| 1 | Acupuncture at Waiguan (TE5) influences activation/deactivation of functional brain areas in ischemic stroke patients and healthy people A functional MRI study显示文摘In the present study, 10 patients with ischemic stroke in the left hemisphere and six healthy controls were subjected to acupuncture at right Waiguan (TE5). In ischemic stroke subjects, functional MRI showed enhanced activation in Broadmann areas 5, 6, 7, 18, 19, 24, 32, the hypothalamic inferior lobe, the mamillary body, and the ventral posterolateral nucleus of the left hemisphere, and Broadmann areas 4, 6, 7, 18, 19 and 32 of the right hemisphere, but attenuated activation of Broadmann area 13, the hypothalamic inferior lobe, the posterior lobe of the tonsil of cerebellum, and the culmen of the anterior lobe of hypophysis, in the left hemisphere and Broadmann area 13 in the right hemisphere. In ischemic stroke subjects, a number of deactivated brain areas were enhanced, including Broadmann areas 6, 11, 20, 22, 37, and 47, the culmen of the anterior lobe of hypophysis, alae lingulae cerebella, and the posterior lobe of the tonsil of cerebellum of the left hemisphere, and Broadmann areas 8, 37, 45 and 47, the culmen of the anterior lobe of hypophysis, pars tuberalis adenohypophyseos, inferior border of lentiform nucleus, lateral globus pallidus, inferior temporal gyrus, and the parahippocampal gyrus of the right hemisphere. These subjects also exhibited attenuation of a number of deactivated brain areas, including Broadmann area 7. These data suggest that acupuncture at Waiguan specifically alters brain function in regions associated with sensation, vision, and motion in ischemic stroke patients. By contrast, in normal individuals, acupuncture at Waiguan generally activates brain areas associated with insomnia and other functions. | Junqi Chen Yong Huang Xinsheng Lai Chunzhi Tang Junjun Yang Hua Chen Tongjun Zeng Junxian Wu Shanshan Qu | 2013 | Neural Regeneration Research2013，8，3： | 8 |
| 2 | Activated and deactivated functional brain areas in the Deqi state: A functional MRI study显示文摘We compared the activities of functional regions of the brain in the Deqi versus non-Deqi state, as reported by physicians and subjects during acupuncture. Twelve healthy volunteers received sham and true needling at the Waiguan (TE5) acupoint. Real-time cerebral functional MRI showed that compared with non-sensation after sham needling, true needling activated Brodmann areas 3, 6, 8, 9, 10, 11, 13, 20, 21, 37, 39, 40, 43, and 47, the head of the caudate nucleus, the parahippocampal gyrus, thalamus and red nucleus. True needling also deactivated Brodmann areas 1, 2, 3, 4, 5, 6, 7, 9, 10, 18, 24, 31, 40 and 46. | Yong Huang Tongjun Zeng Guifeng Zhang Ganlong Li Na Lu Xinsheng Lai Yangjia Lu Jiarong Chen | 2012 | Neural Regeneration Research2012，7，30： | 4 |
| 3 | Specific cerebral activation following true and sham Waiguan(SJ 5) needling Functional magnetic resonance imaging evidence显示文摘Positive activation and negative activation of glucose metabolism can be detected in different brain regions under acupuncture conditions using functional magnetic resonance imaging(fMRI) which reveals acupoint function and location-acupoint specificity.This study observed the regional cerebral activation of the Waiguan(SJ 5) acupoint following true needling at the true Waiguan acupoint,sham needling at the true Waiguan acupoint and true needling at a sham point using fMRI.The fMRI results demonstrated that compared with sham needling,true needling at Waiguan activated the BA8 area and left cerebellum.Compared with needling at the sham point,needling at Waiguan activated the BA2 area,the left cerebellum and the right inferior semilunar lobule.Thus the activated brain areas caused by needling Waiguan may be the basis for treatment of certain diseases. | Yong Huang Xinsheng Lai Baoci Shan Chunzhi Tang Junjun Yang Tongjun Zeng Guifeng Zhang Jiarong Chen Yangjia Lu | 2010 | Neural Regeneration Research2010，5，22： | 3 |
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