|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Comparison of the effects of bevacizumab and ranibizumab injection on corneal angiogenesis in an alkali burn induced model显示文摘·AIM:To investigate the effects of bevacizumab and ranibizumab on corneal neovascularization in an alkali burn-induced model of corneal angiogenesis. ·METHODS:Fifteen Wistar-Albino rats were divided randomly into 3 groups after chemical cauterization of the cornea. The first group received a single dose of 0.1mL saline solution as a control group whereas second and third groups received a single dose of 2.5mg bevacizumab or 1mg ranibizumab by subconjunctival injection, respectively. After three weeks, the rat corneas were evaluated by biomicroscopy and corneal photographs were taken. The percentage of neovascularization area, length of the longest new vessel, corneal oedema and corneal opacity scores were assessed. ·RESULTS:The analysis of digital photographs showed that the percentage of neovascularization area to the total corneal area, the length of the longest new vessel, corneal oedema and opacity scores were significantly lower in both study groups compared to the control group (P <0.05). Additionally, the percentage of corneal neovascularization area, the length of the longest new vessel and corneal opacity score were less with bevacizumab than ranibizumab. ·CONCLUSION:Subconjunctival bevacizumab and ranibizumab treatments may be effective methods in reducing corneal neovascularization. Furthermore, bevacizumab is more effective than ranibizumab in the inhibition of corneal neovascularization. | Ayhan Dursun Mustafa Kemal Arici Feyza Dursun Ayse Vural Ozec Mustafa Ilker Toker Haydar Erdogan Aysen Topalkara | 2012 | International Journal of Ophthalmology(English edition)2012，5，4： | 10 |
| 2 | 胸腺瘤微创切除术的基本原则和标准术语的定义显示文摘根治性手术切除是胸腺瘤的主要治疗手段,手术目的在于完整切除肿瘤及胸腺组织,并且进行彻底的探查排除可能存在的非连续但可切除的病灶。通常主张胸骨劈开的整块切除,R0切除是公认的关乎远期疗效的重要因素。近年随着胸腔镜技术的不断进步,微创手术在胸腺瘤手术中的应用受到了极大地关注,但存在许多值得注意的问题,如何保护膈神经?膈神经切除后是否需要行膈肌折叠术?如何在腔镜下判断是否有上腔静脉和肺静脉的浸润?在微创手术时若切缘很近是否更容易发生胸膜播散?如果一次面对的问题太多,很有可能让微创手术的适用范围又回到从前。如果术后出现不良的结果就更难继续去探索微创技术和如何避免这些问题。多数学者仍对微创手术的结果持谨慎态度,如何确保这些结果与标准开放性手术相当是值得重视的问题。尽管微创手术缩短了住院时间并减轻了患者的疼痛,但与开放手术相比微创手术的肿瘤学优势还没能很好地被报道[1]。只有时间能告诉我们这些微创技术和目前的标准治疗是否相当。虽然有经验的术者采用微创手术可以切除邻近的累及器官,然而在快速拓展微创手术之前必须首先通过直接案例小心评估微创手术的预后结果。普遍认为应避免微创手术切除膈神经和大血管。由于胸腺恶性肿瘤的低发病率特点和微创手术的稀少性特点亟需有共同标准的国际合作。为此国际胸腺肿瘤协作组织(International Thymic Malignancy Interest Group, ITMIG)先由有胸腺瘤微创切除术经验的医生组成初步工作组,在回顾了目前文献中针对胸腺瘤微创切除术的定义、术语和策略后提出了初步建议,由拓展工作组进一步完善后由ITMIG工作组中的更多不同背景的专家进行讨论,最终由ITMIG的成员一致通过。内容涉及胸腺瘤微创手术策略、手术方法的基本概念、基本原则和必须遵守的特定标准等定义。以便在前瞻性的数据库采用连续和系统的方式收集数据来更恰当地评估微创手术。使不同中心之间使用这项技术应用共同的语言,便于中心之间的合作和数据资源共享。 | 付浩 中国胸腺瘤协作组全体成员 Alper Toker Joshua Sonett Marcin Zielinski Federico Rea Victor Tomulescu Frank C.Detterbeck | 2014 | 中国肺癌杂志2014，17，2： | 3 |
| 3 | Total oxidative stress, paraoxonase and arylesterase levels at patients with pseudoexfoliation syndrome and pseudoexfoliative glaucoma显示文摘AIM: To investigate the oxidative stress status of the aqueous humor and serum of patients with pseudoexfoliation(PEX) syndrome and pseudoexfoliative glaucoma(PEG) and to measure paraoxonase(PON) and arylesterase(ARE) levels.