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| 1 | Biomarkers in the clinical management of patients with atrial fibrillation and heart failure显示文摘Atrial fibrillation(AF)and heart failure(HF)are two cardiovascular diseases with an increasing prevalence worldwide.These conditions share common pathophysiologiesand frequently co-exit.In fact,the occurrence of either condition can‘cause’the development of the other,creating a new patient group that demands different management strategies to that if they occur in isolation.Regardless of the temproral association of the two conditions,their presence is linked with adverse cardi-ovascular outcomes,increased rate of hospitalizations,and increased economic burden on healthcare systems.The use of low-cost,easily accessible and applicable biomarkers may hasten the correct diagnosis and the effective treatment of AF and HF.Both AF and HF effect multiple physiological pathways and thus a great number of biomarkers can be measured that potentially give the clinician important diagnostic and prognostic information.These will then guide patient centred therapeutic management.The current biomarkers that offer potential for guiding therapy,focus on the physiological pathways of miRNA,myocardial stretch and injury,oxidative stress,inflammation,fibrosis,coagulation and renal impairment.Each of these has different utility in current clinincal practice. | Ioanna Koniari Eleni Artopoulou Dimitrios Velissaris Mark Ainslie Virginia Mplani Georgia Karavasili Nicholas Kounis Grigorios Tsigkas | 2021 | Journal of Geriatric Cardiology2021，18，11： | 8 |
| 2 | Transcatheter aortic valve replacement and stroke: a comprehensive review显示文摘Transcatheter 大动脉的阀门培植(TAVR ) 与严重大动脉的狭窄和高外科的风险为病人作为一种其他的、很快演变的治疗选择出现了。此后摸破坏复杂并发症主要在 periprocedural 和 30 天的时期追随者 TAVR 正在被限制,与更低、相对经常的频率。早击在过程期间主要由于碎片 embolization,而以后的事件与耐心的特定的因素被联系。尽管临床的击的率常常与起始的 TAVR 经验相比一直在减少,有 MRI 的现代 neuro 成像建议新 ischemic 损害 post-TAVR 是几乎通用的。后者的影响大部分是未知的。然而,他们似乎在 neurocognitive 功能与减小相关。因为 TAVR 被设置扩展它的指示降低外科风险的病人,摸预防在期间并且在 TAVR 以后降临到首要的重要性。基于临床并且 pathophysiological 证据,研究的三根线活跃地向这个方向被采用:在有到有钙化的大动脉的拱门的还原剂操作和接触的一个目的阀门和本国的阀门, antithrombotic 治疗,和插子的保护设备的改进。小心的耐心的选择,过程的设计,和尊重这张易碎的人口的流血风险的定制的 antithrombotic 策略对击追随者 TAVR 组成主要防卫。 | Periklis A Davlouros Virginia C Mplani Ioanna Koniari Grigorios Tsigkas George Hahalis | 2018 | Journal of Geriatric Cardiology2018，15，1： | 7 |
| 3 | The role of echocardiography and CT angiography in transcatheter aortic valve implantation patients显示文摘transcatheter 大动脉的阀门培植(TAVI ) 在于在有严重大动脉的狭窄的病人的其他的治疗。Multimodality 成像使用 transthoracic echocardiography (TTE ) 或 transesophageal echocardiography (脚趾) 和 multislice CT (MSCT ) 为外科手术前的管理组成奠基石技术,仙子程序的指导,列在后面在上面并且可能的 transcatheter 阀门的识别联系了复杂并发症。CT angiography 关于大动脉的体环直径和环绕的区域的全部的定义是更精确的。二维(2D ) echocardiography,与 3D 成像技术(MSCT, MRI 和 3D 脚趾) 相比低估大动脉的阀门体环直径。三维的脚趾成像提供类似于 MSCT 交付的那些的大动脉的阀门体环的大小。pre 程序的 MSCT 组成最小化 paravalvular 的存在的标准答案形式大动脉的流回,最经常的复杂并发症之一。TOE/TTE 和 MSCT 性能能预言心律调整器培植 procedural 以后的可能性。一位新短暂或坚持的先生的存在能被脚趾估计很好。TTE 和脚趾,开始在于为柱子 TAVI 评估的基本考试。在 transcatheter 心阀门失败的情况下, MSCT 能被用作另外的成像技术。 | Emmanouil Chourdakis Ioanna Koniari Nicholas G Kourlis Dimitrios Velissaris Nikolaos Koutsogiannis Grigorios Tsigkas Karl Eugen Hauptmann Bruno Sontag George Hahalis | 2018 | Journal of Geriatric Cardiology2018，15，1： | 4 |
| 4 | Transcatheter versus surgical aortic valve replacement in severe, symptomatic aortic stenosis显示文摘大动脉的狭窄(作为) 是瓣膜的心疾病在的最普通的类型老。外科的大动脉的阀门代替(SAVR ) 是为对待的标准实践严重、作为征兆,却最近新治疗选择出现了。Transcatheter 大动脉的阀门代替(TAVR ) 现在是在在高外科的风险的病人的一种确定的治疗选择。在这评论,我们集中于最近的开发并且以功效和安全在特定的人口比较二个治疗方法(例如在有优先的胸的外科的历史的病人,采用的麻醉打字,存取使用的地点或为永久踱步需要) 。comorbidities (肺的高血压,动脉的高血压和肥胖悖论) 的影响,在象应得进一步的调查的问题一样的 transcatheter 阀门技术的 TAVR 对 SAVR 和进展的划算进一步被讨论。而且,在不同风险范畴(极其高、高、中间、低的风险) 的病人的 TAVR 的结果和复杂并发症被分析。我们强烈相信在下列年期间, TAVR 可以在病人的一个更宽广的组作为选择的治疗演变与与中间、高风险的特征作为并且在那些以外征兆。 | Tsigkas Grigorios Despotopoulos Stefanos Makris Athanasios Koniari Ioanna Armylagos Stylianos Davlouros Periklis Hahalis George | 2018 | Journal of Geriatric Cardiology2018，15，1： | 2 |
