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| 1 | Serum vitamin D and colonic vitamin D receptor in inflammatory bowel disease显示文摘AIM: To determine serum vitamin D levels and colonic vitamin D receptor(VDR) expression in inflammatory bowel disease(IBD) and non-IBD patients and correlate these with histopathology.METHODS: Puerto Rican IBD(n = 10) and non-IBD(n = 10) patients ≥ 21 years old scheduled for colonoscopy were recruited. Each patient completed a questionnaire and provided a serum sample and a colonic biopsy of normal-appearing mucosa. For IBD patients, an additional biopsy was collected from visually diseased mucosa. Serum vitamin D levels were measured by ultra-performance liquid chromatography and mass spectrometry. Hematoxylin and eosin stained tissue sections from colonic biopsies were classified histologically as normal or colitis(active/inactive), and scored for the degree of inflammation present(0-3, inactive/absent to severe). Tissue sections from colonic biopsies were also stained by immunohistochemistry for VDR, for which representative diagnostic areas were photographed and scored for staining intensity using a 4-point scale.RESULTS: The IBD cohort was significantly younger(40.40 ± 5.27, P < 0.05) than the non-IBD cohort(56.70 ± 1.64) with a higher prevalence of vitamin D deficiency(40% vs 20%, respectively) and insufficiency(70% vs 50%, respectively). Histologic inflammation was significantly higher in visually diseased mucosa from IBD patients(1.95 ± 0.25) than in normalappearing mucosa from control patients(0.25 ± 0.08, P < 0.01) and from IBD patients(0.65 ± 0.36, P < 0.05) and correlated inversely with VDR expression in visually diseased colonic tissue from IBD patients(r =-0.44, P < 0.05) and from IBD patients with Crohn's disease(r =-0.69, P < 0.05), but not in normal-appearing colonic tissue from control patients or IBD patients. Control and IBD patient serum vitamin D levels correlated positively with VDR expression in normal colon from control and IBD patients(r = 0.38, P < 0.05) and with patient age(r = 0.54, P < 0.01). CONCLUSION: Levels of serum vitamin D correlate positively with colonic VDR expression in visually normal mucosa whereas inflammation correlates negatively with colonic VDR expression in visually diseased mucosa in Puerto Rican patients. | Yamilka Abreu-Delgado Raymond A Isidro Esther A Torres Alexandra González Myrella L Cruz Angel A Isidro Carmen I González-Keelan Priscilla Medero Caroline B Appleyard | 2016 | World Journal of Gastroenterology2016，22，13： | 5 |
| 2 | Protective effect of carnosol on CC14-induced acute liver damage in rats 显示文摘 | Sotelo-Felix J I Martinez-Fong D Muriel De la Torre P | 2002 | Eur J Gastroenterol Hepatol2002，14，9： | 1 |
| 3 | Diarrhea-predominantIBS patients show mast cell activation and hyperplasia in the jejunum显示文摘 | Guilarte M Santos j de Torres I | 2007 | Gut2007，56，2： | 1 |
| 4 | Kinetics of consumption of fermentation products by anode-respiring bacteria显示文摘 | Torres C I Kato Marcus A Rittmann B E | 2007 | Appl Microbiol Biotechnol2007，77，3： | 1 |
| 5 | Collateral avoids ponzi schemes in incomplete markets显示文摘 | ARAUJO A P(A)SCOA M R TORRES MART(I)NEZ J P | | 0，，4： | 1 |
| 6 | Diarrhoea predominant IBS patients show mast cell activation syndrome,and hyperplasia in the jejunum显示文摘 | Guilarte M Santos J de Torres I | 2007 | Gut2007，56，： | 1 |
| 7 | Synthesis of new phenolic fatty acid esters and their evaluation as lipophilicantioxidants in an oil matrix显示文摘 | Torres D Pealver P Perez-Victoria I etal | 2007 | Food Chemistry2007，105，2： | 1 |
| 8 | Diminished plasma oxytocin in schizophrenic patients with neuroendocrine dysfunction and emotional deficits显示文摘 | Goldman M Marlow-O′Connor M Torres I Carter C S | 2008 | Schizophr Res2008，98，13： | 1 |
| 9 | Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism显示文摘 | TORRES I O KUCHENBECKER K M NNADI C I | 2015 | Nat Commun2015，6，： | 1 |
| 10 | Analysis of the strain transfer in a new FBG sensor for structural health monitoring显示文摘 | Torres B Payá-Zaforteza I Calderón P A | 2011 | Engineering Structures2011，33，2： | 1 |
| 11 | Effect of atmospheric res-idue incorporation in the fluidized catalytic cracking(FCC) feed on product stream yields and composition 显示文摘 | Arandes J M Torre I Azkoiti M J | 2008 | Energy & Fuels2008，22，4： | 1 |
| 12 | Conduction-based modeling of the biofilm anode of a microbial fuel cell显示文摘 | KATO MARCUS A TORRES C I RITTMANN B E | 2007 | Biotechnology and Bioengeering2007，98，6： | 1 |
| 13 | Schizophrenia Research显示文摘 | Goldman M Marlow-O’Connor M Torres I Carter C S | 2008 | 98(1-3):2472008，98，13： | 1 |
| 14 | Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the ie- junum显示文摘 | Guilarte M Santos J de Torres I | 2007 | Gut2007，56，： | 1 |
| 15 | Speciation analysis of selenium compoundsin yeasts using pressurized liquid extraction and liquid chromatography- microwave-assisted digestion-hydride genera-tion-atomic fluorescence spectrometry 显示文摘 | Gomez-Ariza J L Cam De La Torre M A Giraldez I | 2004 | Anal Chim Acta2004，524，12： | 1 |
| 16 | Serum levels and cardiovascular effects of trieyelic antide- pressants and selective serotonin reuptakeinhibitors in de- pressed patients 显示文摘 | Rodriguez de la Torre B Dreher J Malevany I | 2001 | Ther Drug Monit2001，23，4： | 1 |
| 17 | Clear cell carcinoma of the ovary :characterization of its CD44 isoform repertoire 显示文摘 | Sancho - torres I Mesonero C Miller JLM | 2000 | Gynecol Oncol2000，79，2： | 1 |
| 18 | Effect of radio fre quency power and total mass-flow rate on the properties of microcrystalline silicon films prepared by helium-diluted si lane glow discharge显示文摘 | Torres I Barrio R Santos J D | 2010 | Thin Solid Films2010，518，23： | 1 |
| 19 | Quantitative analysis of mineralized white Portland clinkers, the structure of Fluorellestadite显示文摘 | PAJARES I DE LA TORRE A G MARTNEZ-RAMIREZ S | 2002 | Powder Diffr2002，17，4： | 1 |
| 20 | Dietary nucleo- tides modulate mitochondrial function of intestinal mucosa in weanling rats withchronic diarrhea显示文摘 | Arnaud A L6pez-pedrosa J M torres M I | 2003 | Journal of Pediatric Gas- troenterology and Nutrition2003，37，2： | 1 |
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