·METHODS: A total of 78 patients were enrolled in the study, with 26 patients in each separate group. The patients were divided into three groups: the first group entailed PEX syndrome patients, while the second group consisted of patients with PEG and the third group involved patients with no additional systemic diseases,other than the diagnosis of cataract as control. Total oxidative stress(TOS), total antioxidant capacity(TAC),PON, and ARE levels in aqueous humor and serum were measured.·RESULTS: TAC, PON and arylesterase levels in aqueous humor and serum of the PEX syndrome and PEG patients were significantly decreased compared with control group(P <0.05). TOS values were higher in patients with PEX syndrome and PEG than controls(P <0.05). TAC, PON and ARE levels of aqueous humor did not differ significantly between the PEX syndrome and PEG groups·CONCLUSION: These findings are potentially of significance and add to the growing body of evidence for oxidative stress in PEX syndrome and PEG. Decreased antioxidant defense and increased oxidative stress system may play an important role in the pathogenesis of PEX syndrome and PEG. | Feyza Dursun Ayse Vural Ozec Huseyin Aydin Aysen Topalkara Ayhan Dursun Mustafa Ilker Toker Haydar Erdogan Mustafa Kemal Arici | 2015 | International Journal of Ophthalmology(English edition)2015，8，5： | 2 |
| 4 | N2 disease in non-small cell lung cancer patients,diagnosis and evaluation:a Turkish chest surgeon s perspective显示文摘Mediastinal or N2 disease is the most important factor in selecting the optimal treatment strategy in patients without distant metastasis.A direct surgical resection has not generally been accepted as a treatment modality in whom mediastinal nodal involvement is demonstrated.Patients with lung cancer can be diagnosed as clinical N2 disease based on CT and PET-CT characteristics of the mediastinum and the clinical presentation.Invasive diagnostic modalities used in the detection of N2 disease are:mediastinoscopy,endoesophageal ultrasound guided biopsy(EUS),transbronchial needle aspiration(TBNA),endobronchial ultrasound guided biopsy(EBUS),video-assisted thoracoscopic surgery(VATS),and mediastinotomy/extended mediastinoscopy.In this article,the author discusses about invasive and noninvasive techniques on the evaluation of mediastinal disease and presents his experience on this topic. | Alper TOKER | 2008 | 中国肺癌杂志2008，11，5： | 2 |
| 5 | Equilibrium phase relations and thermodynamics of the Cr - O system in the temperature range of 1500℃ to 1825℃ 显示文摘 | Toker N Y Darken L S Muan A | 1991 | Metal and Mater Trans1991，22，22： | 1 |
| 6 | The Prevalence of Demodex folliculorum in blepharitis patients and the normal population显示文摘 | Kemal M Sumer Z Toker M I | 2005 | Ophthalmic Epidemiol2005，12，4： | 1 |
| 7 | An in vitro per- spective to cholinesterase inhibitory and antioxidant activi- ty of five Gentiana species and Gentianella caucasea 显示文摘 | Senol FS Tuzun CY Toker G | 2012 | Int J Food Sci Nutr2012，63，7： | 1 |
| 8 | Multihoming and compatibility显示文摘 | Julian Wright | 2006 | International Journal of Industrial Organization2006，24，1： | 1 |
| 9 | Effect of frequent-replace- ment contact lenses on normal conjunetival flora显示文摘 | Erdogan H Kemal M Toker MI | 2002 | CLAO J2002，28，2： | 1 |
| 10 | Analysis of Chest Injuries Sustained During the 1999 Marmara Earthquake显示文摘 | Alper Toker Turgut Isitmangil Oryal Erdik ?rfan Sancakli Saban Sebit | 2002 | Surgery Today2002，，9： | 1 |