| 5 | Emergence, development, and future of cardio-oncology in China: cardiohypersensitivity, cardiotoxicity and the Kounis syndrome显示文摘To the Editor:Cancer and cardiovascular disease constitute the two major causes of death worldwide. Whereas the incidence of cancer increases among adults up to 74 years of age, above this age the cardiovascular disease surpasses cancer as the primary cause of mortality.[1] Currently, chemotherapy, radiation therapy, and surgery are the main modalities for the treatment of cancer. However, chemotherapy can induce cardiovascular worsening, manifesting as acute and chronic symptomatology. Therefore, the verv interesting report published in Chinese Medical Journal[2] concerning a 60-year-old male patient suffering from coronary artery disease and squamous cell carcinoma of the left lung who developed an ST segment elevation myocardial infarction following treatment with afatinib (tyrosine kinase inhibitor) and gemcitabine (antimetabolite pyrimidine antagonist) and cisplatin (platinum based DNA replication inhibitor) and the subsequent discussion raise several important considerations on cardiac toxicity, cardiac hypersensitivity and the Kounis-hypersensitivity acute coronary syndrome. | Nicholas G. Kounis Ioanna Koniari Panagiotis Plotas George D. Soufras Grigorios Tsigkas Periklis Davlouros George Hahalis | 2019 | Chinese Medical Journal2019，，6： | 2 |
| 6 | Beta-blocker treatment in heart failure patients with atrial fibrillation:challenges and perspectives显示文摘Heart failure(HF)and atrial fibrillation(AF)are common conditions that share similar clinical phenotype and frequently coexist.The classification of HF in patients with preserved ejection fraction(>50%,HFpEF),midrange reduced EF(40%−49%,HFmrEF)and reduced EF(<40%,HFrEF)are crucial for optimising the therapeutic approach,as each subgroup responds differently.Betablocker constitute an important component of our pharmacological regimen for chronic HF.Betablocker administration is reccomended in patients with HF with reduced ejection fraction in stable sinus rhythm,due to improvement of symptoms,the better long termoutcome and survival.The beneficial role of betablocker use in patients with preserved EF still remain unclear,as no treatment showed a positive impact,regarding morbidity or mortality reduction.The presence of AF in HF patients increases as the disease severity evolves and is associated with a higher rate of cardiovascular morbidity and mortality.But more question is the use of betablocker in HF patients irrespective of EF and concomitant AF.There are many conflicting data and publications,regarding the beta blocker benefit in this population.Generally,it is supported an attenuation of betablockers beneficial effect in HF patients with AF.A design of more randomised trials/studies with HF patients and concomitant AF may improve our clinical approach of betablockers use and identify the patients with HF,who mostly profit from an invasive approach. | Emmanouil Chourdakis Ioanna Koniari Dimitrios Velissaris Grigorios Tsigkas Nikolaos G Kounis Neriman Osman | 2021 | Journal of Geriatric Cardiology2021，18，5： | 2 |
| 7 | Atrial fibrillation in patients with systolic heart failure:pathophysiology mechanisms and management显示文摘Heart failure(HF)and atrial fibrillation(AF)demonstrate a constantly increasing prevalence during the 21st century worldwide,as a result of the aging population and the successful interventions of the clinical practice in the deterioration of adverse cardiovascular outcomes.HF and AF share common risk factors and pathophysiological mechanisms,creating the base of a constant interrelation.AF impairs systolic and diastolic function,resulting in the increasing incidence of HF,whereas the structural and neurohormonal changes in HF with preserved or reduced ejection fraction increase the possibility of the AF development.The temporal relationship of the development of either condition affects the diagnostic algorithms,the prognosis and the ideal therapeutic strategy that leads to euvolaemia,management of noncardiovascular comorbidities,control of heart rate or restoration of sinus rate,ventricular synchronization,prevention of sudden death,stroke,embolism,or major bleeding and maintenance of a sustainable quality of life.The indicated treatment for the concomitant HF and AF includes rate or/and rhythm control as well as thromboembolism prophylaxis,while the progress in the understanding of their pathophysiological interdependence and the introduction of the genetic profiling,create new paths in the diagnosis,the prognosis and the prevention of these diseases. | Ioanna Koniari Eleni Artopoulou Dimitrios Velissaris Nicholas Kounis Grigorios Tsigkas | 2021 | Journal of Geriatric Cardiology2021，18，5： | 2 |
