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| 1 | Visual outcome after removal of silicone oil in patients undergoing retinectomy for complex retinal detachment显示文摘AIM:To evaluate the functional outcome after removal of silicone oil(ROSO)in patients undergoing retinectomy for complex retinal detachment.·METHODS:We performed a retrospective case note review of patients who underwent ROSO after retinectomy for complex retinal detachment.Patients with less than 6mo follow up and recurrent retinal detachment following ROSO were excluded.·RESULTS:Thirty-six patients were included.The mean best corrected visual acuity(BCVA)pre-ROSO was1.13 log MAR(SD 0.5).The mean BCVA 3mo following ROSO was 1.16 log MAR(SD 0.53),6mo following ROSO1.13(SD 0.63),and 12mo following ROSO 1.18(SD 0.69).At 12mo after ROSO,the BCVA improved in 38.9%of patients,remained unchanged in 25%,and deteriorated in 36.1%,although there was no statistical significant difference in BCVA after ROSO at 3,6 and 12mo(P=0.93).The size of retinectomy ranged from 15°to 270°(SD 53)and did not influence the visual outcome(P=0.11).·CONCLUSION:There was no statistically significant difference in BCVA between pre-and post-ROSO following retinectomy for complex retinal detachment.There was no statistical difference in visual outcome related to the size of the retinectomy. | Roger Wong Marco De Luca Manoharan Shunmugam Tom Williamson Alistair Laidlaw Valeria Vaccaro | 2016 | International Journal of Ophthalmology(English edition)2016，9，1： | 7 |
| 2 | Parameter-free optic disc detection显示文摘 | Cattleya Duanggate Bunyarit Uyyanonvara Stanislav S. Makhanov Sarah Barman Tom Williamson | 2010 | Computerized Medical Imaging and Graphics2010，，1： | 1 |
| 3 | Macular dis- placement following rhegmatogenous retinal detachment repair 显示文摘 | Edward Lee Tom H Williamson Pirro Hysi | 2013 | Br J Ophthalmol2013，97，10： | 1 |
| 4 | Suprachoroidal Hemorrhage in Pars Plana Vitrectomy显示文摘 | Aman Chandra Wen Xing Mustafa R. Kadhim Tom H. Williamson | 2013 | Ophthalmology2013，，： | 1 |
| 5 | High rate production of concentrated sulfides from metal bearing wastewater in an expanded bed hydrogenotrophic sulfate reducing bioreactor显示文摘Metallurgical wastewaters contain high concentrations of sulfate,up to 15 g L^(-1).Sulfate-reducing bioreactors are employed to treat these wastewaters,reducing sulfates to sulfides which subsequently coprecipitate metals.Sulfate loading and reduction rates are typically restricted by the total H2S concentration.Sulfide stripping,sulfide precipitation and dilution are the main strategies employed to minimize inhibition by H2S,but can be adversely compromised by suboptimal sulfate reduction,clogging and additional energy costs.Here,metallurgical wastewater was treated for over 250 days using two hydrogenotrophic granular activated carbon expanded bed bioreactors without additional removal of sulfides.H2S toxicity was minimized by operating at pH 8±0.15,resulting in an average sulfate removal of 7.08±0.08 g L^(-1),sulfide concentrations of 2.1±0.2 g L^(-1) and peaks up to 2.3±0.2 g L^(-1).A sulfate reduction rate of 20.6±0.9 g L^(-1)d^(-1) was achieved,with maxima up to 27.2 g L^(-1)d^(-1),which is among the highest reported considering a literature review of 39 studies.The rates reported here are 6e8 times higher than those reported for other reactors without active sulfide removal and the only reported for expanded bed sulfate-reducing bioreactors using H2.By increasing the influent sulfate concentration and maintaining high sulfide concentrations,sulfate reducers were promoted while fermenters and methanogens were suppressed.Industrial wastewater containing 4.4 g L^(-1) sulfate,0.036 g L^(-1) nitrate and various metals(As,Fe,Tl,Zn,Ni,Sb,Co and Cd)was successfully treated with all metal(loid)s,nitrates and sulfates removed below discharge limits. | Pieter Ostermeyer Josefien Van Landuyt Luiza Bonin Karel Folens Adam Williamson Tom Hennebel Korneel Rabaey | 2022 | Environmental Science and Ecotechnology2022，，3： | 0 |
| 6 | 急性下呼吸道感染的抗生素处方策略及用药说明——随机对照试验显示文摘背景:在初级医疗机构治疗的疾病中,急性下呼吸道感染最为常见。尽管有关抗生素应用的系统综述很少,且得出的结论各有不同,但仍有许多内科医生开处抗生素。
目的:评价急性下呼吸道感染的三种抗生素处方策略和一种用药说明的有效性。设计、地点及患者:于1998年8月18日至2003年7月30日进行随机对照试验,807例病人均因单纯急性下呼吸道感染而于初级保健机构就诊。按析因设计将病人分为6组:有用药说明书或无用药说明书与3个不同抗生素使用组(立即使用抗生素、不使用抗生素、延后使用抗生素)的任一组合。
干预:三种处方策略包括立即使用抗生素(n=262)、延后使用抗生素(n=272)与不使用抗生素(n=273)。每组大约一半病人给予用药说明书(立即使用抗生素组129例,延后使用抗生素组136例,不使用抗生素组140例)。
主要观测指标:症状持续时间及严重程度。
结果:总共562例(70%)病人交回了完整的日记,78例(10%)病人提供了症状持续时间及严重程度的信息。分级至少为“一个小问题”的咳嗽平均持续11.7天(25%的病人咳嗽持续≥17天)。用药说明书对主要结果没有影响。与不使用抗生素组相比,其他策略并未使咳嗽持续时间(延后使用抗生素组:0.75天;95%可信区间[CI],-0.37~1.88;立即使用抗生素组:0.11天;95%CI,-1.01~1.24)或其他主要结局发生改变。与立即使用抗生素组相比,延后使用抗生素组和对照组较少使用抗生素(分别为96%、20%和16%,P〈0.001),少数病人感到非常满意(分别为86%、77%和72%,P=0.005),少数病人相信抗生素的效果(分别是75%、40%和47%,P〈0.001)。使用抗生素组的病人1个月内复诊者较少(不使用抗生素组、延后使用抗生素组和立即使用抗生素组分别为0.19、0.12和0.11,P=0.04);有用药说明书的病人就诊较多(无用药说明书和有用药说明书者分别为0.11和0.17,P=0.02)。
结论:单纯急性下呼吸道感染者不用抗生素或延后使用抗生素是可以接受的,症状的消失在各组间差别很小,应明显减少抗生素的使用,消除对抗生素效果的迷信。 | Paul Little Kate Rumsby Joanne Kelly Louise Watson Michael Moore Gregory Warner Tom Fahey Lan Williamson 马凌云(译) 文仲光(校) | 2006 | 美国医学会杂志(中文版)2006，25，4： | 0 |
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