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| 1 | Colorectal cancer:Current imaging methods and future perspectives for the diagnosis, staging and therapeutic response evaluation显示文摘In the last 10 years the mortality rate of colorectal cancer(CRC)has decreased by more than 20%due to the rising developments in diagnostic techniques and optimization of surgical,neoadjuvant and palliative therapies.Diagnostic methods currently used in the evaluation of CRC are heterogeneous and can vary within the countries and the institutions.This article aims to discuss in depth currently applied imaging modalities such as virtual computed tomography colonoscopy,endorectal ultrasound,computed tomography(CT)and magnetic resonance imaging(MRI)in the diagnosis of CRC.Special focus is put on the potential of recent diagnostic developments as diffusion weighted imaging MRI,MRI biomarkers(dynamic enhanced MRI),positron emission tomography with 2-(fluorine-18)-fluoro-2-deoxy-D-glucose(FDG-PET)combined with computed tomography(PET/CT)and new hepatobiliary MRI contrast agents.The precise role,advantage and disadvantages of these modalities are evaluated controversially in local staging,metastatic spread and treatment monitoring of CRC.Finally,the authors will touch upon the future perspectives in functional imaging evaluating the role of integrated FDG-PET/CT with perfusion CT,MRI spectroscopy of primary CRC and hepatic transit time analysis using contrast enhanced ultrasound and MRI in the detection of liver metastases.Validation of these newer imaging techniques may lead to significant improvements in the management of patients with colorectal cancer. | Maka Kekelidze Luigia D'Errico Michele Pansini Anthony Tyndall Joachim Hohmann | 2013 | World Journal of Gastroenterology2013，19，46： | 28 |
| 2 | Differing profiles of people diagnosed with acute and chronic hepatitis B virus infection in British Columbia,Canada显示文摘AIM To describe the characteristics of people diagnosed with acute and chronic hepatitis B virus(HBV) infection in British Columbia(BC).METHODS We used data from the BC Hepatitis Testers Cohort(BCHTC),which includes all individuals tested for hepatitis C virus(HCV) or human immunodeficiency virus(HIV) or those diagnosed with HBV or active tuberculosis in BC since 1990.These data were integrated with prescription drug,medical visit,hospitalization and mortality data.HBV cases were classified as acute or chronic according to provincial guidelines.We compared characteristics of individuals by HBV infection group(acute,chronic and negative).Factors associated with acute or chronic HBV infection were assessed with multinomial logistic regression models in comparison to the HBV negative group.RESULTS46498 of the 1058056 eligible BC-HTC participants were diagnosed with HBV infection.4.3% of HBV positive individuals were diagnosed with acute HBV infections while 95.7% had chronic infections.Problematic alcohol use,injection drug use,and HIV or HCV co-infection were more common among individuals diagnosed with acute HBV compared to those with chronic infections and HBV negative individuals.In multivariable multinomial logistic regression models,we observed significant associations between acute or chronic HBV diagnosis and being male,age at HBV diagnosis or birth cohort,South and East Asian ethnicity,HCV or HIV infection,and injection drug use.The odds of acute HBV decreased with increasing age among people who inject drugs,while the opposite was true for chronic HBV.Persons with acute HBV were predominantly White(78%) while those with chronic HBV were mostly East Asian(60%).Relative to Whites,East Asians had 12 times greater odds of being diagnosed with chronic HBV infection.These odds increased with increasing socioeconomic deprivation.CONCLUSION Differences in the profiles of people diagnosed with acute and chronic HBV infection necessitate differentiated screening,prevention,care and treatment programs. | Mawuena Binka Zahid A Butt Stanley Wong Mei Chong Jane A Buxton Nuria Chapinal Amanda Yu Maria Alvarez Maryam Darvishian Jason Wong Gina McGowan Mikhail Torban Mark Gilbert Mark Tyndall Mel Krajden Naveed Z Janjua | 2018 | World Journal of Gastroenterology2018，24，11： | 3 |
