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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Imaging of the temporomandibular joint: An update显示文摘Imaging of the temporomandibular joint(TMJ) is continuously evolving with advancement of imaging technologies. Many different imaging modalities are currently used to evaluate the TMJ. Magnetic resonance imaging is commonly used for evaluation of the TMJ due to its superior contrast resolution and its ability to acquire dynamic imaging for demonstration of the functionality of the joint. Computed tomography and ultrasound imaging have specific indication in imaging of the TMJ. This article focuses on state of the art imaging of the temporomandibular joint. Relevant normal anatomy and biomechanics of movement of the TMJ are discussed for better understanding of many TMJ pathologies. Imaging of internal derangements is discussed in detail. Different arthropathies and commontumors are also discussed in this article. | Asim K Bag Santhosh Gaddikeri Aparna Singhal Simms Hardin Benson D Tran Josue A Medina Joel K Curé | 2014 | World Journal of Radiology2014，6，8： | 5 |
| 3 | Internal nutrient efficiencies of irrigated lowland rice in tropical and subtropical Asia显示文摘 | C Witt A Dobermann S Abdulrachman H.C Gines Wang Guanghuo R Nagarajan S Satawatananont Tran Thuc Son Pham Sy Tan Le Van Tiem G.C Simbahan D.C Olk | 1999 | Field Crops Research1999，，2： | 2 |
| 4 | Accuracy and cost- effectiveness of -2-fluoro deoxy-D- glucose-positron emission tomography scan in potentially resectable non-small cell lung cancer 显示文摘 | Kelly RF Tran T Holmstrom A | 2004 | Chest2004，125，： | 1 |
| 5 | Aspirin resistance显示文摘 | TRAN H A ANAND S S HANKEY G J | 2007 | Thromb Res2007，120，3： | 1 |
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| 7 | Equivalent Plane Strain Modeling of Vertical Drains in Soft Ground under Embankment Combined with Vacuum Preloading显示文摘 | TRAN T A MITACHI T | 2008 | Computers and Geotechnics2008，35，5： | 1 |
| 8 | R-Spondin family members regulate the Wnt pathway by a common mechanism显示文摘 | Kim K A Wagle M Tran K Zhan X Dixon M A Liu S | 2008 | Mol Biol Cell2008，19，： | 1 |
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| 10 | A fuzzy branch and bound-based transmission system expansion planning for the highest satisfaction level of the decision maker显示文摘 | Choi J El-Keib A A Tran T | 2005 | IEEE Trans on Power Systems2005，20，1： | 1 |
| 11 | Robust analysis of the yeast proteome under 50 kDa by molecular-massbased fractionation and top-down mass spectrometry显示文摘 | Kellie J F Catherman A D Durbin K R Tran J C Tipton J D Norris J L Witkowski C E 2nd Thomas P M Kelleher N L | | 0，，01： | 1 |
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| 13 | Elevated plasma fibrinogen and diabetes mellitus are associated with lower inhibition of platelet reactivity with clopidogrel显示文摘 | Ang L Palakodeti V Khalid A Tsimikas S Idrees Z Tran P | 2008 | J Am Coll Cardiol2008，52，： | 1 |
| 14 | Gaussian mixture model based on hidden Markov random field for color image segmen- tation显示文摘 | Tran K A Vo N Q Nguyen T T | 2014 | Lecture Notes in Electrical Engineering2014，280，： | 1 |
| 15 | A peer-to-peer architecture for media streaming显示文摘 | Tran D A Hua K A Do T T | 2004 | IEEE Journal on Selected Areas in Communications2004，22，1： | 1 |
| 16 | Deep venous thrombosis in patients with hematological malignancies after peripherally inserted central venous catheters显示文摘 | Tran H Arellano M Chamsuddin A | 2010 | Leuk Lymphoma2010，51，8： | 1 |
| 17 | Chemokine receptor polymorphisn and risk of acute rejection in human renal transplantation显示文摘 | Abdi R Tran TB Sahagun-Ruiz A | 2002 | J Am Soc Nephrol2002，13，3： | 1 |
| 18 | Semantic Web Services显示文摘 | MCLLRAITH S A TRAN C S | 2001 | IEEE Intelligent Systems2001，3，4： | 1 |
| 19 | Insulin promotion of colon tumors in rats 显示文摘 | Tran TT Medline A Bruce WR | 1996 | Cancer Epidemiol Biomarkers Prev1996，5，12： | 1 |
| 20 | Dexmedetomidine infusion for analgesia and prevention Of emergence agitation in children with obstructive sleep apnea syndrome undergoing tonsillectomy and adenoidectomy显示文摘 | Patel A Davidson M Tran MC | 2010 | Anesth Analg2010，111，4： | 1 |
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