| 8 | Kounis syndrome caused by double allergens: the more allergens present, the easier, the quicker, and the more severe the anaphylaxis显示文摘To the Editor:In the very interesting report published in the Chinese Medical Journal,[1] a 42-year-old Chinese male patient who had not any previous history of cardiovascular disease,but only bee stings without any sequelae,was stung again while was cycling outdoors. | Nicholas G.Kounis Ioanna Koniari Panagiotis Plotas George D.Soufras Grigorios Tsigkas Periklis Davlouros George Hahalis | 2020 | Chinese Medical Journal2020，，15： | 2 |
| 9 | Acute Myocardial Infarction Induced by Anaphylaxis in China: The Kounis Syndrome显示文摘 | Nicholas G Kounis Ioanna Koniari Emmanouil Chourdakis George D Soufras Grigorios Tsigkas Periklis Davlouros George Hahalis | 2018 | Chinese Medical Journal2018，，19： | 2 |
| 10 | Eosinophilic responses to stent implantation and the risk of Kounis hypersensitivity associated coronary syndrome显示文摘 | Nicholas G. Kounis Sotiris Giannopoulos Grigorios G. Tsigkas John Goudevenos | 2011 | International Journal of Cardiology2011，，2： | 1 |
| 11 | From design to manufacturing for mass customization显示文摘 | Tsigkas A Chatzopoulos C | 2009 | Advances in Production Engineering & Management2009，，1： | 1 |
| 12 | Kounis syndrome: a new twist on an old disease 显示文摘 | Kounis NG Mazarakis A Tsigkas G | 2011 | Future Cardiol2011，7，6： | 1 |
| 13 | Kounis syndrome: a new twist on an old disease显示文摘 | Nicholas G Kounis Andreas Mazarakis Grigorios Tsigkas Sotiris Giannopoulos John Goudevenos | 2011 | Future Cardiol2011，，6： | 1 |
| 14 | Eosinophilic responses to stent implantation and the risk of Kounis hypersensitivity associated coronary syndrome 显示文摘 | Kounis NG Giannopoulos S Tsigkas GG | 2012 | Int J Cardiol2012，156，： | 1 |
| 15 | Are bioabsorbable and biodegradable polymer scaffolds still safe or Kounis syndrome is still watching for?显示文摘 | Kounis NG Soufras GD Tsigkas G Hahalis G | 2014 | Chinese Medical Journal2014，，23： | 1 |
| 16 | Anticoagulation for atrial fibrillation in heart failure patients:balancing between Scylla and Charybdis显示文摘The management of heart failure(HF)and atrial fibrillation(AF)in realworld practice remains a debating issue,while the number of HF patients with AF increase dramatically.While it is unclear if rhythm or rate control therapy is more beneficial and under which circumstances,anticoagulation therapy is the cornerstone of the AFHF patients’approach.VitaminK antagonists were the goldstandard during the past,but currently their usage is limited in specific conditions.Nonvitamin K oral anticoagulants(NOACs)have gained ground during the last ten years and considered as goldstandard of a wide spectrum of HF phenotypes.The current manuscript aims to review the current literature regarding the indications and the optimal choice and usage of NOACs in HF patients with AF. | Grigorios Tsigkas Anastasiοs Apostolos Stefanos Despotopoulos Georgios Vasilagkos Angeliki Papageorgiou Eleftherios Kallergis Georgios Leventopoulos Virginia Mplani Ioanna Koniari Dimitrios Velissaris John Parissis | 2021 | Journal of Geriatric Cardiology2021，18，5： | 1 |
| 17 | Stent restenosis, pathophysiology and treatment options: a 2010 update 显示文摘 | Tsigkas GG Karantalis V Hahalis G | 2011 | Hel- lenicI Cardiol2011，52，2： | 1 |
| 18 | Intrinsic platelet reactivity and thrombus burden in patients with ST-elevation myocar- dialinfarction 显示文摘 | Alexopoulos D Xanthopoulou I Tsigkas G | 2013 | Thromb Res2013，131，4： | 1 |
| 19 | Incidence, pathophysiology, predictive factors and prognostic implications of new onset atrial fibrillation following transcatheter aortic valve implantation显示文摘 | Ioanna Konlari Grigorios Tsigkas Nikolaos Kounisx Dimitrios Velissaris Emmanouil Chourdakis Periklis Davlouros George Hahalis | 2018 | Journal of Geriatric Cardiology2018，15，1： | 1 |
| 20 | Stent restenosis,pathophysiology and treatment options:a 2010 update显示文摘 | Tsigkas GG Karantalis V Hahalis G | | 0，，： | 1 |
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