| 3 | The orf virus inhibitor of apoptosis functions in a Bcl-2-like manner, binding and neutralizing a set of BH3-only proteins and active Bax显示文摘 | Dana Westphal Elizabeth C. Ledgerwood Joel D. A. Tyndall Merilyn H. Hibma Norihito Ueda Stephen B. Fleming Andrew A. Mercer | 2009 | Apoptosis2009，，11： | 2 |
| 4 | Parkinson's disease : a rethink of rodent models 显示文摘 | Melrose H L Lincoln S J Tyndall G M Farrer M J | 2006 | Exp Brain Res2006，173，： | 1 |
| 5 | Autologous hematopoietic stem cell transplantation for autoimmune diseases 显示文摘 | Tyndall A Daikeler T | 2005 | Acta Haematol2005，114，4： | 1 |
| 6 | Autologous haemopoietic stem cell transplants for autoimmune diseases-feasibility and transplant-related mortality显示文摘 | Tyndall A Fassas Passweg J | 1999 | Bone Marrow transplantion1999，24，7： | 1 |
| 7 | Intense immunosuppression and stem- cell transplantation for patients with severe rheumatic autoimmune disease a review 显示文摘 | Van Laar JM Tyndall A | 2003 | Cancer Control2003，10，： | 1 |
| 8 | Age - grading methods in adult insects: a review 显示文摘 | Tyndale - Biscoe M | 1984 | BuU Entomol Res1984，74，： | 1 |
| 9 | In vitro assessment of local computed tomography for the detection of longitudinal tooth fractures显示文摘 | Mora MA Mol A Tyndall DA | | 0，，06： | 1 |
| 10 | Position statement of the American Academy of Oral and Maxillofacial Radiology on selection criteria for the use of radiology in dental implantology with emphasis on cone beam computed tomography显示文摘 | Donald A Tyndall Jeffery B Price Sotirios Tetradis | 2012 | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics2012，113，6： | 1 |
| 11 | Nicotine increases codeine analgesia through the induction of brain CYP2D and central activation of co-deine to morphine显示文摘 | McMillan DM Tyndale RF | 2015 | Neuropsychopharmacology2015，40，： | 1 |
| 12 | The global supply chain challenge 显示文摘 | G R Tyndall | 2000 | Supply Chain Management Review2000，3，4： | 1 |
| 13 | Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database显示文摘 | TYNDALL AJ BANNERT B VONK M | 2010 | Ann Rheum Dis2010，69，10： | 1 |
| 14 | Nicotine self-administration in mice is associated with rates of nicotine inactivation by CYP2A5显示文摘 | Siu E C Wildenauer D B Tyndale R F | 2006 | Psychopharmacology (Berl)2006，，184： | 1 |
| 15 | Haemopoietic stem cell transplantation in the treatment of severe autoimmune diseases 2000显示文摘 | Tyndall A Passweg J Gratwohl A | 2001 | Ann Rheum Dis2001，60，7： | 1 |
| 16 | Clinical risk assessment of organ manifestations in systemic sclerosis:a report from the EULAR Scleroderma Trials And Research group database显示文摘 | Walker UA Tyndall A Czirjdk L | 2007 | Ann Rheum Dis2007，66，6： | 1 |
| 17 | Cone-Beam CT Diagnostic Applications: Caries, Periodontal Bone Assessment, and Endodontic Applications显示文摘 | Donald A. Tyndall Sonali Rathore | 2008 | Dental Clinics of North America2008，，4： | 1 |
| 18 | FTIR product study of the reactions CH3O2^ + CH3O2 and CH302 + O3显示文摘 | Tyndall G S Wallington T J and Ball J C | 1998 | J Phys ChemA1998，102，： | 1 |
| 19 | Cytochrome Pd502C9 (CYP2C9) allele frequencies in Canadian Native Indian and Inuit populations 显示文摘 | Gaedigk A Casley WL Tyndale RF | 2001 | Can J Physiol Pharmacol2001，79，10： | 1 |
| 20 | Identification of root canals in molars by tuned - aperture computed tomography 显示文摘 | Nance R Tyndall D Levm L | 2000 | Int Endod J2000，33，4： | 1 |
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