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14篇 您的检索式：作者名="To CS"

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		题名	作者	年代	出处	被引量
	1	MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside显示文摘MicroRNAs(miRNAs) are small, single-stranded, noncoding RNAs that can post-transcriptionally regulate the expression of various oncogenes and tumor suppressor genes. Dysregulated expression of many miRNAs have been shown to mediate the signaling pathways critical in the multistep carcinogenesis of colorectal cancer(CRC). MiR NAs are stable and protected from RNase-mediated degradation, thereby enabling its detection in biological fluids and archival tissues for biomarker studies. This review focuses on the role and application of miRNAs in the prognosis and therapy of CRC. While stage Ⅱ CRC is potentially curable by surgical resection, a significant percentage of stage Ⅱ CRC patients do develop recurrence. MiRNA biomarkers may be used to stratify such high-risk population for adjuvant chemotherapy to provide better prognoses. Growing evidence also suggests that miRNAs are involved in the metastatic process of CRC. Certain of these miRNAs may thus be used as prognostic biomarkers to identify patients more likely to have micro-metastasis, who could be monitored more closely after surgery and/or given more aggressive adjuvant chemotherapy. Intrinsic and acquired resistance to chemotherapy severely hinders successful chemotherapy in CRC treatment. Predictive miRNA biomarkers for response to chemotherapy may identify patients who will benefit the most from a particular regimen and also spare the patients from unnecessary side effects. Selection of patients to receive the new targeted therapy is becoming possible with the use of predictive miRNA biomarkers. Lastly, forced expression of tumor suppressor miRNA or silencing of oncogenic miRNA in tumors by gene therapy can also be adopted to treat CRC alone or in combination with other chemotherapeutic drugs.	Kenneth KW To Christy WS Tong Mingxia Wu William CS Cho	2018	World Journal of Gastroenterology2018，24，27：	29
	2	A meta-analysis显示文摘	De Kieviet JF Piek JP Aarnoudse-Moens CS :Motor development in very preterm and very low-birth-weight children from birth to adolescence	2009	JAMA2009，302，：	1
	3	A novel coronavirus associated with severe acute respiratory syndrome显示文摘	Ksinzek TO Erdman D Goldsmith CS	2003	N Engl J Med2003，348，20：	1
	4	P rogressive agerelated changes in pulmonary tuberculo-sis images and the effectof diabetes显示文摘	Perea GC To rres CS Villarreal VH	2000	Am J Res CritMed2000，162，：	1
	5	Causes of death in HIV patients and the evolution of an AIDS hospice: 1988-2008 显示文摘	Stewart A Chan CS To K etal	2012	AIDSResTreat2012，，：	1
	6	Simulation of a functional neuromuscular stimulation powered mechanical gait orthosis with coordinated joint locking显示文摘	To CS Kirsch RF Kobetic R	2005	IEEE Trans Neural Syst Rehabil Eng2005，13，2：	1
	7	Simulation of a functional neuromuscular stimulation powered mechanical gait orthosis with coordinated joint locking 显示文摘	To CS Kitsch RF Kobetic R	2005	IEEE Trans Neural Syst Rehabil Eng2005，13，2：	1
	8	The National Cancer Centre/Singapore General Hospital experience 显示文摘	Teh CS Ooi LL Hepatic resection for colorectal metastases to the liver	2003	Ann Acad Med Singapore2003，32，2：	1
	9	Systematic evaluation of er- rors occurring during the preparation of intravenous medication 显示文摘	Parshuram CS To T Seto W	2008	CMAJ2008，178，1：	1
	10	' Design and technology teacher's struggle to implement creativity and performativity po]icies 显示文摘	Bill Nicholl P~os McLellan 'We're all in this game whether we like it or not to a number of As to Cs	2008	British Education P~esearch Fournal2008，，5：	1
	11	Fluid transport across the isolated porcine ciliary epithelium 显示文摘	Candia OA To CH Law CS	2007	Invest Ophthalmol Vis Sci2007，48，1：	1
	12	Causes of death in HIV pa- tients and the evolution of an AIDS hospice 1988 2008 显示文摘	Stewart A Chan CS To K	2012	AIDS Res Treat2012，，：	1
	13	Group Ⅰ:Choosing the appropriate method of placement of an enteral feeding tube in the high- risk population显示文摘	Lipman TO Cass Ow Ho CS	1997	Nutrtion Clin Pract1997，，：	1
	14	Simulation of a functional neuromuscular stimulation powered mechanical gait orthosis with coordinated joint locking显示文摘	To CS Kirsch RF Kobetic R	2005	Trans Neural Syst Rehabil Eng2005，13，2：	1

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