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| 1 | HDL signaling and protection against coronary artery atherosclerosis in mice显示文摘Atherosclerosis is a leading underlying factor in cardiovascular disease and stroke,important causes of morbidity and mortality across the globe.Abundant epidemiological studies demonstrate that high levels of high density lipoprotein(HDL) are associated with reduced risk of atherosclerosis and preclinical,animal model studies demonstrate that this association is causative.Understanding the molecular mechanisms underlying the protective effects of HDL will allow more strategic approaches to development of HDL based therapeutics.Recent evidence suggests that an important aspect of the ability of HDL to protect against atherosclerosis is its ability to trigger signaling responses in a variety of target cells including endothelial cells and macrophages in the vessel wall.These signaling responses require the HDL receptor,scavenger receptor class B type 1(SR-B1),an adaptor protein(PDZK1) that binds to the cytosolic C terminus of SR-B1,Akt1 activation and(at least in endothelial cells) activation of endothelial NO synthase(eNOS).Mouse models of atherosclerosis,exemplified by apolipoprotein E or low density lipoprotein receptor gene inactivated mice(apoE or LDLR KO) develop atherosclerosis in their aortas but appear generally resistant to coronary artery atherosclerosis.On the other hand,inactivation of each of the components of HDL signaling(above)in either apoE or LDLR KO mice renders them susceptible to extensive coronary artery atherosclerosis suggesting that HDL signaling may play an important role in protection against coronary artery disease. | Bernardo L Trigatti Mark Fuller | 2016 | The Journal of Biomedical Research2016，30，2： | 8 |
| 2 | Influence of the high density lipopretein receptor SR-BI on reproductiveand cardiovascular pathophysiology显示文摘 | Trigatti B | 1999 | Proc Natl Acad sci USA1999，96，16： | 1 |
| 3 | A role for the scavenger receptor,class B type I in high density lipoprotein dependent activation of cellular signaling pathways显示文摘 | Al-Jarallah A Trigatti BL | 2010 | Biochim Biophys Acta2010，1801，12： | 1 |
| 4 | Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology显示文摘 | TRIGATTI B RAYBURN H VIEALS M | 1999 | Proc Natl Acad Sci U S A1999，96，16： | 1 |
| 5 | Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease,spontaneous myocardial infarctions,severe cardiac dysfunction,and premature death in apolipoprotein E-deficient mice显示文摘 | BRAUN A TRIGATTI B L POST M J | 2002 | Circ Res2002，90，3： | 1 |
| 6 | A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type Ⅰ reveals its key role in HDL metabolism 显示文摘 | Rigotti A Trigatti BL Penman M | 1997 | Proc Natl Acad Sci USA1997，94，12： | 1 |
| 7 | Scavenger receptor class B, type Ⅰ (SR-BⅠ) is the major route for the delivery of high density lipoprotein cholesterol to the steroidogenic pathway in cultured mouse adrenocortical cells显示文摘 | Temel RE Trigatti B DeMattos RB | 1997 | Proc Natl Acad Sci USA1997，94，13： | 1 |
| 8 | Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease,spontaneous myocardial infarctions,severe cardiac dysfunction,and premature death in apolipoprotein E-deficientmice显示文摘 | Braun A Trigatti B L PostM J | | 0，，03： | 1 |
| 9 | Influence of the HDL receptor SR-BI on reproductive and cardiovascular pathophyslology 显示文摘 | Trigatti B Raybum H Vifials M | 1999 | PNAS1999，96，： | 1 |
| 10 | Influence of the high density liporotein receptor SR-B I on rep roductive and cardiovascular pathophysiology显示文摘 | Trigatti B Rayburn H Vinals M | | 0，，： | 1 |
| 11 | Scavenges reseptor class B type I in high density lipop rotein metabolism, atherosclerosis and heart disease: lessons from gene targeted mice 显示文摘 | Trigatti B Covey S Bizvi A | 2004 | Biochem Soc Trans2004，32，1： | 1 |
| 12 | Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease,spontaneous myocardial infarctions,severe cardiac dysfunction,and premature death in apolipoprotein E-deficient mice显示文摘 | Braun A Trigatti BL Post MJ | 2002 | Circ Res2002，90，3： | 1 |
| 13 | Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI显示文摘 | Holm T M Braun A Trigatti B L | | 0，，15： | 1 |
| 14 | Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient mice 显示文摘 | Braun A Trigatti BL Post MJ | 2002 | Circ Res2002，90，3： | 1 |
| 15 | Influence of the HDL receptor SR-BI on lipoprotein metabolism and Atherosclerosis显示文摘 | Trigatti BL Krieger M Rigotti A | 2003 | Arterioscler Thromb Vasc Biol2003，23，4： | 1 |
| 16 | Loss of SR-BⅠ expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions,severe cardiac dysfunction, and premature death in apolipoprotein E-deficient mice显示文摘 | BraunA Trigatti BL Post MJ | 2002 | Circ Res2002，90，3： | 1 |
| 17 | Failure of red blood cell maturation in mice with defects in the high density lipoprotein receptor SR-BI显示文摘 | Holm TM Braun A Trigatti BL | 2002 | Blood2002，99，5： | 1 |
| 18 | A Single Point Mutation in e-COP Results in Temperature-sensitive,Lethal Defects in Membrane Transport in a Chinese Hamster Ovary Cell Mutant显示文摘 | Guo Q Penman M Trigatti BL | | 0，，19： | 1 |
| 19 | Loss of SR- B1 expression leads to the early onset of occlusive atheroscle- rotic coronary artery disease, spontaneous myocardial infarc- tions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient mice显示文摘 | BRAUN A TRIGATTI B L POST M J | 2002 | Circ Res2002，90，3： | 1 |
| 20 | The efficient cellular uptake of high-density lipoprotein lipids via scavenger receptor class B type I require not only receptor-mediated surface binding but also receptor-specific lipid transfer mediated by its extra-cellular domain显示文摘 | Gu X Trigatti B Xu S | 1998 | J Biol Chem1998，273，35： | 1 |
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