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| 1 | 将卒中纳入心血管风险预测工具美国心脏协会/美国卒中协会对医疗卫生专业人员的声明显示文摘背景和目的目前美国针对心血管事件风险预测以及一级和二级预防的指南声明均使用绝对风险估计值来识别血管事件高危患者以及可从特定干预措施中获益的患者。然而,这些指南并未明确地包括卒中患者。本指南对现有证据和争论进行概述以支持:(1)将卒中(尤其是动脉粥样硬化性卒中)患者纳入心血管病绝对风险增高的患者群体;(2)将卒中纳入血管性疾病风险预测工具的转归预测因素。方法和结果写作组成员由委员会联合主席基于先前在相关领域的研究成果来提名,并得到美国心脏协会(American Heart Association,AHA)卒中委员会科学声明监督委员会以及文稿监督委员会的批准。作者采用系统文献回顾(覆盖1980年1月至2010年3月期间的文献)并参考以往公布的指南、个人资料以及专家观点,以归纳现有证据,提出当前知识的不足,并根据AHA标准对适当的问题制定推荐意见。所有写作组成员均有机会对推荐意见进行评论并批准了最终版本。经广泛的AHA内部同行评议以及卒中委员会领导阶层和科学声明监督委员会的审阅后,最终获得AHA科学咨询和协调委员会的批准。将卒中患者(尤其是动脉粥样硬化性卒中患者)纳入冠状动脉和心血管病绝对高危人群的原因如下。首先,有证据显示,缺血性卒中患者发生致死性和非致死性心肌梗死或猝死的绝对风险增高,10年绝对风险≥20%,这一风险阈值已被一些指南用于定义冠状动脉疾病风险等危症。其次,纳入动脉粥样硬化性卒中的原因与纳入糖尿病、周围血管病、慢性肾脏病以及其他动脉粥样硬化性疾病的原因相同,尽管尚缺乏在所有人群或患者中风险增高的统一证据。再次,缺血性卒中的大动脉粥样硬化性卒中亚型与其他这些疾病的病理生理学机制相同。将卒中纳入高危因素将导致高危人群的数量扩大约10%。然而,由于卒中的异质性,尚不确定其他卒中亚型,包括出血性卒中以及非动脉粥样硬化性卒中亚型,是否应被视为具有相同水平的风险,因此有待进一步研究。鉴于卒中对残疾和死亡的影响、卒中与其他血管性疾病预防措施的相似性以及卒中在某些人群中较冠状动脉疾病更高的重要性,将卒中、心肌梗死和猝死纳入心血管事件风险预测工具的转归预测因素是合适的。美国以外的指南常常将卒中患者纳入心血管高危人群,并将卒中作为心脏终点的一个相关转归事件。结论动脉粥样硬化性卒中患者应被纳入会进一步发生冠状动脉粥样硬化事件的高危患者(10年≥20%)。是否应纳入非动脉粥样硬化卒中亚型尚不确定。对于一级预防,缺血性卒中应被纳入绝对风险评估方案的心血管疾病转归事件。将动脉粥样硬化性卒中作为一个高危因素或者更宽泛地将缺血性卒中视作一种转归事件纳入,可能对心血管病的预防具有重要意义,因为被评定为高危风险的患者数量将大幅增加。 | Daniel T. Lackland Mitchell S.V. Elkind Ralph D'Agostino Sr Mandip S. Dhamoon David C. Goff Jr Randall T. Higashida Leslie A. McClure Pamela H. Mitchell Ralph L. Sacco Cathy A. Sila Sidney C. Smith Jr David Tanne David L. Tirschwell Emmanuel Touze Lawrence R. Wechsler 4:~ 尤寿江(译) 于海龙(译) 刘慧慧(译) 张霞(译) 刘春风(译) | 2012 | 国际脑血管病杂志2012，20，11： | 13 |
| 2 | Insensitive Munitions (IM) : A Key Aspect of Improved Munitions Safety显示文摘 | Duncan Watt Eric Deschambault Patrick Touze | 2006 | 含能材料2006，14，5： | 8 |
| 3 | 法国烟雾血管病临床实践指南显示文摘1序言
1.1制定机构
本指南在法国卫生部的组织下由法国脑部和眼部罕见血管疾病中心(reference center for rare vascular diseases of the brain and eye,CERVCO)与法国儿童卒中中心联合起草。 | D. Herve(著) M. Kossorotoff(著) D. Bresson(著) T. Blauwblomme(著) M. Carneiro(著) E. Touze(著) F. Proust(著) I. Desguerre(著) S. Alamowitch(著) J.-P. Bleton(著) A. Borsali(著) E. Brissaud F.Brunelle(著) L. Calviere(著) M. Chevignard(著) G. Geffroy-Greco(著) S. Faesch(著) M.-O. Habert(著) H.De Larocque(著) P. Meyer(著) S. Reyes L. Thines(著) E. Tournier-Lasserve(著) H.Chabriat 郝方斌(译) 张勇(译) 韩聪(译) 段炼(译) | 2018 | 国际脑血管病杂志2018，26，5： | 5 |
| 4 | High-speed water impacts of flat plates in different ditching configuration through a Riemann--ALE SPH model显示文摘The violent water entry of flat plates is investigated using a Riemann-arbitrary Eulerian-Lagrangian(ALE) smoothed particle hydrodynamics(SPH) model. The test conditions are of interest for problems related to aircraft and helicopter emergency landing in water. Three main parameters are considered: the horizontal velocity, the approach angle(i.e., vertical to horizontal velocity ratio) and the pitch angle, a. Regarding the latter, small angles are considered in this study. As described in the theoretical work by Zhao and Faltinsen(1993), for small a a very thin, high-speed jet of water is formed, and the time-spatial gradients of the pressure field are extremely high. These test conditions are very challenging for numerical solvers. In the present study an enhanced SPH model is firstly tested on a purely vertical impact with deadrise angle α=4°. An in-depth validation against analytical solutions and experimental results is carried out, highlighting the several critical aspects of the numerical modelling of this kind of flow, especially when pressure peaks are to be captured. A discussion on the main difficulties when comparing to model scale experiments is also provided. Then, the more realistic case of a plate with both horizontal and vertical velocity components is discussed and compared to ditching experiments recently carried out at CNR-INSEAN. In the latter case both 2-D and 3-D simulations are considered and the importance of 3-D effects on the pressure peak is discussed for α=4° and α=10°. | S.Marrone A.Colagrossi L.Chiron M.De Leffe D.Le Touzé | 2018 | Journal of Hydrodynamics2018，30，1： | 5 |
