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| 1 | Peripheral nerve axons contain machinery for co-translational secretion of axonally-generated proteins显示文摘The axonal compartment of developing neurons and mature peripheral nervous system (PNS) neurons has the capacity to locally synthesize proteins. Axonally-synthesized proteins have been shown to facilitate axonal pathfinding and maintenance in developing central nervous system (CNS) and PNS neurons, and to facilitate the regeneration of mature PNS neurons. RNA-profiling studies of the axons of cultured neurons have shown a surprisingly complex population of mRNAs that encode proteins for a myriad of functions. Although classic-appearing rough endoplasmic reticulum (RER), smooth endoplasmic reticulum (ER) and Golgi apparatus have not been documented in axons by ultrastructural studies, axonal RNA profiling studies show several membrane and secreted protein-encoding mRNAs whose translation products would need access to a localized secretory mechanism. We previously showed that the axons of cultured neurons contain functional equivalents of RER and Golgi apparatus. Here, we show that markers for the signal-recognition particle, RER, ER, and Golgi apparatus are present in PNS axons in vivo. Co-localization of these proteins mirrors that seen for cultured axons where locally-translated proteins are localized to the axoplasmic membrane. Moreover, nerve injury increases the levels and/or aggregation of these proteins, suggesting that the regenerating axon has an increased capacity for membrane targeting of locally synthesized proteins. | Tanuja Merianda Jeffery Twiss | 2013 | Neuroscience Bulletin2013，29，4： | 2 |
| 2 | Variable entity piezometric equations for dislocation density and subgrain diameter and their relevance to olivine and quartz 显示文摘 | Twiss R J | 1986 | Geophysical Monography1986，36，： | 1 |
| 3 | Non-invasive prenatal testing for Down syndrome 显示文摘 | Twiss P Hill M Daley R | 2014 | Semin Fetal Neonatal Med2014，19，1： | 1 |
| 4 | Psychometric performance of the CAMPHOR and SF-36 in pulmonary hypertension显示文摘 | Twiss J Mc Kenna S Ganderton L | 2013 | BMC pulmonary medicine2013，13，1： | 1 |
| 5 | Pathophysiological mechanisms for actions of the neurotrophins 显示文摘 | Twiss JL Chang JH Schanen NC | 2006 | Brain Pathol2006，16，4： | 1 |
| 6 | For the first measurements of correlations between fluctuation in optical fields显示文摘 | Hanbury Brown Twiss | 1956 | Nature1956，177，： | 1 |
| 7 | Radiation Transfer and the Possibility of Negative Absorption in Radio Astronomy显示文摘 | Twiss R O | 1958 | Aust J Phys1958，，11： | 1 |
| 8 | Correlation between photons in two coherent beams of light显示文摘 | Brown R Hanbury Twiss R Q | 1956 | Nature1956，，4497： | 1 |
| 9 | Theory and applicability of a recrystallized grain size paleopiezometer显示文摘 | Robert J. Twiss | 1977 | Pure and Applied Geophysics PAGEOPH (-)1977，，1： | 1 |
| 10 | Radiation transfer and the possibility of negative absorption in radio astronomy显示文摘 | R O Twiss | 1958 | Aust J Phys1958，，11： | 1 |
| 11 | Correlation between photons in two coherent beams of light显示文摘 | Brown R H Twiss R Q | 1956 | Nature1956，4497，： | 1 |
| 12 | Influence ofultraviolet radiation,copper,and zinc on microcystin content in Microcystis aeruginosa (Cyanobacteria)显示文摘 | Gouva S P Boyer G L Twiss M R | 2008 | Harmful Algae2008，7，： | 1 |
| 13 | A test of a new type of stellar in- terferometer on Sirius 显示文摘 | Brown R H Twiss R Q | 1956 | Nature1956，178，4541： | 1 |
| 14 | Comparative toxicity of thallium(Ⅰ),thallium (Ⅲ),and cadmium (Ⅱ) to the unicellular alga chlorella isolated from lake Erie显示文摘 | Ralph L Twiss M R | 2002 | Bull Environ Contam Toxicol2002，68，： | 1 |
| 15 | The sugar absouption test in the evaluation of the gastrointestinal intoler- ance to biphosphonates studies with oral pamidronate显示文摘 | Twiss I M Burggraaf J B Schoemaker R C | 2001 | Clin- ical pharmacology Therapeutics2001，69，6： | 1 |
| 16 | A Validation of Brief Tests of Collection Strength 显示文摘 | Twiss TM | 2001 | Collection Management2001，25，3： | 1 |
| 17 | Limits of applicability of the recrystallized grain size geopiezometer 显示文摘 | Twiss R J Sellars C M | 1978 | Geophysical Research Letters1978，5，5： | 1 |
| 18 | An investigation into ironstimulated phytoplankton productivity in epipelagic Lake Erie during thermal stratification using trace metal clean techniques 显示文摘 | Twiss M R Auclair J C Charlton M N | 2000 | Canadian Journal of Fisheries and Aquatic Sciences2000，57，： | 1 |
| 19 | Bisphosphonates in bone diseases显示文摘 | Sparidans RW Twiss IM Talbot S | 1998 | Pharm World Sci1998，20，5： | 1 |
| 20 | Female stress urinary incontinence where are we? 显示文摘 | Twiss C Rodriguez LV | 2008 | J Urol2008，179，5： | 1 |
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