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2篇 您的检索式：作者名="Tomislav Bulum"

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		题名	作者	年代	出处	被引量
	1	Incretin based therapies:A novel treatment approach for non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease is considered a hepatic manifestation of metabolic syndrome(MS).The current treatment of non-alcoholic fatty liver disease(NAFLD)principally includes amelioration of MS components by lifestyle modifications but the lack of success in their implementation and sustainment arises the need for effective pharmacological agent in fatty liver treatment.Incretins are gut derived hormones secreted into the circulation in response to nutrient ingestion that enhances glucose-stimulated insulin secretion.Glucagon-like peptide-1(GLP-1)is the most important incretin.Its receptor agonist and inhibitors of dipeptidyl peptidase-4(DPP-4)are used in treatment of type2 diabetes mellitus.DPP-4 serum activity and hepatic expression are shown to be elevated in several hepatic diseases.There are several experimental and clinical trials exploring the efficacy of incretin based therapies in NAFLD treatment.They suggest that GLP-1 analogues might have beneficial effect on hepatic steatosis acting as insulin sensitizers and directly by stimulating GLP-1 receptors expressed on hepatocytes.The use of DPP-4 inhibitors also results in hepatic fat reduction but the mechanism of action remains unclear.There is growing evidence that incretin based therapies have beneficial effects on hepatocytes,however further study analysis are needed to assess the long term effect of incretin based therapies on NAFLD.	Kristina Blaslov Tomislav Bulum Karin Zibar Lea Duvnjak	2014	World Journal of Gastroenterology2014，20，23：	10
	2	Effect of exenatide therapy on hepatic fat quantity and hepatic biomarkers in type 2 diabetic patients显示文摘	Kristina Blaslov Karin Zibar Tomislav Bulum Lea Duvnjak	2013	Clinics and Research in Hepatology and Gastroenterology2013，，：	1

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