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| 1 | Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells显示文摘外长的 dopaminergic 神经原(DA 神经原) 的移植是为治疗 Parkinson 的疾病(PD ) 的一条有希望的途径。然而,主要跌倒块是施主 DA 神经原的可靠来源的缺乏。这里,我们证明五 transcriptional 因素 Mash1, Ngn2, Sox2, Nurr1,和 Pitx3 的联合直接并且有效地装改编人成纤维细胞进 DA 像神经原的房间。为为 DA 神经原的各种各样的标记积极的染色的 reprogrammed 房间。他们也显示出典型 DA 举起和生产性质。而且,他们展出了 DA 神经原特定的 electrophysiological 侧面。最后,他们在一个老鼠 PD 模型提供了征兆的地势。因此,我们的直接 reprogrammed DA 像神经原的房间是为 PD 的房间代替治疗的有希望的来源。 | Xinjian Liu Fang Li Elizabeth A Stubblefield Barbara Blanchard Toni L Richards Gaynor A Larson Yujun He Qian Huang Aik-Choon Tan Dabing Zhang Timothy A Benke John R Sladek Nancy R Zahniser Chuan-Yuan Li | 2012 | Cell Research2012，22，2： | 14 |
| 2 | Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy显示文摘Conventional immunohistochemistry(IHC)is a widely used diagnostic technique in tissue pathology.However,this technique is associated with a number of limitations,including high inter-observer variability and the capacity to label only one marker per tissue section.This review details various highly multiplexed techniques that have emerged to circumvent these constraints,allowing simultaneous detection of multiple markers on a single tissue section and the comprehensive study of cell composition,cellular functional and cell-cell interactions.Among these techniques,multiplex Immunohistochemistry/Immunofluorescence(mIHC/IF)has emerged to be particularly promising.mIHC/IF provides high-throughput multiplex staining and standardized quantitative analysis for highly reproducible,efficient and cost-effective tissue studies.This technique has immediate potential for translational research and clinical practice,particularly in the era of cancer immunotherapy. | Wei Chang Colin Tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim | 2020 | Cancer Communications2020，40，4： | 11 |
| 3 | 肿瘤免疫治疗时代的多重免疫组织化学/免疫荧光技术显示文摘常规免疫组织化学(immunohistochemistry,IHC)是组织病理学中广泛应用的诊断技术。但该技术存在诸多局限性,包括观察者间的变异性高,每张组织切片仅能标记一个标志物。本文详细描述了各种多重检测技术,这些技术克服了上述局限性,可在单张切片上同时检测多个标志物,可对细胞组成、细胞功能和细胞间相互作用进行整合研究。在这些技术中,多重免疫组织化学/免疫荧光(multiplex immunohistochemistry/immunofluorescence,mIHC/IF)已成为最具应用前景的技术。mIHC/IF为开展高重复性、高效、高性价比的组织研究提供了高通量多重染色技术和标准化的定量分析。该技术在转化研究和临床实践中,尤其是肿瘤免疫治疗中极具应用价值。 | Wei Chang Colin Tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim | 2021 | 癌症2021，40，9： | 2 |
| 4 | Fluid compliance among patients having haemodialysis:can an educational programme make a difference显示文摘 | Tony Barnett T.L.Y.Jaya Pinikahana Tan Si-Yen | | 0，，： | 1 |
| 5 | Do foreigners facilitate information transmission in emerging markets?显示文摘 | Kee-Hong Bae Arzu Ozoguz Hongping Tan Tony S. Wirjanto | 2012 | Journal of Financial Economics2012，，1： | 1 |
| 6 | Improving the Fairness of FAST TCP to New Flows显示文摘 | Tony Cui Lachlan Liansheng Tan | 2006 | IEEE Communications Letters2006，10，5： | 1 |
| 7 | Nuclear progesterone receptors in the human pregnancy myometrium:evidence that parturition involves functional progesterone withdrawal mediated by increased expression of progesterone receptor-A 显示文摘 | Amy A M Toni N W Huiqing Tan | 2007 | J Clin Endocrinol Metab2007，92，5： | 1 |
| 8 | Twin- screw compounding of poly(methylmethacrylate)/clay nano- composites:Effects of compounding temperature and matrix molecular weight显示文摘 | Liaw Jr Hao Hsueh Tony Yi Tan Tai Sheng | 2007 | Polvrn Int2007，56，： | 1 |
| 9 | Y‐box binding protein 1 is correlated with lymph node metastasis in intestinal‐type gastric cancer显示文摘 | TianTian Guo YingNan Yu George Wai‐Cheong Yip Gyeong Hun Baeg Aye Aye Thike Tony Kiat‐Hon Lim Puay Hoon Tan Ken Matsumoto Boon Huat Bay | 2015 | Histopathology2015，，4： | 1 |
| 10 | Polymorphisms in the IL4 , IL4RA , and FCERIB genes and asthma severity显示文摘 | Andrew J. Sandford Tabassum Chagani Shoukang Zhu Tracey D. Weir Tony R. Bai John J. Spinelli J.Mark FitzGerald Nasser A. Behbehani Wan C. Tan Peter D. Paré | 2000 | The Journal of Allergy and Clinical Immunology2000，，1： | 1 |
| 11 | 指南 抗生素在自限性呼吸道感染初级治疗中的使用:MCE指南概要显示文摘为什么阅读这个概要? 抗生素可能无益于大部分呼吸道感染的初始治疗。呼吸道感染大多数具有白限性,如果不使用抗生素,并发症可能极少发生。然而,在初始治疗的所有抗生素使用中,呼吸道感染就占了60%,抗生素的使用方法在普通临床实践中多种多样,而在高年资处方医师的实践中并没有明显获益的证据。 | Toni Tan Paul Little Tim Stokes 张伟娟(译) 代华平(校) | 2009 | 英国医学杂志中文版2009，12，2： | 0 |
