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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Analytical and numerical studies of noise-induced synchronization of chaotic system 显示文摘 | Toral R Mirasso C R Hernandez Garcia E | 2001 | Chaos2001，11，： | 1 |
| 3 | Beyond rapalog therapy : preclinical pharmacology and antitumor activity of WYE - 125132, an ATP - competitive and specific inhibitor of mTORC1 and mTORC2显示文摘 | YU K SHI C TORAL BARZA L | 2010 | Cancer Res2010，70，2： | 1 |
| 4 | mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer显示文摘 | Yu K Toral Barza L Discafani C | 2001 | Endocr Relat Cancer2001，8，3： | 1 |
| 5 | HLA class Ⅱ polymorphism in patients with type 1 diabetes mellitus from a Brazilian racially admixtured population显示文摘 | Alves C Toralles MB Carvalho GC | | 0，，： | 1 |
| 6 | Contralateral extraaxial hematomas after urgent neurosur- gery of a mass lesion in patients with traumatic brain injury 显示文摘 | Flordells Lasierra JL Garela Fuentes C Toral Vdzquez D | 2013 | Eur J Trauma Emerg Surg2013，39，3： | 1 |
| 7 | Analytical and numerical studies of noise - induced synchronization of chaotic systems 显示文摘 | Toral R Mirasso C R Hernandez -Garcia E | 2001 | Chaos2001，，11： | 1 |
| 8 | Coherence res nance in chaotic electronic circuits显示文摘 | Calvo O Mirasso C R Toral R | 2001 | Electron Lett2001，37，： | 1 |
| 9 | Epidermal growth factor induces an increase in cell adhesion and an arrangement of actin skeleton in stress fibres in pituitary cultured cells from infantile rats but not adult rats显示文摘 | Toral C Solano-Agama M C Luna J | 2003 | J Cell Physiol2003，195，1： | 1 |
| 10 | Optimization of the electroco- agulation process for the removal of copper,lead and cadmium in natural waters and simulated wastewater显示文摘 | Soto-Salazar C Escobar C Toral M I | 2006 | Journal of Hazardous Materials2006，81，4： | 1 |
| 11 | Theory of main resonances in directly modulated diode lasers显示文摘 | MAYOL C TORAL R MIRASSO C R | 2002 | IEEE Journal of Quantum Electronics2002，38，3： | 1 |
| 12 | Analytical and numerical studies of noise-induced synchronization of chaotic systems显示文摘 | Toral R Mirasso C R Hernandez-Garsia E etc | 2001 | Chaos2001，11，3： | 1 |
| 13 | System size coherence resonance in coupled FitzHugh-Nagumo models显示文摘 | Toral R Mirasso C R Gunton J D | 2003 | Europhys Lett2003，61，： | 1 |
| 14 | Epidermal growth factor induces an increase in cell adhesion and an arrangement of actin skeleton in stress fibres in pituitary cultured cells from infantile rats but not adult rats显示文摘 | Toral C Solano-Agama MC Luna J | 2003 | J Cell Physiol2003，195，1： | 1 |
| 15 | System size stochastic resonance in a model for opinion formation 显示文摘 | Tesson C J Toral R | 2004 | Physica A2004，，351： | 1 |
| 16 | Epidermal growth factor induces an increase in cell adhesion and an arrangement of actin skeleton in stress fibres in pituitary cultured ceils from infantile rats but not adult rats显示文摘 | Toral C Solano-Agama MC Luna J | 2003 | J Gell Physiol2003，195，1： | 1 |
| 17 | Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin 显示文摘 | Yu K Toral BL Shi C | 2009 | Cancer Res2009，69，15： | 1 |
| 18 | Thermal inactivation of polyphenoloxidase and peroxidase in Jubileu clingstone peach and yeast isolated from its spoiled puree显示文摘 | Lopes A M Toralles R P Rombaldi C V | 2014 | Food Science and Technology2014，34，1： | 1 |
| 19 | Effect of soy protein supplementation in patients with chronic hepatitis C:A randomized clinical trial显示文摘AIM:To evaluate the effects of soy supplementation on insulin resistance,fatty liver and alanine aminotransferase(ALT) levels in non-diabetic patients with chronic hepatitis C(CHC).METHODS:In a prospective,randomized and singleblinded clinical trial,we compared patients with CHC who had casein as a supplement(n = 80)(control group),with patients who consumed a soy supplement diet(n = 80) [intervention group(IG)].Both groups received 32 g/d of protein for 12 wk.RESULTS:Patients' baseline features showed that 48.1% were overweight,43.7% had abdominal fat accumulation,34.7% had hepatic steatosis and 36.3% had an homeostasis model assessment index of insulin resistance(HOMA-IR) ≥ 3.0.Descriptive analysis showed that protein supplementation diet reduced hepatic steatosis in both groups;however,significant reductions in ALT levels occurred in the soy group.Multiple regression modeling indicated that in the presence of severe fibrosis(F3/F4),g glutamyl transferase elevation and high density lipoprotein(HDL) reduction,the intervention group had 75% less chance of developing hepatic steatosis(OR= 0.25;95% CI:0.06-0.82) and 55% less chance of presenting with an ALT level ≥ 1.5 × the upper limit of normal(ULN)(OR = 0.45,95% CI:0.22-0.89).Soy treatment did not have any effect on insulin resistance(OR = 1.92;95% CI:0.80-4.83),which might be attributed to the fact that the HOMAIR values at baseline in most of our patients were in the normal range.Advanced hepatic fibrosis,an ALT level > 1.5 × ULN and visceral fat were predictors of an HOMA-IR ≥ 3.The IG group had a reduced risk of an ALT level > 1.5 × ULN.An HOMA-IR ≥ 3.0 and HDL < 35 mg/dL were also risk factors for increased ALT.CONCLUSION:Soy supplementation decreased ALT levels and thus may improve liver inflammation in hepatitis C virus(HCV) patients;it also reduced hepatic steatosis in a subgroup of patients but did not change insulin resistance.It should be considered in the nutritional care of HCV patients. | Lucivalda PM Oliveira Rosangela P de Jesus Ramona SSB Boulhosa Carlos Mauricio C Mendes Maria Cecilia Gnoatto Denise C Lemaire Maria Betania P Toralles Lourianne N Cavalcante Andre C Lyra Luiz GC Lyra | 2012 | World Journal of Gastroenterology2012，18，18： | 1 |
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