| 5 | Simulations of helicopter ditching using smoothed particle hydrodynamics显示文摘The present work has been performed in the context of the European H2020 project increased SAfety and Robust certification for ditching of Aircrafts and Helicopters(SARAH)dedicated to improving the safety during aircraft ditching,together with a better understanding of the physics involved during those crucial events.Both numerical and experimental aspects are explored during this project.The present study focuses on the application of the smoothed particle hydrodynamics(SPH)method to the simulation of helicopter ditching,as this method has proved to be particularly adapted to free surface impact cases.Simulations are performed for three different impact configurations,for which the numerical solutions are compared with the experimental results(forces and kinematics)obtained at the wave basin of Ecole Centrale Nantes on a mock-up shape provided by Airbus Helicopters.Elements of sensitivity analysis are also provided when needed,to assess the role of some parameters involved in the helicopter behavior and the fluid pressure forces exerted during the impact. | G.Oger A.Vergnaud B.Bouscasse J.Ohana M.Abu Zarim M.De Leffe A.Bannier L.Chiron Y.Jus M.Gamier S.Halbout D.Le Touze | 2020 | Journal of Hydrodynamics2020，32，4： | 2 |
| 6 | Nasal immunization of mice with human papillomavirus type 16 (HPV-16) virus-like particles or with the HPV-16 L1 gene elicits specific cytotoxic T lymphocytes in vaginal draining lymph nodes显示文摘 | Dupuy C Buzoni Gate D Touze A | 1999 | J Virol1999，73，11： | 1 |
| 7 | Assessment of burned hands reconstructed with Integra (R) by ultra- sonography and elastometry显示文摘 | Danin A Georgesco G Le Touze A | 2012 | Burns2012，38，7： | 1 |
| 8 | Identification of neutral- izing conformational epitopes on the human papillomavirus type 31 major eapsid protein and functional implications 显示文摘 | Fleury MJ Touze A Maurel MC et cd | 2009 | Protein Sci2009，18，7： | 1 |
| 9 | Evaluation of hyperintense vessels on FLAIR MRI for the diagnosis of multiple intracerebral arterial stenoses显示文摘 | Iancu-Gontard D Oppenheim C Touzé E | | 0，，08： | 1 |
| 10 | Insensitive Munitions-A Key Aspect of Improved Munitions Safety 显示文摘 | ERIC DESCHAMBAULT PATRICK TOUZE DUNCAN WATI' | 2008 | Military Technology2008，，9： | 1 |
| 11 | Importance of in-hospital initiation of therapies and therapeutic inertia in secondary stroke prevention: IMplementation of Prevention After a Cerebrovascular evenT (IMPACT) Study 显示文摘 | Touze E Coste J Voicu M | 2008 | Stroke2008，39，6： | 1 |
| 12 | Stroke occurrence and patterns are not influenced by the degree of stenosis in cervical artery dissection显示文摘 | Naggara O Morel A Touze E | 2012 | Stroke2012，43，4： | 1 |
| 13 | Mechanism of ischemic infarct in spontaneous cervical artery dissection显示文摘 | Morel A Naggara O TouzéE | 2012 | Stroke2012，43，5： | 1 |
| 14 | Risk of myocardial infarction and vascular death after transient ischemic attack and ischemic stroke:A systematic review and meta-analysis显示文摘 | Touze E Varenne O Chatellier G | 2005 | Stroke2005，36，12： | 1 |
| 15 | The L1 major capsid protein of human papillomavirus type 16 variants affects yield of virus-like particles produced in an insect cell expression system显示文摘 | Touze A El Mehdaoui S Sizaret PY | 1998 | Journal of Clinical Microbiology1998，36，7： | 1 |
| 16 | DWI lesions and TIA etiology improve the prediction of stroke after TIA显示文摘 | Calvet D Touze E Oppenheim C | 2009 | Stroke2009，40，1： | 1 |
| 17 | DWI lesions and TIA etiology improve the prediction of stroke after TIA显示文摘 | Calvet D Touzé E Oppenheim C | 2009 | Stroke2009，40，： | 1 |
| 18 | DWI lesions and TIA etiology improve the prediction of stroke after TIA 显示文摘 | Calvet D Touze E Oppenheim C | 2009 | Stroke2009，40，： | 1 |
| 19 | Added value of high-resolution MR imaging in the diagnosis of vertebral artery dissection显示文摘 | Naggara O Louillet F Touze E | 2010 | AJNR Am J Neuroradiol2010，31，9： | 1 |
| 20 | Identification of type?specific and cross-reactive neutralizing conformational epitopes on the major capsid protein of human papillomavirus type 31显示文摘 | Fleury MJ Touze A Alvarez E et ol | 2006 | Arch Virol2006，151，8： | 1 |
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