| 12 | 基因组和转录组测序整合分析揭示混合型肝癌的不同分子亚型显示文摘文章简介原发性肝癌每年造成全球约70万病人死亡且过半死亡病例来自中国,其致死率在所有癌种中高居第二。肝癌主要分为3种类型:肝细胞癌(约80%)、肝内胆管癌(约15%)和混合型肝癌(约5%)。混合型肝癌兼具肝细胞癌和胆管细胞癌两种成分,是预后最差的一种肝癌。 | 薛瑞栋 陈璐 张冲 藤田征志 Ruoyan Li Shu-Mei Yan Choon Kiat Ong Xiwen Liao Qiang Gao Shota Sasagawa Yanmeng Li Jincheng Wang Hua Guo Qi-Tao Huang Qian Zhong Jing Tan Lisha Qi Wenchen Gong Zhixian Hong Meng Li Jingmin Zhao Tao Peng Yinying Lu Kiat Hon Tony Lim Arnoud Boot Atushi Ono Kazuaki Chayama Zemin Zhang Steve George Rozen Bin Tean Teh Xin Wei Wang Hidewaki Nakagawa 曾木圣 白凡 张宁 | 2020 | 科学新闻2020，，2： | 0 |
| 13 | Changes in segment coordination variability and the impacts of the lower limb across running mileages in half marathons:Implications for running injuries显示文摘Background:Segment coordination variability(CV)is a movement pattern associated with running-related injuries.It can also be adversely affected by a prolonged run.However,research on this topic is currently limited.The purpose of this study was to investigate the effects of a prolonged run on segment CV and vertical loading rates during a treadmill half marathon.Methods:Fifteen healthy runners ran a half marathon on an instrumental treadmill in a biomechanical laboratory.Synchronized kinematic and kinetic data were collected every 2 km(from 2 km until 20 km),and the data were processed by musculoskeletal modeling.Segment CVs were computed from the angle-angle plots of selected pelvis-thigh,thigh-shank,and shank-rearfoot couplings using a modified vector coding technique.The loading rate of vertical ground reaction force was also calculated.A one-way MANOVA with repeated measures was performed on each of the outcome variables to examine the main effect of running mileage.Results:Significant effects of running mileage were found on segment CVs(p≤0.010)but not on loading rate(p=0.881).Notably,during the early stance phase,the CV of pelvis frontal thigh frontal was significantly increased at 20 km compared with the CV at 8 km(g=0.59,p=0.022).The CV of shank transverse vs.rearfoot frontal decreased from 2 km to 8 km(g=0.30,p=0.020)but then significantly increased at both 18 km(g=0.05,p<0.001)and 20 km(g=0.36,p<0.001).Conclusion:At the early stance,runners maintained stable CVs on the sagittal plane,which could explain the unchanged loading rate throughout the half marathon.However,increased CVs on the frontal/transverse plane may be an early sign of fatigue and indicative of possible injury risk.Further studies are necessary for conclusive statements in this regard. | Tony Lin-Wei Chen Duo Wai-Chi Wong Yan Wang Qitao Tan Wing-Kai Lam Ming Zhang | 2022 | Journal of Sport and Health Science2022，11，1： | 0 |
| 14 | Trends in yeast diversity discovery显示文摘Yeasts,usually defined as unicellular fungi,occur in various fungal lineages.Hence,they are not a taxonomic unit,but rather represent a fungal lifestyle shared by several unrelated lineages.Although the discovery of new yeast species occurs at an increasing speed,at the current rate it will likely take hundreds of years,if ever,before they will all be documented.Many parts of the earth,including many threatened habitats,remain unsampled for yeasts and many others are only superficially studied.Cold habitats,such as glaciers,are home to a specific community of cold-adapted yeasts,and,hence,there is some urgency to study such environments at locations where they might disappear soon due to anthropogenic climate change.The same is true for yeast communities in various natural forests that are impacted by deforestation and forest conversion.Many countries of the so-called Global South have not been sampled for yeasts,despite their economic promise.However,extensive research activity in Asia,especially China,has yielded many taxonomic novelties.Comparative genomics stud-ies have demonstrated the presence of yeast species with a hybrid origin,many of them isolated from clinical or industrial environments.DNA-metabarcoding studies have demonstrated the prevalence,and in some cases dominance,of yeast species in soils and marine waters worldwide,including some surprising distributions,such as the unexpected and likely common presence of Malassezia yeasts in marine habitats. | Teun Boekhout Anthony S.Amend Fouad El Baidouri Toni Gabaldón József Geml Moritz Mittelbach Vincent Robert Chen Shuhui Tan Benedetta Turchetti Duong Vu Qi-Ming Wang Andrey Yurkov | 2022 | Fungal Diversity2022，，3： | 0 |
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