| 11 | Effect of latanoprost/timolol and dorzolamide/tiomolol on intraocular pressure after phacoemulsification surgery显示文摘·AIM:To evalaute the effect of fixed-combination latanoprost 0.005%/timolol maleate 0.5% and dorzolamide hydrochloride 2%/timolol maleate 0.5% on postoperative intraocular pressure after phacoemulsification cataract surgery.·METHODS:This study is a prospective,randomized,double-masked and placebo-controlled.The study included 90 eyes of 90 patients which were scheduled to have phacoemulsification surgery.Patients were randomly assigned preoperatively to 1 of 3 groups (30 eyes of 30 patients).Two hour before surgery,the patients received one drop latanoprost/timolol (group 1),dorzolamide/timolol (group 2) and placebo (group 3,control group).The IOPs were measured at preoperative and postoperative 4,8,and 24 hours.·RESULTS:The preoperative mean intraocular pressure was not statistically significant between both drug groups and control group.In group 1 and 2,the postoperative mean IOP [group1:(14.03?à3.15)mmHg and group 2:(14.16?à4.43)mmHg] at 24 hours were significantly lower than the control group [(16.93?à3.70)mmHg,(P <0.05)].In addition,the postoperative mean IOP of group 1 [(14.90±3.69)mmHg] at 8 hours was significantly lower than the control group [(17.70?à3.89)mmHg,(P <0.05)],but there was no significant difference between group 2 [(16.16?à5.23)mmHg] and control group at 8 hours (P >0.05).·CONCLUSION:When compared with placebo,the use of preoperative fixed combination of latanoprost/timolol and dorzolamide/timolol is an effective method for preventing intraocular pressure elevation in 24 hours after phacoemulsification surgery,but did not completely prevent IOP spikes.· | Haydar Erdogan Ayse Vural Ozec Cengiz Caner Mustafa Ilker Toker Mustafa Kemal Arici Aysen Topalkara | 2011 | International Journal of Ophthalmology(English edition)2011，4，2： | 1 |
| 12 | Trabecular carcinoma of the skin显示文摘 | Toker C | 1972 | Arch Dermatol1972，105，1： | 1 |
| 13 | Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)显示文摘 | Dutil EM Toker A Newton AC | 1998 | Curr Biol1998，8，25： | 1 |
| 14 | Refractive errors of medical students in Turkey:one year follow-up of refraction and biometry显示文摘 | Onal S Toker E Akingol Z | 2007 | Optom Vis Sci2007，84，3： | 1 |
| 15 | Deep vein thrombosis prophylaxis in trauma patients显示文摘 | Toker S Hak DJ Morgan SJ | 2011 | Thrombosis2011，15，： | 1 |
| 16 | Effect of pretreatment with artichoke extract on carbon tetrachloride-induced liver injury and oxidative stress显示文摘 | Mehmetcik G Ozdemirler G Kocak Toker N | 2008 | Experimental and Toxicologic Pathology2008，60，： | 1 |
| 17 | Gingival recession: epidemio- logy and risk indicators in a university dental hospital in Turkey显示文摘 | Toker H Ozdemir H | 2009 | Int J Dent Hyg2009，7，2： | 1 |
| 18 | Trabeculen carcinoma of the skin显示文摘 | | 1972 | ArchDermatol1972，105，： | 1 |
| 19 | Second and third cardiac valve reoperations: factors influencing death and long-term survival显示文摘 | Toker ME Eren E Guler M | 2009 | Tex Heart Inst J2009，36，6： | 1 |
| 20 | Supplementary all-pass sections with reduced number of passive elements using a single current conveyor 显示文摘 | TOKER A OZCAN S KUNTMAN | 2001 | International Journal of Electronics2001，88，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员