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective bind- ing patterns显示文摘 | Moore S Jaeschke H Kleinau G | 2006 | J Med Chem2006，49，13： | 1 |
| 10 | Dynamic expression of transforming growth factor-betas (TGF-beta) and their type Ⅰ and type Ⅱ receptors in the synovial tissue of arthritic rats 显示文摘 | Mussener A Funa K Kleinau S | 1997 | Clin Exp Immunol1997，107，1： | 1 |
| 11 | From molecular details of the interplay between transmembrane helices of the thyrotropin receptor to general aspects of signal transduction in family a G-proteincoupled receptors (GPCRs) 显示文摘 | Kleinau G Hoyer I Kreuchwig A | 2011 | J Biol Chem2011，286，25： | 1 |
| 12 | Two-machine Shop Scheduling Problems with Batch Processing显示文摘 | U Kleinau | 1993 | Math Comp Modelling1993，17，： | 1 |
| 13 | Defining structural and functional dimensions of the extracellular thyrotropin receptor region显示文摘 | Kleinau G Mueller S Jaeschke H | 2011 | ] Biol Chem2011，286，22： | 1 |
| 14 | From molecular details of the interplay between transmembrane helices of the thyrotropin receptor to general aspects of signal transduetion in family a G-proteitrcoupled receptors (GPCRs) 显示文摘 | Kleinau G Hoyer I Kreuehwig A | 2011 | J Biol Chem2011，286，25： | 1 |
| 15 | Up-regulation of CD64-expressing monocytes with impaired FcγR function reflects disease activity in polyarticular psoriatic arthritis显示文摘 | Matt P Lindqvist U Kleinau S | 2015 | Scand J Rheumatol2015，44，： | 1 |
| 16 | Homologous type II collogen-induced arthritis in rats characterization of the disease and demonstration of clinical distinct forms of arthritis in two strains of rats after immunization with the same collagen preparation显示文摘 | Larsson P Kleinau S Holmdahl R | 1990 | Arthritis Rheum1990，33，5： | 1 |
| 17 | Induction and suppression of collagen-induced arthritis is dependent on distinct Fcγ receptors显示文摘 | Kleinau S Martinsson P Heyman B | 2000 | J Exp Med2000，191，： | 1 |
| 18 | Homologous type Ⅱ collagen induced arthritis in rats显示文摘 | Larson P Kleinau S Holmdahl R | 1990 | Arthritis Rheum1990，33，5： | 1 |
| 19 | Comparative sequence and structural analyses of G - protein-coupled receptor crystal structures and implications for molecular models显示文摘 | Worth C L Kleinau G Krause G | 2009 | PLoS ONE2009，4，9： | 1 |
| 20 | Dynamic expression of transforming growth factor-betas (TGF-beta) and their type Ⅰ and type Ⅱ receptors in the synovial tissue of arthritic rats显示文摘 | Mussener A Funa K Kleinau S | 1997 | Clin Exp Immunol1997，107，1： | 1 |
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