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2篇 您的检索式:作者名="Tong Minhui"
    题名 作者 年代 出处 被引量
1Research on Contact Strength between Roller Screw Pair on Hoisting Mechanism Applied in Deep Sea Crane显示文摘Wang Hui Tong Minhui Zheng Pei 2013Applied Mechanics and Materials2013,,9:1
2Development and transdifferentiation into inner hair cells require Tbx2显示文摘Atohl is essential for the development of both outer hair cells(OHCs)and inner hair cells(IHCs)in the mammalian co chlea.Whereas Ikzf2 is necessary for OHC development,the key gene re quired for IHC development remains unknown.We found that deletion of Tbx2 in neonatal IHCs led to their transdifferentiation into OHCs by repressing 26.7%of IHC genes and inducing 56.3%of OHC genes,including Ikzf2.More importantly,persistent expression of Tbx2 coupled with transient Atohl expression effe ctively reprogrammed non-sensory supporting cells into new IHCs expressing the functional IHC marker vGlut3.The differentiation status of these new IHCs was considerably more advanced than that previously reported.Thus,Tbx2 is essential for IHC development and co-upregulation of Tbx2 with Atohl in supporting cells represents a new approach for treating deafness related to IHC degeneration.Zhenghong Bi Xiang Li Minhui Ren Yunpeng Gu Tong Zhu Shuting Li Guangqin Wang Suhong Sun Yuwei Sun Zhiyong Liu 2022National Science Review2022,9,12:1
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